FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Wanqin Xu,Qun Liu,Xu Zeng,Xiaobo Sun,Wuyin Weng,Yucang Zhang
Cinnamaldehyde-DL-lactic acid DES enhances chitosan film performance. • Covalent immobilization of cinnamaldehyde via Schiff base reaction. • Composite film exhibits UV-blocking, antifogging, and antibacterial activities. • The CS(CIN:LA)60 film effectively extends grape shelf-life. To address the issues of non-degradability in traditional petroleum-based packaging materials and the limitations of chitosan (CS) films (e.g., poor mechanical properties, insufficient water resistance, and single functionality), this study incorporated a deep eutectic solvent (DES) composed of cinnamaldehyde (CIN) and DL-lactic acid (LA) into the CS matrix to fabricate high-performance composite films. The effect of DES content on the structure and properties of the composite films was investigated. FTIR and XPS analyses suggested that a fraction of the aldehyde groups of CIN participated in Schiff base formation with the amino groups of CS. Together with hydrogen-bond reorganization and LA induced protonation of CS amino groups, these interactions contributed to the regulation of the CS network. When the DES content was 60% of the dry weight of CS, the resulting CS(CIN:LA)60 film exhibited the optimal comprehensive performance: its tensile strength (TS) reached as high as 41.57 MPa; the water contact angle (WCA) was approximately 100°, indicating good hydrophobicity; the water vapor transmission rate (WVTR) was reduced to 560.2 g/(m 2 ·24h); meanwhile, it possessed excellent ultraviolet (UV) shielding ability, remarkable anti-fogging performance, and good antibacterial activity. Grape preservation experiments demonstrated that the CS(CIN:LA)60 film could effectively inhibit microbial growth, reduce water loss, and delay fruit softening and the degradation of nutritional components. Compared with commercial polyethylene (PE) cling film, the composite film showed advantages in antibacterial activity, anti-fogging performance, and the maintenance of several grape quality attributes. This study provides a new strategy for the development of green food packaging materials. Download: Download high-res image (552KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
RARE METALS
·
2026
·Vol. 45
·期 9
·e70521
·
IF 12.1
Wei Jiang,Bonan Sun,Qian Li,Wen Xia,Qianqian Liu,Peng Han,Hao Wang,Juanwen Cao,Xu Li,Shenghan Lou
en This link goes to a English section zh This link goes to a Chinese section Conductive hydrogels show great potential in flexible electronics and biomedical devices, yet their practical applications are often hindered by insufficient mechanical strength, poor environmental stability, and limited functionality. To address these challenges, this study has developed a hydrogel platform that integrates diagnosis and treatment, enabling real-time monitoring and sealing of gastrointestinal defects. Through a well-designed multi-dynamic network, the hydrogel integrates tissue-like stretchability (fracture strain up to 1420%), strong wet adhesion (adhesion strength 43 kPa), and broad-spectrum antibacterial activity. Leveraging its unique hybrid ionic electronic conductive network, the material enables simultaneous capture of electrophysiological signals (ECG and EMG) and mechanical motions (intestinal peristalsis, cardiac contraction, and gastric activity), achieving multimodal physiological monitoring. Remarkably, while providing a continuous and stable signal sensing, the hydrogel effectively seals gastrointestinal defects, demonstrating excellent defect sealing capability. This work presents a hydrogel platform that breaks through the limitations of conventional single-function materials, offering an innovative solution for closed-loop intelligent diagnostic therapeutic systems, with significant potential in next-generation bioelectronic medicine. 摘要 en This link goes to a English section zh This link goes to a Chinese section 导电水凝胶在柔性电子和生物医学器件领域展现出巨大潜力,但其实际应用常常受到机械强度不足、环境稳定性差以及功能有限等问题的制约。为了解决这些挑战,本研究开发了一种集诊断与治疗于一体的水凝胶平台,可实现胃肠道缺损的实时监测与封闭。通过精心设计的多重动态网络,该水凝胶兼具类组织的高延展性(断裂应变最高可达1420%)、优异的湿态黏附性能(黏附强度为43 kPa)以及广谱抗菌活性。得益于其独特的离子与电子混合导电网络,该材料能够同时采集电生理信号(如心电和肌电)以及机械运动信号(如肠蠕动、心脏收缩和胃部活动),从而实现多模态生理监测。值得注意的是,在提供连续稳定信号感知的同时,该水凝胶还能有效封闭胃肠道缺损,表现出优异的缺损封闭能力。该研究提出了一种突破传统单一功能材料局限的水凝胶平台,为构建闭环式智能诊疗系统提供了创新性解决方案,在下一代生物电子医学中具有重要应用潜力。
