ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
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IF 6.6
Xiao Liang,Qi Huang,Yang Wu,Deyu Zhu,Zhuangzhuang Wei,Qing Feng,Zhilong Chen,Yibing Chen,Ping Ma,Xu Yang,Cuiyu Bao,Xinyu Bao
Background Polystyrene microplastics (PS-MPs) represent a major environmental contaminant, capable of building up in various organisms, including animals and plants. They can increase through the food chain, ultimately threatening human health. Recent research has indicated a possible association between exposure to PS-MPs in the environment and heart damage; nevertheless, the specific mechanisms behind this connection are not yet fully understood. Objectives This study aimed to investigate the toxic effects of PS-MPs exposure on cardiac health. We specifically elucidated the underlying mechanisms through which PS-MPs exacerbate doxorubicin hydrochloride (DOX)-induced cardiac injury, emphasizing oxidative stress, ferroptosis, and dysregulation of mitochondrial dynamics. Furthermore, we examined the protective effects of two antagonists: Ferrostatin-1 (Fer-1) and luteolin (Lut), against PS-MPs-induced cardiac injury. Methods C57BL/6 mice were categorized into eight distinct groups: the blank control group (saline), the PS-MPs exposure group (PS-MPs), the DOX modeling group (DOX), the combined exposure group of PS-MPs and DOX (PS-MPs+DOX), and the treatment groups with Fer-1 and Lut (PS-MPs+Fer-1, PS-MPs+Lut, PS-MPs+DOX+Fer-1, PS-MPs+DOX+Lut). The entire experimental duration spanned five weeks. We evaluated the effects of PS-MPs and DOX on cardiac function using electrocardiography and assessed their impact on cardiac injury through histopathological analysis of the heart. Concurrently, we examined the effects of PS-MPs and DOX on mitochondrial structure via mitochondrial electron microscopy. Furthermore, we analyzed the heart organ coefficient, myocardial injury markers (CK-MB, CTnT), oxidative stress biomarkers (ROS, MDA, GSH, 4-HNE, Nrf2), ferroptosis-related markers (Fe 2 + , GPX4, SLC7A11), mitochondrial damage markers (ATP, Complex III, Complex V), mitochondrial dynamics-related markers (OPA1, MNF2, DRP1), as well as serum metabolomics. Results Our findings reveal that exposure to PS-MPs exhibits significant cardiotoxic effects, influencing heart rate changes in mice and leading to abnormal in oxidative stress levels and ferroptosis-related proteins within myocardial tissue. Concurrently, exposure to PS-MPs leads to changes in mitochondrial structure and dynamics, further exacerbating oxidative stress and ferroptosis. Ultimately, PS-MPs aggravate DOX-induced cardiac injury. However, Fer-1 and Lut have a good improvement effect on the above situation. Furthermore, metabolomic analyses suggest that pathways and metabolites involved in cAMP signaling, the TCA cycle, tryptophan metabolism, and the metabolism of xenobiotics by cytochrome P450 may also play significant roles. Conclusion PS-MPs exposure can further exacerbate DOX-induced cardiac injury in mice, a process characterized by oxidative damage, activation of the ferroptosis pathway, and alterations in mitochondrial dynamics. Furthermore, luteolin, a naturally occurring active compound, plays a significant role in ameliorating this process.
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JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Su Qian,Huang Li,Zhang Youjin,Yang Zhiyong
Carbon dots (CDs) have been broadly employed in many fields due to their excellent fluorescence property, especially in pharmaceutical analysis. Herein, we developed a simple and rapid method to prepare the phosphorus-nitrogen (P, N) co-doped carbon dots via a 3-minute 50-second microwave-assisted synthesis, using N-butyldiethanolamine as the carbon source with phosphoric acid accelerating the CDs formation reaction. The prepared CDs (termed CD1) were characterized by TEM, FT-IR, XPS, XRD and fluorescence spectroscopy. P, N co-doped CDs exhibited notable water solubility, a quantum yield of 19.7% and good photobleaching resistance. Taking advantage of their superior fluorescence, these CDs served as a bright-blue probe for tigecycline detection through fluorescence quenching. The sensor displayed excellent selectivity and anti-interference ability against common coexisting drugs (e.g., voriconazole, ceftazidime, amikacin). Under optimized conditions, a wide linear range (1-936 µM) between F 0 / F and Tigecycline concentration was established, with a correlation coefficient (R) of 0.984, and the detection limit (LOD) was calculated to be 1.10 µM. Furthermore, we clarified the fluorescence quenching mechanism of CD1 toward tigecycline, which was attributed to the internal filtration effect (IFE). Thus, this work demonstrated a novel P, N co-doped CD-based sensing strategy for rapid tigecycline monitoring.
