TALANTA
·
2023
·
IF 6.1
Yufeng Wang,Mingqiang Zou,Yan Chen,Fang Tang,Jianjun Dai,Yong Jin,Cong Wang,Feng Xue
Sulfamethazine (SM2) is an antibacterial drug，which has been extensively used in human and veterinary medicine, long-term consumption of which may lead to the accumulation of sulfonamides in the body. Detection of sulfonamides often uses microbiological approaches, mass spectrometry and chromatography, which are expensive and time-consuming. Surface-enhanced Raman scattering-based immunochromatographic assay (SERS-ICA) has been recently applied in the detection. Herein, a Janus-labeled Au nanoparticle with subnanosized SiO 2 -monoclonal antibody and SERS reporter (DTNB) modified simultaneously ( mAb AuNp DTNB ) has been developed in a SERS-based lateral flow immunosensor, which can be used for rapid, quantitative and ultrasensitive detection of sulfamethazine residue in milk. The mAb AuNp DTNB exhibits a specific array on a paper stripe, which not only identifies sulfamethazine but also straightforwardly exposes the Raman reporter between the AuNps via self-assembly. The detection sensitivity of SERS-ICA for sulfamethazine reached 0.1 pg/mL, which was far below the previously published value by ELISA and the maximum residue limit set by the European Union. The entire SERS-ICA detection for sulfamethazine was completed within 15 min. Furthermore, high accuracy for this assay was exhibited in the spiking experiment with a recovery percentage of 88.1%–112.7%. The results demonstrated that this SERS-ICA can potentially be applied in point-of-care testing as an ultrasensitive and quantitative to semi-quantitative analytical method.
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2023
·
IF 4.3
Bo Ma,Qian Xu,Huajun Yao,Yalin Chen,Yiyang Wang,Yunfei Yang,Hongfang Shen,Youjun Lu
As a promising strategy, Localized surface plasmon resonance (LSPR) is applied to improve the efficiency of metal–semiconductor photocatalysts. However, current research have focused on maximizing the LSPR effect in a single structure, rather than the simultaneous consideration of the synergy between integrated structural characteristics and LSPR effect. Here we designed an integrated structure of Cu 2 O@Au/Cu 2 O heterostructure particles (HPs), which were provided with both the core–shell heterostructure (Cu 2 O@Au) and the inter-embedded heterostructure (Au/Cu 2 O). Cu 2 O@Au/Cu 2 O HPs showed much enhanced photocatalytic performance than pure Cu 2 O and other heterostructures with single structural characteristics. Experimental characterization and theoretical simulation confirm that the integrated heterostructure follows the three-in-one synergy, which include the LSPR effect of Au nanoparticles, the light scattering based on core–shell heterostructure, and the effective charge separation based on inter-embedded heterostructure. The concept of integrated heterostructure cooperated with LSPR effect provides a new strategy to design future catalysts.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 8
·1-11
·
IF 5.7
Fei Jianwen,Yang Wei,Dai Yin,Xu Wei,Fan Huizhu,Zheng Yani,Zhang Jun,Zhu Wanying,Hong Junli,Zhou Xuemin
A novel magnetic nanozyme Fe 3 O 4 @MXene-Au nanocomposite, which possessed higher peroxidase-like activity than that of Fe 3 O 4 nanoparticles and Fe 3 O 4 @MXene nanocomposites, was developed. The outstanding magnetic properties of the nanozyme endowed it with the ability of simple and rapid separation, achieving great recyclability. Based on Fe 3 O 4 @MXene-Au nanocomposites and glucose oxidase (Glu Ox), a highly selective colorimetric biosensor for glucose detection was developed. Fe 3 O 4 @MXene-Au nanocomposites can catalyze H 2 O 2 produced from glucose catalyzed by glucose oxidase to ·OH and oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxidized TMB (oxTMB) with a significant absorbance at 652 nm. The linear range of glucose was 0–1.4 mM under optimal conditions, with a limit of detection (LOD) of 0.11 mM. Glucose in human whole blood was successfully detected with satisfactory recoveries. Furthermore, a facile agarose hydrogel detection platform was designed. With smartphone software, glucose detection can be realized by the agarose hydrogel platform, demonstrating the potential in on-site and visual detection of glucose. Graphical abstract
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Guiyin Li,HaiMei Li,Xinhao Li,Huapeng Huang,Huimin Bian,Jintao Liang,Zhide Zhou