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yanzhi Chen,Jiawen Zhang,Xinnuo Wang,Molan Zhang,Lijun You,Kseniya Hileuskaya
Agaricus bisporus chitosan coated metformin-encapsulated nanoliposomes. • ACS coating improved nanoliposome stability and encapsulation retention. • A-M-L improved glycemic control and lipid metabolic profiles in T2DM mice. • A-M-L mitigated gastrointestinal inflammation and preserved mucosal integrity. • ACS modification enhanced intestinal mucoadhesion and ileal retention. Gastrointestinal intolerance and limited intestinal residence remain important challenges in the long-term oral use of metformin (MET) for type 2 diabetes mellitus (T2DM). Although liposomal encapsulation can improve drug delivery, unmodified MET-encapsulated liposomes remain vulnerable to gastrointestinal disruption and premature leakage, which undermines their therapeutic potential. To address this limitation, Agaricus bisporus -derived chitosan (ACS) was employed as a bioactive macromolecular coating to construct MET-encapsulated liposomes (MET-LP). The ACS coating reversed the surface charge of MET-LP, improved colloidal dispersion, and enhanced storage stability, with 0.5% ACS-modified MET-encapsulated liposomes (A-M-L) retaining 83.1% encapsulation efficiency after 21 days at 4 °C. In T2DM mice, 1.0% A-M-L produced stronger glycemic control, lowering fasting blood glucose from 14.3 to 8.6 mmol/L, reducing HbA1c by approximately 32.9%, and decreasing the area under the curve (AUC) of the oral glucose tolerance test (OGTT) by 37.7%. Moreover, A-M-L improved serum lipid profiles and hepatic oxidative-stress-related indicators and was associated with lower ileal inflammatory cytokine levels and better-maintained gastrointestinal tissue morphology in T2DM mice. ACS modification also enhanced the intestinal retention of labelled liposomal carriers, as indicated by a 233.3% higher ileal fluorescence intensity of 0.5% A-M-L than unmodified MET-LP in SD rats. Collectively, these findings indicate that ACS modification improved the formulation stability, intestinal retention of labelled liposomal carriers, and hypoglycemic performance of MET-encapsulated liposomes.
✓ 已验证
DOI
高影响因子
FIBERS AND POLYMERS
·
2026
·
IF 3.1
Tang Ci,Liu Siying,Li Xuan,Yang Jing
Herbal extracts possess antioxidant and broad-spectrum antibacterial activity, which can efficiently inhibit the growth of multiple pathogenic microorganisms. However, their inherent disadvantages, including poor aqueous solubility and inferior physicochemical stability, severely hinder their practical application. Herein, a co-loaded dual-network polysaccharide hydrogel was engineered to tackle these challenges. Baicalin (BA) was first encapsulated into cyclodextrin to yield a BA inclusion complex, which was embedded within a crosslinked hydrogel network built from chondroitin sulfate and carboxymethyl chitosan. Berberine hydrochloride (BH), a synergistic antibacterial candidate, was co-loaded in situ during hydrogel synthesis to attain combined antibacterial effects of baicalin and berberine hydrochloride. The antibacterial results confirm that the BH-BA inclusion complex effectively lowers the individual effective antibacterial concentrations of both agents, showing prominent synergistic activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). The resultant hydrogel displayed enhanced structural stability, favorable mechanical properties, excellent biocompatibility, as well as pH-responsive drug release profiles. After incubation with the dual-network hydrogel, the survival rates of Escherichia coli and Staphylococcus aureus reached 12.67 ± 3.06% and 7.33 ± 2.08%, respectively, accompanied by a DPPH radical scavenging capacity of 82.08± 6.99%. Among all tested groups, the OCBBC group displayed the most pronounced effect in promoting cell migration, achieving a cell scratch wound healing rate of 72.46 ± 1.75%. This dual-network hydrogel provides a feasible avenue to construct high-efficiency antibacterial biomaterials and paves the way for innovative antibacterial treatment modalities.
