EXPERIMENTAL GERONTOLOGY
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2026
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IF 5.1
Jingkai Di,Shuang Wang,Zijian Guo,Yijing Di,Nan Yang,Talante Juma,Yinqi Long,Likun Qi,Yongping Cao,Chuan Xiang
RHOB inhibition is a central mechanism underlying BPA-induced OA-NAFLD comorbidity. • RHOB downregulation drives BPA-induced comorbidity via Hippo/IL-17 signaling and Glycolipid dysregulation. • Immune imbalance contributes to the comorbidity between OA and NAFLD. • Single-cell sequencing shows RHOB predominantly in hepatocytes (NAFLD) and HomC clusters (OA). • Rescue experiments confirmed restoring RHOB restoration reverses these pathological effects. Background This study focuses on exploring the co-morbid mechanisms by which Bisphenol A (BPA) induces non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA). Method This study identified potential BPA targets utilizing the SwissTargetPrediction database. These targets were integrated with genes associated with NAFLD and OA, which were screened via Weighted Gene Co-expression Network Analysis and differential gene expression analysis. To elucidate the underlying biological mechanisms, functional enrichment and immune infiltration analyses were conducted. Core genes associated with comorbidity were pinpointed via machine learning. The interactions and cellular localization were further validated by molecular docking, molecular dynamics simulations, and single-cell transcriptomics. Finally, in vitro experiments were employed to verify the effects on chondrocyte function, and hepatic lipid metabolism. Results Functional enrichment analysis indicates that BPA-induced NAFLD and OA comorbidity pathways are enriched in muscle cell proliferation, DNA metabolism, and inflammation pathways. RHOB has been identified as a core gene, participating in disease progression by regulating signaling pathways such as Hippo and IL-17. Single-cell sequencing revealed that RHOB is primarily expressed in hepatocytes and cholangiocytes in NAFLD, while enriching in HomC and EC cell clusters in OA. In vitro experiments confirmed that BPA exposure suppresses RHOB expression, thereby promoting lipid accumulation in hepatocytes and impairing chondrocyte function. Concurrently, rescue experiments demonstrated that its overexpression significantly reversed these pathological states. Conclusion BPA exposure drives the co-morbidity of OA and NAFLD by inhibiting RHOB. Consequently, limiting BPA exposure or modulating the RHOB pathway represents a viable approach for intervening in related diseases.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Bin Wen,Fan Chen,Yi Ran,Dongyun Que,Zhihao Zhang,Youwei Zeng,Yuyuan Yao
Molybdenum disulfide (MoS₂) is a promising inorganic co-catalyst for Fenton processes due to its structural durability and avoidance of secondary organic pollution. However, the conventional 2H-phase MoS₂ suffers from intrinsically low conductivity, severely limiting Fe 3+ reduction in the Fenton reaction. Herein, L-cysteine served as a multifunctional precursor during the preparation of MoS₂, promoting a slow-release sulfur supply, carbon‑nitrogen co-doping, and the prevention of restacking. The carbon and nitrogen co-doped molybdenum disulfide (CN-MoS 2 ) architecture was fabricated via a single-step hydrothermal reaction mediated by sodium molybdate, thiourea, and L-cysteine. Remarkably, benefiting from the introduction of L-cysteine, the resulting CN-MoS 2 exhibited a high 1 T-phase content (68%), abundant sulfur vacancies, and a substantially reduced particle size. CN-MoS 2 accomplished near-complete elimination of carbamazepine (CBZ) within merely 3 min, yielding a prominent apparent rate constant of 0.7111 min −1 , which is a 19-fold kinetic acceleration over thiourea-derived MoS 2 . CN-MoS₂ also exhibited high TOC removal, broad-spectrum degradation, and robust CBZ removal under various water conditions. Additionally, electrochemical analyses further verified that CN-MoS₂ reduced charge-transfer resistance and enriched electron density, thereby facilitating rapid electron shuttling to Fe 3+ . Concurrently, quenching experiments and electron paramagnetic resonance (EPR) diagnostics unambiguously validated SO 4 •- , 1 O 2 and O 2 •- as the driving reactive forces. Moreover, a continuous-flow device incorporating a CN-MoS 2 -based membrane exhibited outstanding performance in wastewater purification. This work offers a new strategy for designing high-activity co-catalysts for advanced oxidation processes.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Mengxia Ji,Zhen Tao,Tiange Wei,Yifan Shao,Qing Xu,Jinman Yang,Jiexiang Xia,Huaming Li
