INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Ce Zheng,Chunyu Liu,Hailiang Chen,Ning Wang,Xia Liu,Guozhen Sun,Weihong Qiao
Wound dressing is of significant importance to promote cutaneous wound healing process. To develop an effective wound dressing, a PVA/DA hydrogel was prepared using a Poly (vinyl alcohol)/Dextran-aldehyde solution blend, followed by crosslinking via freeze-thaw method and freeze-drying. We characterized the hydrogel by infrared spectroscopy, mechanical property tests, swelling behavior test and biocompatibility test. Results showed that the PVA/DA hydrogels had a 3-dimensional, highly porous structure with uniformly distributed pores of 5–10 μm, strong tensile strength of 5.6 MPa, efficient ability to absorb fluid of 6 time its weight and suitable water vapor transmission rate of 2100 g m −2 day −1 to keep a moist environment and good biocompatibility shown by very low hemolysis and no cytotoxicity. In wound healing tests using a full-thickness skin wound model, macroscopic observations showed that the wound covered by the PVA/DA hydrogel almost reached complete healing faster by 10 days, while histological analysis indicated a faster regeneration of skin. Thus, the PVA/DA hydrogel was suitable for application as a wound dressing and may have potential for use in various biomedical applications.
研究领域:
材料科学
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生物医学工程
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
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2025
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IF 6.2
Dandan Wei,Guanhua Jiao,Yinghua Tao,Liuxin Yang,Tao Liu,Fengya Jing,Tianzhu Zhang
Development of an antiadhesion polypropylene (PP) mesh in hernia repair is a recognized need because its efficacy is limited by severe abdominal adhesions. The porous structure of PP mesh can facilitate the integration between prosthetic material and abdominal tissue and promote the repair of abdominal wall defect. Herein, an antiadhesion composite hydrogel coating composed of polyvinyl alcohol (PVA) and hyaluronic acid methacrylate (HAMA) is fabricated on the surface of PP mesh through ultraviolet photopolymerization combined with freezing–thawing method. The resulted composite hydrogel coated PP mesh retain 43.33% of the pore structure by this way. In vitro tests proved the as-prepared PP mesh exhibit excellent hydrophilicity and biocompatibility. Meanwhile, the hydrogel coating shows good stability on the surface of PP mesh in phosphate buffered saline medium. After implantation in a rat abdominal wall defect model, the modified PP mesh effectively prevents the formation of adhesion by reducing inflammatory response and suppressing excessive deposition of collagen fiber. Immunohistochemical staining results demonstrate that the modified PP mesh can not only decrease the expression of IL-6, TNF-α, and CD68 but also promote the expression of CD31. Thus, this type of PP mesh with preventing postoperative adhesions and improving angiogenesis may be a promising clinical prosthetic material.
研究领域:
生物医学工程
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材料科学
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组织工程
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外科研究
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产品关联
DOI
高影响因子
STARCH-STARKE
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2021
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IF 2.741
Qifeng Chen,Yunjia Wang,Fushou Yin,Wenxiong Wang,Guangxue Chen,Peisheng Lin
Medical dressings require good antibacterial and mechanical properties. Polyvinyl alcohol based medical dressings are commercially available, and the antimicrobial properties of chitosan and cerium ions are known, and nanocellulose possesses excellent comprehensive properties, such as non-toxicity, biocompatibility, and biodegradability. In this study, polyvinyl alcohol-chitosan/cerium-nanocellulose (PVA-Cs/Ce-CNF) composite hydrogels are prepared by a freeze-thaw method and characterized by scanning electron microscope and X-ray diffraction. It is expected to improve antibacterial activity of the composite hydrogels by adding a small amount of cerium, and their biological activity will not be affected. In addition, the effects of chitosan/cerium (Cs/Ce) complexes and nanocellulose with different contents on properties are investigated. The results show that PVA-Cs/Ce-CNF composite hydrogels have a 3D, highly porous structure with distributed pores of 8–30µm, good skin viscosity, efficient ability to absorb fluid, and suitable water vapor transmission rate of 2000—2500 g m −2 day −1 . Two hydrogels in specific ratio show good strong tensile strength of 132.6 and 130.1 kPa respectively, and their elongation at break are over 400%. The PVA-Cs/Ce-CNF composite hydrogels are non-toxic, and they have inhibitory effect on Escherichia coli and Staphylococcus aureus . These results suggest that the PVA-Cs/Ce-CNF composite hydrogels have great potential as medical dressings.
研究领域:
材料科学
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生物医学工程
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药学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Shuchun Gan,Bo Xu,Xiong Zhang,Jianhao Zhao,Jianhua Rong
Physically cross-linked double-network (DN) hydrogels are capturing more and more attention due to their good mechanical properties and self-recovery ability. However, they usually suffer from complicated preparation process and fussy performance regulation, which severely limit their applications in many fields. Herein, we fabricated a physically cross-linked poly(vinyl alcohol)-(2-hydroxypropyltrimethyl ammonium chloride chitosan) (PVA-HACC) DN hydrogels without organic solvents or toxic cross-linking agents via a simple two-step method of freezing/thawing and immersion processing. The effects of immersion time and concentration of Na 3 Cit solution on the structures and mechanical properties of the hydrogels were investigated. The obtained hydrogels exhibited excellent mechanical properties including high elastic modulus (1.44 MPa), high strength (a maximal tensile fracture stresses of 4.14 MPa and a maximal compressive stresses of over 70 MPa at 98% strain), and superior fracture toughness (17.09 MJ/m 3 ). In addition, good self-recovered property and anti-fatigue performance were realized for the hydrogels owing to the reversible HACC ionic networks. The preparation of PVA-HACC DN hydrogels offers a new guidance for the design and synthesis of environmentally friendly DN hydrogels with outstanding mechanical properties and broad application prospects.
研究领域:
材料科学
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高分子化学
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机械工程
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）