JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Fan Rong,Zhouyu Lu,Yuxuan Wang,Yujia Lu,Guanyi Li,Yiyang Shao,Yanwen Zhang,Zixin Wang,Bin Hao,Yunsheng Yuan,Yaxue Zhao,Haijie Han,Yin Wang
APN-activated self-immolative nanoantibiotic was developed. • H 2 S/Cip co-delivery enabled synergistic anti-inflammatory/antibacterial effects. • The corneal repair from bacterial keratitis was significantly accelerated. Pseudomonas aeruginosa (PA)-induced bacterial keratitis represents one of the most severe corneal infections usually accompanied by prominent inflammatory infiltration. Clinical fluoroquinolone-based therapies yield unfavorable therapeutic outcomes due to the insufficient ocular bioavailability and compromised anti-inflammatory efficacy. In the present work, we report a molecularly engineering strategy to conjugate ciprofloxacin (Cip) with a self-immolative carbonyl sulfide (COS)/hydrogen sulfide (H 2 S) donating motif. The resulting prodrug (termed ASCip) could spontaneously self-assemble into nanosheets in aqueous solution, thereby improving ocular surface retention and drug bioavailability. Importantly, ASCip could be specifically activated by aminopeptidase N (APN), which is overexpressed at the inflammatory sites, enabling the controlled and simultaneous release of Cip and H 2 S, to realize antibacterial and anti-inflammatory effects. In vitro evaluations of this carrier-free nanoantibiotic revealed potent antibacterial activity against PA upon APN activation, favorable biocompatibility, and significant anti-inflammatory effects via modulating the inflammatory mediators and promoting macrophage polarization towards the anti-inflammatory M2 phenotype. In a murine model of PA-infected keratitis, the nanoantibiotic efficiently eradicated pathogens, attenuated ocular inflammation, and remarkably accelerated corneal repair, providing a promising strategy to improve the efficacy of fluoroquinolone-based therapies against bacterial keratitis. More importantly, the strategy developed provides a versatile way to co-deliver COS/H 2 S with other functional motifs. The Cip prodrug ASCip could self-assemble into well-defined nanoantibiotics to enhance ocular retention. Upon APN activation, a spontaneous self-immolative reaction could be triggered to co-deliver H 2 S and Cip simultaneously, enabling synergistic anti-inflammatory and antibacterial effects that promote corneal repair in bacterial keratitis. Download: Download high-res image (114KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·
IF 3.8
Hongxing Zhan,Hailu Wang,Yuanbing Li,Shujing Li,Zhen Cai,Zhe Qiao
This study focuses on the corrosion behavior of Al 2 O 3 –SiO 2 refractory materials under high-temperature CO atmospheres in hydrogen metallurgy, systematically revealing the occurrence form of Fe element in mullite–corundum ceramics with different Fe 2 O 3 contents. By simulating hydrogen metallurgy conditions and integrating thermodynamic analysis, phase evolution, and microstructural characterization, a dual intragranular and grain boundary corrosion mechanism was identified: (1) Fe 3+ in the [Al/FeO 6 ] octahedron of the mullite crystals were reduced to Fe 2+ and leached out of the lattice, resulting in charge imbalance and lattice distortion within the structure, thus reducing the stability of the mullite crystal. (2) Migrated Fe and impurities element at grain boundaries promote glass phase precipitation, while leached Fe 2+ reduces glass viscosity by disrupting Si–O networks, forming low-viscosity liquids that accelerate mullite dissolution. Results demonstrate a critical Fe 2 O 3 doping threshold (10 wt%), beyond which mullite undergoes reductive dissociation accompanied by hercynite and low-melting phase formation (ferrocordierite, fayalite). Hercynite and glass phase contents exhibit near-linear increases with Fe content. This work clarifies the valence of the Fe element and its gradient-driven microstructural failure mechanisms under hydrogen metallurgy conditions, providing theoretical foundations for optimizing reduction-resistant mullite-based linings.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Yifei Wang,Yingdong Yang,Yuxing Liu,Xinkang Zhang,Fengming Mo,Tao Huang,Yongjiang Shan,Ting Wu,Fei Zhang,Xiangshu Chen,Hidetoshi Kita
