Food Chemistry-X
·
2025
·
IF 8.2
Yuxin Wang,Jin Liu,Suzhen Li,Jizhen Fu,Xiaowen Wang,Li Li,Xu Jing
The widespread use of triazole fungicides has raised concerns over residual. This study presents an automated, environmentally friendly, simple, and efficient method for detecting triazole fungicides in food samples, utilizing high-throughput liquid processing, dispersive liquid-liquid microextraction, and ultra-high-performance liquid chromatography-tandem mass spectrometry. The automated liquid handling workstation was employed to automate the whole sample pre-treatment process. Fatty acid, bio-based solvent, and saturated sodium chloride solution were used as the extractant, dispersant, and demulsifier, respectively. The whole operation process obviated the use of toxic reagents and eliminated the need for time-consuming centrifugation. The linear ranged from 0.01 to 1 μg L −1 with limits of detection and quantification of 0.003 μg L −1 and 0.01 μg L −1 , respectively. Ten triazole fungicides were successfully detected in food samples with recoveries of 70.1 %–105.7 %. The automation of dispersive liquid-liquid microextraction demonstrates huge potential for broad applicability within the field of food safety testing.
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Food & Function
·
2025
·
IF 5.4
Le Wang,Houzhen Lu,Haitao Gui,Zifu Ni,Zhongke Sun,Zihua Wang,Zhihua Wang,Xuanyan Liu,Qipeng Yuan
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease (IBD) posing a significant health threat. This study explored the protective effects of D-tagatose against DSS-induced colitis in mice and its underlying mechanisms using H&E staining, AB-PAS staining, immunofluorescence, immunohistochemistry, ELISA, qPCR, western blotting, and other assays. D-Tagatose improved colitis by increasing body weight and colon length, with decreased DAI (disease activity index) and histopathological scores. The results showed that D-tagatose inhibited the secretion of myeloperoxidase (MPO), inflammatory enzymes (iNOS and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) as well as increased the content of anti-inflammatory cytokines (IL-10) in vitro. In addition, D-tagatose enhanced the expression of tight junction proteins (ZO-1 and Occludin) and mucin (MUC-2). Furthermore, D-tagatose was able to modulate the gut microbiota dysbiosis caused by DSS-induced UC and increased the content of short-chain fatty acids (SCFAs). This study indicated that D-tagatose attenuated DSS-induced UC by modulating inflammatory cytokines, restoring intestinal barrier function, maintaining gut microbiota homeostasis, and enhancing SCFA production. These findings provide D-tagatose as a safe and effective novel functional food strategy for the prevention and treatment of UC.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Pengge Wei,Jianxiang Liu,Jing Zhao,Longshan Zhao
Traditional maceration extraction methods for dioscin typically involve substantial consumption of organic solvents and long extraction times. The present study aimed to develop a green and sustainable extraction procedure for the extraction of Dioscin from Dioscorea nipponica Makino (DNM). A series of switchable natural deep eutectic solvent (SNADES) based on medium chain fatty acids were prepared to achieve high extraction efficiency of Dioscin from DNM. As a result, hexanoic acid and heptanoic acid were selected as the optimal solvents. The optimal extraction conditions were as follows: a molar ratio of 1:1, a liquid-solid ratio of 50 mL·g −1 , an ultrasonic duration of 50 min, and a polarity switch phosphoric acid dosage of 800 μL without additional salt. The SNADES-UALLME method established in this study minimizes the use of organic reagents and provides a new insight for development of green extraction methods for active ingredients from traditional Chinese medicine.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Pan Wang,Bangfeng Yin,Ping Zou,Zhenjia Zheng,Dan Wang,Peiyou Qin,Wenting Zhao,Yuanyuan Zhao,Ye Liu,Xiaoyan Zhao
To address the limitation of resveratrol (Res) related to its low bio-accessibility and poor stability, Res-pectin complexes with varying degrees of esterification were developed. The encapsulation efficiency of Res in these complexes was determined, revealing the following order: Res-L106 > Res-L13 > Res-H121 > Res-H115. Upon non-covalent interaction with pectins, Res exhibited enhanced stability, reduced crystallinity, and modified microstructure. The complexes exhibited stable particle sizes across a pH range of 4 to 8, with the Res-L106 complex showing minimal sensitivity to variations in ionic strength and temperature. All complexes exhibited improved antioxidant activities compared to pectins alone, with the Res-L106 complex displaying the highest activity. The complex enhancing the bio-accessibility of Res follows the order of Res-L106 > Res-L13 > Res-H121 > Res-H115. Additionally, all complexes promoted the production of short-chain fatty acids (SCFAs), with butyric acid being the predominant product. Notably, the Res-L106 complex exhibited the highest SCFAs-producing capacity. In conclusion, this study provides valuable insights into the design and optimization of strategies to enhance the bioavailability of Res, highlighting the potential of low-esterified pectin as an effective delivery carrier for bioactive compounds.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Wenxia Zhang,Juan Zhang,Chao Wang,Man Liu,Jie Liu,Lifeng Xiao,Jiangang Chen