A direct Z -scheme heterojunction was constructed between carbon nitride and BiOBr 0.5 I 0.5 ultrathin nanosheets. • The optimized composite achieved 84% BPA removal efficiency under visible light irradiation within 40 min. • The internal electric field at the heterointerface drives a direct Z-scheme charge transfer pathway. • The h + , •O 2 − , and •OH were identified as dominant active species via ESR and scavenging experiments. • Enhanced spatial carrier separation and preserved redox ability synergistically boost photocatalytic degradation activity. Bismuth oxyhalide-based solid solutions have excellent visible light absorption and oxidation capabilities, but limited charge separation efficiency hinders their applications. In this study, a Z-scheme heterojunction involved ultrathin polymeric carbon nitride (CN) and BiOBr 0.5 I 0.5 solid solution (BOBI) nanosheets was synthesized for BPA photodegradation. The well-matched energy bands and work function difference between CN and BOBI promote efficient separation and transfer of photogenerated carriers. Meanwhile, CN/BOBI retains the strong reduction capacity of CN and the strong oxidation capacity of BOBI, which is conducive to the generation of more reactive oxygen species (ROS, •OH and •O 2 − ) and holes. Based on these advantages, CN/BOBI exhibits excellent bisphenol A (BPA) removal performance. The optimized CN/BOBI-2 composite achieves an 84% BPA removal efficiency under visible light irradiation. This work establishes a scalable strategy for modulating solid solution photocatalysts via heterojunction engineering, which can be applied to sustainable environmental remediation. Download: Download high-res image (213KB) Download: Download full-size image
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POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Jing Wang,Wei Bai,Gongying Wang,Chen Li,Qingyin Wang
Bis(4-(2-hydroxyethoxy)phenyl)fluorene polycarbonate is a transparent thermoplastic resin characterized by a high refractive index and low birefringence, yet it has a relatively low molecular weight. To further increase the polymer's molecular weight, this study synthesized α-ZnS and β-ZnS, along with their coexisting phase, through a precipitation method to catalyze the transesterification polycondensation of bisphenol A (BPA), 9,9-bis[4-(2-hydroxyethoxy)phenyl]fluorene (BPEF), and diphenyl carbonate (DPC) via melt ester exchange polycondensation. It was found that the acidic sites generated during calcination contribute to enhanced catalytic activity, leading to a high-molecular-weight polycarbonate ( M w = 87,363). Concurrently, the tensile strength (89.02 MPa) increased as the molecular weight rose. Notably, varying the ZnS content (0.085–1.67 g/kg) in the incorporated polycrystalline phase not only effectively catalyzed the polymerization reaction but also increased the refractive index without significantly affecting the transmittance. Highlights Polycrystalline ZnS was synthesized through precipitation and calcination for catalytic applications. The medium-strength acid sites on ZnS notably augmented the molecular weight of polycarbonate (PC). The high M w PC matrix elevated the tensile strength to 89.02 MPa. PC doping with ZnS increased the refractive index without a significant reduction in transmittance. The PC/ZnS composites demonstrated outstanding UV-shielding properties and thermal stability.
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POLYMER
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2026
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IF 5.1
Zhenyao Zhang,Xiaoming Qi,Liming Wang,Hongbo Dai,Jieyang Qiu,Qingqing Ni
Carbon fiber-reinforced epoxy composites are widely used in engineering applications owing to their excellent specific strength, modulus and cost performance. However, the brittleness and poor recyclability of the thermosetting epoxy matrix severely limit their sustainability. In this study, bisphenol A-type epoxy resin and bisphenol A were used as raw materials, and a 2-methylimidazole/tetrabutylammonium bromide catalytic system was employed to successfully prepare a high strength and toughness thermoplastic epoxy resin (TPE) via solution polymerization. The resulting TPE exhibited a weight-average molecular weight ( M w ) of 43078 g/mol and a polydispersity index of 1.29. In addition, the TPE exhibited outstanding mechanical and thermal performance, with high tensile strength of 76 MPa, toughness of 30.7 MJ m −3 and T d5% of 423 ° C. Carbon fiber-reinforced thermoplastic epoxy composites (CF/TPE) were fabricated via the prepreg compression molding process. The CF/TPE composites exhibited a tensile strength of 1022.7 MPa, flexural strength of 1042.5 MPa and interlaminar shear strength (ILSS) of 65.2 MPa. The TPE matrix can be efficiently dissolved in polar solvents, enabling the intact recovery of both carbon fibers and the TPE matrix. This approach provides a TPE to replace conventional thermosetting epoxy while also enabling an effective preparation-recycling route for sustainable use of carbon fiber composites.