Capturing and recovering CO2 from steel industry gases is essential for environmental preservation since it lowers greenhouse gas emissions and raises CO concentrations. Because of its high selectivity, energy efficiency, and continuous operation, membrane separation technology has a lot of potential for CO2 separation. In the present work, a hydroxyl free radical (•OH), generated by the addition of a small amount of sodium persulfate to the precursor solution, was introduced for the first time to induce the synthesis of the ZSM-58 crystals and membranes. Hydroxyl free radicals can promote the depolymerization and condensation of silica sources during the synthesis process, thereby accelerating nucleation and crystallization. Compared with the precursor solution without sodium persulfate, the synthesis time of the membrane can be reduced by 30%, the resulting zeolite membrane exhibits a CO2/CO separation factor of 16 and a high CO2 permeance of 1.5 × 10–7 mol m–2 s–1 Pa–1. In addition, CO2/N2 and CO2/CH4 separation performances were also tested to evaluate the membrane quality. The separation factor of the equimolar CO2/N2 and equimolar CO2/CH4 mixtures reached 28.6 and 248.3 at 298 K at 0.1 MPa, accompanying the corresponding CO2 permeance of 1.3 × 10–7 mol m–2 s–1 Pa–1 and 1.5 × 10–7 mol m–2 s–1 Pa–1, respectively. This research presents an innovative and effective method for fabricating zeolite membranes.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2025
·
IF 3.1
Li Quanyang,Yu Liang,Shen Lv,Fu Jiankun,Zhou Ru,Hao Min,Jiang Juncheng
Polypropylene (PP) is a widely used thermoplastic resin known for its strong properties, including chemical stability, electrical insulation, and high abrasion resistance. However, its low ignition point and rapid burning rate pose significant fire risks, necessitating the incorporation of flame retardants. In this study, cobalt metal–organic framework (Co-MOF), melamine polyphosphate (MPP), and expandable graphite (EG) were combined to enhance the flame retardancy of PP. The optimal blending ratio was determined, and the results showed that PP/MPP/2 mass% Co-MOF/15 mass% EG composites exhibited superior flame retardancy. These composites achieved a critical oxygen index (LOI) of 28%, a V-0 rating in the UL-94 test, and significantly reduced heat release and smoke production during combustion. The synergistic effect of MPP, Co-MOF, and EG facilitated the formation of a dense, thermally stable carbon layer, which effectively hindered flame propagation and improved fire safety. These findings provide valuable insights for the development of flame-retardant PP materials. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Hui Su,Furong Ye,Siyi Zhang,Changcun Han,Jipeng Dong,Zhixin Dai,Xinguo Ma,Lei Ge
The sluggish anodic oxygen evolution reaction (OER) kinetics remains a critical bottleneck for sustainable hydrogen production via water electrolysis. Guided by Density Functional Theory (DFT) calculations, we engineered Fe-CoS 2 /Ni 3 S 4 dual-site catalysts where Co 3+ and Fe 3+ centers synergistically optimize p-d orbital hybridization to enhance OER kinetics. Operando analyses reveal Co 3+ as primary active sites facilitating rate-limiting OOH* → O 2 desorption with Gibbs free energy (ΔG) reduced by 0.94 eV, while Fe-induced electron delocalization lowers intermediate coupling barriers. Notably, the catalyst facilitates dynamic reconstruction, generating metastable Co 3+ species with optimized eg orbital occupancy (t 2 g 5 eg 1 configuration) and strengthened p-d hybridization via Fe-mediated charge transfer. This electronic synergy enables ultralow overpotentials of 156 mV (hydrogen evolution reaction HER) and 230 mV (OER) at 50 mA cm −2 , with a cell voltage of 1.48 V for overall water splitting at 10 mA cm −2 . The dual-site architecture simultaneously suppresses metal dissolution (<12 % after 20 h) while maintaining 89.2 % initial activity. This work establishes a dual-regulation strategy: atomic-level orbital engineering for OER intermediate optimization and dynamic surface reconstruction for HER-active phase stabilization, offering a paradigm for designing robust bifunctional electrocatalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2025
·
IF 9.7
Rijia Liu,Bolin Wu,Changru Xu,Chaojun Zhang,Meng Han,Meiting Zhao,Wein-Duo Yang,Rui Liu
This work developed an ultrasonically assisted synthesis of nickel cobaltite (NiCo 2 O 4 ) modified electrode for simultaneous detection of Furazolidone (FRZ) and Metronidazole (MTR) in biological samples. The structural and chemical properties of the as-prepared electrodes were systematically characterized through multiple analytical techniques. The NiCo 2 O 4 -modified glassy carbon electrode (NiCo 2 O 4 /GCE) demonstrated exceptional performance with wide linear ranges of 0.005–200 μM for MTR and 0.01–150 μM for FRZ, with remarkably low detection limits of 2.57 nM and 29.13 nM, respectively. The sensor exhibited excellent selectivity against common interferents, good reproducibility, and maintained > 90 % activity after 30 days. NiCo 2 O 4 /GCE can be used to detect MTR and FRZ in real pharmaceutical and serum samples, achieving excellent recovery rates within the range of 94.0 % to 114.0 %. This work not only presents a superior sensing platform for antibiotic monitoring but also establishes ultrasound-assisted synthesis as an effective strategy for developing advanced bimetallic oxide electrocatalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2025