Low-density lipoprotein (LDL) is a key biomarker involved in cardiovascular disease (CVD) risk assessment. Early-stage diagnosis of CVD complications by monitoring LDL levels could be a significant clinical tool and the first step toward adopting efficient therapy. Herein, a novel label-free electrochemical aptasensor for LDL detection was developed via the molybdenum disulfide-gold nanoparticle- ferrocene-carboxylic acid nanosheets (MoS 2 -Au-Fc NSs) enhanced signal amplification strategy. The MoS 2 -Au-Fc NSs were used not only as the biocompatible substrate for LDL aptamer (LDLapt) stabilization due to the increasing electrical conductivity and effective surface area, but also as a redox probe for monitoring the changes of the electrochemical signal because of good electroactive properties of Fc . The aptasensor fabrication steps were investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). When LDL was captured onto the sensor via the specific affinity of the LDLapt, the formed LDLapt-LDL complexes shed from the electrode and enhanced the electron transfer rate on the electrode surface, resulting in an increase of the peak current. Thus, LDL can be easily detected by measuring the changes of peak current. Under ideal circumstances, the aptasensor was linearly correlated with logarithm LDL concentration from 0.001 to 100.0 μg/mL with R 2 of 0.9914, and a low detection limit of 0.42 ng/mL. Furthermore, the LDL detected by aptasensor in actual serum samples with good actual errors (0.73%–5.00%) and satisfactory relative standard deviations (RSDs) (0.04%–0.84%). This study provides a new analytical method for measuring the level of LDL which is specifically up-regulated in CVD patients at an early stage.
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Analytical Methods
·
2023
·Vol. 15
·期 37
·4842-4850
·
IF 3.1
Zhiyou Zeng,Xiaoyu Yang,Yongguo Cao,Sanshan Pu,Xinyu Zhou,Rongli Gu,Yiqian Zhang,Caijun Wu,Xiaojun Luo,Yi He
Nowadays, the presence of highly toxic and persistent residues of pesticides in water and food around the world is becoming a serious problem, and so their rapid and sensitive detection is critical to human health. In this work, a 3D composite nanoparticle of porous PDA (polydopamine) microspheres and Au NPs (PPDA@Au NPs) was proposed as a SERS substrate to detect pesticides. Porous PDA as a substrate was first synthesized with F127 (Pluronic F127), dopamine hydrochloride, and 1,3,5-TMB (1,3,5-trimethylbenzene) under weakly alkaline conditions by a one-step method. Then, HAuCl4 was in situ reduced in the pores of PPDA spheres and grew sequentially for effecting the reducibility of PPDA. As a result, uniform 3D PPDA@Au NPs with “hot spots” were successfully synthesized as SERS substrates, which could effectively avoid the agglomeration of gold nanoparticles to greatly improve the sensitivity and uniformity of the SERS platform. At the same time, methyl parathion, 4-chlorophenol, and 2,4-D as representatives of pesticides were detected with the proposed PPDA@Au NP-based SERS platform, with detection limits lower than 7.26, 7.52, and 11 ng mL−1, separately. The current work presents a simple preparation method to prepare sensitive and uniform SERS platform PPDA@Au NPs, which have potential for applications in actual pesticide and drug testing.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 4
·1769-1780
·
IF 3.9
Yumin Chen,Linxuan Zhu,Yuling Yang,Di Wu,Yan Zhang,Weiwei Cheng,Xiaozhi Tang
A high-performance Au@MIL-101/PMMA/DT surface-enhanced Raman scattering (SERS) substrate was fabricated for sensitive and stable detection of paraquat by self-assembling metal organic framework–modified Au nanoparticles (Au@MIL-101) on a poly(methyl methacrylate) (PMMA) film and then immobilizing the formed substrate onto a duct tape (DT). The highly closely packed Au@MIL-101 array provided intensive hotspots for SERS sensing. The MIL-101 layer modified on the surface of Au nanoparticles could absorb paraquat to the electromagnetic enhancement area of Au nanoparticles. The DT on the bottom made the substrate smoother, which is beneficial for achieving a more stable detection performance. As a result, the constructed substrate exhibited outstanding uniformity with relative standard deviations of 9.47% and storage stability for 2 months. For detecting paraquat, the substrate showed a low detection limit of 7.1 × 10 −9 M (1.83 µg/kg) and wide linear range from 10 −8 to 10 −2 M. Furthermore, the substrate showed good detection performance in real cereal samples with desirable recovery rates from 91.57% to 102.32%.
