ADVANCED FUNCTIONAL MATERIALS
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2023
·Vol. 33
·期 48
·2305379
·
IF 19
Jiaona Zhang,Wanting Wang,Jiahao Zhu,Jialiang Wang,Changbin Zhao,Tianyu Zhu,Qinqi Ren,Qi Liu,Rui Qiu,Min Zhang,Xinwei Wang,Hong Meng,Kuan-Chang Chang,Shengdong Zhang,Mansun Chan
Flexible electronics based on complementary metal-oxide-semiconductor (CMOS) technology have enabled a smart soft world. However, the trade-off among flexibility, density, and electrical performance has been a long-lasting unresolved issue. Here, a monolithic three-dimensional (M3D) CMOS design is proposed to address this problem and realize ultra-flexible electronics with high electronic-performance and integration. This design utilizes vertically stacked p-type carbon nanotube transistors and n-type indium gallium zinc oxide ones, which share common gates and drains, saving the inter tier vias required in the traditional M3D structure to reduce routing and improve flexibility. With this design, CMOS logic gates, multi-stage circuits, ring oscillators (ROs) and memory modules, are demonstrated. This design enables circuits to save up to 45% of area compared with their planar counterparts. Particularly, inverters exhibit a record-high gain of 191, and 55-stage ROs can operate well even after bending at a 500-µm radius for 50 cycles, exhibiting the highest flexibility among the reported ones. The ultra-flexible and high-integration RO enables a wearable light recorder to collect harmful blue light shining into human eyes by simply attaching the circuits on a contact lens. This integration method provides possibilities for developing complex-function wearable electronics.
研究领域:
电子工程
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材料科学
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集成电路设计
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DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-18
·
IF 9.429
Chen Youlu,Chen Zuoguan,Duan Jianwei,Gui Liang,Li Huiyang,Liang Xiaoyu,Tian Xinxin,Liu Kaijing,Li Yongjun,Yang Jing
Peripheral vascular disease (PVD) is a common clinical manifestation of atherosclerosis. Vascular endothelial growth factor (VEGF) gene therapy is a promising approach for PVD treatment. However, due to single-gene therapy limitations and high H2O2 pathological microenvironment, VEGF gene therapy are not as expectations and its clinical application are limited. Synergistic effects of Nerve factors and vascular factors in angiogenesis have attracted attention in recent years. In this study, VEGF and nerve growth factor (NGF) genes co-delivery nanoparticles (VEGF/NGF-NPs) were prepared by using H2O2 responsive 6s-PLGA-Po-PEG as a carrier. 6s-PLGA-Po-PEG could react with H2O2 specifically due to the internal peroxalate bond. Angiogenic effects of VEGF/NGF-NPs has been evaluated in cells and hindlimb ischemia mice model. Results showed that VEGF/NGF-NPs promoted VEGF and NGF co-expression simultaneously, eliminated excessive H2O2, strengthened reactions between SH-SY5Ys and HUVECs, and finally enhanced migration, tube formation, proliferation and H2O2 damage resistance of HUVECs. VEGF/NGF-NPs also recovered blood perfusion, promoted the expression of VEGF, NGF, eNOS and NO, and enhanced vascular coverage of pericytes. Treatment effects of VEGF/NGF-NPs may related to VEGF/eNOS/NO pathway. Altogether, VEGF/NGF-NPs eliminated excessive H2O2 while achieving gene co-delivery, and promoted stable angiogenesis. It’s a promising way for PVD treatment by using VEGF/NGF-NPs.Graphical Abstract
研究领域:
生物医学工程
·
分子生物学
·
基因治疗
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血管医学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Bingjie Li,Jinbin Pan,Ruijie Zhang,Bing Han,Yujie Zhao,Guijun Liu,Yujie Tong,Yujing He,Guangchao Xie,Ruxia Liu,Ting Zhou,Quan Zhang,Shao-Kai Sun
High-resolution vascular imaging at tens of micrometers in deep tissues in vivo remains a critical challenge. Ultrahigh field susceptibility-weighted imaging (SWI) holds promise but lacking compatible high-sensitivity imaging probes. Herein, we show a holmium (Ho)-based nanoprobes-enhanced SWI strategy for ultrahigh-resolution imaging of cerebral microvessels at 9.4 T. The polyethylene glycol (PEG)-NaHoF 4 nanoprobes (NPs) fabricated via coprecipitation synthesis combined with PEG modification possess uniform size, appropriate hydrodynamic size (20 nm), good biocompatibility, and long circulation half-life (710 min). Notably, the PEG-NaHoF 4 NPs exhibit high r 2 / r 1 742.7) and T 2 * relaxivity ( r 2 *, 73.16 s -1 mM -1 ) under 9.4 T due to the large magnetic moment (∼10.6 μ B ) and short electronic relaxation time (∼10 -13 s) of Ho 3+ . The high susceptibility of PEG-NaHoF 4 NPs in blood vessels induces a significant blooming effect, resulting in a magnified vascular appearance on SWI. In vivo high-resolution imaging of cerebral microvessels with diameters as small as 10 μm is achieved using PEG-NaHoF 4 NPs-enhanced SWI under 9.4 T. In two representative brain disease models, glioma and stroke, this nanoprobe enables high-resolution visualization of tumor vasculature and post-stroke collateral circulation, respectively. Our study offers a new paradigm for precise diagnosis of vascular-related diseases, providing a robust tool for their diagnosis, treatment, and prognosis assessment.
