JOURNAL OF MATERIALS SCIENCE
·
2015
·Vol. 50
·期 9
·3399-3408
·
IF 2.371
Gao Yongju,Zhao Songfang,Zhang Guoping,Deng Libo,Li Jinhui,Sun Rong,Li Liyi,Wong Ching-Ping
Hierarchically porous organosilica microspheres have been facilely synthesized by improved self-assembly of flexible-bridged organosilica precursor without templates and harsh conditions. Subsequently, monodispersed silver nanoparticles (Ag NPs) are in situ grown on the porous microspheres via silver mirror reaction.
The as-prepared hybrid composites of Ag supported on porous microspheres are characterized by scanning electron microscopy, energy-dispersive spectroscopy, transmission electron microscopy, X-ray diffraction, thermal gravimetric analysis and nitrogen adsorption and desorption, respectively. These results indicate that not only Ag NPs (20–40 nm) are grown on the organosilica uniformly but also the content of Ag NPs immobilized in the hybrid materials can be well controlled by simply tuning the amount of the Ag(NH 3 ) 2 OH. The resultant hybrid microspheres exhibit remarkable and durable performances for the reduction of 4-nitrophenol to 4-aminophenol by NaBH 4 in aqueous solution. Moreover, the catalytic kinetic mode can be tuned by adjusting the parameter in catalytic reaction, and it can be recycled for seven successive cycles with excellent conversion of 100 % within 8 min. Therefore, the present structure design and scalable route for the synthesis of hierarchical catalyst can provide a highly efficient solution for the reduction of nitro-aromatic compounds in the view of environmentally friendly strategy.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2015
·Vol. 17
·期 12
·1-15
·
IF 2.184
Qin Zhiguo,Zhang Jie,Chi Huibo,Cao Feng
Abstract This study was mainly aimed to evaluate the potential use of a novel ocular drug delivery system, organic–inorganic hybrid nanocomposites based on chitosan derivatives and layered double hydroxides (LDH). Organic polymers of chitosan–glutathione (CG) and pre-activated chitosan–glutathione (CG-2MNA) were successfully synthesized and characterized. LDH with intercalated phacolysin (PCL), including larger hexagonal LDH–PCL (Lh-LDH–PCL), larger spherical LDH–PCL (Ls-LDH–PCL), smaller hexagonal LDH–PCL (Sh-LDH–PCL), CG hybrid LDH–PCL (LDH–PCL-CG), and CG-2MNA hybrid LDH–PCL (LDH–PCL-CG-2MNA), were prepared. The nanocomposites with particle size of 107.2–274.9 nm were characterized by powder X-ray diffraction, Fourier transform infrared, transmission electron micrographs, etc. In vivo precorneal retention studies showed that the detectable time of all nanocomposites was prolonged from 2 to 6 h in comparison to PCL saline. Accordingly, the AUC 0–6h values of Lh-LDH–PCL, Ls-LDH–PCL, Sh-LDH–PCL, LDH–PCL-CG, and LDH–PCL-CG-2MNA nanocomposites were increased by 2.27-, 2.08-, 3.08-, 4.67-, and 3.36-fold, respectively. The Draize test and hematoxylin and eosin staining demonstrated that modified LDH had no eye irritation after single and repeated administration. These results indicated that chitosan derivatives-LDH hybrid nanocomposite dispersion could be a promising ocular drug delivery system to improve precorneal retention time of drugs. Graphical Abstract Thiolated chitosan-LDH hybrid nanocomposite dispersion could be a promising ocular drug delivery system to improve precorneal retention time of drugs and may facilitate penetration of drugs into tissues of the eyes.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2015
·Vol. 50
·期 19
·6339-6348
·
IF 2.371
He Beibei,Zhao Qingguo,Zeng Zhigang,Wang Xiaohong,Han Sheng
Au@CeO 2 core–shell nanostructure catalysts were synthesized by hydrothermal reaction method. The effect of hydrothermal reaction time and calcination temperature on the textural and morphological characteristics of the catalyst was investigated by TEM, SEM, XRD, XPS, ICP, UV–Vis, and N 2 adsorption–desorption techniques. The results proved that gold core and CeO 2 shell formed simultaneously at the beginning of the reaction. By extending the hydrothermal reaction time, both the grain size of Au core and CeO 2 shell increased. The crystallization degree of CeO 2 and the interaction between Au and CeO 2 were also enhanced. The 90 % CO conversion temperature (T 90 % ) of Au@CeO 2 declined from 187 to 142 °C with the hydrothermal reaction time extended from 6 to 20 h. After 70-h reaction, the catalytic activity was still maintained without any loss. The effect of the calcination temperature on the catalytic performance was also investigated and it turned out that high calcination temperature has a positive influence on the catalytic activity. The likely active sites are the interface between Au core and CeO 2 shell. Gold content, metal–support interaction (MSI), and oxygen vacancy are all related to the activity. The excellent performance of 20 h-600 °C-Au@CeO 2 in catalytic activity and stability results from the joint effects of these triple factors.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2015
