ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Yang Feng,Rui Liu,Lichun Zhang,Ziyan Li,Yingying Su,Yi Lv
Near-infrared (NIR) persistent luminescence (PersL) nanoparticles based on trivalent chromium-doped gallates (ZGO) as nanocarriers show great potential for theranostics, owing to their autofluorescence-free background and deep tissue penetration. However, high drug loading capacity of ZGO nanocarriers remains a big challenge. Herein, raspberry-like mesoporous Zn1.07Ga2.34Si0.98O6.56:Cr0.01 (designated as Si-ZGO) is first developed via a unique silica-assisted targeted etching strategy. The composition, morphology, NIR PersL capacities, and drug loading/releasing abilities of Si-ZGO have been explored. These results exhibit that Si-ZGO possess multiple inspiring characteristics including (i) spherical raspberry-like mesoporous morphology with a large cavity (total pore size ∼5.0 nm) and high specific surface area (∼80.653 m2·g–1), promising excellent drug loading capacity (∼62 wt %); (ii) tunable sizes from 80 to 180 nm and improved aqueous-dispersibility, facilitating cellular uptake and permeation and retention (EPR) effect; (iii) new deep traps related to oxygen vacancies, achieving the brighter NIR PersL. These outstanding merits enable the further nanosystem (DOX-BSA@Si-ZGO) for proof-of-concept theranostics excellent chemotherapy effect, tumor-specific trackable ability, and pronounced NIR afterglow imaging in vivo. This work demonstrates the great potentials of Si-ZGO nanorasperries as a multifunctional theranostics platform, even more it hopefully could inspire other constructions of advanced functional materials.
研究领域:
材料科学
·
生物医学工程
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Junpeng Shi,Xia Sun,Shenghui Zheng,Liang Song,Fangrong Zhang,Tobias Madl,Yun Zhang,Hongwu Zhang,Maochun Hong
The photodynamic therapy (PDT) as a promising antitumor therapy technique is greatly hampered by the low tissue penetration of light and the photothermal effect of prolonged irradiation. Near-infrared (NIR) persistent luminescence nanoparticles (NPLNPs) possess the potential for application in next-generation PDT. However, owing to the low re-excitation efficiency of NPLNPs in deep tissue, the current PDT nanoplatform based on NPLNPs is faced with the disadvantage of decreased PDT efficiency induced by persistent luminescence (PersL) decay at the lesion site. Herein, NPLNPs, Zn1.3Ga1.4Sn0.3O4:Cr3+ (ZGS), with small particle sizes and excellent optical properties are synthesized via a simple acetylacetonate combustion method. The ZGS can be repeatedly excited by the biological window (659 nm) light to produce a strong NIR (700 nm) PersL. The response efficiency of ZGS to the wavelength in the biological window has been greatly improved by doping Sn4+ into the ZnGa2O4 matrix, which is 55 times higher than that of traditional ZnGa2O4:Cr3+. We further develop a PDT nanoplatform by modifying a photosensitizer on its surface. The PDT experiments show that the developed nanoplatform can achieve continuous and efficient tumor PDT with a depth of up to 3 cm by repeated excitation using a 659 nm LED. The NPLNPs largely solve the problem of the low re-excitation efficiency after NIR PersL decay of traditional NPLNPs in deep tissue applications and will further promote the application of NIR PLNPs in the biomedical field.
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
Biomaterials Science
·
2020
·Vol. 8
·期 11
·3095-3105
·
IF 6.183
Yuyang Xia,Hongying Bao,Jie Huang,Xiaodi Li,Chenggong Yu,Zhijun Zhang,Haishui Wang
Human mesenchymal stem cells (hMSCs) are promising in the treatment of pulmonary fibrosis (PF). However, the behavior of hMSCs after transplantation, including dynamic translocation, location and survival, impeding the clinical application of hMSCs in PF is still ambiguous. Herein, we report an effective dual-labeling strategy combining endogenous bioluminescence imaging (BLI) and exogenous near-infrared-persistent luminescence (NIR-PL) imaging for in situ visualization of the transplanted stem cells. The long persistent luminescence nanoparticles (LPLNPs), Zn1.1Ga1.8Ge0.1O4:Cr3+,Eu3+, were developed to track the dynamic translocation, position and distribution of the transplanted hMSCs, taking advantage of their long-lasting NIR-PL imaging ability and minimal autofluorescence background interference. Moreover, in virtue of their ability to express red-emitting firefly luciferase (RfLuc), the living stem cells after transplantation could be discriminated from the dead cells by BLI. This facile pattern contributes to the in situ monitoring of stem cells regarding their spontaneous behavior in vivo and therefore deepening our knowledge in the role played by the transplanted hMSCs in PF therapy.
