Pharmaceuticals
·
2024
·Vol. 17
·期 3
·291
·
IF 4.3
Nannan Kang,Jun Ma,Yuling Hu,Rongrong Di,Lei Wang,Xuanling Zhang,Yisheng Lai,Yu Liu
Background: Breast cancer is a commonly diagnosed cancer worldwide. Human MutT homolog 1 (MTH1) is found to be elevated in breast tumors and cancer cells need MTH1 for survival. Pharmacological inhibition of MTH1 may be potentially beneficial in the treatment of breast cancer. Methods: MA−24 was screened by malachite green colorimetric assay for MTH1 inhibitors and the kinetic characteristics of MA−24 were assessed. The features of MA−24’s binding with MTH1 were ascertained through molecular docking, and the cytotoxic activity of MA−24 was validated in vitro and in vivo. Target engagement assays, comet assay, and Western blot confirmed the intracellular target and mechanism of MA−24. Results: MA−24 shows potent antitumor bioactivity both in vitro and in vivo. MA−24 competitively inhibited the MTH1 and further induced DNA strand breaks, leading to increased apoptosis of cancer cells depending on the upregulation of the cleaved-caspase 3–cleaved-PARP axis. In particular, MA−24 exhibited a powerful efficacy and safety in vivo (tumor growth inhibition rate: 61.8%). Conclusions: MA−24 possesses a broad spectrum of breast cancer cytotoxicity and offered valuable insights for overcoming the challenges of chemotherapy-related toxicity, which holds great potential for the further development MA−24 as an anti-cancer drug.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2023
·
IF 4
Yuanlei Huang,Mengdi Lv,Binglian Guo,Guojing Hu,Yong Qian,Zhi Su,Xuling Xue,Hong-Ke Liu
Breast cancer (BC) is one of the most common malignant tumors and often accompanied by inflammatory processes. Inflammation is an essential component of the tumor microenvironment, which might influence tumor proliferation and metastasis. Herein, three metal–arene complexes MA-bip-Ru, MA-bpy-Ir, and MA-bpy-Ru were prepared by tethering the non-steroidal anti-inflammatory drug meclofenamic acid (MA). Among them, MA-bip-Ru and MA-bpy-Ir showed lower cytotoxicity towards cancer cells, but MA-bpy-Ru showed significantly high selectivity and cytotoxicity towards MCF-7 cells through the autophagic pathway and exhibited no toxicity against normal HLF cells, showing potential for selective treatment of tumor cells. MA-bpy-Ru could also effectively destroy the 3D multicellular tumor spheroids, demonstrating its potential for clinical application. Besides, MA-bip-Ru, MA-bpy-Ir, and MA-bpy-Ru exhibited anti-inflammatory properties superior to MA, notably downregulating the expression of cyclooxygenase-2 (COX-2) and inhibiting the secretion of prostaglandin E2 in vitro. These findings demonstrated that MA-bpy-Ru was capable of intervening in inflammatory processes and showed the potential of MA-bpy-Ru to act as a selective anticancer agent, thus presenting a new mechanism of action for metal–arene complexes.
研究领域:
肿瘤学
·
药物化学
·
无机化学
·
癌症生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Results in Engineering
·
2024
·
IF 6
Thi Thi Mar,Yunlong Xue,Yu Chang,Zijian Yu,Zhongxiao Du,Bing Cao,Rui Zhang
Pervaporation emerges as a promising technique for brine treatment. In this investigation, we employed a PVDF substrate layer and applied various coating solutions using a simple spray technique to produce a composite pervaporation membrane. The composite membrane's chemical structure, morphology, hydrophilicity, swelling property, surface roughness, and crosslinking conditions were thoroughly investigated. Notably, the PVDF/PEI/P(SS-MA) composite membrane exhibited outstanding desalination performance, demonstrating high salt rejection and flux of 308.7 ± 13.8 kg m −2 h −1 when subjected to a 3.5 wt% sodium chloride solution. Even at an elevated brine concentration of 20 wt%, the membrane maintained a commendable flux of 88.76 ± 5.4 kg m −2 h −1 at 72 °C. These findings underscore the efficacy of the developed composite membrane for brine desalination applications.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jian Zhang,Tianlin Li,Qingyan Yuan,Yunjia Wu,Yibo Dou,Jingbin Han