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.4
Huidong Fang,Shiai Xu,Siyu Han,Bin Zhao,Chao Zhang,Wanji Zhou
T-shaped droplet microfluidic device was used for preparing 5-Fu-loaded chitosan microspheres. • 5-Fu-loaded chitosan microspheres exhibit pH-responsive release patterns and sustainable release characteristics for up to 60 days. • The average particle size of the microspheres is 3.90 ± 0.57 μm, and the particle size distribution is narrow. • Drug-loaded microspheres of different particle sizes have different drug release rates and cycles. Microsphere formulations are a promising drug delivery system for targeted response and prolonged sustained release. However, conventional emulsification crosslinking methods for microsphere preparation usually result in a broad particle size distribution, large particle size, poor uniformity, and consequently erratic drug release kinetics. In this investigation, chitosan microspheres encapsulating 5-Fluorouracil (5-Fu CS-MS) were fabricated using a T-type droplet microfluidic device, and the formulation was optimized by single-factor experiments. The resulting microspheres had a consistent drug release profile, a smooth surface, high monodispersity, and a uniform particle size distribution with an average particle size of 3.90 ± 0.57 μm. The polymer-drug interaction in 5-Fu CS-MS was analyzed using FTIR and XRD. The XPS and EDS results confirmed the occurrence of a Schiff base reaction between glutaraldehyde (GA) and chitosan (CS), indicating successful encapsulation. TGA results revealed that the cross-linking reaction enhanced the thermal stability of the microspheres. Biocompatibility assessments using Human umbilical vein endothelial cells (HUVEC) line demonstrated the safety and compatibility of the fabricated microspheres. More importantly, the in vitro release results illustrated a pH-responsive drug release profile and sustained release of 5-Fu CS-MS for a period up to 60 days. In summary, the CS sustained-release microspheres produced using the microfluidic technique have the potential for intelligent response, precise drug delivery, and prolonged sustained release of small-molecule drugs. Download: Download high-res image (197KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Xiaoyun Zheng,Yixuan Liu,Yingqi Li,Weilin Zhou,Xianying Chen,HaiYu Feng,Xiaorong Lin,Yong Hu,Yun Chen,Chao Huang,Xiguang Ye
Chitosan-carbon quantum dots-tellurium nanoparticles (CS-CQDs-TeNPs) was a multifunctional nanozyme integrating high stability, photoluminescence, and enzyme-like catalytic activity. • Hg 2+ specifically triggered the oxidase-like activity of CS-CQDs-TeNPs through a ping-pong mechanism. • The mechanism proceeded via in-situ formation of HgTe, which catalyzed ROS (O 2 - /·OH) generation to oxidize the substrate for colorimetric detection. • The CS-CQDs-TeNPs-based colorimetric sensor demonstrated high selectivity and strong anti-interference capability, enabling reliable detection of Hg 2+ in environmental water samples. • The sensor performed on-site detection and simultaneous detoxification of Hg 2 (via conversion to HgTe), presenting a dual-function platform for mercury pollution control. Herein, a CS-CQDs-TeNPs-based colorimetric sensor was developed for the highly sensitive detection and simultaneous harmless conversion of Hg 2+ . In the presence of Hg 2+ , the oxidase-like activity of CS-CQDs-TeNPs was specifically triggered, and its catalytic kinetics followed the ping-pong mechanism. Under conditions of pH 4.0 and 30 °C, the colorimetric sensor constructed from 38.6 μg/mL CS-CQDs-TeNPs and 1.040 mmol/L TMB exhibited optimal activity, demonstrating a V max of 83 (10 −8 ·M·s −1 ) and a K m of 13 mmol/L. Mechanistic studies indicated that Hg 2+ reacted with CS-CQDs-TeNPs to form HgTe in situ. The generated