研究领域:
医学
·
细胞生物学
·
影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Jingwei Liu,Yanjie Liang,Shao Yan,Dongxun Chen,Shihai Miao,Fei Xie,Weili Wang
Near-infrared (NIR, 700–900 nm) emissive persistent phosphors have been given substantial attention in the past decade due to their bright future for many advanced applications from night vision surveillance to biomedical imaging. Here, we report the intense NIR persistent luminescence from a series of Bi 2+ -activated persistent luminescence materials achieved by the cation disorder strategy in CaSnO 3 host. Taking Ca 0 . 95 (Na,Gd) 0.025 SnO 3 :Bi 2+ as an example, it exhibits long-lasting NIR afterglow with a peak maximum at 805 nm assigned to the 2 P 3/2 (1)→ 2 P 1/2 transition of Bi 2+ and a long persistence time of more than 24 h after the ceasing of external excitation. More importantly, NIR self-sustained luminescence can be triggered by wideband irradiation with ultraviolet to visible light over 230–550 nm. As expected, 365 nm UV lamp, natural sunlight and LED flash can all effectively charge these NIR persistent phosphors and induce commendable NIR persistent luminescence performance. Considering the invisibility of NIR emission to the naked eye, very broad persistent luminescence excitation band, and long-lasting NIR luminescence after excitation, these Bi 2+ -activated NIR persistent phosphors are expected to find important applications in optical information storage and anti-counterfeiting fields.
研究领域:
材料科学
·
光学材料
·
光子学
·
信息安全
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2017
·
IF 8.402
Junpeng Shi,Xia Sun,Shenghui Zheng,Jinlei Li,Xiaoyan Fu,Hongwu Zhang
Multifunctional nanoplatforms with multimodal imaging and cancer therapy capabilities have attracted attention in biomedical applications . Near-infrared persistent luminescence nanoparticles (NPLNPs) were considered one of the most promising candidates for constructing multifunctional nanoplatforms due to the absence of in situ excitation and high signal-to-noise ratios (SNRs). Here, we report a novel NPLNP mSiO 2 @Gd 3 Ga 5 O 12 :Cr 3+ , Nd 3+ (mSiO 2 @GGO) as multifunctional nanoplatforms for multimodal imaging and cancer therapy. These NPs exhibited a persistent luminescence (745 nm) of more than 3 h in the first near-infrared window (NIR-I) after UV excitation, which can realize high SNRs and long-term in vivo imaging. Moreover, these NPs showed excellent NIR luminescence (1067 nm) in the second near-infrared window (NIR-II) under 808 nm excitation, which is more suitable for deep tissue imaging due to the lower photon scattering and deeper tissue penetration of NIR-II luminescence. Furthermore, the host Gd 3 Ga 5 O 12 with high Gd 3+ concentration showed a high r 1 value (10.70 mM −1 s −1 ) and was suitable for T 1 MR imaging. The mesoporous silica nanoparticles (mSiO 2 ) served as a framework to control the mSiO 2 @GGO particle morphology and provide low toxicity and drug loading capacity for cancer therapy.
研究领域:
生物医学
·
纳米医学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2021
·Vol. 10
·期 1
·2101669
·
IF 9.926
Zhihao Zhou,Shuai Zhang,Yakun Le,Hong Ming,Yang Li,Shi Ye,Mingying Peng,Jianrong Qiu,Guoping Dong
Spinel configuration is a kind of broadly considered host candidate when designing persistent luminescence (PersL) materials due to the easy generation of vacancies and anti-site defects. Here, a new strategy of defect enrichment for the activation of PersL is proposed, and in contrast to the spinel configuration, it is demonstrated that the crystal structure of near inverse spinel ensures more numerous defects to activate the near-infrared (NIR) PersL of Fe 3+ . Fe 3+ -doped MgGa 2 O 4 displays the PersL band in the range of 600 to 900 nm and possesses a super-long PersL duration time >15 h. The optical analysis and the calculation of density functional theory unravel that the near inverse spinel structure can lower the carrier transfer barriers to accelerate the formation of carrier trap states within the bandgap. Therefore, more numerous defects in this structure may participate in the trapping and de-trapping process by comparison with the normal spinel configuration. These findings are expected to accelerate the development of new PersL materials through Fe 3+ doping toward versatile biological applications in NIR window.
