LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Siyao Zhong,Haizhi Huang,Xiaoyao Wang,Xiaoping Yu,Xuping Shentu
The residues of furazolidone and its metabolites (3-amino-2-oxazolidinone [AOZ]) in food would have adverse effects on humans. Herein, a colorimetric and fluorescent dual-signal output immunochromatographic method with a zirconium-based porphyrin metal-organic framework (PCN-222) as the signal label was developed for the detection of 3-[(4-carboxyphenyl) monomethyl] amino-2-oxazolidinone (CPAOZ), a derivative of furazolidone metabolite. PCN-222 was synthesized using the solvothermal method, and the material was characterized via scanning electron microscopy, Fourier-transform-infrared spectroscopy, and powder X-ray diffraction, which proved the successful synthesis of PCN-222. Synthesized PCN-222, as a nanotag, was bound to antibodies to prepare PCN-222-mAbs with dual optical properties. Under the optimized conditions, PCN-222- lateral flow assay (LFA) exhibited a great linear relationship in the range of 0.25–100 ng/mL. The visual limit detection of CPAOZ using colorimetric and fluorescent signals were 1.0 ng/mL and 0.5 ng/mL, respectively, and the sensitivity was 5- and 10-fold higher than that of the colloidal gold-based LFA method. In addition, PCN-222-LFA was successfully applied to the detection of CPAOZ in shrimp, chicken and milk samples achieving satisfactory recoveries from 92.34% to 117.44%. This study provides an alternative, convenient and sensitive method for the rapid detection of veterinary drug residues.
研究领域:
食品安全检测
·
分析化学
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2022
·
IF 7.926
Jinjuan Xue,Meng Yuan,Jiamin Gao,Zewu Zhang,Mingxin Wang,Shuaishuai Ma
In this work, a novel PCN-222 metal−organic framework based multitasking membrane was developed for separation of emulsified oils as well as photo-Fenton degradation of refractory aromatic pollutants and inactivation of pathogenic bacteria in water. Fe(III)@PCN-222 nanorods were prepared via impregnation method and subjected to amino-modification, and then robustly anchored on polydopamine (PDA) decorated PVDF membrane via catechol-amine reaction. The as-prepared N-Fe(III)@PCN-222/PDA/PVDF composite membrane exhibited underwater superoleophobicity, and showed high separation efficiency (above 99.4 %) as well as relatively favorable permeation flux (874.9–1592.3 Lm −2 h −1 ) in the separation of emulsified oils ranged from nanoscale to microscale from water. Meanwhile, the membrane serving as a recyclable photo-Fenton platform showed an extensive degradation capacity towards aromatic contaminants and high inactivation activity against bacteria under visible light. The grafted Fe(III) is used as an electron acceptor to promote the separation of photo-generated charge carriers, adjusted the band structure to shorten the bandgap value, and can be reduced to Fe(II) by photo-generated electrons as a Fenton-like catalyst. The photo-Fenton mechanism was studied in detail from the aspects of photoelectric properties, band structure and reactive oxygen species . This work could promote the application of PCN subclass MOFs based superwetting membrane as a recyclable platform for complex wastewater treatment .
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Siqi Chen,Tingting Li,Donglian Deng,Yibing Ji,Ruijun Li
This work innovatively integrated the peroxidase-mimicking activity and red emission property of Fe@PCN-222 framework, designed a cascade reaction system for dual-mode glucose sensing. The Fe 3+ doping significantly improved the catalytic activity of Fe@PCN-222 that can oxidize the substrate o -phenylenediamine (OPD) to generate diminophenazine (DAP) with emission at 566 nm in the presence of H 2 O 2 . Similarly, the Fe@PCN-222 was used to catalyze the colorless TMB to produce blue oxidized TMB (oxTMB) showed absorption at 652 nm. When coupled with glucose oxidase (GOx), the linear ranges of ratiometric fluorescence mode and colorimetric mode for glucose sensing were 1–100 and 10–300 μM, respectively. And the limits of detection (LOD) of 0.78 and 2.41 μM for two modes were obtained, respectively. In addition, the practicability of Fe@PCN-222 nanozyme-based cascade reaction system for detection of glucose in human serum and saliva samples was successfully investigated. It is of great importance to integrate more functions into one skeleton to achieve dual-mode and optimal-performance sensing for expanding potential applications.
