npj Flexible Electronics
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2022
·Vol. 6
·期 1
·1-8
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IF 12.019
Lin Sen,Hu Shuang,Song Wei,Gu Miaoqing,Liu Junchen,Song Jianan,Liu Zhenglian,Li Ziwei,Huang Kun,Wu Yufeng,Lei Ming,Wu Hui
New-generation human body motion sensors for wearable electronics and intelligent medicine are required to comply with stringent requirements in terms of ultralight weight, flexibility, stability, biocompatibility, and extreme precision. However, conventional sensors are hard to fulfill all these criteria due to their rigid structure, high-density sensing materials used as the constituents, as well as hermetical and compact assembly strategy. Here, we report an ultralight sensing material based on radial anisotropic porous silver fiber (RAPSF), which has been manufactured by phase separation and temperature-controlled grain growth strategy on a modified blow-spinning system. The resistance of RAPSF could be dynamically adjusted depending on the deflected shape. Furthermore, an all-fiber motion sensor (AFMS) with an ultra-low density of 68.70 mg cm −3 and an overall weigh of 7.95 mg was fabricated via layer-by-layer assembly. The sensor exhibited outstanding flexibility, breathability, biocompatibility, and remarkable body motion recognition ability. Moreover, the AFMS was shown to have great potential as an artificial intelligence throat sensor for throat state identification at the accuracy above 85%, allowing one to spot the early onset of the viral throat illness.
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Journal of Energy Storage
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2022
·
IF 8.907
Jing Li,Yongjin Zou,Lei Jin,Fen Xu,Lixian Sun,Cuili Xiang
In this study, we modified graphene sheets with polydopamine, used abundant oxygen-containing groups to adsorb metal ions in a hydrothermal process, and obtained graphene-supported NiMoO 4 nanorod composite materials after pyrolysis . NiMoO 4 nanorods were uniformly dispersed on the surface of a reduced graphene oxide layer under strong electrostatic adsorption. The specific capacitance of the composite material measured at a current density of 1 A g −1 was 856 F g −1 (514 C g −1 ), and an asymmetric supercapacitor composed of activated carbon exhibited an energy density of 48 Wh kg −1 at a power density of 800 W kg −1 . After 5000 cycles of charging and discharging, a capacitance retention rate of 73% was achieved. Therefore, PDA-rGO@NiMoO 4 composite materials are promising candidate materials for supercapacitor electrodes.
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Nano-Micro Letters
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2022
·Vol. 14
·期 1
·1-13
·
IF 23.655
Jiang Meifang,Mu Pengzhou,Zhang Huanrui,Dong Tiantian,Tang Ben,Qiu Huayu,Chen Zhou,Cui Guanglei
The double-network binder shows excellent adhesive and self-healing abilities, which help suppress electrode volume expansion and stabilize the electrode interface upon cycling.
This binder induces a Li 3 N/LiF-rich solid electrolyte interface layer, which can suppress continuous electrolyte decomposition.
Superior electrochemical performance can be achieved in Si/Li half cells and LiNi 0.8 Co 0.1 Mn 0.1 O 2 /Si full cells, even with a high loading of Si electrode.
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Acta Pharmaceutica Sinica B
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2022
·
IF 14.903
Yunting Zhang,Min Jiang,Guangsheng Du,Xiaofang Zhong,Chunting He,Ming Qin,Yingying Hou,Rong Liu,Xun Sun
The rise of nanotechnology has opened new horizons for cancer immunotherapy. However, most nanovaccines fabricated with nanomaterials suffer from carrier-related concerns, including low drug loading capacity, unpredictable metabolism, and potential systemic toxicity, which bring obstacles for their clinical translation. Herein, we developed an antigen self-assembled nanovaccine, which was resulted from a simple acryloyl modification of the antigen to induce self-assembly. Furthermore, a dendritic cell targeting head mannose monomer and a mevalonate pathway inhibitor zoledronic acid (Zol) were integrated or absorbed onto the nanoparticles (denoted as MEAO-Z) to intensify the immune response. The synthesized nanovaccine with a diameter of around 70 nm showed successful lymph node transportation, high dendritic cell internalization, promoted costimulatory molecule expression, and preferable antigen cross-presentation. In virtue of the above superiorities, MEAO-Z induced remarkably higher titers of serum antibody, stronger cytotoxic T lymphocyte immune responses and IFN- γ secretion than free antigen and adjuvants. In vivo , MEAO-Z significantly suppressed EG7-OVA tumor growth and prolonged the survival time of tumor-bearing mice. These results indicated the translation promise of our self-assembled nanovaccine for immune potentiation and cancer immunotherapy.