·Vol. 75
·期 1
·25-30
·
IF 1.532
Chen Jin,Chen Qinmiao,Ni Yi,Yamaguchi Yoshinori,Wang Tingting,Jia Zhen,Dou Xiaoming,Zhuang Songlin
Abstract
In the present work, Cu 2 ZnSnS 4 (CZTS) nanoparticles (NPs) for use in low-cost thin film solar cells were successfully synthesized using a facile open-air solution route. Copper(II) chloride dihydrate, zinc(II) acetate dihydrate, tin(II) chloride, and thiourea were used as reagents, and oleylamine was employed as solvent. The effect of varying the Zn content in the precursor solution on the structural, morphological, compositional, and optical properties of the as-synthesized CZTS NPs was investigated via X-ray diffraction, scanning electron microscopy and transmission electron microscopy, energy dispersive X-ray spectroscopy and ultraviolet–visible–infrared spectroscopy, respectively. As observed, the properties of the as-synthesized NPs improved with increasing Zn precursor contents from 0.75 to 1.5 mmol. For instance, the crystallinity of the as-synthesized NPs improved gradually and the band gap energy was tuned from 1.28 to 1.41 eV. The Zn/Sn ratio increased from 0.51 to 0.86, whereas the Cu/(Zn + Sn) ratio decreased from 0.95 to 0.7 with increasing Zn precursor contents. The results indicated that the obtained CZTS NPs, prepared with a Zn precursor content of 1.5 mmol, are a good light-absorbing layer material for application in thin film solar cells. Graphical Abstract
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CELL BIOCHEMISTRY AND BIOPHYSICS
·
2014
·Vol. 71
·期 2
·945-950
·
IF 2.38
Chen Qing-quan,Han Xuesong,Wang Wan-ming,Zhao Liangyu,Chen Aimin
Danggui Sini decoction (DSD), a famous Chinese medicine, has been used therapeutically in various diseases. In this study, we tried to investigate whether and how DSD could ameliorate myelosuppression in an animal model, in which myelosuppression is induced by cyclophosphamide treatment. The myelosuppression model was established by intraperitoneal injection of 100 mg/kg cyclophosphamide in mice. Flow cytometry was used to assess cell numbers and evaluate the bone marrow cell cycle distribution. Spleen samples were collected, and the mRNA expression levels of thrombopoietin (TPO) and c - Mpl were analyzed by RT-PCR. Our results demonstrated that DSD could significantly elevate the level of bone marrow hematopoietic stem progenitor cells in myelosuppression mice model. DSD also accelerated cell proliferation by switching cell cycles from G0/G1 phase to S and G2/M phase. Moreover, DSD significantly elevated the mRNA expression level of TPO , but not c - Mpl in spleen. Overall, the present results indicated that DSD is a promising Chinese medicine that is highly potent to ameliorate myelosuppression induced by chemotherapy by upregulating TPO expression.
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PubMed
高影响因子
Microfluidics and Nanofluidics
·
2015
·Vol. 19
·期 4
·829-836
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IF 2.528
He Weiqi,Xiao Jingrong,Zhang Zhengtao,Zhang Weiying,Cao Yiping,He Rongxiang,Chen Yong
A cost-effective method that used electroplating to fabricate a 3D polydimethylsiloxane (PDMS) passive micromixer was developed in this work. The mixer fabrication process characteristics were as follows: The chip design was transferred to indium tin oxide (ITO) glass via photolithography; the ITO glass was vertically immersed in a nickel electroplating solution; and the ITO glass was raised up by controlling by the syringe pump, while electroplating was in progress. In this method, the height of the mixing structure could increase gradient from 15 to 30 μm. Compared with a flat structure, this structure could increase mixing efficiency by at least 10 %. The mixing efficiency with this 3D microstructure can reach more than 80 %. This 3D microstructure fabrication method can be easily integrated with other PDMS functional structures for future point-of-care diagnostic applications because of the advantages of this technique.