研究领域:
生物化学
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医学诊断
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2025
·
IF 10.5
Haizhi Huang,Hefei Wang,Keyu Du,Xiaoping Yu,Xuping Shentu
Lateral flow immunoassay (LFIA) is an affordable and rapid technique for detecting veterinary drugs such as sulfonamides (SAs). However, balancing accuracy, sensitivity, and convenience remains a challenge. To address this, a microfluidic chip-based LFIA utilizing a zirconium-based organic framework, PCN-222@liposome, was developed to simultaneously detect four Sas: sulfamethizole, sulfamethoxazole, sulfamethoxydiazine, and sulfathiazole, with both colorimetric and fluorescent dual-signal detection. In this study, PCN-222 was modified with liposomes to enhance its biocompatibility and water solubility. Characterization through scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, and Fourier-transform infrared spectroscopy, confirmed the successful incorporation of liposomes with PCN-222. Under optimized conditions, the PCN-222@liposome-LFIA demonstrated high sensitivity, with detection limits ranging from 0.01 to 0.05 μg/L using fluorescent signals—10 times more sensitive than conventional gold nanoparticle-based LFIA. Finally, the PCN-222@liposome-LFIA integrated with the microfluidic chip successfully detected the four SAs in chicken, shrimp, and milk samples, with recoveries ranging from 89.65 % to 118.78 %. This study presents a simple, sensitive, and efficient method for the rapid detection of veterinary drug residues.
研究领域:
分析化学
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兽医学
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纳米技术
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食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Peide An,Defeng Hu,Yide Han,Hao Meng,Xia Zhang
On accounting of the structure advantages of MOFs in the enzyme mimics and enzyme immobilization, in this work, the Hemin@PCN-222 (Mn) is constructed through an in-situ hydrothermal route by covalently bonded the –COOH of Hemin with the Zr(IV) of PCN-222 (Mn). With the help of the synergistic effects, the resulting Hemin@PCN-222 (Mn) represents excellent peroxidase-like activities in comparison with the single Hemin and PCN-222 (Mn) with a special enzyme activity of 6.71 U mg −1 . The Hemin@PCN-222 (Mn) was then employed as a carrier to immobilize the glucose oxidase (GOx), the immobilization conditions were optimized. Based on that, the optimized GOx@hemin@PCN-222 (Mn) was applied in the following cascade reaction: the glucose oxidation in the presence of oxygen catalyzed by the immobilized GOx firstly, and then the produced H 2 O 2 worked as an oxidant to oxidize ABTS. The quantity of produced ABTS + was monitored to assess the catalytic efficiency, and the contrast experiments were conducted over the mixture of the natural GOx and HRP. The above cascade process could also be used to detect the glucose, and the detection limit is determined. The high efficiency and the stability of the resulting GOx@hemin@PCN-222 (Mn) highlights the prospect applications of the MOFs-based enzyme mimics in the bio-catalysis and biosensing.
研究领域:
生物化学
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催化
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生物传感器
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Desen Zhou,Xuan Zhang,Zheng Li,Jun Zhang,Tielin Wang,Shaowen Cao
Photocatalytic conversion of CO 2 to usable fuels provides a new strategy for solving energy problems and the greenhouse effect. Porphyrin-based metal-organic frameworks (MOFs) are promising in photocatalysis due to their remarkable light harvesting ability, and the metal active site and its coordination environment can be further adjusted to achieve the high activity. In this work, g-C 3 N 4 /PCN-222 composites with different porphyrin metal centers were fabricated and the g-C 3 N 4 /PCN-222(Fe III ) catalyst showed the highest photocatalytic CO 2 reduction performance than that of g-C 3 N 4 /PCN-222(Fe II ) and other g-C 3 N 4 /PCN-222( M , M = Co, Ni, Cu, Zn) composites. Experimental studies and theoretical calculations showed that the axial coordination in g-C 3 N 4 /PCN-222(Fe III ) distorts the square planar field (Fe-N4) to quasi-octahedral coordination, which led to the moderate adsorption ability of CO 2 reduction intermediate (*CO), resulting in the high photocatalytic activity.