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高影响因子
BIORESOURCE TECHNOLOGY
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2026
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IF 8.2
Yueru Fang,Lan Zhang,Kuok Ho Daniel Tang,Ronghua Li
3D macroporous chitosan-bentonite foam composite was fabricated via ice-templating. • Bisphenol capture is governed by hydrogen bonding and polar interactions. • BPS preferentially engages –NH sites via its –SO 2 – group revealed by FTIR. • Efficient bisphenol removal was achieved across diverse real water matrices. • Preliminary capture of heavy metals and microplastics was also demonstrated. Bisphenols (BPA, BPF and BPS) are emerging contaminants with well-documented endocrine-disrupting effects, and their environmental occurrence often coincides with heavy metals and microplastics. In this study, a three-dimensional chitosan/bentonite composite foam (CBF) was fabricated via directional ice-templating and systematically evaluated as a recoverable adsorbent for bisphenols. The CBF exhibited stable adsorption performance, with kinetics following the pseudo-second-order model and isotherms well described by the Langmuir model, achieving moderate maximum capacities of 13.69 to 16.27 mg/g under a monolithic, manually recoverable design. High removal efficiencies were maintained over a wide pH range (2.0–10.0) and under varying ionic strength conditions. Spectroscopic and thermodynamic analyses indicate that bisphenol adsorption is governed by hydrogen bonding, polar interactions, and pore confinement effects, with selectivity among analogues modulated by their analogue-specific interaction pathways with the functional groups of CBF. The positive enthalpy change and increasingly negative Gibbs free energy further support a spontaneous and endothermic adsorption process. Preliminary tests further indicated that the macroporous framework was capable of capturing heavy metal ions (Pb(II), Cd(II)) and physically entrapping representative microplastics (PLA, PS, PE), suggesting potential applicability beyond bisphenols. Within its intended design scope of prioritizing operational simplicity over maximum capacity, CBF offers a monolithic platform with facile manual separation and minimal secondary turbidity. This combination of low-cost raw materials, monolithic recoverability, and multi-class pollutant applicability distinguishes CBF from conventional powdered adsorbents and is relevant to the practical treatment of bisphenol contaminated water under complex matrix conditions. Download: Download high-res image (83KB) Download: Download full-size image
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高影响因子
Surfaces and Interfaces
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2026
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IF 6
Huan Song,Le Song,Fangzhou Wu,Yonglei Xing,Xiaoyong Jin,Fang Wan,Gang Ni
Non-metal doping provides a route to tune metal sites in carbon catalysts for peroxymonosulfate (PMS) activation. Here, a phosphorus-modified N-doped carbon catalyst with an ultralow cobalt loading (Co2-P1-NC; 0.14 wt% Co) was prepared. Under optimized conditions, the Co2-P1-NC/PMS system removed phenol (Ph) within 2.5 min, with an apparent pseudo-first-order rate constant of 2.068 min −1 . Co-free NC and P-NC showed only limited activity, indicating that Co-containing sites account for most of the catalytic enhancement. Quenching tests, electron paramagnetic resonance (EPR), PMSO probing, in situ Raman spectroscopy, electrochemical measurements, and premixing experiments collectively support the coexistence of radical and nonradical routes, with high-valent Co species and interfacial electron transfer making major contributions under the tested conditions. Density functional theory calculations using representative CoN 4 and CoN 3 P models showed that P substitution made PMS adsorption more favorable (from −2.56 to −3.38 eV), whereas the calculated O–O bond length and Bader charge changed only slightly; the adsorption enhancement is therefore attributed mainly to altered geometry and interfacial electronic interactions. P modification also reduced the measured Co leaching concentration from 0.016 to 0.005 mg L −1 . The catalyst rapidly removed several phenolic pollutants, although activity declined during reuse and was inhibited by carbonate and humic acid. These results demonstrate a promising low-Co catalyst design while identifying stability and water-matrix effects as priorities for further development. Download: Download high-res image (308KB) Download: Download full-size image
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Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 5
·123972
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IF 7.5
Hasan Ubaid Ullah,Hang Liu,Tao Lin,Chao Liu