研究领域:
医学影像学
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神经科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2021
·Vol. 11
·期 8
·2067
·
IF 5.076
Ying Tian,Tao Wang,Qingxia Zhu,Xingcai Zhang,Anita Sagadevan Ethiraj,Wen-Ming Geng,Hong-Zhang Geng
Improved OLED systems have great potential for next-generation display applications. Carbon nanotubes (CNTs) and the conductive polymers poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS) have attracted great interest for advanced applications, such as optoelectronic products. In this paper, the simultaneous enhancement of the conductivity, roughness, and adhesion properties of transparent conductive films with PEDOT: PSS/CNTs is reported. These films prepared by a simple spin-coating process were successfully used to produce high-performance organic light-emitting diodes (OLEDs) with an improved lifetime. Addition of PEDOT: PSS lowered the film sheet resistance and CNTs helped to enhance the stability and maintain the lifetime of the OLEDs. In addition, treatment with methanol and nitric acid changed the morphology of the polymer film, which led to greatly reduced sheet resistance, enhanced substrate adhesion, and reduced film roughness. The best performance of the film (PEDOT: PSS: CNT = 110: 1, W/W) was 100.34 Ω/sq.@ 90.1 T%. High transmittance, low sheet resistance, excellent adhesion, and low roughness (3.11 nm) were achieved synchronously. The fabricated OLED demonstrated a low minimum operating voltage (3 V) and could endure high voltage (20 V), at which its luminance reached 2973 cd/m2. Thus, the incorporation of CNTs within PEDOT: PSS electrodes has great potential for the improvement of the performance of OLED devices.Keywords:carbon nanotubes;PEDOT: PSS;spin coating;OLEDs;lifetime
研究领域:
材料科学
·
光电技术
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显示技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Zhixing Wang,Peng Liu,Peng Ye,Sheng Dai,LuYing Liu,Ping Yang
Dopamine has been widely used for surface modification of cardiovascular medical devices as it forms films on most substrates that provide functional groups for surface chemical modification. However, under oxidative stress, the phenolic hydroxyl group on dopamine can undergo reversible transformation into phenol-semiquinone-quinone, which can cause cytotoxicity and immunotoxicity. In this study, we measured the effects of semiquinone on the behavior of vascular wall cells and inflammatory cells under oxidative stress via ultraviolet irradiation with a hydrogen peroxide diluent. Na2S2O3 was used as a stabilizer to obtain a semiquinone-rich poly-dopamine film, then phenol-semiquinone-quinone ratio on its surface was evaluated at three irradiation-oxidation time points. We found that the poly-dopamine film with ultraviolet irradiation in hydrogen peroxide solution for 15 min had the highest semiquinone occupancy of 19.18%. In the experimental group irradiated for 15 min, endothelial cells were cultured statically for 3 days and the number of surface adherent endothelial cells in the group with added semiquinone stabilizer was reduced to 73% of that in the group without stabilizer, indicating that semiquinone rich surface inhibits adhesion and proliferation of endothelial cells; Smooth muscle cells were cultured statically for 3 days, and the number of adherent smooth muscle on surfaces without stabilizer was reduced to 75% of that on surfaces with stabilizer added, indicating that semiquinone rich surfaces promote smooth muscle proliferation. These results demonstrate that semiquinone can adversely affect the repair effect after implantation of cardiovascular materials. Therefore, our study provides a reference for the application and optimization of dopamine in cardiovascular implant materials.