Organic acid modification can significantly enhance the performance of iron-based catalysts in Fischer–Tropsch synthesis (FTS) by regulating the quantity and type of functional groups on the catalyst surface. In this study, efficient Fe/ZrO2 catalysts were prepared using impregnation and environmentally friendly solid-state synthesis methods, and the effects of different organic acids on catalytic performance were systematically investigated. The catalysts were rigorously evaluated under industrially relevant FTS conditions, with reaction temperatures set at 270 °C for the impregnation method and 250 °C for the solid-state grinding method under 20 bar and WHSV = 5400 mL/(gcat·h). Comprehensive characterization techniques were employed to reveal the complex relationship between catalytic activity and structural characteristics. We systematically studied the effects of organic acids with different quantities of carboxyl and hydroxyl groups on improving FTS catalytic performance. The results show that citric acid (CA) significantly enhanced the catalytic activity in the CA-Fe/ZrO2 system. At a 6% Fe loading, a CO conversion of 39.89% was achieved at 270 °C, while maintaining a relatively low CH4 selectivity. The hydroxyl and carboxyl groups of CA can form stable complexes with metal ions, which improves the dispersion of iron, enhances the reducibility of iron oxides, promotes the formation of active Hägg iron carbide (χ-Fe5C2), facilitates chain growth, and ultimately boosts the production of valuable C5+ hydrocarbons. These findings highlight the potential of CA in optimizing iron-based FTS catalysts, offering important theoretical insights and practical guidance for future industrial applications.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Yawen Zhang,Hongli Zhang,Jiangong Ma,Jing Zhao,Huajuan Yin,Xu Jing,Xiaowen Wang
With the advent of new-generation green extraction solvents, deep eutectic solvents (DESs) present significant prospects for the extraction of bioactive substances. In this study, saponins were extracted from oats using an ultrasonic-assisted method with green DESs, replacing conventional toxic organic solvents. Adding sodium chloride markedly reduced solubility, resulting in the separation of two phases from the extract: DES and water. The saponins were separated into the water phase, while the DES was reused in subsequent extractions, supporting extractant recycling and promoting sustainable development. Adding salt offers a more gentle, convenient, and cost-effective alternative to current phase separation methods, such as pH adjustment, temperature variation, and carbon dioxide or nitrogen gas application. Optimizing the extraction and recovery parameters yielded the highest oat saponin extraction efficiency at 18.73 mg g –1 , and the recovery was 86.4 %. When compared with ethanol extracts, DES extracts exhibited superior antioxidant activity. Lastly, the greenness of this extraction method was confirmed through three greenness evaluation programs of greenness. The extraction method based on emerging responsive solvents can be extended to other hydrophilic bioactive substances.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Shengli Ding,Mengqi Wang,Guiqing Lin,Yanrong Song,Ji Zhang,Yufei Zhang,Mingming Zheng
Inspired by the natural crystal evolution trajectory of corals, this study introduces a mild two-step “defective pre-growth/crystallization” strategy to in situ encapsulate Candida antarctica lipase B (CaLB) within covalent organic frameworks (COFs). Rapidly formed amorphous polymer microspheres serve as the core skeletal structure. Upon enzyme adsorption onto their surfaces, these microspheres undergo crystalline readjustment to embed the enzymes and form a protective exoskeleton. The resulting CaLB@TPB-TFPB COF-I biocatalyst demonstrates superior thermal stability, organic solvent tolerance, and reusability compared to both free lipase and commercial Novozym 435. It achieves a 95.7% conversion rate for caproic acid esterification under anhydrous conditions and maintains over 90% conversion efficiency across seven consecutive cycles. This work also elucidates the multiple critical roles of water in enzymatic ester synthesis. This coral-inspired encapsulation approach leverages the tunable properties of COFs to enhance enzyme performance, offering an efficient solution for the biocatalytic synthesis of flavor esters.