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MOLECULAR THERAPY
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2022
·
IF 12.91
Hua-Hua Liu,Yang Xu,Cao-Jie Li,Shu-Jung Hsu,Xia-Hui Lin,Rui Zhang,Jie Chen,Jun Chen,Dong-Mei Gao,Jie-Feng Cui,Xin-Rong Yang,Zheng-Gang Ren,Rong-Xin Chen
Matrix stiffness promotes hepatocellular carcinoma (HCC) metastasis. This study examined the contribution of lipid metabolic reprogramming to matrix stiffness-induced HCC metastasis. HCC cells were cultured on mechanically tunable polyacrylamide gels and subjected to lipidomic analysis. The key enzyme that responded to matrix stiffness and regulated lipid metabolism was identified. The comparative lipidomic screening revealed that stearoyl-CoA desaturase 1 (SCD1) is a mechanoresponsive enzyme that reprogrammed HCC cell lipid metabolism. The genetic and pharmacological inhibition of SCD1 expression/activity altered the cellular lipid composition, which in turn impaired plasma membrane fluidity and inhibited in vitro invasive motility of HCC cells in response to high matrix stiffness. Knockdown of SCD1 suppressed HCC invasion and metastasis in vivo . Conversely, the overexpression of SCD1 or exogenous administration of its product oleic acid augmented plasma membrane fluidity and rescued in vitro invasive migration in HCC cells cultured on soft substrates, mimicking the effects imposed by high matrix stiffness. In human HCC tissues, collagen content, a marker of increasing matrix stiffness, and increased expression of SCD1 together predicted poor survival of HCC patients. An SCD1-dependent mechanoresponsive pathway that responds to increasing matrix stiffness in the tumor microenvironment promotes HCC invasion and metastasis through lipid metabolic reprogramming.
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MOLECULAR PHARMACEUTICS
·
2022
·
IF 5.364
Xiaozhu Chen,Hong Zhang,Chu Wang,Yue Su,Min Xiong,Xiaohua Feng,Daishi Chen,Zhaoyang Ke,Lu Wen,Gang Chen
Overexpression of apoptotic factors in the inner ear is generally proven to induce ototoxicity. This has aroused research interest in various antiapoptotic drugs, the most representative of which is curcumin (CUR). In this study, two nanoformulations of CUR were developed with sustained-release behavior to improve their protective effects against ototoxic hearing loss (HL), which were the nanoparticles of CUR-loaded poly(lactic acid–glycolic acid) (CUR-PLGA NPs) and CUR-loaded chitosan-coated PLGA NPs (CUR-CS/PLGA NPs). The obtained results revealed that both CUR-NPs provided otoprotection in vitro and in vivo, and their effective doses in guinea pigs were much less than that of dexamethasone, which was clinically used to treat HL. Moreover, relative to CUR and CUR-PLGA NPs, CUR-CS/PLGA NPs exhibited the highest accumulation in HEI-OC1 cells and guinea pigs’ cochlea. In pharmacodynamic experiments, the optimal administration timing was investigated, and CUR-CS/PLGA NPs showed sustained efficacy and the best hearing improvement at all tested sound frequencies. Lastly, the protective effect of CUR nanoformulations was further validated via inhibition of Caspase-3 and Bax activation, thereby reducing the concentration of reactive oxygen species and protecting mitochondrial integrity in hair cells. Collectively, CUR-CS/PLGA NPs demonstrated potent and lasting effects against ototoxic HL, making our novel formulation a promising candidate for the alleviation of sensorineural HL.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
An Jing,Tang Shanliang,Hong Gaobo,Chen Wenlong,Chen Miaomiao,Song Jitao,Li Zhiliang,Peng Xiaojun,Song Fengling,Zheng Wen-Heng