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Journal of the Taiwan Institute of Chemical Engineers
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2026
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IF 6.9
Yuchen Yang,Yanhua Liu,Qiong Bu,Changjia Gong,Jianbin Zhang,Dianming Li,Ziyuan Yang,Jie Ren,Libang Feng
Background The metallization of carbon fibers (CFs) has become a promising strategy to significantly enhance electrical conductivity, enabling advanced applications in electromagnetic interference (EMI) shielding and electrothermal systems. Nevertheless, conventional metallization techniques often suffer from insufficient interfacial adhesion, intricate processing steps, and unfavorable environmental implications. Method In this study, a rapid and environmentally benign approach is proposed, combining tannic acid (TA)-mediated surface functionalization with microwave-assisted reduction. TA modification (CF@TA) enables the chelation of silver ions onto the CF surface, which are subsequently reduced in situ to generate silver nanocrystals (CF@TA-Ag(N)). Microwave irradiation expedites reaction kinetics and promotes uniform deposition, resulting in a dense, continuous, and strongly adherent silver layer (CF@TA-Ag(L)) within only 5 minutes. Significant finding The CF@TA-Ag(L) specimens exhibit an electrical conductivity of 17,480 S·m -1 , representing a 670-fold increase compared with pristine CFs. These fibers retain mechanical integrity after 200 bending cycles, 30 min of ultrasonication and 100 tape cycles. Moreover, a high EMI shielding effectiveness of 75.2 dB is achieved, accompanied by notable low-voltage electrothermal performance, reaching 59.2 °C at only 1 V. This facile fabrication route offers substantial potential for applications in electromagnetic protection and energy-efficient heating technologies.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zhen Zhang,Xiaojian Tian,Yuxiao Sun,Dandan Han,Bang Gu,Dan Wu,Armin Rezayan,Xian Wu,Jingpeng Zhao,Jianshe Wang,Tianliang Lu,Renfeng Nie,Xiaoqin Si,Chunbao Xu,Yongsheng Zhang
Vanadium-based catalysts are widely used in the oxidation of carbohydrates to produce formic acid (FA), a promising liquid organic hydrogen carrier, but still suffers from low yield due to the formation of CO 2 . This study found that the spatially isolated VO x on active carbon (AC) can significantly increase FA yield from 43.5 to 72.9% in glucose oxidation compared with free VO x . Two specific roles of AC were revealed. Firstly, the oxygenated functional groups, high surface area and abundant microporous of AC, play a crucial role in the atomic dispersion of VO x , resulting in a heterogeneous, single-site VO x -AC catalyst. The isolated VO x site favors the oxidative C C bond cleavage in glucose via a stepwise α-cleavage pathway, thus improving FA selectivity. Secondly, the conductive AC acts as an electron buffer, which accelerates the catalytic redox cycle between V 5+ and V 4+ of the isolated VO x sites, thus increasing the reaction activity. The prepared single-site VO x -AC catalyst is reusable and can generate a concentrated FA solution (4.7 wt%) by simple filtration of the solid catalyst. This work presents a simple method for the production of H 2 energy carrier from biomass and provides a fundamental basis for designing efficient catalytic systems for aqueous-phase oxidation reactions.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Weifang Jiang,Xueer Huang,Fengling Tian,Qi Wei,Kaxi Chen,Xuehui Tang,Jinfang Nie,Jianmei Zou,Di Huang,Yun Zhang
This work initially describes a highly sensitive colorimetric assay with smartphone readout that enables instrument-free, determination of hypochlorite (ClO − ) ion. The assay exploited analyte-induced anti-aggregation of Au nanoparticle (AuNP), which attenuated their Tyndall effect (TE). In the absence of the analyte, dithiothreitol (DTT) molecules (each bearing two terminal thiol groups) could form strong Au S bonds with the AuNP to induce the aggregation of these nanoprobes. This not only produced a familiar surface-plasmon-resonance-based red-to-blue color change but also markedly intensified the TE signal of the reaction mixture. In the presence of the ClO − , on the other hand, the analyte rapidly oxidized the thiol groups of DTT, thereby preventing the AuNP aggregation. These nanoprobes thus remained their original dispersed state, giving a red color and a weak TE response. The TE signal was inversely related to the ClO − concentration. Under optimized conditions, this new method, which required only an inexpensive 635 nm laser pointer to generate a red or red-yellow TE, offered far better visual discrimination of analyte concentration than the conventional SPR-based approach, reaching a visual limit of detection (LOD) of ~0.25 μM (~0.02 mg·L −1 ), ten-fold lower than that of the latter. Coupling the new assay with a smartphone for portable TE readout further allowed for linear quantification of ClO − over the 0.05–90 μM (0.0036–6.4 mg·L −1 ) range, lowering the quantitative LOD to ~14.2 nM (~0.001 mg·L −1 ) (3σ), about 30 times lower than that achieved by the traditional UV–Vis spectroscopy. The recovery of ClO − in four types of tested water samples (i.e., tap water, mineral water, pond water and pool water) ranged from 97.64 to 108.38%, additionally confirming the analytical accuracy and practical utility of the TE-enhanced smartphone-assisted equipment-free quantitative method developed herein.
