ACS Applied Bio Materials
·
2026
·Vol. 9
·期 15
·6927-6940
·
IF 5.6
Peng Haorui,Zhang Yulin,Dai Qiyuan,Ding Yilin,Chen Hexuan,Zhang Shuai,Luo Huitong,Cao Xiaodong
The management of bone injuries arising from traumatic or pathological origins necessitates biomaterial platforms that bridge immediate hemorrhage control and long-term osteogenic guidance within a single implantable system. In this study, we fabricated a chitosan-based composite cryogel (CMS-BG/BMP2) using dual-template mesoporous bioactive glass (dMBG). By using the double-template agent method, we enhanced the specific surface area of bioactive glass, optimized its pore architecture, improved the loading efficiency of bone morphogenetic protein 2 (BMP2), and achieved its controlled release, thereby circumventing the adverse effects caused by excessive local concentration of BMP2. The cryogel exhibited over 20 kPa compressive strength, favorable cyclic compression resistance, and controlled degradation (∼50% mass loss in 28 days). Hemocompatibility assays confirmed its safety, while dMBG incorporation enhanced blood cell adhesion and hemostatic efficacy without compromising biocompatibility. In vitro tests showed that the composite promoted mice bone marrow mesenchymal stem cells (BMSCs) migration and osteogenic differentiation by upregulating ALP activity, calcium nodule formation, and osteogenesis-related genes. This multifunctional material integrates hemostasis, structural support, and bioactivity, offering great potential for the clinical treatment of hemorrhagic bone defects.
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BIOSENSORS & BIOELECTRONICS
·
2026
·
IF 11.8
Yu-Ling Wang,Chen Chen,Jia-Yao Xu,Yu-Jie Jing,Bing Wang,Jing Zhang,Yan-Ming Liu,Jun-Tao Cao
Sensitive and accurate detection of tumor markers is crucial for disease diagnosis, yet numerous challenges still exist due to limitations of single-mode assays. This work constructed a universal dual-mode sensing platform combining closed bipolar electrode (cBPE) and split-type immunoassay, which realized simultaneous electrochemiluminescence (ECL) and electrochromic detection of proteins upon a single potential stimulus. Specifically, on the cBPE, L012 served as the ECL emitter at the anode, while Prussian blue (PB) film at the cathode acted as the electrochromic sensing unit. Applying a single potential stimulus could trigger simultaneous ECL emission and the color change from blue PB to white Prussian white. By virtue of MgO 2 @GOx-Ab 2 signal probes as bioprobe, a split-type immunoassay was developed for prostate-specific antigen (PSA) detection. The target-induced production of H 2 O 2 from cascade glucose oxidation and MgO 2 hydrolysis greatly enhanced the anodic ECL signal and facilitated the cathodic PB reduction. Consequently, the strategy achieved the highly sensitive and visual dual-mode assay for PSA, yielding the limits of detection of 2.7 × 10 −12 g/mL for ECL detection and 3.1 × 10 −9 g/mL for electrochromic sensing, respectively. The study opened up an avenue for developing simultaneous multi-mode sensing platforms toward more biomarkers.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124392
·
IF 7.5
Xinya Wang,Yongshuo Zhang,Zihao Li,Qi Wang,Wei Zhang,Yanjie Wu,Mingxing Chen
Janus membrane has been attracting more and more attention in field of oil-water separation, owing to its asymmetric wettability on opposite surfaces. Inspired by the special structure of lotus leaves and Setaria viridis, we successfully fabricated dual-bioinspired Janus nanofiber membranes via sequential electrospinning and low-temperature hydrothermal synthesis. The structure and performance were modulated by adjusting Zn(NO 3 ) 2 ·6H 2 O concentration and Zn(Ac) 2 ·2H 2 O addition amount. Specifically, with the Zn(NO 3 ) 2 ·6H 2 O concentration increasing from 0 g·L −1 to 22.2 g·L −1 , the diameter of ZnO NWs increased and the hydrophilic nanofiber layer became denser. When Zn(NO 3 ) 2 ·6H 2 O concentration was 14.8 g·L −1 , the hydrophilic nanofiber layer of obtained Janus nanofiber membrane exhibited excellent separation performance for oil-in-water emulsions with remarkable separation flux of 1957.68 L·m −2 ·h −1 and high separation efficiency of 98.53%. Moreover, the hydrophobic nanofiber layer showed relatively excellent separation performance for water-in-oil emulsions with remarkable separation flux of 1336.77 L·m −2 ·h −1 and high separation efficiency of 98.98%. Additionally, with Zn(Ac) 2 ·2H 2 O addition amount increasing from 0 wt% to 2.0 wt%, the growth density of ZnO NWs increased, while the diameter decreased slightly. Correspondingly, the separation flux and separation efficiency of hydrophilic nanofiber layer for oil-in-water emulsions increased with increase of Zn(Ac) 2 ·2H 2 O addition amount. Besides, the incorporation of ZnO NWs endowed the Janus nanofiber membranes with intrinsic antibacterial properties against both E. coli and S. aureus . Our study not only emphasized the tunability of Janus nanofiber membranes but also highlighted their dual functionality as effective option for effective oil-water separation and antibacterial barriers.