The most common working mechanism of photodynamic therapy is based on high-toxicity singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on oxygen consumption. Recently, Type I photodynamic therapy has been found to have better hypoxia tolerance to ease this restriction. However, few strategies are available on the design of Type I photosensitizers. We herein report an unexpected strategy to alleviate the limitation of traditional photodynamic therapy by biotinylation of three photosensitizers (two fluorescein-based photosensitizers and the commercially available Protoporphyrin). The three biotiylated photosensitizers named as compound 1 , 2 and 3 , exhibit impressive ability in generating both superoxide anion radicals and singlet oxygen. Moreover, compound 1 can be activated upon low-power white light irradiation with stronger ability of anion radicals generation than the other two. The excellent combinational Type I / Type II photodynamic therapy performance has been demonstrated with the photosensitizers 1 . This work presents a universal protocol to provide tumor-targeting ability and enhance or trigger the generation of anion radicals by biotinylation of Type II photosensitizers against tumor hypoxia.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
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IF 4.326
Haoxiang Zhu,Youdi Zhang,Xusheng Guo,Youwei Cheng,Lijun Wang,Xi Li
5-Hydroxymethylfurfural (HMF) is a high-value biomass-derived platform chemical derived from renewable biomass, which is a great alternative to petroleum-based chemicals; however, it cannot be produced on a large scale at present because of the limitation of a low HMF yield and costly production. In this work, an experimental study of one-pot production of HMF from glucose in an acetone–water solvent was conducted. The effects of inorganic salts (in specific, NaCl) on miscible solvents were studied because inorganic salts could affect the phase structure of solvents. We also study the influence of the ratio between Lewis acid and Brønsted acid (L/B) on the dehydration reaction. After parameter optimization experiments, up to 64.5% HMF yield was obtained at the condition of C0 = 1.25 w/v %, CAlCl3 = 1.25 w/v %, CHCl = 10 mmol·L–1, T = 160 °C, and o/a = 80/20, and the optimized L/B was 1.25 kg·mol–1. Finally, an economic and efficient HMF production process including HMF purification and catalyst recycling was proposed; the HMF product could be produced and separated with high recovery (∼88%) and purity (∼85%) in the process. Our findings and analysis would provide support for the choice of the reaction system and bifunctional catalyst synthesis in the subsequent industrial demonstration development.
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ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Xiuxiu Zou,Chen Huang,Ting Wu,Kuizhong Shen,Yan Lin,Yiqiang Wu,Yonghao Ni,Guigan Fang
Cellulosic fiber (CF) has gained extensive attention as the flexible and supporting substrate of silver nanowires (AgNWs) due to its excellent mechanical properties and high specific surface area. However, its susceptibility to corrosion and abrasion still remains a limiting factor for widespread adoption in flexible electronic devices. Herein, we report a lignin-abundant cellulosic fiber (LCF)/AgNW conductive paper synthesized through a sample self-assembly method. Benefiting from the strong chemical/physical properties of the presence of lignin in the LCF, the LCF/AgNW paper was proved to possess enhanced stability to various chemical corrosions and excellent conductive reliability and reusability during mechanical abrasions (i.e., bending and friction). Importantly, the LCF/AgNW paper exhibited a high conductivity of 4561.88 S/cm at the laden AgNWs of 18.57 wt %, much higher than that of the CF/AgNW paper and other reported biomass-based conductive papers. Moreover, the LCF/AgNW paper also showed superior thermal management performances, possessing sensitive temperature driving capacity and rapid heat dispersive capacity. These efforts could provide a facile and feasible route for the design of next-generation heat dissipation components for flexible smart devices.