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CARBOHYDRATE POLYMERS
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2026
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IF 12.5
Dehong Lu,Huimin Yao,Nouman Ali Shah,Sajid Ali,Li-Yan Zeng,Ping Shi,Yuan-Sen Liu,Ziru Dai,Hafiz Umer Javed
The growing demand for sustainable and active food-packaging materials has increased interest in biodegradable biopolymers with improved functional performance. This study developed multifunctional chitosan (CS) films incorporating deep eutectic solvents (DESs) as green bioactive plasticizers to improve antioxidant, antibacterial, and mechanical properties. DESs were prepared using choline chloride with five organic acids, including citric (CA), malic (MA), oxalic (OA), lactic (LA), and ascorbic acids (AA), and the resulting DESs were evaluated for antioxidant and antibacterial activities. AA-DES and OA-DES showed the highest activities and were incorporated into CS films individually and combined (CS-AA-OA) at 1% concentration. Structural characterization (FTIR, XRD, SEM, TGA) and functional assessments were conducted to evaluate mechanical, thermal, and bioactive performance. The CS-OA film exhibited superior mechanical strength (56.42 MPa; 9.10% EB), while CS-AA-OA achieved the highest radical-scavenging activity (DPPH 88.15%, ABTS 98.44%) and strong antibacterial efficacy against E. coli (24.7 ± 0.34 mm) and S. aureus (22.8 ± 0.52 mm). The soil burial test confirmed excellent biodegradability, and coating applications on mushrooms and bananas effectively reduced browning, weight loss, and firmness degradation. The combined incorporation of AA-DES and OA-DES enhanced CS film structure and bioactivity, providing a sustainable, high-performance material for active food packaging.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Dapeng Cui,Ziyuan Yang,Yupeng Zhang,Xiaopeng Suo,Ming Cheng,Shuang Fan,Cheng Yang,RuiXia Yu,Tao Wang,Lei Li,Jiaxin Cui,Zhongdi Liu,Runjia Fu,JianDong Fei
Effective remodeling of the wound regenerative microenvironment is pivotal for achieving rapid and high-quality healing in diabetic wounds. Yet, current therapeutic strategies are largely constrained by their inability to orchestrate temporally programmed drug delivery that aligns with the dynamic and stage-specific demands of the healing process. To address this challenge, we engineered a sequentially dual-drug releasing wound dressing (PCC-PF), designed to deliver time-resolved biochemical and biophysical cues that reprogram the regenerative microenvironment and accelerate wound repair. The PCC-PF scaffold markedly enhanced the regenerative activity of key cell populations, including fibroblasts and endothelial cells, while fostering a favorable tissue microenvironment. Importantly, dual-phase delivery of the incorporated drugs accelerated the closure of infected wounds in diabetic rats. This sequential drug release strategy, enabling precise and dynamic microenvironmental remodeling, presents a promising paradigm for advancing the clinical management of diabetic wounds.
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FOOD CHEMISTRY
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2026
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IF 10.4
Ruican Wang,Ying Zhang,Haoxin Cui,Wenhui Fu,Dongfei Tan,Qisijing Liu,Xuemeng Ji,Liye Zhu,Shuo Wang
Keratin-rich pig hoof waste remains underutilized due to poor solubility and limited bioavailability. This study aimed to evaluate structural, functional, and bioactive properties of hydrolyzed pig hoof keratin (HPHK) obtained via commercial protease hydrolysis of native keratin (PHK). PHK and HPHK were compared for amino acid profile, molecular weight (SDS-PAGE, SEC), thermal stability (TGA), and structure (FTIR), with further assessment of functionalities and bioactivities. Hydrolysis reduced β-sheet content and molecular weight (~13 → 3.1 kDa), improving solubility and digestibility. HPHK exhibited excellent oil-holding (>4 g/g) and foaming (>200%) capacities but poor emulsification. Antioxidant (IC 50 ~ 1 mg/mL) and ACE-inhibitory (IC 50 ~ 8 mg/mL) activities were confirmed by in vitro and in silico analyses. Acid, heat, and simulated digestion contributed to reduced bioactivity. These findings highlight HPHK's potential as a functional and bioactive ingredient and underscores the need to optimize hydrolysis condition for desired functionalities and bioactivity.
