MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2025
·
IF 4.6
Di Chang,Zihan Wu,Zixian Wang,Jianlin Chen,Siyuan Zhang,Caiyu Pei,Chi Li,Siyuan Zhao,Jiaqing Wang,Yifei Shi,Jincheng Huang,Zhuoyin Peng,Jian Chen
The inorganic perovskite solar cells (PSCs) exhibit superior thermal stability to the organic-inorganic hybrid PSCs. However, halide defects with low formation energy are often present at grain boundaries of the inorganic perovskite films. This results in many defects of Pb 2+ uncoordinated with halides, causing in non-radiative recombination in the films. In this work, cesium fluoride (CsF) was chosen as an additive in the CsPbI 2 Br precursor solution, in which Cs + can passivate the A-site vacancy defects in CsPbI 2 Br perovskite films; fluoride ion (F − ) has a smaller ionic radius and is more electronegative than chloride ion (Cl − ), iodide ion (I − ), and bromide ion (Br − ), which may allow it to fit in the smaller spaces in the host lattice, as well as weaken the lattice strain and improve the stability of the desired phase. Based on this strategy, CsF-treated carbon-based hole-transport-layer-free CsPbI 2 Br PSCs were obtained with a champion photovoltaic conversion efficiency of 13.45 %, short-circuit current density of 15.15 mA/cm 2 , open-circuit voltage of 1.18 V, and fill factor of 75 %. Meanwhile, the CsF-treated CsPbI 2 Br PSCs possessed better environmental stability compared to the un-treated counterpart due to the introduction of the more hydrophobic F − . This strategy provides a simple and feasible strategy for the development of efficient and stable inorganic PSCs.
研究领域:
材料科学
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光伏技术
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纳米能源
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表面化学
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半导体器件
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DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Shuning Chen,Tengfei Ren,Xiaoying Zhang,Zuoyong Zhou,Xia Huang,Xiaoyuan Zhang
Heterogeneous catalytic ozonation (HCO) is attractive for water decontamination and catalyst is a core element. However, it is difficult to maintain high efficiency and stability of catalysts under stern conditions. In this study, we proposed Mn-loaded C-SiO 2 -Framework (Mn-CSF) which contained stable silica core and robust carbon shell for efficient catalytic ozonation. The pseudo-first-order kinetic rate constant for oxalic acid removal of Mn-CSF catalytic ozonation was 160 % and 875 % higher than those of Mn-SiO 2 and pristine CSF, respectively. Mn-CSF was also proven effective in gasification wastewater treatment , where the COD was decreased to 46 mg·L −1 , 37 % lower than that of Mn-SiO 2 . These results indicated that the graphitization carbon layer and Mn significantly enhanced the activity of the catalyst. Furthermore, a fulvic-like component and a protein-like component were recognized through 3D-EEM in coal gasification wastewater. It was proven that Mn-CSF catalytic ozonation exhibited higher fulvic-like component and protein-like component removal compared with ozonation. Moreover, O 2 − and 1 O 2 were identified to be responsible for organic degradation in this research. Sufficient external specific surface area and porous structure were important for complex wastewater treatment. Specifically, external specific surface area could enhance the degradation of macromolecular organics while porous structures were vital for smaller molecular pollutant removal . The results highlighted that Mn-CSF was a promising HCO catalyst for advanced wastewater treatment, and this study provided evidence of relationship between structure of catalysts and HCO efficiency.
研究领域:
环境科学
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化学工程
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DOI
PubMed
高影响因子
CORROSION SCIENCE
·
2024
·
IF 7.4
Chuangfang Tao,Huanyi Liao,Bin Chen,Weiguo Mao,Jie Wang,Cuiying Dai,Zheqiong Fan,Zhe Zhou,Jinglv Zuo
The (PyC-C sf )/ZrB 2 -SiC-ZrC ceramics are fabricated by reactive spark plasma sintering (RSPS) at 1200 °C. The sample has a low density and intact pyrolytic carbon modified carbon fiber (PyC-C sf ). After three cycles of ablation (heat flux = 2.38 MW/m 2 , t = 120 s), samples demonstrate excellent resistance to oxidative ablation. The mass recession rate and linear recession rate for the sample are 3.41 g/m 2 ∙s and 0.68 µm/s, respectively. Excessive content of carbon destroys the oxide layer by forming large amounts of CO 2 during the ablation process. The inner layer of intact PyC-C sf aggregates around the borosilicate which are denser in the oxide layer. Finally, a porous ZrO 2 -SiO 2 layer and a dense ZrO 2 -SiO 2 -C sf layer are formed on the surface of the sample which resists ablation.