研究领域:
生物医学工程
·
细胞生物学
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DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2021
·
IF 5.467
Guangyong Zeng,Ke Wei,Haiyan Zhang,Jun Zhang,Qingquan Lin,Xiaojie Cheng,Arijit Sengupta,Yu-Hsuan Chiao
The oily wastewater is one of the major waste streams generated due to industrialization. The membrane technology has prominent advantages in the field of oily wastewater treatment . In present investigation, halloysite nanotubes (Hal) and polydopamine (PDA) were utilized to synergistically modify MXene followed by the fabrication of a series of Hal@MXene-PDA two-dimensional (2D) composite membranes by vacuum filtration. Observing the morphology of the membrane and exploring the change in interlayer space by scanning electron microscope (SEM), atomic force microscope (AFM) and X-ray diffraction (XRD), it was confirmed that, the composite membrane was successfully modified. The results revealed that, the Hal@MXene-PDA composite membrane exhibits higher hydrophilicity compared to the virgin membrane. The pure water flux using the composite membrane was found to be 5036.2 L·m −2 ·h −1 ·bar −1 , and the rejections of petroleum ether and lubricating oil were evaluated as 99.8%. The modified membrane(M6) also shows good anti-fouling ability in the anti-fouling cycle test and hence can be considered as a potential candidate for oil-water separation.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hui Su,Yucheng Qiu,Jing Luo,Fei Liu,Jun Yang,Xiaofeng Sui,Yue Zhang,Yumei Zhang,Xianyu Zhou
Vascular anastomosis is the cornerstone in microsurgery. To assist complicated microvascular anastomosis with diameters <0.6 mm, nonsuture cuff technique was developed. However, cuff tube made from polyamide is not degradable, and their long-term retention in the body may cause stiffness in blood vessels at the anastomotic site. Thus, development of a biodegradable cuff tube would greatly enhance surgical operability and biosafety. In this study, biocompatible poly-L-lactic acid (PLLA) was chosen as the raw material to prepare cuff tube for nonsuture cuff technique. A customized ‘C’ shaped nozzle was adopted during the melting extruding process, and then was subjected to a water-cooling bath to maintain the round shape and inner diameter of 582 μm ± 20 μm. Its crystallization behavior was controlled through the cooling procedure to achieve the expected mechanical properties and operability. Its good hemocompatibility and genotoxicity were validated by various in vitro assays. Consequently, a PLLA cuff tube with a radial tensile strength of 12 MPa and an elastic modulus of 1685 MPa was prepared and used to assist establishing a rat orthotopic hindlimb transplantation model, which indicated that our PLLA cuff tube was suitable for microvascular anastomosis in organ or tissue repair.
研究领域:
医学
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生物材料学
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外科手术
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产品关联
DOI
PubMed
高影响因子
iScience
·
2024
·
IF 4.6
Ziyang Gao,Erqian Huang,Wanting Wang,Lizhong Xu,Wanyue Xu,Ting Zheng,Menglong Rui
Summary Synapses are fundamental components of the animal nervous system. Synaptic cytoskeleton is essential for maintaining proper neuronal development and wiring. Perturbations in neuronal microtubules (MTs) are correlated with numerous neuropsychiatric disorders. Despite discovering multiple synaptic MT regulators, the importance of MT stability, and particularly the polarity of MT in synaptic function, is still under investigation. Here, we identify Patronin, an MT minus-end-binding protein, for its essential role in presynaptic regulation of MT organization and neuromuscular junction (NMJ) development. Analyses indicate that Patronin regulates synaptic development independent of Klp10A. Subsequent research elucidates that it is short stop (Shot), a member of the Spectraplakin family of large cytoskeletal linker molecules, works synergistically with Patronin to govern NMJ development. We further raise the possibility that normal synaptic MT polarity contributes to proper NMJ morphology. Overall, this study demonstrates an unprecedented role of Patronin, and a potential involvement of MT polarity in synaptic development.
研究领域:
神经生物学
·
细胞生物学
·
发育生物学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Zhi Jiang,Hezhuang Liu,Jihua Zou,Yixuan Huang,Zhaoquan Xu,Caihong Li,Desheng Liu
With the rapid advances in metal halide perovskite optoelectronics, eliminating toxic lead from perovskites has been an urgent demand. However, state-of-the-art lead-free perovskite photodetectors are still challenged with issues of low photoresponse, poor stability, etc. Here, all-inorganic lead-free perovskite (Cs3Cu2I5) single crystals that possess good stability under air exposure are synthesized via a facile solid reaction method. Meanwhile, a higher photoluminescence quantum yield of 95.2% and a prolonged carrier lifetime of 1.127 μs are obtained by further optimizing the synthesis. Benefiting from the polyporous surface and hollow structure of Cu-7,7,8,8-tetracyanoquinodimethane (CuTCNQ) microtubes, more Cs3Cu2I5 nanocrystals can adhere on the innershell and outershell of CuTCNQ-15 microtubes. This unique structure contributes to the improved efficiency of utilizing incident light and promotes charge carrier generation and transportation. As a result, the hierarchical CuTCNQ/Cs3Cu2I5 (hollow microtube/nanocrystal) heterostructure phototransistor exhibits a high responsivity of 88.36 A W–1 and a large detectivity of 1.66 × 1012Jones. The proposed lead-free perovskites and mixed-dimensional heterojunctions are promising for sensitive light detection.