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Advanced Science
·
2026
·
IF 14.1
Kailang Liu,Haocheng Ran,Haohui Ou,Peiying Chen,Cheng Qi,Tiantian Kong,Zhou Liu
Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical implementation. Here, we report magneto-coacervate droplets constructed from gelatin, poly(diallyldimethylammonium chloride) (PDDA), and superparamagnetic Fe 3 O 4 @SiO 2 nanoparticles. These magneto-coacervate droplets exhibit reversible sol–gel transitions controlled by temperature and pH, tunable surface charge properties for electrostatically driven molecular enrichment, and precise three-dimensional manipulation under external magnetic fields. These magneto-coacervate droplets can serve as multifunctional platforms, greatly increasing the practical use of phase-separated microreactors in environmental remediation, biochemical processing, and targeted biomedical interventions. Demonstrated applications include efficient capture and recycling of microplastic pollutants, magnetically enhanced catalytic enzyme cascades with reaction rates 2–3 times higher than those of conventional methods, and targeted vascular embolization through controlled in situ gelation.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·Vol. 36
·期 63
·e77025
·
IF 19.9
Xuan Weng,Peilin Li,Chenyang Jia,Xinkai Guo,Wen Sun,Hai Jiang
Flexible sensors are evolving from single-parameter to multi-modal measurement. Dual-modal flexible tactile sensors capable of detecting both temperature and pressure are essential for human–machine interaction and wearable health monitoring. Here, we present a flexible dual-modal sensor constructed from a sponge framework decorated with MXene–Ag 2 Se nanocomposite. The heterogeneous MXene–Ag 2 Se interfaces enhance carrier transport and conductivity. A three-electrode configuration with spatially separated in-plane thermoelectricity and out-of-plane piezoresistivity enables effective decoupling of temperature and pressure sensing. The MXene–Ag 2 Se@sponge sensor demonstrates high pressure sensitivity (2.202 kPa − 1 in 0–25 kPa, 0.466 kPa − 1 in 25–60 kPa, and 0.076 kPa − 1 in 60–300 kPa), a fast response time (37 ms) for pressure sensing, and excellent durability. For temperature sensing, it achieves an ultralow detection limit of 0.2 K, a high Seebeck coefficient of 175.47 µV/K, and stable cycling performance. In addition, the MXene–Ag 2 Se@sponge dual-modal sensor is applied to human pulse monitoring, joint motion detection, and finger temperature measurement, highlighting its potential for wearable biomedical sensing. Furthermore, a sensor array was also implemented as electronic skin, enabling simultaneous temperature-pressure mapping with high spatial resolution. This work provides a promising strategy for intelligent robotics and flexible electronics.