HgTe catalyzed the generation of reactive oxygen species from O 2 . These reactive oxygen species, in combination with the surface oxygen vacancies of the CS-CQDs-TeNPs, synergistically oxidized TMB, thus resulting in a colorimetric response. The CS-CQDs-TeNPs-based colorimetric sensor exhibited excellent selectivity, anti-interference capability, and considerable detection potential, while converting Hg 2+ into low-toxicity HgTe during detection, thus realizing the integration of detection and remediation. This study provides a novel strategy for designing environmentally responsive nanozymes and remediating Hg 2+ pollution.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 5
·e71088
·
IF 4.1
Hui Yuan,Tai Feng Lin,Xue Mei Liu,Zi Qi Xie,Xin Yang,Yun Jing Luo
Human consumption of food contaminated with oxytetracycline (OTC) residues can lead to its accumulation in the body and cause harm. In this study, due to the trace residues of OTC in food, surface imprinting technology was employed to prepare oxytetracycline magnetic molecularly imprinted polymers (OTC-MMIPs). This was achieved using Fe 3 O 4 @SiO 2 as the core, modified with chitosan, and with OTC as the template molecule. OTC-MMIPs were used to adsorb OTC. After combining with AuNPs, the OTC-MMIPs@AuNPs composite was used to adsorb OTC, and then SERS was employed for detection. According to the kinetic adsorption experiment, the maximum adsorption capacity of OTC-MMIPs was 44.58 mg g −1 , with a 7% decrease in adsorption capacity observed after four cycles of reuse. Following the adsorption of OTC onto OTC-MMIPs@AuNPs, detection was performed using SERS. A linear relationship was established between the intensity of the characteristic peak at 1329 cm − 1 and the OTC concentration, achieving a detection limit of 6.67 × 10 −12 M. Furthermore, the method was validated in pure milk samples, the recovery rate ranges from 91.73% to 96.22%. These results demonstrate the feasibility of the proposed method for detecting OTC in pure milk.
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Wenchao Li,Guitao Deng,Li Wan,Yucheng Liu,Fanrong Ai,Jinhua Hong,Kui Zhou
Lanthanum-doped hydroxyapatite nanowires (La-HAW) were successfully synthesized via a hydrothermal method and integrated into cryogenically 3D-printed chitosan (CS) porous scaffolds. Owing to their enhanced osteogenic activity and inherent antibacterial properties, these scaffolds represent a promising strategy for bone tissue engineering applications. Comprehensive characterization confirmed that the La-HAW possessed high aspect ratios (>1000), uniform elemental distribution, and successful incorporation of La 3+ into the hydroxyapatite lattice via XRD, XPS, and EDS analyses. In vitro biological evaluations revealed that La-HAW significantly promoted the osteogenic differentiation of MC3T3-E1 pre-osteoblasts, evidenced by elevated alkaline phosphatase (ALP) activity and enhanced calcium mineralization, while maintaining excellent biocompatibility. Additionally, La-HAW exhibited strong antibacterial efficacy, with inhibition rates of 90 ± 2% against Escherichia coli and 78 ± 3% against Staphylococcus aureus . When structured into porous chitosan-based scaffolds via cryogenic 3D printing, the resulting CS/La-HAW scaffolds exhibited hierarchical porosity with favorable degradation kinetics, high swelling capacity, and improved cellular adhesion and proliferation. The unique nanowire morphology provided abundant anchoring sites that promoted cell adhesion, spreading, and cytoskeletal extension, synergistically enhancing osteogenic induction. These findings highlight the dual-functional capability of La-HAW based scaffolds, combining enhanced osteogenesis with inherent antibacterial properties, positioning them as a promising platform for bone regeneration.