研究领域:
材料科学
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航空航天工程
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DOI
高影响因子
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
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2024
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IF 3.9
Junpu Li,Yan Guo
Background Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. Cryptococcal antigen (CrAg) testing from serum and cerebrospinal fluid (CSF) has been regarded as a gold standard for early diagnosis. This study aimed to develop and validate a rapid and sensitive sandwich chemiluminescent magnetic microparticle immunoassay (CMIA) for quantitative detection of CrAg in sera.Research design and methods CMIA is based on magnetic beads modified with capture antibodies and biotinylated antibodies and Streptavidin-polyHRP, where biotinylated antibodies functioned as the recognition element and Streptavidin-polyHRP as the signal component. Assay parameters were first optimized, and then assay performances were evaluated.Results Under optimized conditions, the total runtime of the CMIA was 22 min. The assay had a wide linear range (2 –10,000 ng/mL) and high analytical sensitivity (0.24 ng/mL), together with acceptable reproducibility, accuracy, and stability. Besides, it exhibited no cross-reactivity with other pathogens. Importantly, the assay showed 92.91% (95% CI, 80.97–93.02%) overall qualitative agreement with a commercial ELISA kit in a retrospective cohort of 55 cases with confirmed cryptococcal infection, and 72 controls without evidence of invasive fungal disease (IFD).Conclusion These results demonstrated that the present study paved a novel strategy for reliable quantitative detection of CrAg in sera.
研究领域:
医学微生物学
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免疫学
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临床诊断
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产品关联
DOI
PubMed
高影响因子
MOLECULAR HUMAN REPRODUCTION
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2021
·Vol. 27
·期 11
·
IF 4.025
Guo Fang,He Yongpei,Fan Yixian,Du Zhenzhen,Sun Huanhuan,Feng Zuohua,Zhang Guimei,Xiong Ting
Evidence accumulated in recent years has revealed that neutrophils are involved in the initial establishment of endometriosis, which is well-known as a chronic inflammatory disease. So far, why and how neutrophils promote the formation of early endometriosis are still unclear. In this study, using a mouse model of endometriosis, we demonstrated that endometriosis mice (EMs mice) had a significantly increased number of neutrophils in peritoneal fluids and lesions, and increased levels of granulocyte colony-stimulating factor (G-CSF) and IL-6 in serum and peritoneal fluids compared to the control group. In the neutrophils and uterine fragments co-injection experiment, neutrophils regulated by G-CSF and IL-6 had a similar effect to neutrophils from EMs mice, increasing the number, area, weight and microvessel density (MVD) of endometriotic lesions. Blocking the effect of G-CSF and IL-6 in EMs mice resulted in a decrease in the number, area and weight of endometriotic lesions. Following the depletion of neutrophils in vivo using a anti-Ly6G antibody, the MVD in the lesions of mice treated with neutrophils from EMs mice and neutrophils from pG/pI6 mice were significantly reduced. Neutrophils from EMs mice and neutrophils from pG/pI6 mice altered the expression levels of Mmp9, Bv8 and Trail genes compared to the neutrophils from PBS-treated mice. IL-6 together with G-CSF induced a higher expression of phospho-STAT3 and STAT3 in neutrophils. These findings suggest that neutrophils modulated by G-CSF and IL-6 through the STAT3 pathway alter the expression levels of the angiogenesis-related genes Mmp9, Bv8 and Trail, and may promote the establishment of early endometriosis.