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高影响因子
CHROMATOGRAPHIA
·
2015
·Vol. 78
·期 15
·979-985
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IF 1.411
Li Gongheng,Zhang Xinfeng,Zhang Leilei,Xu Shuxia,Li Chongying
In this study, an efficient sample pretreatment method, salt-assisted graphene oxide dispersive solid phase microextraction (SA-GO-DSPME), was established for extraction of malachite green (MG) and crystal violet (CV). The dispersive graphene oxide was found to be easily aggregated and completely centrifuged in the presence of NaCl. The adsorption kinetic of SA-GO-DSPME was shown to be quite fast (equilibrium time = 5 min). Key parameters that influenced extraction efficiency including sample pH, the eluent type, GO amount, extraction time, NaCl concentration and centrifuging time were investigated. Coupled with SA-GO-DSPME, high-performance liquid chromatography (HPLC) could be used for sensitive detection of MG and CV with detection limits down to 1.7 and 0.3 ng mL −1 for MG and CV, respectively. The relative standard deviations for extraction reproducibility ( n = 5) were 1.8 % for MG and 3.8 % for CV. The proposed method has been successfully applied for detection of MG and CV in real water samples, and the recoveries ranged from 89.7 to 116.4 %. This simple and fast extraction method may provide a promising alternative for extraction of trace amount of MG and CV in complicated samples.
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高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2015
·Vol. 24
·期 8
·3327-3333
·
IF 1.402
Ye Lianbao,Wu Jie,Yang Jiebo,Chen Weiqiang,Luo Yan,Zhang Yanmei
Abstract HGF/c-Met signaling pathway has come into the spotlight as a promising therapeutic target for inhibiting tumor growth and has become one of the leading molecular targets in cancer. Various strategies are currently in development to disrupt the HGF–Met signal transduction pathway, in which small molecular inhibitors have been a particularly active field. On the basis of the structures of two c-Met inhibitors, PF-04217903 and JNJ-38877605, some novel 7-[(quinolin-6-yl)methyl] purines ( 4a – 4e ) were rationally designed on the principle of bioisosterism strategy. These compounds were synthesized and evaluated as novel c-Met inhibitors. Molecular docking experiments analyzed the results and explained the molecular mechanism of eminent activities to c-Met. The results showed that all the title compounds were active against c-Met enzyme to some extent. Though these compounds did not demonstrate inhibition as we expected, this study provided important information for building diversification of chemical library and molecular docking experiment supplied the basis for further research works. Graphical Abstract Some novel
7-[(quinolin-6-yl)methyl] purines as potential c-Met inhibitors have been designed and prepared. Their synthesis and spectral characterization are reported here.
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高影响因子
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
·
2015
·Vol. 22
·期 4
·677-686
·
IF 0.875
Wang Lei,Liu Wenfang,Li Shuang,Liu Tingting,Yan Xingxing,Shi Yuye,Cheng Zeneng,Chen Chuanpin
Conventional ways to produce microfluidic devices cost a lot due to the requirements for cleanroom environments and expensive equipment, which prevents the wider applications of microfluidics in academia and in industry. In this paper, a dry film photoresist was utilized in a simple way to reduce the fabrication cost of microfluidic masters. Thus, a fast prototyping and fabrication of microstructures in polydimethylsiloxane microchips through a replica molding technology was achieved in a low-cost setting within 2.5 h. Subsequently, major manufacturing conditions were optimized to acquire well-resolved microfluidic molds, and the replicated microchips were validated to be of good performance. A T-junction channel microchip was fabricated by using a dry film master to generate water droplets of uniform target size. Meanwhile, a gated injection of fluorescein sodium and a contactless conductivity detection of Na + were both performed in a crosslink channel microchip via capillary electrophoresis, in other words, this fast prototyping and fabrication method would be an efficient, economical way to embody structural design into microfluidic chips for various applications.