✓ 已验证
DOI
高影响因子
Biomedical Materials
·
2026
·Vol. 21
·期 3
·035031
·
IF 3.9
Changle Lu,Bailei Li,Jiali Liu,Xinyu Gao,Zhen Zhang,Yu Zhou,Qilong Cao,Xiaojun Liu,Rongqing Zhang
Diabetic wound healing remains a clinical challenge due to impaired repair, often leading to complications such as infection and tissue necrosis. Here, we present a novel dual-drug-loaded hydrogel formulated using oxidized hyaluronic acid (OHA) and catechol-modified chitosan (CS-pC). This system is engineered to enhance the local bioavailability of polydatin (PD) and delay the release of tetramethylpyrazine (TMP), achieving superior release performance and synergistic effects compared to single-drug formulations; thus, this system enables synergistic modulation of the target inflammatory microenvironment and promotes angiogenesis, thereby facilitating effective diabetic wound healing. The hydrogel exhibited a porous structure (100–200 μm) and moderate swelling (119.67% ± 6.66% at 24 h). Approximately 80% of TMP and PD were sustainably released within 48–52 h, aligning with clinical dressing intervals. In diabetic mice, it accelerated wound closure to 98.01% within 14 d—20.63% higher than controls. Most notably, the hydrogel significantly promoted wound healing, as evidenced by: (1) upregulation of vascular endothelial growth factor (VEGF) and α-SMA expression (RT-qPCR: 3.2-fold for VEGF and 3.7-fold for α-SMA vs control); (2) enhanced cell migration (3.1-fold vs control) and angiogenesis (1.3-fold vs control); and (3) increased expression of CD31, TGF-β1 and collagen types I and III (IHC). These results demonstrate the therapeutic potential of the OHA/CS-pC/TMP/PD hydrogel for diabetic wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
·
2026
·Vol. 116
·期 3
·117523
·
IF 1.8
Huifeng Yang,Xiaoyi Li,Yimin Su,Jianxin Guo,Tengfei Wang,Zhigang Wang,Hai Fu,Zhi Chen,Zhongjian Xie,Defa Li
Purpose Acute respiratory infections caused by bacterial and viral pathogens pose a major global health burden. The recombinase polymerase amplification (RPA)-CRISPR-Cas12a system offers a promising point-of-care testing (POCT) platform, but its field deployment is limited by the instability of lyophilized reagents. This study aims to develop a composite lyoprotectant to enhance the stability of the RPA-CRISPR-Cas12a system for respiratory pathogen detection. Materials and methods A composite lyoprotectant composed of trehalose and carboxymethyl chitosan (Tre-CMC) was formulated at various mass ratios. The optimal ratio was identified by evaluating matrix microstructure, enzyme activity retention, and primer-dimer suppression. The lyophilized system was tested for sensitivity, specificity, and long-term stability against six respiratory pathogens (H1N1, IBV, Neisseria meningitidis , SARS-CoV-2, Streptococcus pneumoniae , and human adenovirus) using real-time fluorescence and gel electrophoresis. Results This study establishes a promising proof-of-concept framework for an integrated, lyophilized RPA-CRISPR–Cas12a diagnostic system. The optimal Tre: CMC ratio (2:1) produced a porous, non‑hygroscopic matrix that preserved reagent integrity. The lyophilized system achieved a detection limit of 10 copies/reaction within 30 min for all six pathogens, with 100% specificity. After six months of storage at 4°C, RPA enzyme activity remained above 89%, and Cas12a-crRNA complex functionality was fully retained. Tre-CMC significantly reduced primer-dimer formation and nonspecific background fluorescence. While clinical evaluation using 21 nasopharyngeal swab samples demonstrated 100% concordance with RT-qPCR—preliminarily supporting the system's potential diagnostic accuracy—we acknowledge that this initial methodological framework requires broader and more rigorous downstream validation with larger clinical cohorts to formally establish its robust diagnostic performance. Conclusion The Tre-CMC composite lyoprotectant effectively stabilizes the RPA-CRISPR-Cas12a system, enabling cold-chain-independent storage and reliable POCT for respiratory pathogens in resource-limited settings.