研究领域:
免疫学
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生殖医学
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炎症
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分子生物学
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DOI
PubMed
高影响因子
Biomaterials Science
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2020
·Vol. 8
·期 20
·5666-5676
·
IF 6.183
Qi Wei,Na Shen,Haiyang Yu,Yue Wang,Zhaohui Tang,Xuesi Chen
Combretastatin A4 nanoparticles (CA4-NPs), which notably inhibit tumor growth, were found to cause tumor regrowth due to the intratumoral enrichment of M2-type macrophages after treatment. Since BLZ945, an inhibitor of CSF-1 receptor (CSF-1R), depletes and inhibits the proliferation of M2-type macrophages, it has the potential to relieve the immunosuppressive microenvironment and improve anti-tumor therapy of CA4-NPs. However, CSF-1R exists widely, not only in macrophages, and BLZ945 could cause potential hepatotoxicity. It is necessary to establish a tumor-targeting drug delivery system to reduce the off-target and side effects of BLZ945. In this study, FXIIIa substrate peptide A15 decorated BLZ945 nanoparticles (A15-BLZ-NPs) were developed, in which, BLZ945-poly(D,L-lactide) (BLZ945-PLA), produced by ring-opening polymerization, was encapsulated in poly(ethylene glycol)-poly(D,L-lactide) (PEG5k-PLA5k), and A15 was decorated on the surface PEG segment. A15-BLZ-NPs could crosslink with fibrin through elevated FXIIIa and specifically target intratumoral coagulation spots induced by CA4-NPs. In vivo studies showed that CA4-NPs induced enhanced distribution of BLZ945 in tumors, as the BLZ945 content was 3.75-fold in the CA4-NP + A15-BLZ-NP group compared to that of A15-BLZ-NP single treatment. Meanwhile, compared to the CA4-NP group, the combination treatment significantly reduced the proportion of M2-type macrophages (from 64.4% to 24.5%) and enriched cytotoxic T lymphocytes (from 1.5% to 18.9%) in tumors, suggesting that A15-BLZ-NPs remodeled and activated tumor immunity after CA4-NP treatment. Furthermore, the combined treatment effectively improved the tumor inhibition rate to 73.4%, which was significantly higher than that of CA4-NP (15.5%) or A15-BLZ-NP (23.9%) single treatment. This work established a novel combination strategy for anti-tumor therapy.
研究领域:
肿瘤学
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药理学
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免疫学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
MICROBIOLOGY AND IMMUNOLOGY
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2017
·Vol. 62
·期 3
·187-194
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IF 1.706
Cenrong Zhang,Wei Xu,Jian Chen,Ran Guan,Shicheng Bi,Haibo Jin,Xuemei Cui,Fushan Shi,Songhua Hu
In the present study, the adjuvant effect of soybean oil containing ginseng root saponins (SO-GS-R) on the immune response to foot-and-mouth disease vaccine (FMDV) in mice was investigated. When immunized with FMDV antigen emulsified in an SO-GS-R formulation, mice generated remarkably higher serum antibody and cytokine responses than mice immunized with FMDV antigen alone. To elucidate the mechanisms underlying the adjuvant effect of SO-GS-R, we measured cytokines in serum and muscle tissue after intramuscular injection of SO-GS-R. The results showed that injection of SO-GS-R significantly increased the levels of IL-1β, IL-5, IL-6, G-CSF, KC, MCP-1, MIP-1α, and MIP-1β in both serum and muscle. These results suggested that SO-GS-R recruits neutrophils, eosinophils, T cells and macrophages, causing immune cell recruitment at the injection site, driving antigen-presenting cells to actively participate in the onset of immunity, and amplifying the immune responses. Considering its adjuvant activity and plant-derived properties, SO-GS-R should be further studied for its adjuvant effect on vaccines used in food animals.