Transition-metal compounds (oxides, sulfides, hydroxides, etc.) as lithium-ion battery (LIB) anodes usually show extraordinary capacity larger than the theoretical value due to the transformation of LiOH into Li2O/LiH. However, there has rarely been a report relaying the transformation of LiOH into Li2O/LiH as the main reaction for LIBs, due to the strong alkalinity of LiOH leading to battery deterioration. In this work, layered silicate MgAl saponite (MA-SAP) is applied as a −OH donor to generate LiOH as the anode material of LIBs for the first time. The MA-SAP maintains a layered structure during the (dis)charging process and has zero-strain characteristic on the (001) crystal plane. In the discharging process, Mg, Al, and Si in the saponite sheets become electron-rich, while the active hydroxyl groups escape from the sheets and combine with lithium ions to form LiOH in the “caves” on sheets, and the LiOH continues to decompose into Li2O and LiH. Consequently, the MA-SAP delivers a maximum capacity of 536 mA h·g–1 at 200 mA·g–1 with a good high-current discharging ability of 155 mA h·g–1 after 1000 cycles under 1 A·g–1. Considering its extremely low cost and completely nontoxic characteristics, MA-SAP has great application prospects in energy storage. In addition, this work has an enlightening effect on the development of new anodes based on extraordinary mechanisms.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMBIOCHEM
·
2025
·
IF 2.8
Shiqi Luo,Wei Song,Guipeng Hu,Jian Wen,Xiaomin Li,Cong Gao,Jia Liu,Wanqing Wei,Liming Liu
Graphical Here, we have constructed a dual-enzyme ( Ec TnaA, Ma FMO) cascade pathway for the biosynthesis of indigo from L-tryptophan and enhanced the enzymatic activity of Ma FMO through mechanism-guided rational design. Subsequently, by optimizing promoters and increasing copy numbers to regulate the expression levels of Ec TnaA and Ma FMO D197E , under optimal conditions, E. coli IND-13 achieved the highest yield to date using glucose as the substrate. Indigo is widely used in dyes, medicines and semiconductors materials due to its excellent dyeing efficiency, antibacterial, antiviral, anticancer, anti-corrosion, and thermostability properties. Here, a biosynthetic pathway for indigo was designed, integrating two enzymes ( Ec TnaA, Ma FMO) into a higher L-tryptophan-producing the strain Escherichia coli TRP. However, the lower catalytic activity of Ma FMO was a bottleneck for increasing indigo titers. To overcome this limitation, the enzyme activity of Ma FMO was enhanced through mechanism-guided rational design. The optimal mutant obtained in this study, Ma FMO D197E , whose k cat / K m was 1.34 times that of the wild type, and its specific activity was 2.36 times that of the wild type. In addition, the expression levels of Ec TnaA and Ma FMO D197E were regulated by optimizing the promoters and increasing the copy number to generate the strain E. coli IND-13. Finally, in the optimal fermentation conditions (220 rpm, 0.05 % Tween-80), the strain E. coli IND-13 achieved the indigo titer of 568.52 mg/L in a 5-L bioreactor, with the yield and productivity of 2.62 mg/g and 12.96 mg/L/h (the highest to date), respectively. The results presented here can lay a foundation for further construction of cell factories for indigo and its derivatives with industrial application potential.