研究领域:
材料科学
·
光学物理
·
生物医学工程
✓ 已验证
DOI
高影响因子
Acta Biomaterialia
·
2024
·
IF 9.4
Peng Lin,Junpeng Shi,Lin Liu,Jinyuan Wang,Zhengxia Yang,Xia Sun,Maochun Hong,Yun Zhang
Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have significant potential in diagnostic and therapeutic applications owing to their unique persistent luminescence (PersL). However, obtaining high-performance NIR PLNPs remains challenging because of the limitations of current synthesis methods. Herein, we introduce a spatial confinement growth strategy for synthesizing high-performance NIR PLNPs using hollow mesoporous silica (hmSiO 2 ). By calcining precursor ions in the hollow cavity, the yolk size of NIR PLNPs was regulated, yielding well-dispersed Zn 1.3 Ga 1.4 Sn 0.3 O 4 : Cr 0.005 , Y 0.003 @hmSiO 2 (ZS) with a yolk-shell structure. Compared to the conventional template method, ZS synthesized via the spatial confinement growth strategy exhibited a 7.7-fold increase in PersL intensity and a threefold increase in specific surface area. As a proof of concept, ZS@PpIX@CaP-AMD (ZPSC-AMD) nanoparticles, with potential for sonodynamic therapy (SDT), were synthesized by loading the sonosensitizer protoporphyrin IX (PpIX) into ZS, coating it with a calcium phosphate (CaP) shell, and modifying it with a tumor-targeting molecule plerixafor (AMD-3100). The tumor enrichment behavior of ZPSC-AMD was monitored by sensitive NIR PersL to guide SDT. Simultaneously, ZPSC-AMD enabled the precise monitoring of tumor accumulation, thereby guiding effective SDT. In addition, Ca 2+ released from CaP degradation increased the level of reactive oxygen species during SDT, promoting tumor cell apoptosis. This study outlines a reliable design and synthesis approach for high-performance NIR PLNPs and promotes their development in biomedical applications. Statement of Significance The potential of near infrared (NIR) persistent luminescence nanoparticles (PLNPs) in bio applications is hindered by limitations in the synthesis method. In this article, we proposed a spatial confinement growth strategy of high-performance NIR PLNPs. The obtained PLNPs with yolk-shell structure showed a 7.7-fold increase in PersL intensity and a 3-fold increase in specific surface area, compared with the commonly used template method. Due to the advantages, sonodynamic therapeutic nanoparticles were constructed based on the above PLNPs, where persistent luminescence was used for ultrasensitive imaging to determine the optimal timing in sonodynamic therapy. In addition, the multifunctional calcium phosphate shell elevated the intracellular reactive oxygen species level to promote tumor cell apoptosis.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2022
·Vol. 10
·期 4
·2205320
·
IF 17.521
Ruoping Wang,Junpeng Shi,Qian Zhang,Qiang Peng,Xia Sun,Liang Song,Yun Zhang
Rheumatoid arthritis (RA) is a common, chronic, and highly disabling autoimmune disease characterized by difficult treatment, long disease duration, and easy recurrence. The development and application of high-sensitivity theranostic probes for RA that will facilitate precise monitoring of disease progression and enable effective treatment are currently hotspots in the field of RA theranostics. In this study, mZMI@HA, a dual-triggered theranostics nanoprobe, is constructed based on near-infrared persistent luminescence nanoparticles (NIR-PLNPs) for precise RA treatment and therapeutic evaluation. This is the first reported use of high-sensitivity autofluorescence-free imaging based on NIR-PLNPs for precise RA treatment and therapeutic evaluation. Compared with the NIR fluorescence imaging probe-indocyanine green, the signal-to-background ratio of persistent luminescence (PersL) imaging is improved nearly 14-fold. Using PersL imaging to guide photothermal therapy and controllable drug release through NIR/pH-responsiveness, the progress of collagen-induced RA is relieved. Additionally, the therapeutic evaluation of RA by PersL imaging is consistent with clinical micro-computed tomography and histological analyses. This study demonstrates the potential of NIR-PLNPs for high-sensitivity imaging-guided RA treatment, providing a new strategy for RA precise theranostics.