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Food Bioscience
·
2026
·
IF 6.2
Jiwei Song,Yunpeng Shao,Yuan Yao,Zicheng Zhang,Yaqin Ren,Linyu Mei
Surface-enhanced Raman scattering (SERS) has emerged as a powerful analytical technique for ultrasensitive and rapid detection. However, the performance of SERS substrates largely depends on their ability to generate intense localized electromagnetic fields at nanoscale hot spots, while simultaneously achieving high sensitivity and signal reproducibility remains a major challenge. In this work, a highly ordered SU-8 micropillar array was fabricated by Ultraviolet Lithography(UL), followed by biomimetic modification with polydopamine (PDA) to achieve the uniform immobilization of silver nanoflowers (AgNFs). The resulting three-dimensional (3D) AgNFs/PDA/SU-8 micropillar SERS substrate integrates the structural advantages of the 3D architecture, the abundant electromagnetic hot spots and physical enrichment effect generated by densely packed AgNFs, and the interfacial regulation provided by PDA, thereby synergistically enhancing the SERS performance. The substrate exhibited an enhancement factor(EF) of 2.16 × 10 9 for Rhodamine 6G (R6G), with an experimental limit of detection as low as 1 × 10 −14 M (S/N = 3) and a relative standard deviation below 8.30%. Furthermore, the limits of detection for enrofloxacin (ENR), clothianidin (CLO), and 100 and 800 nm polystyrene (PS) particles in seawater reached 1 × 10 −13 M, 1 × 10 −14 M, 2.5 μg mL −1 , and 0.6 mg mL −1 , respectively. Simultaneous detection of multiple contaminants was also successfully achieved in complex food matrices, including mineral water, milk, and liquor. This work provides an effective strategy for constructing high-performance 3D SERS substrates and demonstrates their promising potential for food safety monitoring and aquatic environmental analysis.
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ENVIRONMENTAL POLLUTION
·
2026
·
IF 7.2
Jing Zhou,Bo Zhao,Jie Liu,Junhan Ruan,Li Lin,Yi Li
N -nitrosomorpholine (NMOR), as a highly carcinogenic N -nitrosamine, has been widely detected in urban sewer systems. NMOR ranged from 27.2 to 817 ng/L in winter, follow by summer (2.09–453 ng/L), in raw wastewater collected from pumping stations connected to a Wastewater Treatment Plant (WWTP). Especially in winter, NMOR was detected (200–295 ng/L) in the influent, with residue of 98.0–116 ng/L in the effluent. Therefore, it is necessary to control NMOR before the WWTP. However, the corresponding precursors and transformation mechanisms in sewer systems are not yet fully understood. This study has identified NMOR precursors in sewer systems by nontarget analysis combined with targeted analysis. NMOR formation was confirmed by nitrosation and chloramination through distinct pathways from a known (morpholine, MOR) and two unreported ( N -methylmorpholine, NMM and N -methylmorpholine- N -oxide, NMMO) precursors. In addition, NMM and MOR were detected up to 8.65 and 14.3 μg/L in raw wastewater, as well as up to 0.250 and 1.17 μg/L in the effluent. NMOR formation by chloramine could reach to 73.0 ng/L. This study demonstrated the extensive presence of NMOR precursors in raw and treated wastewater, in which new identified precursor NMM might significantly contribute formation of NMOR.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Qin Yao,Meiling Liang,Kunling Yang,Cheng Qi,Tiantian Kong,Bernard P. Binks,Zhou Liu
Motivated by gas-accessible thin liquid films in lung alveoli, we develop gas marble-film reactors in which particle-stabilized bubbles confine an ultrathin freestanding liquid film within a jammed solid shell. Hexagonal PET (poly(ethylene terephthalate)) plates, in addition to conventional spherical particles, generate faceted gas marbles with planar film regions that improve optical access. We quantify the pressure limits of microsphere- and plate-stabilized shells during inflation and deflation, and describe their response using a capillary–granular framework. In this framework, inflation rupture is governed by capillary breakthrough at particle-defined throats, whereas deflation collapse reflects the combined resistance of capillarity and interparticle jamming. The mechanically defined films then serve as gas-accessible interfacial reactors in two proof-of-concept demonstrations. In a Tollens reaction, aerosolized glucose delivery through the external gas phase localizes silver reduction to liquid-wetted regions of the particle shell, producing spatially patterned silver-deposited microspheres. In biological assays, plate-stabilized shells provide flat observation windows for monitoring aerobic E. coli growth and its inhibition by levofloxacin. These results establish gas marbles as programmable colloidal film reactors whose structure, pressure stability, and interfacial function can be coupled through particle geometry and capillary jamming. Download: Download high-res image (101KB) Download: Download full-size image
