TALANTA
·
2024
·
IF 5.6
Yameng Li,Peilin Wang,Huan Wang,Zhenrun Li,Zihui Liang,Qiang Ma
MiRNA-214 can regulate the expression of their downstream target genes after post-transcriptional and are involved in the biological processes of triple negative breast cancer (TNBC). In this work, the small-sized luminescent Nb 2 C nanosheet-based whispering gallery mode-enhanced electrochemiluminescence (ECL) strategy was successfully constructed to detect miRNA-214 in TNBC. Firstly, we have synthesized small-sized luminescent Nb 2 C nanosheets from Nb 2 AlC MXene. The Nb 2 C nanosheets not only exhibited more stable chemical properties and reduced the defects of the large sheet structures, but also possessed the quantum confinement effect with the discrete energy level. As a result, the prepared small-sized Nb 2 C nanosheets had unique luminescent and electrochemical properties. Furthermore, in order to improve the ECL performance of Nb 2 C nanosheets, SiO 2 microspheres were self-assembled on the electrode surface by gas-liquid interface method to form whispering gallery mode structure. Because the light was continuously reflected at the interface of the microcavity in the whispering gallery mode, the ECL signal of Nb 2 C luminescent nanosheets was amplified largely. Finally, the whispering gallery mode-based ECL sensing platform was established. The results showed that the biosensor had a good linear correlation between the ECL intensity and the logarithm of concentration of miRNA-214 in the range of 10 fM to 100 nM with a limit of detection of 2.5 fM. The actual detection of miRNA-214 content in clinical TNBC tissue samples was realized successfully.
研究领域:
材料科学
·
分析化学
·
生物医学工程
·
癌症生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Wei Yang,Zheng Yang,Jing Wang,Wei Lu,Weihua Wang
MXenes materials are novel promising candidates for the next generation energy storage devices. In this work, we designed a facile avenue using biomass derived carbons (PCarbons) and Nb 2 C MXenes as raw materials via sonication treatment to obtain Nb 2 C-PCarbons composites (Nb 2 C-PCarbons CPs). As a result, the prepared Nb 2 C-PCarbons CPs achieved a relative high specific capacitance up to 465.6 F·g −1 in the three-electrode system with 6 M KOH electrolyte. The fabricated symmetric supercapacitors (SSCs) displayed the ultra-high energy density (126.9 Wh·kg −1 ) in ion liquid electrolyte and the long cycling life after 10,000 cycles. Meanwhile, the obtained Nb 2 C-PCarbons CPs were also applied as cathode materials in the aqueous zinc ion batteries (AZIBs), achieving the maximum discharge specific capacity of ca. 239.7 mAh·g −1 with good cycling stability. Thus, our work provides an efficient method to modify the MXenes as bi-functional materials for the potential high-value utilization in SSCs and AZIBs.
研究领域:
材料科学
·
能源存储
·
纳米技术
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Guanghui Yang,Jinlai Zhao,Shaozhen Yi,Xuejuan Wan,Jiaoning Tang
Conventional fluorescent probes are either easily photobleached or non-biodegradable, which often leads to the unstable fluorescence signal output and long-term biological toxicity. Therefore, the development of novel fluorescent materials with both excellent photostability and biodegradability is of great significance for further broadening their application in numerous research fields. In this work, Nb 2 C quantum dots (Nb 2 C QDs) with pristine crystallographic structures of Nb 2 C MXene phases and surface oxygen-containing species are synthesized by an ultrasound assisted physicochemical exfoliation in tetrapropylammonium hydroxide. Detailed analyses indicate that the Nb 2 C QDs not only possess excellent chemical- and photo-stable fluorescence emission but also achieve successful application in fluorescence sensing of heavy metal ions and fluorescence imaging. More importantly, it is confirmed that the Nb 2 C QDs present high biocompatibility and unique biodegradation property responsive to human myeloperoxidase, implying the application safety of Nb 2 C QDs in vivo . Under the background of ever-growing and stringent requirements for biosafety and technical stability, the chemical- and photo-stability, biocompatibility, biodegradability, and most importantly the promising fluorescence sensing/imaging characteristic of the obtained Nb 2 C QDs may argue well for their future applications in environmental monitoring, biomedical diagnosis, visual display, and anti-counterfeiting.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
生物医学工程
·
环境科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wen Ma,Mingxia Liu,Mengling Tu,Gang Wang,Jun Li,Fen Liu,Jian Yang,Xianjiang Li
Five two-dimensional multi-layered MXenes namely MO 2 C, Ti 2 C, V 2 C, Nb 2 C and Ta 2 C were synthesized by a one-step exfoliation process and evaluated as laser desorption ionization mass spectrometry (LDI-MS) matrices for fast detection of small biomolecules for the first time. Among them, Nb 2 C exhibited the best performance due to its high carrier mobility, strong photo-induced charge transfer resonance and good UV absorption ability. A simple, universal and efficient LDI-MS platform was established for small biomolecule analysis based on the Nb 2 C matrix. Key factors that affect LDI-MS efficacy were investigated and the established method demonstrated ultraclean MS background, high sensitivity with detection limits low to fmol level and good reproducibility. The Nb 2 C-based LDI-MS platform was successfully applied in the rapid determination of 13 amino acids (AAs) in human serum and 3 AAs, as potential biomarkers, were found to be significantly down-regulated in major depressive disorder patients. This work proved the feasibility of Nb 2 C MXene as an LDI-MS matrix and provided a promising and universal platform for the rapid detection of small molecules in biomedical research.