研究领域:
合成生物学
·
微生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Petroleum
·
2021
·
IF 0
Heng Wang,Junying Hu,Zhi Yang,Zebin Yin,Qi Xiong,Xiankang Zhong
A highly efficient and environment-friendly scale inhibitor (MA-VA-VS) was synthesized via free radical solution polymerization method, where maleic anhydride (MA), vinyl acetate (VA) and vinyl sulfonate (VS) acted as monomers, while ammonium persulfate was used as initiator. The inhibition performance and the structure as well as properties was characterized using static jar measurement and dynamic test, Fourier transform infrared spectroscopy and thermogravimetric analysis. The surface morphology and composition of scale formed in the solution were examined using scanning electron microscopy and X-ray diffraction, respectively. The binding energies of inhibitor with calcite (104) face were calculated using Materials Studio 2017 (MS) at 323 K. The results show that the inhibition efficiency gradually increases with increasing inhibitor concentration. While as the Ca 2+ concentration increases, the efficiency first increases and then decreases. With the increase in temperature or pH, the efficiency generally decreases. It is confirmed that the inhibition efficiency can reach 91.4% when 150 mg/L MA-VA-VS is used in a flow condition. Both the calculated binding energy and inhibition performance evaluation results demonstrate that the scale inhibition performance of MA-VA-VS is better than a commercial scale inhibitor (HPMA). The excellent inhibition performance of this inhibitor is due to its chelation and dispersion properties.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
ADVANCED MATERIALS
·
2026
·
IF 29.1
Jiyao Wei,Biao Li,Yu Tong,Weihua Ning,Yong Wang,Deren Yang,Xuegong Yu
Despite rapid efficiency gains in perovskite–silicon tandem solar cells (P/Si TSCs), state-of-the-art devices continue to rely heavily on methylammonium (MA)-containing wide-bandgap (WBG) perovskites, where MA facilitates crystallization but intrinsically accelerates thermal degradation and halide segregation. Achieving efficient, thick (>700 nm), MA-free WBG perovskites on textured silicon remains an unresolved challenge. Here, a coordination network coupled with π–π stacking work is designed to synchronize kinetics in MA-free FACs-based perovskite and promote conformal integration with textured silicon. A compact heterocyclic molecule simultaneously forms hydrogen-bonds with FA cations and coordinates with the Pb–I framework, while engaging in π–π stacking with underlying self-assembled monolayers. This multi-interaction synergy regulates nucleation and drives vertical crystal growth, yielding void-free buried interfaces and columnar grains spanning the full film thickness. The reconstructed interface exhibits reduced trap density and favorable energy-level alignment, enabling efficient hole extraction and suppressing electron back-transport and mixed-halide segregation. Consequently, the 1.68 eV MA-free perovskite device achieves an efficiency of 24.04%. Monolithic P/Si TSCs reach 33.04% efficiency, maintaining >90% initial performance after 1600 h of maximum power point tracking. This work establishes a generalizable strategy to decoupling crystallization control from MA incorporation, enabling durable and high-performance tandem photovoltaics.
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·
IF 3.5
Wenhao Dou,Bingzhu Wang,Daxin Li,Haobo Jiang,Xiaoliang Sun,Ling Li,Yingying Wang,Zhihua Yang,Dechang Jia,Yu Zhou
To enhance the ablation resistance of porous C sf /MA–SiBCN composites, the polymer infiltration and pyrolysis (PIP) process is adopted to obtain layered C sf /SiBCN composites containing MA–SiBCN and PDCs–SiBCN. After ablation for 10 s, the ablative layer fails to remain on the C sf /MA–SiBCN surface with mass ablation rate of 0.062 g/s and linear ablation rate of 0.208 mm/s, while the dense C sf /SiBCN surface is covered by a dense and stable ablative layer mainly consisting of amorphous SiO 2 glassy phase due to the synergistic ablation effect of MA–SiBCN and PDCs–SiBCN, which could resist the intense scour by ablation flame and prevent internal corrosion, and thus the ablation resistance improves with a 37% decrease in mass ablation rate (0.039 g/s) and an 18% decrease in linear ablation rate (0.171 mm/s), respectively.
研究领域:
材料科学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2019
·
IF 3.073
Tingting Guan,Qin Yan,Lizhi Wan,Songhong Zhang,Linhong Xu,Jianli Wang,Junxian Yun
For preparing cryogel beads by the micro-flow-focusing and cryo-polymerization method, liquid–liquid flow patterns and slug characteristics for the system of Dex-MA and ethyl acetate and the system of Dex-MA-HEMA and ethyl acetate in a cross-shaped square microchannel were studied. The aqueous solutions of Dex-MA-HEMA and Dex-MA were used as the dispersed phase and ethyl acetate as the continuous phase. The formation mechanism of the slug flow was illustrated by analyzing the interaction of the interfacial tension between the dispersed and continuous phases, inertial forces and viscous forces of the dispersed phase and the continuous phase. The flow pattern maps for the two systems were proposed and five regimes were identified, i.e., the slug flow, bubbly flow, jetting flow, unstable flow and stratified flow. The slug lengths and the droplet diameters were also measured experimentally and correlated. The results showed that the formation of the slug flow was related to the interaction of the forces of the continuous phase and dispersed phase. The inertial and viscous force of the continuous phase promoted while the viscous force of the dispersed phase resisted the formation of the slug flow. The interfacial tension and the inertial force of the aqueous phase were shifting their effects which either promoted or resisted the formation of the slug flow. The flow pattern maps have a good agreement with those proposed in the literatures. The velocity of the continuous phase was more influential on the length of the slug segment. The obtained correlation of slug length and the droplet diameter could be helpful to the preparation of the cryogel beads.