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Zhengjia Zhu,Hui Chen,Yushuai Bai,Jingjie Zhang,Mingdong Yi,Zhaoqiang Chen,Guangchun Xiao,Chonghai Xu
ZTA/Cr 2 O 3 ceramics were fabricated by gelcasting via gelcasting followed by pressureless sintering. The effects of pH, dispersant content, ball-milling time, solid loading, and Cr 2 O 3 content on slurry rheological properties, green body properties, sintering densification behavior, and mechanical properties were investigated. The addition of Cr 2 O 3 effectively decreased slurry viscosity and improves flowability, facilitating the preparation of high-solid-loading slurries. The green body relative density and flexural strength reached optimum values at a solid loading of 54 vol%, reaching 54.83% and 19.7 ± 0.27 MPa, respectively. After sintering at 1600 °C for 3 h, the optimum mechanical properties were obtained at a Cr 2 O 3 content of 0.4 vol%. The Vickers hardness, flexural strength, and fracture toughness were 17.17 ± 0.26 GPa, 581.22 ± 9.20 MPa, and 6.59 ± 0.32 MPa m 1/2 , respectively. Compared with Cr 2 O 3 -free ZTA ceramics, the hardness, flexural strength, and fracture toughness increased by 5.5%, 17.58%, and 10.75%, respectively. The enhanced mechanical properties are mainly attributed to the synergistic effects of the solid-solution incorporation of Cr 3+ in the α-Al 2 O 3 lattice, the resulting changes in lattice parameters, grain refinement, improved densification, and enhanced stability of the t-ZrO 2 phase. Furthermore, complex-shaped ZTA/Cr 2 O 3 ceramic components were successfully fabricated, showing no visible defects and uniform shrinkage after sintering, providing useful guidance for the near-net-shape fabrication of high-performance ceramic components.
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ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·11084-11103
·
IF 5.2
Muniyandi Vigneshwaran,Mansoor Farukh,Chen Weiqiang,Li Yan,Weng Zixiang,Thirunavukkarasu Naveen,Wu Lixin
Unstable
layer detachment and uncontrolled interfacial curing remain
critical limitations in conventional bottom-up photopolymerization
resin vats, where high-surface-energy release films promote strong
resin-vat adhesion, and unrestricted photon flux at the resin-vat
boundary leads to excessive bottom-layer cross-linking, together resulting
in mechanical disturbance during separation and dimensional inaccuracy.
To address these coupled challenges, this study reports a dual-interface
engineered resin vat that decouples interfacial adhesion and curing
regulation through independent material design. A superamphiphobic
superlow-adhesion interface (SLAI) minimizes interfacial bonding at
the release surface, while a carbon quantum dot-incorporated polydimethylsiloxane
(CQD-PDMS) optical layer is introduced at the vat window to modulate
interfacial photon flux and confine polymerization within the intended
layer thickness. Compared with the conventional release film interface,
the proposed synergistic interfacial control significantly reduced
separation forces during layer detachment from 5 to 15 N to 0.25–3
N, depending on resin viscosity and processing conditions, corresponding
to a maximum reduction of up to 95% under optimized conditions. Simultaneously,
dimensional fidelity was substantially improved, reducing the Z -direction deviation from approximately 7% to 0.2%. Importantly,
the optical modification preserves high transparency and demonstrates
stable performance over 10,000 consecutive printing cycles. By establishing
a materials-driven strategy that simultaneously regulates adhesion
energy and interfacial curing density, this work provides a scalable
pathway for stabilizing detachment mechanics and enhancing dimensional
precision in vat photopolymerization without altering the resin chemistry.