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CHEMISTRY OF MATERIALS
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2026
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IF 7
Wanqi Li,Qinqin Cui,Xu Fei,Yao Li,Cong Wang,Sheng Cheng,Longquan Xu
Achieving precise and controllable drug release remains a significant challenge for hydrogel dressings. In this study, the hydrogel network was modified with functionalized cyclodextrin to enhance its thermal responsiveness and shrinkage capacity. Additionally, cuttlefish ink nanoparticles were incorporated as a natural photothermal agent to enable precise temperature regulation. As a result, the modified hydrogel exhibited controllable drug release behavior within a temperature range of 36 to 46.5 °C. Under this strategy, a shrinkage ratio of 60.54% and gallic acid release rate of 85.17% were achieved. Furthermore, the hydrogel demonstrated antibacterial performance (>90%), high biocompatibility (cell viability >90%), and significant antioxidant activity. This hydrogel system shows significant potential for application in intelligent drug delivery platforms, infected wound dressings, and combined photothermal therapy.
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APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Mingli Yue,Zhikuan Feng,Long Gao,Ying Fu,Fei Ye
Drug delivery systems utilize micro-nanomaterials as drug carriers, encapsulating drugs within micro-nanoparticles and releasing them to target tissues or cells via specific pathways. This technology enhances drug stability, prolongs drug retention time in the body, and reduces damage to healthy tissues. This study successfully synthesized novel carbon-doped zinc oxide (C/ZnO) micro-nanomaterials and employed polydopamine (PDA) for surface modification, resulting in the construction of C/ZnO/PDA carriers. Experimental results demonstrate that PDA modification significantly enhances the drug delivery performance of the material. This composite material exhibits a 5-Fu loading efficiency of 37.8%, representing a 1.15-fold increase compared to unmodified C/ZnO. In vitro release tests demonstrate sustained drug release characteristics, showing a 1.62-fold increase over the unmodified system. In addition, these medicine particles significantly enhanced the indicators of antibacterial and bactericidal efficacy. In vitro cell experiments also confirmed that the drug carrier can enhance the lethality of the drug against HepG2 cells. Research on the binding energy between the carrier and the drug revealed that PDA modification promotes drug-carrier binding, resulting in more stable overall adsorption. These findings demonstrate the potential application value of micro-nanoparticle-based targeted drug delivery systems in disease prevention and treatment.
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DYES AND PIGMENTS
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2026
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IF 3.9
Shen Zhang,Zhuo Wang
In consideration of the potential threat, the establishment of efficient approach for fluazinam determination is necessary. Based on the superior property of carbon dots and biomass, sulfur doped biomass-based carbon dots (SBCDs) were constructed using a simple hydrothermal approach, in which peanuts were applied as carbon sources with the addition of methionine. The well-dispersed SBCDs displayed optimal emission wavelength of 435 nm under the excitation wavelength of 364 nm. Owing to the detection principle of fluorescence quenching through static quenching and inner filter effects, the SBCDs were used to detect fluazinam with a broad linear range of 0-100 μM and a detection limit of 0.026 μM. Additionally, the SBCDs also exhibited temperature sensing with a wide linear range of 15-95 °C. Moreover, the as-prepared SBCDs were effectively used for the determination of fluazinam in tap water and orange juice samples. The SBCDs displayed tremendous potential for the sensing of fluazinam and temperature.
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CHINESE JOURNAL OF CATALYSIS
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2026
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IF 17.2
Miao-Miao Shi,Yue-Xuan He,Ning Zhang,Di Bao,Da-Ming Zhao,Hai-Xia Zhong,Jun-Min Yan,Qing Jiang
Ammonia (NH 3 ) is seen to be promising hydrogen carrier, but its decomposition into hydrogen (H 2 ) has been plagued by high operating temperature (400‒700 °C) and long start-up time. Here, we present that directly electrochemical liquid NH 3 decomposition (ELADH) method could realize efficient onsite H 2 generation at room-temperature, whereas active and stable electrocatalytic system is challenging. Through rationally optimizing the electrolysis system with Ru catalysts, we achieved an active and durable ELADH into H 2 under ambient temperature. It was found that Ru nanoparticles (Ru NPs) with (101) facet could effectively promote the favorable N-H dissociation and hydrogen desorption, and thus accelerate the slow reaction kinetics. The as-prepared Ru NPs on nitrogen carbon exhibit lower potential of ‒1.01 V vs . NHE at ‒10 mA cm ‒2 and larger current density of ‒910 mA cm ‒2 at ‒1.47 V vs . NHE, superior to Ru single atoms and commercial Pt/C. Importantly, this system affords stable H 2 evolution under 100 h continuous electrolysis without apparent degradation, far beyond the reported catalysts. This work paves the new way of room-temperature onsite H 2 production and presents insightful understanding of the electrochemical liquid ammonia splitting process.
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