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Xiuli Ren,Linna Chang,Yanan Hu,Xingjun Zhao,Shibo Xu,Zepeng Liang,Xifan Mei,Zhenhua Chen
Bacterial biofilms often hinder the healing of infected chronic wounds. Hence, it is significant to explore ways to destroy bacterial biofilms. In this work, a photothermal therapy strategy of designing Au clusters modified ZIF-8 MOFs ( [email protected] ) as peroxidase-like catalytic nanozyme was proposed for bacterial infected wound healing. Under near-infrared laser (NIR), the prepared [email protected] present enhanced peroxidase-like activity and excellent photothermal response properties. [email protected] achieved bacterial membrane disruption rate of 66.3% and MRSA clearance rate up to 97%. [email protected] also catalyzed endogenous H 2 O 2 to OH and achieved almost 97.4% healing rate in animal experiments. The prepared [email protected] with peroxidase-like catalytic nanozyme properties has great potential in the treatment of infected diabetic wounds through bacterial membranes disruption and protein leakage promotion.
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Nano Research
·
2023
·Vol. 16
·期 5
·6278-6289
·
IF 9.9
Xu Jialun,Zhang Zhihua,Yu Daiyi,Du Wei,Song Nan,Duan Xuezhi,Zhou Xinggui
The catalytic performances over propylene epoxidation with H 2 and O 2 (HOPO process) are significantly affected by the properties (e.g., surface properties, Ti coordination, and morphology) of titanosilicate zeolite. Introducing urea into zeolite synthesis is a simple and convenient method to modify these properties of titanosilicate zeolite. Uncalcined pore-blocked titanium silicalite-1 (TS-1, i.e., TS-1-B) with the lower urea dosage possesses more defective structure and unsaturated coordinated Ti sites verified by 29 Si nuclear magnetic resonance (NMR) and X-ray photoelectron spectroscopy (XPS) analysis, which results in a high initial activity and hydrogen efficiency; while the high surface acidity generated by these Ti species leads to a continuous decrease in the activity and the propylene oxide (PO) selectivity during the reaction. As the amount of urea gradually increases, the TS-1-B samples present the reduced surface defects and defective and unsaturated Ti species. Specially, TS-1-B-0.30U presents the weaker PO adsorption on PO-diffusion reflectance infrared Fourier transform spectra (DRIFTS), and thus results in the high stable PO formation rate and selectivity over its Au catalyst. Furthermore, a flat-plate-like shape with a shorter thickness of 100 nm along the b-axis direction is observed on the urea-modified TS-1. Compared with the conventional ellipsoidal TS-1 with crystal sizes of 200 and 500 nm, the flat-plate-like TS-1-0.30U displays the less surface defects, unsaturated Ti species, and the weaker Lewis acid, which is favorable for the desorption and intracrystalline diffusion of PO, thus reduces the occurrence of side reactions for the improved selectivity and stability. This work may provide a reference for developing titanium-containing materials with high activity and stability over HOPO reaction.