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ACS Applied Nano Materials
·
2026
·Vol. 9
·期 29
·13721-13740
·
IF 5.8
Yuan Yifang,Wang Chaoli,Li Na,Chen Hongwei,Zhou Zichao,Zhang Chongyang,Zhang Haiou,Wang Shengchao,Yu Qing,Cheng Xiaogang,Jiang Wenkai
Intratumor microorganisms can promote tumor initiation,
development,
metastasis, and therapeutic resistance in cancer. Previous studies
have indicated that Porphyromonas gingivalis ( P. gingivalis ) accelerates the progression
of oral squamous cell carcinoma (OSCC) through enhancing cancer cell
stemness, promoting immune evasion, regulating cyclins, modulating
inflammatory cytokine profiles, and remodeling the tumor microenvironment.
In this study, a high detection rate of intratumor and intracellular P. gingivalis was observed in OSCC clinical patients,
which suggested a potential association between P. gingivalis and OSCC pathogenesis. However, whether
synergistic elimination of P. gingivalis during antitumor therapy can slow OSCC progression remains unknown.
Thus, we engineered an anisotropic Janus nanoparticle-based drug delivery
system utilizing Au nanoparticles (AuNPs) and porous silica carriers
for tumor-targeted synergistic therapy. The Au–Ce6–SiO 2 -MTZ Janus nanoparticles (denoted as JCM) prevent primary
tumor growth through the photosensitizer Chlorin e6 (Ce6)-mediated
photodynamic therapy (PDT) and eliminate intracellular P. gingivalis via metronidazole (MTZ) simultaneously.
Our results demonstrate that the Au–Ce6–SiO 2 -MTZ Janus NPs enhance targeted nanomedicine delivery to tumor sites
and improve the relevant therapeutic outcomes of P. gingivalis -infected models by synergistic antitumor-antibacterial in vitro and in vivo . Overall, this study
introduces an effective OSCC treatment using a Janus nanoplatform
that integrates antibacterial and photodynamic functions. It successfully
targets tumor-promoting P. gingivalis , enhancing antitumor efficacy compared to PDT alone, while ensuring
good biocompatibility.
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Water
·
2026
·Vol. 18
·期 14
·1694
·
IF 3.5
Deling Fan,Yucen Liu,Wen Gu,Shuai Sun,Weilong Xing,Zhen Wang,Lili Shi,Lei Wang,Zheng Fang
Pharmaceuticals and personal care products (PPCPs) are contaminants of emerging global concern, yet their long-term fate and distribution in strategic trans-boundary water source areas remain underexplored. This study conducted a comprehensive monitoring campaign spanning from 2018 to 2020, with six sampling campaigns carried out in August 2018, December 2018, May 2019, August 2019, December 2019, and May 2020, to investigate the occurrence, spatiotemporal dynamics, source apportionment, and ecological risks of 54 PPCPs in the surface water and sediments of the Taipu River in eastern China. Utilizing non-target screening via liquid chromatography high-resolution mass spectrometry (LC-HRMS), 54 PPCPs across 15 categories were detected, with average total concentrations of 28.60 ng/L in surface water and 13.01 ng/g in sediments. Sulfonamides, quinolones, and non-steroidal anti-inflammatory drugs (NSAIDs) dominated the aqueous phase (with bisphenol A and sulfamethoxazole highly prevalent), while hormones (e.g., estriol) and quinolones (e.g., ciprofloxacin (CIP)) exhibited significant accumulation in the benthic zone. Spatiotemporal analysis revealed a seasonal pattern where PPCP concentrations were higher in the dry season than in the wet season, primarily driven by hydrological dilution and climate-induced degradation. Furthermore, Positive Matrix Factorization (EPA PMF 5.0) extracted five distinct source factors for each matrix. Specifically, surface water pollution was primarily driven by domestic wastewater, municipal effluents, medical discharges, and localized pharmaceutical emissions, whereas sediments acted as a long-term sink predominantly for domestic wastewater, agricultural/veterinary runoff, and municipal/industrial emissions. Ecological risk assessment indicated that while most of the nine high-frequency contaminants posed low risks, specific compounds such as CIP, SM2, and E3 presented medium risks in surface water, whereas ENR, CIP, and SPI posed medium risks in sediments. These findings emphasize that the continuous multi-source input and the resulting pseudo-persistence of PPCPs in sediments warrant prioritized continuous attention and targeted pollution control strategies in the Taipu River Basin.
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