研究领域:
生物工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Shuang-Lin Hu,Ying-Ming Li,Wen-Juan Hu,Jose Hobson,De-Yi Wang
Unsaturated polyester resin (UPR) composites with excellent flame retardancy and high mechanical property is a great challenge to its widely application. In present work, a highly efficient flame retardant (MA-DOPO) containing nitrogen, sulfur and phosphorus elements was designed via a nucleophilic substitution reaction of amino and aldehyde groups. For the UPR/MA-DOPO 15 composites, its tensile strength was 28.3 MPa, which was 19.9 % higher than that of neat UPR attributing to the formation of hydrogen bonds with UPR. It should be noted that tensile strength of UPR/MA-DOPO 20 composites reached the highest 39.6 MPa, showing a growth trend with the enhancement of incorporation amount of MA-DOPO. Meanwhile, the UPR/MA-DOPO 15 composites passed the UL-94 V-0 rating with a LOI of 27.0%, and the peak heat release rate (PHRR) and total heat release rate (THR) were reduced by 35.1% and 41.6% in cone calorimeter (CC) test comparing to that of neat UPR respectively. Moreover, the detailed flame-retarding mechanism of MA-DOPO was investigated by the thermogravimetric infrared spectroscopy (TG-IR), Raman spectrum, X-ray photoelectron spectroscopy (XPS) and pyrolysis-gas chromatography/mass spectrometry (PY-GC/MS), in which the releasement of inert gas in gas-phase and the catalytic carbonation in condensed phase jointly taking effect.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 48
·2204733
·
IF 15.153
Yuwei Duan,Kun He,Lu Yang,Jie Xu,Wenjing Zhao,Zhike Liu
Suppressing defects at the interface between the TiO 2 electron transport layer (ETL) and perovskite film is critical for high efficiency and stable perovskite solar cells (PSCs). Herein, a siloxane derivative diethylphosphatoethylsilicic acid (PSiOH) is developed to modify the interface of TiO 2 ETL/FA 0.83 Cs 0.17 PbI 3 perovskite. Comprehensive characteristics reveal that silicon hydroxyl ( Si OH) in PSiOH can reduce surface defects, improve the electrical properties and optimize the energy band structure of TiO 2 by forming a Si O Ti bond, while the phosphate bond ( PO) in PSiOH can passivate Pb-related defects on the perovskite bottom surface. Consequently, PSiOH-modified PSCs yield a remarkable power conversation efficiency of 24.20% and improved air, thermal, or illumination stabilities. This study provides insight into passivation defects at the buried interface for efficient and stable PSCs.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2017
·Vol. 12
·期 10
·1095-1103
·
IF 4.083
He Li,Chunzhi Li,Jian Chen,Lina Liu,Qihua Yang
Graphical Pore it on : A bifunctionalized pyridine–zinc-based porous organic polymer, Py-Zn@MA, is synthesized and used for the co-catalyst-free cycloaddition of epoxides with CO 2 . The high activity of Py-Zn@MA is attributed to its bifunctional nature with ZnBr 2 and pyridine activating the epoxide in a cooperative way. The catalyst can be easily prepared on a large scale and shows good substrate universality for the cycloaddition of epoxides. The synthesis of solid catalysts for the co-catalyst-free cycloaddition of CO 2 has attracted much attention. Herein, we report a hierarchical porous organic polymer, Py-Zn@MA, that is able to catalyze the cycloaddition reaction of epoxides and CO 2 without using any additives or co-catalyst to afford turnover frequency (TOF) values as high as 250 and 97 h −1 at 130 °C by using pure and diluted CO 2 (simulating flue gas), respectively. These results are superior to those obtained from previously reported heterogeneous co-catalyst-free systems. The high activity of Py-Zn@MA is mainly attributed to its bifunctional nature with ZnBr 2 and pyridine activating the epoxide in a cooperative way. Notably, Py-Zn@MA can be easily prepared on a large scale without using any catalyst and the chemicals are cost effective. Moreover, Py-Zn@MA shows good substrate universality for the cycloaddition reactions of epoxides. Our designed porous organic polymer Py-Zn@MA material has the potential to serve as an efficient catalyst for the direct conversion of flue gas with epoxides into value-added cyclic carbonates.
研究领域:
催化化学
·
材料科学
·
环境化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）