研究领域:
生物医学工程
·
诊疗学
·
纳米技术
·
成像科学
·
风湿病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2018
·
IF 2.732
Jinlei Li,Chengcheng Wang,Junpeng Shi,Penghui Li,Zhenfeng Yu,Hongwu Zhang
Here, a kind of porous nanoparticles GdAlO 3 :Cr 3+ , Sm 3+ (GAO:Cr,Sm) which own magnetic resonance and long persistent luminescent properties have been synthesized. The spherical morphology and narrow size distribution would allow the GAO:Cr,Sm nanoparticles to be utilised as a drug carrier and the drug release results indicate that the GAO:Cr,Sm drug carriers have an excellent drug sustained properties. Applying the Cr 3+ and Sm 3+ coped with gadolinium aluminate as the NIR persistent luminescence center and the energy transfer resonance from Gd 3+ to Cr 3+ , these nanoparticles exhibit excellent NIR persistent luminescence at 732 nm under the UV irradiation of 254 nm and it can persist for about half an hour. In addition, they possess a longitudinal relaxivity (r 1 ) value of 4.75 mM −1 s −1 , which means that these nanoparticles could be applied for MR imaging as contrast agents. Carboxymethyl Chitosan was modified on the surface of GAO:Cr,Sm nanoparticles to make them owning excellent biocompatibility and low toxicity and these nanoparticles were successful to realize in vivo imaging. Hence, the well-defined nanoprobes of GAO:Cr,Sm exhibit great potential in biomedicine as trackable drug carriers and in vivo imaging agent due to the dual-model imaging property.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
成像科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 48
·18404-18414
·
IF 8.067
Shaoxing Lyu,Pengshang Zhou,Jiaren Du,Xiaomeng Wang,Tengyue Wang,Panqin Wang,Henggang Wang,Shan Sun,Hengwei Lin
Near-infrared (NIR) emitting phosphors with persistent luminescence have attracted much interest in the past decade, due to their widespread applications in medical diagnostics, night-vision surveillance, multi-level anti-counterfeiting, and security encryption. Although NIR luminescent materials have been extensively investigated, it is challenging to explore novel phosphors or new compositions with tunable NIR persistent luminescence performance. Herein, chemical unit co-substitution is explored in a series of NIR emitting Zn1−2xLixGa2+xO4:Cr3+ solid solutions. Substitution with [Li+–Ga3+] for the [Zn2+–Zn2+] unit results in tunable emission in the deep-red and NIR regions coming from the typical Cr3+ emission of the 2E → 4A2 and 4T2 → 4A2 transition. Upon UV or X-ray irradiation, intense NIR persistent luminescence is realized and composition-related variation of trap distributions and densities are identified. Importantly, a higher trap density of the Cr3+-doped solid solutions (i.e., x = 0.2–0.4) than that of the benchmark NIR persistent phosphor of ZnGa2O4:Cr3+ and LiGa5O8:Cr3+ is achieved. This work proves the feasibility of chemical unit co-substitution in developing new NIR persistent phosphors, which can motivate further exploration of luminescent materials with novel properties.
研究领域:
材料科学
·
光学
·
光子学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2023
·Vol. 34
·期 17
·175601
·
IF 3.5
Jing Fu,Qi-Yan Lv,Yan-Shuai Li,Xiaojie Song,Qi Zhu,Xueling Ren,Hui-Fang Cui
Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) with high brightness, small sizes, good hydro-dispersivity, and intrinsic surface-functional groups are desirable in biological applications. In this work, Cr3+-doped zinc gallogermanates Zn1+xGa2−2xGexO4:Cr (ZGGC) PLNPs were hydrothermally synthesized via 3-aminopropyltriethoxysilane (APTES) as an additive, or APTES and cetyltrimethylammonium bromide (CTAB) as two co-additives. Addition of APTES not only dramatically enhances the 696 nm NIR luminescence intensity, but also obviously decreases the particle size and introduces amino groups. In particular, the x = 0.1 series ZGGC (ZGGC0.1) with the addition of n moles equivalent APTES (ZGGC0.1-nA) had smaller particle sizes than the x = 0.2 counterpart (ZGGC0.2-nA). The NIR afterglow intensities increased with the APTES introduction. The ZGGC0.2-2.5A sample (also named as ZGGC, Si, -NH2) exhibited maximum luminescence intensities both in solid and aqueous states. With APTES, Si atom is doped and –NH2 groups are modified, the trap depth and density become larger, and the afterglow intensities and decay time are significantly enhanced. More notably, co-addition of CTAB (ZGGC0.2-2.5A-C) (also named as ZGGC, Si, −NH2') further enhances hydro-dispersivity and luminescence intensity, decreases particle sizes, and results in more prominent amino groups. The trap density is drastically higher than that without CTAB (i.e. ZGGC0.2-2.5A). Change of Cr3+ microenvironment in the crystal and more defects introduction contribute to the enhanced brightness. As expected, the ZGGC,Si,-NH2' PLNPs possess excellent biocompatibility, deep tissue penetration and distinguished bioimaging properties, and rechargeability with orange LED light. The ZGGC,Si,-NH2' PLNPs should provide to be an excellent nanomaterial for various functionalization and bioimaging applications.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
光学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）