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JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Shuo Xie,Wenbin Zhang,Yike Han,Xinyan Dong,Wanning Li,Penghui Li,Liyun Kong
The accurate determination of pharmaceuticals and personal care products (PPCPs) in wastewater is crucial for comprehensive environmental risk assessment and human exposure evaluation. Given the complex matrices of aqueous environmental samples, efficient sample preparation remains a critical challenge in analytical procedures. This study presents an ionic liquid-based aqueous two-phase system (IL-ATPS) extraction methodology used as a pretreatment step prior to high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for the simultaneous determination of 38 PPCPs. A mechanistic investigation revealed that target analytes with more hydrogen-bonding sites and higher hydrogen-bond donor (HBD) capacity exhibited enhanced solubility in ILs. In addition, IL anions with stronger hydrogen-bond acceptor (HBA) capacity further improved the solubility of the 38 PPCPs. These findings indicate that hydrogen bonding between analytes and ILs likely played a critical role in the dissolution mechanism. The established IL-salt ATPS extraction method utilized a 15 mL aqueous sample, 0.2 g tetraethylammonium acetate ([N 2222 ][OAc]), and 12 g K 2 HPO 4 , with a 1-minute vortex mixing. Compared with traditional solid phase extraction (SPE), this approach significantly reduced the sample volume from 1 L to 15 mL, avoided the use of volatile organic solvents, simplified the overall processing, and enabled rapid (<15 minutes) pretreatment. The method demonstrated excellent sensitivity with limits of detection (LODs) ranging from 0.00013 to 0.11 ng/mL. Method validation via standard addition experiments demonstrated satisfactory accuracy, yielding recoveries between 74.3 and 129.8 %. Precision was assessed using both intra-day and inter-day measurements. The intra-day relative standard deviations (RSDs) ranged from 0.7 % to 19.9 %, while the inter-day RSDs ranged from 1.4 % to 18.4 %, demonstrating that the method provides consistent and reproducible results under controlled laboratory conditions. These findings underscore the present IL-based ATPS extraction method, followed by HPLC-MS/MS analysis, as an eco-friendly, robust, and scalable approach for PPCPs monitoring in aqueous environmental samples, offering potential applications in environmental monitoring and risk assessment.
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Journal of Future Foods
·
2026
·
IF 7.2
Bingkun Bao,Ying He,Jufang Li,Xiangyu Li,Hao Shi,Jinkuan Chen,Jinhan Zhao,Koukou Duan,Hongyu Zhang,Qinggang Xie,Jane Shearer,Zhigang Liu,Yongbo She
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder primarily characterized by social deficits and repetitive behaviors. 2’-Fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT), the two human milk oligosaccharides (HMOs) approved for infant formulas in China, have exerted potentials to modulate gut microbiota, immune system, and cognitive function. Yet the exact mechanism underpinning the etiology of HMOs on improving neurodevelopment and particularly the ASD-related cognitive impairments remain unclear. In this study, mouse model of ASD was established via maternal immune activation (MIA), specifically by introducing polyinosinic:polycytidylic acid (poly(I:C)) to pregnant mice. Male offspring were selected and received either an individual (2’-FL or LNnT) or a combination (2’-FL+LNnT) interventions for 6 weeks. As expected, ASD mice exhibited significant social deficits and repetitive stereotyped behaviors, accompanied by neuroinflammation and decreased expression of BDNF, and morphological changes in cortex as well as hippocampal area. Regardless of the type of sources, HMOs ameliorated ASD-like behaviors in ASD mice, attenuated neuroinflammatory responses, and elevated BDNF expression. Additionally, the HMOs alleviated intestinal inflammation, enhanced gut barrier, and modulated the gut microbiota structure by upregulating the abundance of beneficial bacteria ( Akkermansia, Lactobacillus , and Butyricicoccus ). Notably, the combination of two HMOs also promoted the production of short-chain fatty acids (SCFAs). In addition, flow cytometry analysis showed a significant increase in the regulatory T cell (Treg) ratio and an decrease in T helper 17 cell (Th17) ratio in the mesenteric lymph nodes of ASD mice following the combination intervention. These findings suggest that the promising efficacy of HMOs, particularly the combination of 2’-FL and LNnT, on counteracting ASD-related pathophysiological changes may be mediated by the gut-immune-brain axis.