·
IF 8
Fei Xiao,Wei Peng,Kaiyuan Li,Bihe Yuan,Gaëlle Fontaine,Serge Bourbigot
Natural wood is a pervasive sustainable structural material with efficiency, aesthetically pleasing, usefulness, and durability, which is widely used in building construction. However, the fire safety of wood is unsatisfactory for many advanced engineering structures and applications. To address this issue, a highly fire-safe wood hybrid was developed, inspired by transparent wood, through partial delignification and co-impregnation with multi-component flame retardants. The results showed that partial removal of lignin from wood (∼5 wt%) significantly increased the loading of flame retardants from 70 wt% to 133 wt%. Furthermore, it provided exceptional self-extinguishing and fire retardancy to the wood hybrid. The vertical burning test revealed that the wood hybrid did not self-propagate when directly exposed to an open flame and rapidly self-extinguished when removed from the igniting flame. Notably, it did not ignite at an external heat flux of 50 kW/m 2 (cone calorimetry experiment), and the recorded peak heat release rate was reduced by more than 85 % compared to the original wood. It is demonstrated that the co-impregnation of guanidine phosphate and boric acid modifies the thermal decomposition pathway of wood hybrid during burning, allowing the wood to form homogeneous and dense char residues. These carbonaceous structures were embedded with phosphate and borophosphate species, which provide the char residues with improved resistance to oxidation and higher thermal stability, preventing heat and oxygen from infiltrating the underlying wood. In summary, this work provides a facile delignification and co-impregnation strategy that greatly improves the fire retardancy of wood and represents a promising approach toward highly fire-safe structural materials.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2025
·
IF 12.1
Xuefen Song,Muhammad Ayyob,Panpan Su,Jian Cui,Wenxiu Li,Meng Zhang,Xuemin Zhang,Zhongwei Chen
The acidic electrolyte and highly oxidizing environment of proton exchange membrane water electrolysis (PEMWE) pose significant challenges to the stability of Ru-based anode catalysts and limit their practical applications. In this study, Co-doped RuO 2 nanocrystals are synthesized using a one-step annealing method of Co-exchanged Ru-bpydc derivatives. The catalyst demonstrated excellent oxygen evolution reaction (OER) performance, achieving a low overpotential of 205 mV at 10 mA cm −2 and superior stability, retaining activity for over 1000 h without degradation. Advanced characterization techniques revealed that cobalt doping increases oxygen vacancies and manipulates the reaction pathway by boosting the adsorbate evolution mechanism (AEM) and suppressing the participation of lattice oxygen in OER. Density functional theory (DFT) calculations further confirmed that the electron transfer between Ru and Co site via bridge O in the structure of Ru─O─Co optimized the adsorption energy of oxo-intermediates to promote AEM, thereby boosting stability. In addition, the Co─RuO x catalyst exhibited good performance as an anode in a PEMWE, demonstrating stable operation for over 100 h at a current density of 100 mA cm −2 . This work presents a viable approach to designing highly active and durable OER catalysts, making significant contributions to the advancement of PEMWE technology.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 15
·1-15
·
IF 3
Lv Tingting,Wang Hong,Li Ding,Li Ruihai,Yang Chengliang,Zhao Wei,Cui Zhenyu,Li Jianxin
Organophosphorus pesticide contaminated sites have been categorized as a global priority contaminated site type for remediation due to the excessive accumulation of persistent organic pollutants. This study investigated the removal effect of phorate (PHR) in polluted soil through co-solvent-assisted alkaline activation of persulfate (PS) system, and evaluated the contribution of the co-solvent to the desorption behavior and solubilizing effect of PHR. Results showed that a high PHR degradation rate of 56.1% was obtained on the second day under the following conditions: 40% (v/v) acetonitrile (ACN) as co-solvent, C PS = 382 mmol L –1 , pH 12, and a W L /W s ratio of 1:2. It was a significant improvement over the system without co-solvent (19.9%). Moreover, a degradation rate of PHR was up to 93.9% on the 21st day under the optimized operating conditions, which was significantly higher than that observed in the persulfate oxidation system (13.1%) and the alkaline hydrolysis system (33.6%). The critical active species, including sulfate radicals \(S{O}_{4}^{\bullet -}\) and hydroxyl radicals (•OH) for the oxidation of PHR in contaminated soil during the alkaline-activated persulfate system were identified using electron spin resonance (ESR) and radical quenching experiments. The degradation pathways involved both hydrolytic pre-activation and radical mineralization. Furthermore, the luminescent bacteria tests demonstrated that the luminescence inhibition rate of the PHR-contaminated soil decreased from an initial value of 100% (highly toxic) to 16.2% (low toxicity) after remediation. In summary, this study offers a promising approach for the remediation of organophosphorus pesticide-contaminated soils.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Yonglin Liu,Shuran He,Hanfei Gao,Xinyi Wang,Qingjian Zhang,Wei Tian,Baorong Duan,Lin Liu