研究领域:
分析化学
·
生物医学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Sustainable Energy & Fuels
·
2020
·Vol. 5
·期 4
·963-972
·
IF 5.503
Sen-Wang Wang,Zhen-Hong He,Jian-Gang Chen,Kuan Wang,Zhong-Yu Wang,Pan-Pan Guo,Jie Lan,Weitao Wang,Zhao-Tie Liu
Hydrogenolysis of biomass-derived lignin sources is highly important for the conversion of renewable biomass resources to biofuels. However, lots of developed catalysts suffer from the drawbacks of expensive precious metal catalysts and/or operation under harsh conditions. In the present work, Co–Ni bimetallic catalysts were prepared and applied in catalyzing hydrogenolysis of Caryl–O aromatic ethers with high activities under the promotion of Nb2C MXene additive. Especially, the hydrogenolysis of diphenyl ether (DPE), a 4–O–5 model compound, to cyclohexane (cy) and cyclohexyl alcohol (cy-ol) could be achieved over the Co2Ni1Ox–Nb2C MXene catalytic system at 120 °C and under 5 bar of H2, which are mild conditions in comparison with those for the developed heterogeneous precious-metal-free catalysts. The excellent catalytic performances stemmed from the strong interaction between Co and Ni species and the promotion of Lewis acidic sites offered by Nb2C MXene. The proposed reaction pathway involved the direct hydrogenolysis of DPE route, in which DPE was initially hydrogenolyzed to benzene and phenol. They were further hydrogenated to cy and cy-ol. The present work not only develops a noble-metal-free bimetallic catalyst for utilization of biomass-derived lignin sources, but also provides a novel strategy for using the Nb2C MXene material.
研究领域:
催化化学
·
能源材料科学
·
生物质转化
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Xiaolong Lu,Zhiwei Xu,Yi Shi,Qi Wang,Jialu Jia,Nan Sun,Bijun Fang,Ningyi Yuan,Jianning Ding
Structure engineering gives rise to tremendous opportunities for creating materials with marvelous morphologies and properties. Limited by the unique etching preparation method and vulnerable resistance to oxidation , structure engineering of MXenes, especially, mesoporous morphology construction, remains an obstacle. Here, we put forward a facile strategy to fabricate mesoporous MXene nanosheets by microexplosion process assisted uneven sheets exfoliation and quantum dots detaching, with left structure voids acting as mesopores. The universality of proposed strategy for different MXenes, including Ti 3 C 2 , Nb 2 C and Ti 2 C, was also testified. As a concept of proof, the distinct mesostructures provide abundant active sites and improve ion diffusion kinetics, thus boosting the energy storage performance of Ti 3 C 2 MXenes. This work not only sheds new light to the fabrication of mesoporous MXenes, but also demonstrates performance optimization through structure engineering.