研究领域:
免疫学
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兽医学
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药理学
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DOI
PubMed
高影响因子
CARBON
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2026
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IF 12.7
Huan Guo,Wenhao Dou,Ruifeng Li,Bingzhu Wang,Yonghui Yu,Yong She,Yongzhong Zhao,Jianjun Sha
It is crucial to address the challenges for low-temperature densification and interfacial reactions during the fabrication of multi-element ultra-high temperature ceramic matrix composites. In this paper, C sf /(Hf, Ta)B 2 -(Hf, Ta)C-SiC composites were prepared via reactive hot-press sintering at low temperatures. The intrinsic connection between the fiber content, microstructure, and mechanical behavior of the composites was elucidated. The results indicated that the ultrasonic dispersion combining with fast hot-press sintering effectively promoted the uniform dispersion of C sf in the matrix and achieved densification at 1700 °C. The composites exhibited an undamaged fiber-matrix interface without observable interfacial phase, demonstrating that low-temperature preparation effectively prevented fiber degradation from interfacial reactions. Compared to the unreinforced ceramics, the composites showed decreased flexural strength and fracture toughness, yet possessed higher work of fracture and larger critical crack size. This indicated that fiber addition improved the damage tolerance and structural reliability by inhibiting the catastrophic brittle fracture behavior inherent to monolithic ceramics. The composite with 20 vol% C sf offered the best balance of strength, toughness and non-catastrophic failure behavior. The flexural strength and fracture toughness were 260.6 MPa and 4.82 MPa m 1/2 , respectively. Download: Download high-res image (531KB) Download: Download full-size image
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DOI
高影响因子
LARYNGOSCOPE
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2022
·
IF 2.97
Tiancong Liu,Yang Sun,Zhaohui Guo,Weiliang Bai
Objectives Allergic rhinitis (AR) is an inflammatory autoimmune disease with disorder of the nasal mucosa. Cadherin 26 (CDH26), an alpha integrin-binding epithelial receptor, is regulated during allergic inflammation. This study aimed to investigate whether CDH26 contributes to the severity of AR. Study design In vivo and in vitro. Methods We investigated the effects of CDH26 knockdown by lentivirus (LV)-mediated shRNA on ovalbumin (OVA)-induced AR mice and IL-13-stimulated human nasal epithelial cells (NECs). Results CDH26 mRNA and protein expression was significantly increased in the nasal mucosa of AR patients and mice. Intranasal instillation of LV-shCDH26 alleviated allergic symptoms and decreased the histological changes of nasal mucosa in AR mice. Furthermore, the serum levels of OVA-specific IgE, IgG, pro-inflammatory factors IL-25, IL-33, and TSLP were decreased in AR mice with CDH26 knockdown. With regard to AR-induced Th2 inflammation, LV-shCDH26 intervention effectively decreased the distribution of CD4 + /GATA3 + Th2 cells, and the mRNA expression of IL-4, IL-5, and IL-13 in the nasal mucosa. CDH26 knockdown down-regulated the expression of β-catenin but not for E-cadherin and ZO-1 in nasal mucosa induced by AR. In vitro, CDH26 knockdown inhibited the protein expression of TSLP, GM-CSF and eotaxin in NECs, and CDH26 overexpression remarkably promoted the production of these inflammatory factors in IL-13-induced NECs. Conclusions CDH26 knockdown attenuates the AR-induced inflammatory response both in vivo and in vitro. Level of Evidence NA Laryngoscope , 2022
研究领域:
免疫学
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分子生物学
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过敏
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呼吸医学
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产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2022
·
IF 10.633
Xiang Yu,Lin Zhu,Xiaohui Liang,Bochuan Yuan,Minshu Li,Shen Hu,Pingtian Ding,Lina Du,Junwang Guo,Yiguang Jin
Exposure to a nuclear accident or a radiological attack may cause serious death events due to ionizing radiation-induced injury and acute radiation syndrome (ARS). Recombinant human granulocyte colony-stimulating factor (G-CSF) is now used for the treatment of ARS. However, the current injection formulation might not ensure treatment as early as possible after a nuclear accident, resulting in a decrease in therapeutic efficiency. In the present study, we have developed a G-CSF wearable system (GWS) consisting of a commercial microchip, a temperature sensor , a gamma-ray detection sensor, a flexible heater, and a G-CSF temperature-sensitive microneedle (GTSMN) patch. G-CSF-containing hyaluronic acid solutions were cast into the mold to obtain G-CSF microneedles (GMNs), which were coated with a temperature-sensitive layer of dodecanoic acid-cetylamine salt to obtain GTSMNs. The flexible heater was prepared by jet printing Ag nanoparticle inks. The GWS and its components are explored and optimized in the aspects of electronics, mechanics, heat transfer and drug diffusion . The γ radiation signal is sensitively monitored by the GWS. The wearable G-CSF system immediately releases G-CSF into the body in response to signal feedback and provides maximal protection against ionizing radiation-induced injury. Therefore, the GWS is a promising wearable system against emergent ionizing radiation injury. Statement of significance Ionizing radiation-induced injury is always the very important public health problem all the global people care. Some medicines have been applied to protect the body from the injury. Unfortunately, sometimes the injuries accidently happen and the medicines cannot be administered in time, leading to serious acute radiation syndrome. Here, we design a wearable system loading G-CSF that has been approved by FDA to protect the body from ionizing radiation-induced injury. This system consists of a commercial microchip, a temperature sensor, a Gamma-ray detection sensor, a flexible heater, and a G-CSF temperature-sensitive microneedle patch. It can monitor γ radiation and immediately release G-CSF into the body to protect the body to the maximal extent. Therefore, the system is a promising wearable medical device against emergent ionizing radiation injury.