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高影响因子
PLANT AND SOIL
·
2015
·Vol. 390
·期 1
·337-349
·
IF 2.952
Fan Xianwei,Hu Haiyang,Huang Guiyuan,Huang Feiyan,Li Youzhi,Palta Jairo
Background and aims Plant-growth promoting rhizobacteria (PGPR) can promote plant performance under water deficit, but the physiology and biochemistry of the promoting process induced by PGPR under different water deficits is not well known in maize ( Zea mays L). Methods A glasshouse study was conducted to determine the effects of Burkholderia sp. LD-11 on morphophysiological traits for plant growth and homeostasis between reactive oxygen species (ROS) and antioxidant enzymes under five regimens in two maize inbred lines. Results Soil inoculation with Burkholderia sp. LD-11 promoted biomass accumulation and improved instantaneous water-use efficiency (WUEi), regardless of the soil water availability. It also triggered production of indole-3-acetic acid (IAA), decreasing the accumulation of abscisic acid (ABA) induced by the water deficit, alleviated ROS accumulation, and resulted in a reduction in lipid peroxidation induced by the water deficits. Soil inoculation also enhanced the tolerance to water deficit through reducing stomatal aperture by increasing the sensitivity of stomatal conductance ( g
s ) to small changes in ABA concentration in the leaves. Conclusions Soil inoculation with Burkholderia sp. LD-11 enhanced root systems and WUEi, offering a potential avenue for improving maize tolerance to water deficit.
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高影响因子
Science China-Materials
·
2015
·Vol. 58
·期 9
·693-703
·
IF 0
Liu Jian,Zhao Yuheng,Liu Jialong,Wang Shouguo,Cheng Yan,Ji Muwei,Zhou Yuanmin,Xu Meng,Hao Weichang,Zhang Jiatao
Heterovalent doping represents an effective method to control the optical and electronic properties of semiconductor nanocrystals (NCs), such as the luminescence and electronic impurities (p-, n-type doping). Considering the phase structure diversity, coordination varieties of Cu atoms in Cu 2 S NCs, and complexity of Cu doping in II-VI NCs, monodisperse Cu 2 S NCs with pure hexagonal phase were synthesized firstly. Then through cation exchange reaction between Cd ions and well-defined Cu 2 S NCs, dominant Cu(I) doped CdS NCs were produced successfully. The substitutional Cu(I) dopants with controllable concentrations were confirmed by local atom-specific fine structure from X-ray absorption near edge structure (XANES), extended X-ray absorption fine structure (EXAFS) spectroscopy, elemental analysis characterizations from X-ray photoelectron spectroscopy (XPS) and the electron spin resonance (ESR) measurement. The dominant and strong Cu(I) dopant fluorescence was verified by their absorption and photoluminescence (PL) spectra, and PL lifetime. Finally, the band positions and the p-type conductivities of the as-prepared Cu 2 S and Cu(I) doped CdS NCs were identified by ultraviolet photoelectron spectroscopy (UPS) measurements. The high monodispersity of NCs enables their strong film-scale self-assembly and will hasten their subsequent applications in devices.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2015
·Vol. 27
·期 2
·2022-2030
·
IF 1.569
Liu Hongli,Wang Shirong,Xiao Yin,Li Xianggao
This work aims at studying the structure of monomers on the dispersity of carbon black (CB) in a non-aqueous medium Isopar L. The polymethacrylate-grafted CB nanoparticles were prepared by a redox polymerization method. A series of methacrylate monomers containing alkyl side chain with different length and structure were employed for grafting. The structure and composition of polymethacrylate-grafted CB particles were characterized by a combination of FTIR, TGA and XPS. The particle size distribution, average diameter, contact angle to water and Isopar L and zeta potential of the prepared CB particles were investigated to provide insights into the effects of the monomer structure on the dispersity of modified CB particles in Isopar L. TEM images demonstrated that aggregation of modified CB particles reduced distinctly. The surface of CB particles changed from hydrophilic to hydrophobic after modification. Moreover, it is also found that the more branching or the longer the monomers used in the modification, the narrower the particle size distribution and the higher the zeta potential. The display prototype based on polymethacrylate-grafted carbon black particles showed an improved display performance under the electric field of 0.30 V μm −1 . Especially, the EPD based on ethylhexyl methacrylate modified CB particles displayed the highest contrast ratio of 8.36 and minimum response time (527 ms) compared with the ones prepared with other modified particles.
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高影响因子
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