✓ 已验证
DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Fengfan Yu,Ruirui Wang,Yanhang Wang,Mengjie Qian,Jintao Sun,Jinwen Song,Jinte Zou,Jun Li
Short-term chitosan (CTS) dosing shortened granulation time from 27 to 9 days. • CTS improved TN removal after nitrification recovered from initial inhibition. • CTS promoted sludge granulation through cationic bridging and physical nucleation. • CTS reduced sludge zeta potential and enhanced EPS secretion during granulation. • CTS@Fe 3 O 4 enabled tracking of CTS migration into aggregates during granulation. This study investigated the feasibility of accelerating aerobic granular sludge (AGS) formation by short-term in-situ dosing of chitosan (CTS) in sequencing batch reactors. Compared with the control reactor, short-term CTS dosing during start-up markedly promoted biomass aggregation, shortened the complete granulation time from 27 to 9 days, and produced larger and denser granules with superior settleability. In the CTS-amended reactor, the mean granule size reached 752 µm, while sludge volume index at 30 min (SVI 30 ) rapidly decreased to 59.4 mL/g within 24 h and stabilized at 38.2–44.8 mL/g during steady operation. Mechanistic analyses showed that CTS reduced sludge surface electronegativity, stimulated extracellular polymeric substance (EPS) secretion, and functioned as both a cationic bridging agent and a physical nucleation core. These roles were further supported by direct visualization using CTS-coated Fe 3 O 4 particles as a tracer. Temporary pH control applied to activate the cationic properties of CTS initially suppressed nitrification, but the inhibition was reversible. After recovery, the CTS reactor achieved superior total nitrogen (TN) removal, with an average effluent TN of 8.6 mg/L compared with 15.3 mg/L in the control. The enhanced TN removal may be associated with the combined effects of larger and more compact granules and the possible contribution of residual CTS as supplementary electron donor. Microbial analysis further revealed the enrichment of EPS-producing and structural bacteria, especially Thiothrix , in the CTS reactor. Overall, short-term in-situ CTS dosing provides a simple and biocompatible strategy for rapid AGS start-up and improved nitrogen removal. Download: Download high-res image (212KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Chen Tang,Hongju Zeng,Yufei Lao,Man Jia,Shiyu Ou,Meng Qin,Liping Li
The pervasive contamination of aquatic systems by microplastics and nanoplastics (MNPs) poses substantial threats to environmental safety and human health, highlighting a pressing demand for eco-efficient and sustainable removal approaches. However, existing chitosan aerogel techniques encounter issues of limited adsorption capacity, and potential environmental toxicity. Drawing inspiration from the rapid fluid transport properties of fiber-reinforced bamboo cell walls, this study developed a green, vertically aligned porous vanillin-chitosan aerogel. This optimized aerogel exhibits outstanding underwater compression performance, achieving a high removal efficiency (>99%) and exceptional adsorption capacity (221.1 ± 2.22 mg·g −1 ) for polystyrene (PS) MPs. Furthermore, the aerogel maintained robust removal efficiencies (>90%) across various MNPs (including PS, polyethylene terephthalate (PET), and polymethyl methacrylate (PMMA)) and within real environmental water matrices. Notably, the material exhibited excellent reusability, retaining over 92% adsorption efficiency after five regeneration cycles. It also demonstrated remarkable mechanical durability, maintaining a 99.99% height retention and an energy loss coefficient of 0.65 after 20 compressive cycles. Under dynamic flow conditions, 1.37 g of chitosan aerogel crosslinked with vanillin (CSV2) removed 99.9% of PS MNPs within 3 h across all tested concentrations. By reconciling an exceptionally high adsorption capacity with a completely green synthesis route, this bamboo-inspired aerogel provides a safe and highly sustainable strategy for practical MNPs remediation.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）