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BIOSENSORS & BIOELECTRONICS
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2022
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IF 12.545
Yibo Yan,Long Jiang,Song Zhang,Xiantao Shen,Chuixiu Huang
Development of a specific “light-up” sensor for detection of psychoactive drug has been a great challenge in forensic analysis. To achieve this goal, an aggregation induced emission (AIE) functional monomer containing both phenylboronic group and double bond was synthesized for construction of molecularly imprinted polymers (MIPs) based fluorescent sensor. In this AIE-MIP sensor, the AIE fluorophore could vibrate freely in the absence of the target analyte (cathinone, CAT), while this vibration was restricted after the specific molecular recognition , leading to “light-up” character of the corresponding sensor. FT-IR and LC-MS characterizations proved the AIE monomer was successfully introduced onto AIE-MIPs. SEM analysis indicated the AIE-MIPs was ∼140 nm in diameter. Binding experiments indicated the AIE-MIPs owned high specificity towards CAT. Fluorescent studies confirmed that the “light-up” capability of the AIE-MIPs was highly selective. On this basis, the AIE-MIP sensor was applied in detecting CAT in forensic samples. The sensor reached a detection limit of 0.32 μmol L -1 and exhibited a linear range of 2–12 μmol L -1 . Compared to previously reported MIPs based electrochemical sensors and fluorescent sensors for measurement of CAT drug and its analogue, the present AIE-MIP sensor showed much higher sensitivity. To the best of our knowledge, this is the first time that an AIE functional monomer was synthesized for molecular imprinting , and also the first “light-up” AIE-MIP sensor to be reported. We believe that this versatile design of the specific “light-up” sensor can be used as a general protocol for construction of advanced sensor in various fields.
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ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 21
·2112645
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IF 19.924
Maogen Zhu,Zhechen Fan,Kangli Xu,Yuting Fang,Wei Sun,Yongchun Zhu
Lithium-metal batteries show great promise as the next generation rechargeable batteries with high theoretical energy density. Unfortunately, Li metal anodes suffer from serious corrosion of the electrolyte and by-products shuttled from cathode during cycling, such as O 2 in Li-O 2 batteries. Here, an oxygen-resistant and self-eliminating passivated layer is fabricated through a Wurtz-type reaction between Li metal and dichlorodimethylsilane (DCDMS). This passivated layer guarantees Li metal great stability with O 2 and inhibits the dendritic growth by eliminating the unpredictable fresh Li dendrites in their infancy stage. In addition, this passivated layer is constructed of LiCl and Poly(dimethylsilylene) phases, which provide good Li + transport, self-eliminate the undesirable by-products. The symmetric battery with this protective layer can achieve a stable Li plating/stripping with 500 h at O 2 atmosphere. Consequently, the Li-O 2 battery can maintain a stable cycling with more than 200 times and the Li||NCM811 battery presents excellent cycling performance (300 cycles at 0.5 C) and rate capacity (130.3 mA h g −1 at 5 C). This work provides both material and method breakthroughs for the development of electrode protection, which promotes the practical application of silanes and its ramification in alkali metal batteries.
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Catalysts
·
2022
·Vol. 12
·期 1
·83
·
IF 4.501
Cuiping Yu,Weilong Wu,Min Gao,Yu Liu
Asymmetric catalysis is the preferred method for the synthesis of pure chiral molecules in the fine chemical industry. Cellulose has long been sought as a support in enantioselective catalysis. Dialdehyde cellulose (DAC) is produced by the selective oxidation of cellulose and is used to bind 5,5′-diamino Binap by forming a Schiff base. Here, we report the synthesis of modified cellulose-supported Rh as a novel biomass-supported catalyst and the characterization of its morphology, composition, and thermal stability. DAC-BINAP-Rh was a very effective catalyst in the asymmetric hydrogenation of enamides and could be easily recycled. This work provides a novel supported catalyst that broadens the applications of cellulose in asymmetric catalysis.Keywords:asymmetric hydrogenation;cellulose;BINAP;heterogeneous catalysis
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