Organic micropollutants (OMPs) pose significant risks to aquatic ecosystems and drinking water safety. This study developed nitrogen–impregnated granular activated carbon (N-GAC) with ammonium chloride as a precursor to enhance OMP removal through surface functionalization. Optimal nitrogen loading (∼0.1 wt%) achieved minimal surface area loss (1.4%) while shifting the point of zero charge (pH pzc ) from pH ∼8 to 10. Four structurally diverse OMPs, including naproxen (NPX), bisphenol-A (BPA), diclofenac (DCF), and ibuprofen (IBP), were evaluated to establish structure-performance relationships. The most remarkable improvement was achieved in NPX removal, with pseudo first-order rate constants increasing by 67% at pH 6. The maximum adsorption capacity of IBP increased by 240%, compared to virgin GAC. Mechanistic investigations revealed that nitrogen impregnation could increase the abundance of pyridinic nitrogen and pH pzc , likely resulting in enhanced π-π electron donor-acceptor interactions, electrostatic attraction at environmentally relevant pH, and hydrogen bonding interactions between OMPs and GAC. Rapid small-scale column tests with settled water from a drinking water treatment plant validated practical applicability, achieving 86%, 70%, 33%, and 43% higher removal for NPX, BPA, DCF, and IBP respectively than virgin GAC over 30000 bed volumes treated. This study provides insights into a mechanism-driven strategy for enhancement in GAC performance targeting OMP removal.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Zitong Yang,Jingyu Deng,Yili Zhang,Wenkai Qi,Yali Li,Yuxia Zhang
TT-COF/RGO three-dimensional porous structure improves electronic conductivity and stability. • Electrochemical signals are amplified through the electrodeposition of silver nanoparticles. • MIPs achieve highly selective and specific capture of BPA. • A linear range of 0.25–500 nM and a detection limit 0.09 nM. Herein, we developed an electrochemical sensor based on molecularly imprinted polymers (MIPs) for the sensitive detection of bisphenol A (BPA) in food samples. The sensing platform was constructed based on ternary AgNPs/TT-COF/RGO hybrid architecture. Subsequently, a molecularly imprinted polymer (MIP) film was electrodeposited onto the modified electrode using o -phenylenediamine ( o -PD) as the functional monomer and BPA as the template molecule. By integrating the high surface area of RGO, the readily accessible binding sites of TT-COF, and the efficient electron-transfer capability of AgNPs, the ternary AgNPs/TT-COF/RGO hybrid architecture achieves highly sensitive BPA detection. Under optimized conditions, the sensor exhibited a wide linear range of 0.25–500 nM and a low detection limit of 0.09 nM. With its excellent selectivity and sensitivity, the proposed sensor serves as a reliable platform for accurate BPA detection in complex food matrices. We propose an electrochemical sensor based on a MIP/AgNPs/TT-COF/RGO composite for highly selective detection of BPA in complex food samples. The sensor features a tightly integrated composite of RGO and TT-COF, which possesses ordered channels and an electron-rich surface, forming a three-dimensional porous conductive framework that significantly enhances electron transfer efficiency. AgNPs are then electrodeposited onto this framework, leveraging their localized surface plasmon resonance effect and catalytic activity to further amplify the electrochemical response signal at the interface. Finally, the incorporation of MIP enables specific recognition of BPA. Following systematic optimization, the sensor exhibits a broad linear range (0.25–500 nM) and low detection limit (0.09 nM), along with excellent selectivity, reproducibility, and stability. Download: Download high-res image (144KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Jingwen Dong,Junjie Zhou,Shuguang Huang,Junmei Mu,Ye Tian,Zhifei Ding,Yihui Li,Aiping Wang,Zhanwei Zhou,Zeyu Xu,Minjie Sun
Near infrared light-triggered three-dimensional adaptive release in depth, time and dose for the treatment of diabetic foot ulcers. • A triphasic sequential NO release hydrogel achieves antibacterial, angiogenic and remodeling effects. • Triphasic sequential strategy for adapting NO dosage enhances the NO metabolic microenvironment at the wound condition, ultimately expediting wound healing. Diabetic foot ulcer (DFU) requires spatiotemporal coordinated modulation of the inflammatory response and tissue regeneration process, which is still the bottleneck. Here, a triphasic-sequential hydrogel was explored to tackle the infection treatment and tissue regeneration in DFU. The PDA@B6/L-Arg hydrogel was loaded with near infrared-responsive polydopamine nanoparticles, carrying the nitric oxide (NO) donors for different healing stages. Upon exposure to laser irradiation, 1) the PDA@B6/L-Arg hydrogel rapidly released a substantial amount of nitric oxide (NO) (μM) from N , N ′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine (BNN6), thereby synergistically achieving effective anti-bactericidal and anti-inflammatory effects; 2) L-Arg, as the substrate for nitric oxide synthases NOS, provided the support for deep angiogenesis; 3) the hydrogel degraded, allowing the released L-Arg to penetrate the wound and promote additional extracellular matrix remodeling. Compared to non-sequential NO therapy, PDA@B6/L-Arg hydrogel exhibited spatiotemporal modulation, enhancing the biofilm inhibition and angiogenesis. Furthermore, PDA@B6/L-Arg hydrogel, as a reactive oxygen species-scavenging agent, simultaneously attenuating inflammatory to improve the healing efficiency of chronic wounds, achieving 97.9% closure of infected wounds. It offers a promising therapeutic option for managing diabetic foot ulcers.