研究领域:
材料科学
·
纳米技术
·
能源存储
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Nan Li,Yutong Ye,Tianyi Zhou,Chunyan Ma,Na Li,Yi Liu,Hongli Chen
Bovine serum albumin (BSA) was used as a model protein to investigate the mechanism of guanidine hydrochloride (GdnHCl) induced unfolding and the protective effect of Nb 2 C nanosheets. Spectroscopic and structural analyses showed that GdnHCl induced concentration-dependent unfolding of BSA through a native to intermediate to unfolded transition, accompanied by fluorescence quenching, emission red shift, secondary structure rearrangement, and decreased thermal stability. Mechanistic studies indicated that this process was closely associated with disruption of the water hydrogen-bond network rather than simple direct denaturant protein binding. Raman analysis showed that GdnHCl decreased strong hydrogen bonds while increasing weak hydrogen bonds, and the resulting water-structure reorganization was highly correlated with the unfolding degree of BSA, with a Pearson correlation coefficient of 0.978. Nb 2 C nanosheets effectively suppressed GdnHCl-induced unfolding, increasing the unfolding midpoint concentration from 3.66 to 4.71 mol/L in the presence of 50 μg/mL Nb 2 C. Nb 2 C also alleviated the loss of ordered secondary structure and improved the thermal stability of unfolded BSA, increasing the melting temperature from 43.9 to 61.0 °C. Fluorescence quenching and isothermal titration calorimetry demonstrated that Nb 2 C interacted spontaneously with BSA mainly through hydrogen-bond-dominated interfacial interactions. This work provides a solvent centered perspective on chemical denaturation and identifies Nb 2 C as a promising nanochaperone for protein conformational protection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yifan Yan,Fuchao Yang,Yanru Zheng,Yuting Du,Zhiguang Guo
Icing causes severe economic losses and safety hazards, and existing anti/de-icing materials suffer various limitations. Nb 2 C remains relatively unexplored in this field, and this is the first report using Nb 2 C MXene for photothermal anti/de-icing applications. Inspired by dragonfly wing veins, a micro-nano grid structure was laser-engraver on an Al substrate, followed by simple spraying to fabricate a Nb 2 C/MWCNTs composite coating (PCNA). The bio-inspired microstructure delivers excellent hydrophobicity (CA: 152°, SA: 3.2°) to reduce ice nucleation and adhesion, while enabling efficient light trapping for solar energy utilization. Under 1-sun illumination, PCNA rapidly heated to 76.4 °C and melted a 0.5 cm 3 ice in 90 s; at −15 °C, it delays 15 μL water droplet freezing to 1411 s with ice adhesion strength of 7.97 ± 0.54 kPa. The coating also exhibits good anti-fouling and mechanical durability.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Di Shang,Xinru Wang,Haiyu Lei,Jiamin Wei,Hualin Lin,Sheng Han
Generalizable anode via interfacial kinetics: MXene scaffold + conversion chalcogenide + surfactant-guided control. • Nb 2 C: 2D percolation network and stress buffer; FeS 2 : high capacity; CTAB: nanospheronization, uniform anchoring, C–S–C linkages. • In situ hydrothermal + electrostatic guidance: Nb 2 C@FeS 2 @CTAB heterostructure with expanded interlayers and uniform current. Nb 2 C@FeS 2 @CTAB heterostructured composite anode was fabricated via a dual-phase modification strategy to enhance the electrochemical performance of lithium-ion batteries. The constructed heterointerface markedly shortens Li + migration pathways within the active phase and reduces the energetic barriers (0.36 eV) for ion migration and diffusion, thereby improving high-rate capability and energy storage performance. Experiments demonstrate that the Nb 2 C@FeS 2 @CTAB composite delivers excellent rate characteristics and high capacity, achieving a discharge specific capacity of 1296 mAh g −1 and stable operation for 100 cycles. Moreover, at a high current density of 5 A g −1 , it maintains a discharge specific capacity of 219 mAh g −1 with robust cycling stability over 2000 cycles. These findings offer a new design paradigm for FeS 2 -based anodes and underscore the potential of Nb 2 C@FeS 2 @CTAB heterostructures for high-performance battery applications.