研究领域:
材料科学
·
光学工程
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Lu He,Qing-Qing Bi,Yue Ma,De-Yi Wang
Aiming to improve the flame retardancy efficiency and rheological properties of hydroxides commonly used in asphalt, a combined flame retardant was fabricated using aluminium hydroxide (ATH), halloysite nanotube (HNT) and ferrocene. The optimal loading of flame retardant and process parameters for asphalt preparation were determined through an orthogonal experimental design. Through microscopic observation, the combined flame retardant was evenly dispersed within the asphalt matrix, with minimal agglomeration and segregation. Asphalt containing the combined flame retardant achieved an improved limiting oxygen index (LOI) value of 28.1 %, accompanied by a 30.9 % and 41.2 % reduction in peak of heat release rate (PHRR) and peak of smoke production rate (PSPR) compared to conventional Styrene-Butadiene-Styrene (SBS) modified asphalt used in asphalt pavement. In-depth mechanism analysis revealed that the formation of high-quality charring layers was facilitated by the catalytic reaction of ferrocene and catalytic oxidation of gases produced during asphalt combustion. Moreover, the improved network crosslinking function in asphalt significantly enhanced the rheological properties observed in the dynamic shear rheometer (DSR) and multiple stress creep recovery (MSCR) tests. Prospectively, this study provides an effective approach for simultaneously achieving prominent fire safety and enhanced rheological properties of asphalt through a simple preparation method.
研究领域:
材料科学
·
火灾安全工程
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2018
·
IF 5.08
Juan Zhou,Huiyan Ying,Mingyu Wang,Dandan Su,Guozhong Lu,Jinghua Chen
A dual layer conduit, which consists of collagen I-hyaluronic acid (Col-HA, external layer) and collagen I-heparin (Col-HP, inner layer), has been developed. This conduit not only meets the structural requirement of nature blood vessel, but also presents favourable mechanical performance after crosslinking via EDC. In addition, its biological properties are evaluated through culturing with fibroblast cell (Cos-7) on Col-HA surface and vascular endothelial cell (HMEC) on Col-HP layer. Results demonstrate that the conduit can support Cos-7 and HMEC adhesion, proliferation and elongation on respective side. This dual layer conduit would be a new choice of artificial vascular scaffold and improve blood vessel regeneration for tissue engineering.
研究领域:
生物材料学
·
组织工程学
·
再生医学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2016
·Vol. 8
·期 8
·4588-4598
·
IF 7.76
Wenya Xu,Junyan Dou,Jianwen Zhao,Hongwei Tan,Jun Ye,Masayoshi Tange,Wei Gao,Weiwei Xu,Xiang Zhang,Wenrui Guo,Changqi Ma,Toshiya Okazaki,Kai Zhang,Zheng Cui
Two innovative research studies are reported in this paper. One is the sorting of semiconducting carbon nanotubes and ink formulation by a novel semiconductor copolymer and second is the development of CMOS inverters using not the p-type and n-type transistors but a printed p-type transistor and a printed ambipolar transistor. A new semiconducting copolymer (named P-DPPb5T) was designed and synthesized with a special nonlinear structure and more condensed conjugation surfaces, which can separate large diameter semiconducting single-walled carbon nanotubes (sc-SWCNTs) from arc discharge SWCNTs according to their chiralities with high selectivity. With the sorted sc-SWCNTs ink, thin film transistors (TFTs) have been fabricated by aerosol jet printing. The TFTs displayed good uniformity, low operating voltage (±2 V) and subthreshold swing (SS) (122–161 mV dec−1), high effective mobility (up to 17.6–37.7 cm2 V−1 s−1) and high on/off ratio (104–107). With the printed TFTs, a CMOS inverter was constructed, which is based on the p-type TFT and ambipolar TFT instead of the conventional p-type and n-type TFTs. Compared with other recently reported inverters fabricated by printing, the printed CMOS inverters demonstrated a better noise margin (74% 1/2 Vdd) and was hysteresis free. The inverter has a voltage gain of up to 16 at an applied voltage of only 1 V and low static power consumption.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）