研究领域:
生物医学工程
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辐射防护
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药物传递系统
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材料科学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
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2022
·
IF 6.064
Wang Xu-Dong,Yu Wei-Jia,Liu Jia-Hui,Du Jie,Chen Kang-Nan,Hu Qin-Qin,Sun Wen-Long,Ying Guo-Qing
The clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) is limited by its short serum half-life. In this study, a long-acting strategy for site-specific modification of rhG-CSF with 1-pentadecyl-1H-pyrrole-2,5-dione (C15 fatty chain-maleimide, C15-MAL) was studied in mixed DMSO-aqueous solutions. The factors influencing the conjugation reaction were investigated and optimized, and a high yield of the desired product (C15-rhG-CSF) was achieved. Subsequently, C15-rhG-CSF product was efficiently purified using preparative liquid chromatography, and further characterized. Circular dichroism spectroscopy analysis showed that the secondary structure of C15-rhG-CSF had no significant difference from unmodified rhG-CSF. C15-rhG-CSF retained 87.2% of in vitro bioactivity of unmodified rhG-CSF. The pharmacokinetic study showed that the serum half-life of C15-rhG-CSF in mice was 2.08-fold longer than that of unmodified rhG-CSF. Furthermore, C15-rhG-CSF by single-dose subcutaneous administration showed better in vivo efficacy than those of both PEG10k-rhG-CSF by single-dose administration and rhG-CSF by multiple doses administration. This study demonstrated the potential of C15-rhG-CSF being developed into a novel drug candidate as well as an efficient process for the development of long-acting protein and peptide drugs.
研究领域:
药学
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生物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
Fundamental Research
·
2023
·
IF 6.2
Zhuo Cheng,Yan Hu,Yingqi Liu,Xuan Wang,Rui Xue,Kaiyong Cai,Liqi Li,Menghuan Li,Zhong Luo
ABSTRACT Post-resection tumors with microscopic foci and immunosuppressive microenvironments have high risk of recurrence and metastasis but respond poorly to various therapies. Herein, we propose a biomimetic hydrogel as a biocompatible, biodegradable and bioadhesive postoperative dressing that could be formed in situ by NaIO 4 -initiated thiourea-catechol crosslinking after syringe-injection into the resection cavity. The thiourea or catechol-bearing hyaluronic acid (HA) precursors are also separately engineered with phenylboronic acid and β-cyclodextrin (β-CD) groups, potentiating the reversible immobilization of (1S, 3R) RAS-selective lethal 3 (RSL3) and glycosylated granulocyte macrophage-colony stimulating factor (GM-CSF) without invasive chemical reactions. Meanwhile, the interconnected porous superstructure of the hydrogels allows the incorporation and self-regulated delivery of PD-L1 antibody (aPD-L1). RSL3-induced immunogenic ferroptosis and GM-CSF could cooperatively trigger robust adaptive tumor-specific immune responses, while aPD-L1 further alleviates the accumulated immunoresistance of tumor cells due to interferon γ-mediated PD-L1 upregulation, thus stimulating potent local and whole-body antitumor immunity to prevent postoperative tumor recurrence and metastasis. The biomimetic hydrogel may serve as a promising solution for the postoperative treatment of solid tumors.
研究领域:
生物医学工程
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免疫疗法
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癌症研究
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材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）