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TRIBOLOGY LETTERS
·
2026
·Vol. 74
·期 2
·34
·
IF 3.5
Yang Jing,Liu Xiao,Chen Qiang,Guo Pingxia,Feng Kai,Cai Meirong
As global environmental standards grow increasingly strict, developing eco-friendly, high-efficiency water-based lubrication additives has become a pivotal focus in tribology. In this work, three novel heterocycle-, phosphorus-, and sulfur-free protic ionic liquids (PILs), namely EDG-HA, EDG-OA, and EDG-LA, were successfully synthesized and employed as additives in aqueous lubricant systems with the objective of alleviating the environmental contamination and biological toxicity problems related to conventional lubricant additives. A systematic evaluation of the PILs revealed that lubricants blended with the additives demonstrate significantly superior corrosion protection and lubricating performance when compared to pure water. Specifically, the 1% EDG-LA lubricating solution reduced the friction coefficient (COF) and wear volume (WV) by approximately 69.3% and 94.5%, respectively. By combining quartz crystal microbalance (QCM) adsorption tests and X-ray photoelectron spectroscopy (XPS) analysis, the lubrication mechanisms were clarified: PILs form robust physical adsorption and tribo-chemical reaction film on metal friction pairs, effectively preventing direct metal-to-metal contact. The current research promotes the development of water-soluble additives with potential eco-friendly and high-efficiency through a novel perspective. Graphical
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Soft Matter
·
2026
·
IF 2.9
Chaoyu Zhao,Xinyue Jiang,Yuqun Xie
Liquid–liquid phase separation (LLPS) in the pre-Ouzo region governs the early-stage aggregation of amphiphiles, dictating the non-equilibrium evolution of soft materials. However, classical turbidimetry, which defines phase boundaries by macroscopic cloudiness, is blind to this metastable regime. Here, we introduce an integrated fluorescence–microscopy ternary phase mapping approach that directly probes the pre-Ouzo region in a canonical ethanol–water–amphiphile system. This method reveals critical aggregation concentrations that are 2–3 orders of magnitude below the binodal—a regime inaccessible to turbidimetry. Applying this diagram to naturally aged Baijiu (1–20 years), a dynamically evolving colloidal system, uncovers a pronounced aging-enhanced solubilization: the dissolution ratios of key amphiphiles (hexanoic acid and ethyl hexanoate) exceed 96%, with dissolved concentrations far surpassing static equilibrium predictions. Mechanistic investigations show that this phenomenon arises from the synergistic restructuring of ethanol–water hydrogen-bond networks and the expansion of hydrophobic microdomains. Our work not only provides a high-resolution tool for mapping non-equilibrium phase behavior but also establishes a direct link between slow microstructural evolution and the emergence of kinetically stabilized, supersaturated states in complex fluids.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Hailong Qiao,Yurong Wang,Qiang Chen,Pingxia Guo,Xiao Liu,Meirong Cai,Feng Guo
Environmentally benign water-based lubricants are attracting increasing attention as alternatives to conventional oil-based lubricants that may cause environmental pollution. Herein, three protic poly(ionic liquid)s (PPILs) are synthesized by combining a copolymeric cation with carboxylate anions of different alkyl chain lengths. The PPILs are employed as additives in aqueous lubricants, and their viscosity-enhancing capability and tribological performance are systematically evaluated. Quartz crystal microbalance (QCM), electrical contact resistance (ECR), X-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectrometry (TOF-SIMS) are used to elucidate the lubrication mechanism. The results demonstrate that PPILs significantly improve the viscosity, corrosion resistance, and tribological properties of water-based lubricants. Notably, the kinematic viscosity of a 6% PPD-Oa aqueous solution increases by two orders of magnitude compared with deionized water, while the corresponding wear volume and coefficient of friction are reduced by approximately 77% and 70%, respectively. Mechanistic investigations indicate that interfacial adsorption and friction-induced chemical processes jointly generate a protective layer at the sliding interface, thereby imparting excellent lubricity and load-bearing capability to the lubricant. Moreover, the three sulfur-free and halogen-free PPILs represent environmentally benign additives with strong potential for application in metalworking fluids and hydraulic systems.
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