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IONICS
·
2023
·Vol. 29
·期 5
·1991-2003
·
IF 2.8
Yuhui Cui,Jinghao Lu,Lijuan Yang,Zheng Hao,Runjin Wu,Qian Li,Shijia Xu,Libin Yang
In proton exchange membrane fuel cells (PEMFCs), the most advanced catalysts are mainly carbon loaded with platinum (Pt), but the cathodic catalytic active center is too low to match the oxidation activity and rate at the anode. Co atoms doped into the lattice of Pt alloy change the electronic structure of platinum and reduce the binding energy of oxygen atoms. Au or Rh atoms embedded into the lattice of Pt 3 Co alloy compensate the defect and enhance the activity and rate of the oxygen reduction. Through base on density functional theory (DFT), the adsorption energy for oxygen on Pt 3 Co, Au-Pt 3 Co, and Rh-Pt 3 Co and the segregation energy of Co atoms were calculated. The results show that Au or Rh doped weakens the binding energy of Pt for oxygen on the Pt 3 Co alloy and improves the activity and stability of oxygen reduction. Compared with Rh, the introduction of Au element shows better effects in the electrocatalytic reaction process. Graphical Abstract
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JOURNAL OF SOLID STATE CHEMISTRY
·
2023
·
IF 3.3
Yawen Guan,Shanshan Fu,Wanyu Song,Xueyan Zhang,Bangyu Liu,Fang Zhang,Fang Chai
4-nitrophenol (4-NP) is a harmful aromatic compound to environment. The catalytic hydrogenation of 4-NP was considered as a profitable approach due to the valuable organic intermediate product. High efficiency catalysts are crucial. Herein, Cu–Au bimetallic nanospheres (BNSs) with sea urchin structure were fabricated by tuning the reaction condition and ratio of precursors. The Cu–Au BNSs exhibited effective catalytic activity in the reduction of 4-NP and K 3 [Fe(CN) 6 ]. The optimum catalyst can be determined as the Cu–Au BNSs prepared by 15 mL AA, 4-NP can be reduced to 4-AP in 150 s (k = 3.02 × 10 −2 s −1 ) with TOF value of 0.149 (s −1 ). The reusability of Cu–Au BNSs was evaluated with high effectiveness, the catalytic activity remained negligible loss over 18 cycles with efficiency over 95%, indicated their good reusability, which can be attributed to the synergistic effect of Cu–Au BNSs. The fabrication of bimetallic nanostructures provided an efficient approach to design efficient catalyst.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Haixia Hu,Mingqin Wu,Liping Yao,Huiling Deng,Jiang Hu,Yukun Huang,Xiao Yang,Lijun Wang,Xianggui Chen
Recently, aptamer-enhanced nanozyme activity sensing platforms have gained considerable attention in the bioanalytical and diagnostic fields due to their simplified operations, rapid speed of analysis and visual observation convenience. However, the ability of an aptamer to enhance nanozyme activity has thus far been restricted by oligonucleotide type and length, in turn resulting in the typically high limit of detection (LOD) of aptamer-enhanced nanozyme activity sensing platforms. In this study, a novel cytosine-rich single-stranded DNA (C-rich ssDNA) was designed to overcome these drawbacks and, thereby, significantly enhance the peroxidase-like activity of Fe 3 O 4 @Au nanoparticles (NPs). The ability of this C-rich ssDNA to enhance the peroxidase-like activity of Fe 3 O 4 @Au NPs was shown to be 30% more effective than aptamers. To verify this outstanding performance, a C-rich ssDNA-enhanced Fe 3 O 4 @Au NPs activity sensing platform was developed for the detection of Salmonella Typhimurium ( S. Typhimurium). Under optimum conditions, the novel colorimetric method realized quantitative S. Typhimurium determination ranging from 2.8 × 10 1 to 2.8 × 10 6 CFU/mL, with an ultralow detection limit of 1.8 CFU/mL. Additionally, the feasibility of the proposed colorimetric method was validated in spiked lettuce and milk, with LODs of 2.7 and 3.2 CFU/mL, respectively. These results indicate the significant potential of this novel colorimetric method for effective S . Typhimurium detection in food samples.
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Reaction Chemistry & Engineering
·
2023
·Vol. 8
·期 8
·1981-1992
·
IF 3.9
Li Sun,Mengying Sun,Yuan Zhi,Hua Zhang,Yuejin Shan,Binlin Dou,Jian Chen,Lixin Zhang
The continuous-flow (C-F) reduction process has been limitedly applied in the treatment of dyeing wastewater owing to the weak catalytic performance of the reactors employed. In this work, a small tubular packed reactor and its module are designed, fabricated and used for the C-F reduction of nitro and azo compounds in dyeing wastewater. Here, Au–Co–CoOx-coated glass beads with superior catalytic activity are chosen as packing materials, prepared without any toxic chemical agents. By means of the reactor, 4-nitrophenol (4-NP) can be completely removed and its removal rate is determined to be 100 μmol h−1. After that, a novel strategy for the tandem module is proposed to further enhance the removal rate of 4-NP. Based on the tandem module, the removal rate of 4-NP can be dramatically boosted to 1900 μmol h−1. Meanwhile, the rate constant for the C-F reduction of 4-NP can reach up to 0.44 s−1. Furthermore, the tandem module displays satisfactory operating stability, reusability and reliability in real water samples. In addition, the tandem module first achieves the C-F reduction of 2-nitrophenol, 3-nitrophenol, methyl red and methyl orange. Clearly, the reactor and its module can effectively extend the application of the C-F reduction process in dyeing wastewater treatment.
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