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高影响因子
Nature Communications
·
2026
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IF 18.1
Zhang Dengzheng,Tian Qingbai,Wang Yuanfang,Liu Yanbiao,Li Binrong,Zhang Yang,Zhang Menglin,Lyu Cong,Xu Xing
Precisely designed self-driven single-atom catalysts (SACs) can achieve efficient degradation of emerging contaminants (ECs) without oxidants addition, but such systems often exhibited selectivity limited to electron-donating ECs, lacking broad-spectrum degradation capability. To address this limitation, a triple-reaction-center catalyst (Co 0 /CoN 2 -SAC) is designed in this study, integrating an electron-deficient region based on carbon framework and an electron-enriched region featuring both metallic cobalt (Co 0 ) and atomically dispersed CoN 2 sites. The electron-deficient region facilitates ECs adsorption through π–π interactions, and the CoN 2 sites in the electron-enriched region serve as electron acceptors, extracting electrons from electron-donating ECs. While the Co 0 sites in the electron-deficient region serve as the electron donor for donating the electron towards electron-withdrawing ECs accompanying with reactive atomic hydrogen (H*) and •OH attacking, enabling efficient reductive degradation of electron-withdrawing ECs. As a result, the Co 0 /CoN 2 -SAC system exhibits broad-spectrum degradation capability for both electron-donating and electron-withdrawing ECs, whereas the acid-leached counterpart lacking Co 0 shows activity solely toward electron-donating species. Elucidation of this simultaneous oxidation-reduction mechanism provides critical insights for the rational design of adaptive catalytic systems capable of treating complex wastewater matrices, ensuring robust contaminant removal across diverse industrial and municipal water treatment applications.
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Hao Wang,Jianbin Ju,Yuji Ruan,Guihua Ruan,Yipeng Huang
Pre-oxidation‑carbonization regulated PAN-derived porous carbon flowers, preventing collapse and enabling N/O co-doping. • PCF-400's 400 °C carbonization retains active sites, enhancing adsorption efficiency of NSAIDs. • PCF-400 exhibits superior NSAIDs selectivity, high NSAIDs adsorption (Qe ≥ 12.69 mg g −1 ) and fast kinetics (5 min equilibrium). Flower-shaped porous carbons are attractive in separation science. Herein, the controlled synthesis of porous carbon flowers (PCF) was realized by pre-oxidation and carbonization treatments of flower-shaped polyacrylonitrile (PAN) particles. The pre-oxidation treatment at 230 °C transferred the linear polymer chain of PAN to six-membered ring structure, enhancing the thermal stability to avoid the collapse of flower-shape in carbonization process. Then, the subsequent carbonization promoted the crosslinking and formation of alicyclic and graphitic structures. The carbonization at moderate temperature (400 °C) enabled the remaining of some oxygen-containing groups and the formation of nitrogen-doped carbon structure, which was responsible for the improved adsorption efficiency for non-steroidal anti-inflammatory drugs (NSAIDs). In addition, higher adsorption efficiency of PCF than that of porous carbons in other morphologies for NSAIDs was demonstrated. The PCF carbonized at 400 °C (PCF-400) showed sufficient adsorption capacity (12.69–18.59 mg g −1 ) and selectivity for NSAIDs. An SPE-HPLC method based on PCF-400 was proposed for extraction and analysis of trace NSAIDs in environmental water samples. The SPE-HPLC method showed a wide linear range (1–400 ng mL −1 ) and low detection limits (0.38–0.56 ng mL −1 ) for three kinds of NSAIDs. The intra-day and inter-day relative standard deviations (RSDs) of this method were 1.85%–2.77% and 3.17%–3.63%, respectively. The recoveries of NSAIDs in spiked samples ranged from 89% to 103% by the SPE-HPLC method. This study not only provides a simple synthetic method for preparing carbon materials with controllable morphology and adjustable heteroatom content, but also offers an analytical method for detection of trace NSAIDs in complex environmental matrices. Download: Download high-res image (126KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）