s The study investigated the removal of Cr(Ⅲ) and Cd(Ⅱ) by argillaceous limestone (AL) in a binary adsorption system. The results indicate that AL’s capacity to adsorb Cr(Ⅲ) is enhanced by the presence of Cd(Ⅱ). Conversely, the presence of Cr(Ⅲ) significantly decreases the adsorption of Cd(Ⅱ). The adsorption mechanisms involve precipitation, chelation, and ion exchange. AL’s adsorption behavior was well described by the pseudo-second-order kinetic model, suggesting that the adsorption process was dominated by chemical interactions and the monolayer adsorption pattern. The pH affects adsorption primarily by altering the protonation degree of the AL surface. In the single-component system, the maximum adsorption capacity for Cr(III) reached 30.98 mg·g⁻ 1 at pH 7.0, while that for Cd(Ⅱ) reached 38.80 mg·g⁻ 1 at pH 8.0. In the binary system, Cr(Ⅲ) achieved its highest adsorption capacity (42.56 mg·g⁻ 1 ) at pH 6.0, while Cd(Ⅱ) exhibited a maximum capacity of 19.16 mg·g⁻ 1 at pH 7.0. The presence of Na⁺ and Ca 2 ⁺ ions reduced the adsorption efficiency, with greater inhibition observed as ionic strength increased. This study clarifies the composite adsorption behavior of AL in multi-ion systems and can advance the direct application of natural minerals in environmental pollution remediation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2024
·
IF 9
Ying Xu,Dongling Wang,Bowen Luo,Xiaodong Zhang,Yuanbo Huang,Huanghuang Zhuang,Riyang Shu
An efficient hydrogenolysis for organosolv lignin was proposed by using Co/C coupled with NaOH catalyst in this work. A boosted aromatic monomer yield was achieved, which was superior to the noble metal-based catalysts. The optimal 15%Co/C catalyst coupled with NaOH exhibited the best hydrogenolysis performance, with lignin conversion of 94.5 % and aromatic monomers yield of 43.4 %. Wherein, the product of benzyl alcohols showed the highest yield 23.5 %. The recycling performance of 15%Co/C catalyst was outstanding, with lignin conversion above 92.8 % after three runs and the yield of aromatic monomer slightly dropped to 38 %. The hydrogenolysis reaction pathway was also investigated based on the β-O-4 dimer model compound study. 2-(2-methoxyphenoxy)-1-phenyl ethanol was selected as lignin β-O-4 dimer model compound, and the hydrogenolysis reaction was conducted efficiently at 160 °C under the synergistic catalysis effect of metal sites and base sites. NaOH promoted the initial depolymerization of lignin through protonation, which improved the accessibility of lignin product to Co/C catalyst, and thus enhanced the reactivity of catalytic hydrogenolysis. NaOH also facilitated the etherification of intermediate products with solvents. And the presence of Co metal site stabilized free radicals and inhibited monomer product etherification. This catalytic system provides a potential strategy for the large-scale lignin utilization, with the advantage of high efficiency and handleability.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Lin Ma,Hao Wu,Daheng Liu,Pengjie Zhang,Wei Sun,Xiaohui Liang,Jiewu Cui,Yu Zhang,Dianqing Yu,Fuchun Liu,En-Hou Han
It remains a challenge to develop electromagnetic wave absorbers with wide effective absorbing bandwidth (EAB). In this work, one-dimensional (1D) cobalt-based metal-organic framework (MOF)-derived composites were exploited on whose surfaces are decorated with nanoparticles. The EAB can reach up to 6.7 GHz with the corresponding matching thickness only 2.2 mm, which is far greater than those of most similar composites. The unique 1D rod microstructures possess a large length-to-diameter ratio and can provide a longer conductive path in a relatively small volume, which can reduce the length of electron transmission paths, and thus improve the overall conductivity. The composites contain a large number of cobalt/carbon heterogeneous interfaces, which can enhance the interface polarization phenomenon. Additionally, the impedance matching can be controlled in balance due to the double-component feature of the composites. The successful preparation of the cobalt-based MOF-derived composites with an ultra-wide EAB can significantly improve the upper limit of EAB of similar composites.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）