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Kang Li,Jiaoqun Zhu,Weibing Zhou,Lilong Sun,Shouqin Tian
To improve the photocatalytic performance of single-phase Bi 2 WO 6 , the heterojunction construction is usually employed to effectively separate and transport photo-induced carriers. Herein, MXene/Bi 2 WO 6 heterojunction (NB2 and VB2) with face-to-face contact and hierarchical structure was constructed by growing ultrafine Bi 2 WO 6 nanosheets on the surface of two-dimensional MXene (Nb 2 C and V 2 C) materials. Compared with the original Bi 2 WO 6 , the hybrids exhibited a larger specific surface area (42.17 m 2 ∙g −1 for NB2, 50.15 m 2 ∙g −1 for VB2), and displayed significant enhancements in the photodegradation of anionic MO (13.8-fold, 6.5-fold), cationic RhB (9.1-fold, 4.5-fold), and neutral phenol (8.5-fold, 6.1-fold), respectively. This is mainly attributed to the heterostructures via face-to-face coupling which can facilitate the tuning of the photoresponsive properties and internal energy level structure, as well as the generation of free radicals ( • O 2 - , • OH, and h + ) for the stepwise redox process in photodegradation. Therefore, this work is expected to expand the diverse use of Non-Ti 3 C 2 MXene in photocatalysis, meanwhile provide important guidance for the harmless treatment of organic pollutants.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Kunxian Chen,Qian Zhou,Yujie Fu,Hao Wang,Xiaolian Wang
Pristine Nb 2 C/Ti 3 C 2 dual MXenes enable composition-controlled MgH 2 catalysis. • A 1:2 Nb 2 C/Ti 3 C 2 ratio is optimal at only 5 wt% total catalyst loading. • 6.81 wt% H 2 is released within 3 min at 300 °C. • 4.56 wt% H 2 is absorbed within 20 s at 50 °C under 55 bar H 2 . • 91%/90% capacity is retained after 30 hydrogenation/dehydrogenation cycles. MXene catalysts can improve MgH 2 kinetics, but composition effects in dual pristine MXenes at fixed loading remain unclear. Here, Nb 2 C/Ti 3 C 2 was optimized by Nb 2 C etching time, single-MXene loading, mass ratio, and total loading. Nb 2 C etched for 70 h showed low residual Al, intact layers, and the highest surface area. At 5 wt% total catalyst, Nb 2 C:Ti 3 C 2 = 1:2 gave the best overall performance. It released 6.81 wt% H 2 in 3 min at 300 °C and 6.02 wt% in 10 min at 250 °C, and absorbed 4.56 wt% H 2 in 20 s at 50 °C under 55 bar H 2 . The apparent dehydrogenation activation energy was 71.25 ± 8.73 kJ·mol −1 , 53.7% below the MgH 2 reference. After 30 cycles, hydrogenation/dehydrogenation capacity retentions were 91%/90%. XRD and SEM confirmed reversible MgH 2 /Mg conversion and cycling-related morphology changes. XPS survey of the optimized dual-MXene composite confirmed the coexistence of Ti- and Nb-containing species, while reaction-state XPS of the individual Ti 3 C 2 - and Nb 2 C-containing composites showed reaction-dependent surface reconstruction. Together, these results support composition-dependent catalytic contributions, whereas simultaneous Ti-Nb reconstruction in the optimal dual system remains unverified.
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Kunyan Nie,Jianbo Li,Heng Lu,RuiLin Zhang,Yu’an Chen,Fusheng Pan
Magnesium hydride (MgH 2 ) is a solid-state hydrogen storage material with promising applications. However, its slow hydrogen release rate at low temperatures (<573 K) and high hydrogen release energy barrier severely limit its practical applications. In this work, a bimetallic oxide (cubic NaNbO 3 ) with side length of 1–10 μm was derived from Nb 2 CT x MXene through a simple hydrothermal reaction, which has a high catalytic activity. The MgH 2 -5 wt% NaNbO 3 composite can rapidly release 6.18 wt% H 2 in 12 min at 260 °C and uptake 3.45 wt% H 2 in 90 min at 30 °C. The activation energy for dehydrogenation (E a ) of MgH 2 -5 wt% NaNbO 3 composite was calculated to be 84.72 kJ/mol, which is much lower than that of milled MgH 2 (150.98 kJ/mol). In addition, hydrogenation and dehydrogenation cycling test results indicated that the composite material presents excellent stable cycling durability, with a capacity retention rate of 99.7 % after 40 cycles, with almost no capacity degradation. The excellent hydrogenation and dehydrogenation ability is mainly contributed by the combined effect of NaMgH 3 , NaNbO 3 , Nb metal and NbH x . The results of this work are instructive for the design of high-properties catalysts to enhance the hydrogen storage capacity of Mg/MgH 2 system.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）