研究领域:
材料科学
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环境科学
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化学工程
·
催化
✓ 已验证
产品关联
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Haoxiang Zhu,Ying He,Yaqi Liu,Jianhua Guo,Jingxuan Zhu,Yunzhe Li,Kun Qian
BACKGROUND Pyrethroids are widely used insecticides due to their efficacy and safety for humans, yet their toxicity to beneficial insects like bees remains a critical environmental concern. Developing controlled-release formulations to mitigate non-target toxicity and enhance pesticide efficiency is imperative for sustainable agriculture. RESULTS In this experiment, two types of PCN-222 materials, with small and large particle sizes, were synthesized using a solvothermal method. Bifenthrin (Bif) was loaded onto PCN-222 to prepare the controlled-release agent Bif@PCN-222. The structure and properties of the prepared materials were characterized by morphology observation, infrared spectroscopy, thermogravimetric analysis, and contact angle measurements. The experimental findings indicated that Bif@PCN-222 demonstrated excellent release performance under alkaline conditions and exhibited better wettability on cabbage leaves compared to commercial formulations. Additionally, the Bif@PCN-222 controlled-release agent significantly improved resistance to UV photodegradation. Safety evaluations showed that Bif@PCN-222 had minimal impact on the growth of Zoysia grass and notably reduced toxicity to bees. CONCLUSION These results show that we have successfully prepared Bif@PCN-222, which can enhance the pest control effect, reduce the toxicity to non - target organisms, and have a relatively small impact on plant growth and the number of soil microflora. © 2025 Society of Chemical Industry.
研究领域:
环境科学
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农业化学
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纳米技术
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农药制剂
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生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Hong Li,Yiming Wang,Rongxiu Guo,Jianwei Zheng,Zejun Sun,Xinyue Zhang,Ying Guo,Hongna Jia,Qionglin Liang,Hong-bin Sun
The heterogeneously tandem catalytic synthesis is a step-economic and work-up-saving strategy for producing chemicals, but it usually requires a special catalyst to achieve the sequential catalytic reactions . The development of metal organic frameworks provides an opportunity to fabricate multifunctional catalysts. In this work, a MOF-based sandwich-nanostructure catalyst UiO-66-NH 2 @Pt@PCN-222 is fabricated, which is made of the UiO-66-NH 2 as the core, Pt nanoparticles as the interlayer, and the defective PCN-222 as the shell. The developed catalyst shows outstanding performance for the tandem catalytic synthesis, which is the hydrogenation of nitroarenes cascaded with β-dicarbonyl compounds to form β-ketoenamines. The selectivity of β-ketoenamines reached 98% upon the completed hydrogenation of p-nitrotoluene. The stable PCN-222 shell can be regarded as an active armor, which not only protects the Pt particles from leaching or agglomerating, but also has plenty of acid sites that are conducive to the second-step condensation. At the same time, the kinetic studies show that the armor layer also affects the activity of hydrogenation, so that the hydrogenation and condensation reactions can proceed simultaneously to give the best selectivity. Various substituted dicarbonyl compounds and structurally different nitroarenes completed the conversion with excellent conversion (90–99%) and selectivity (87–98%), and this nanocatalyst can be recycled for up to six cycles without the expense of activity.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2020
·
IF 0
Enqing Liu,Jiangping Zhu,Weijun Yang,Fan Liu,Can Huang,Shuangfeng Yin
In this work, a functionalized metal–organic layer (MTTB MOL) was first synthesized and characterized, where MTTB means that it was synthesized from TTB (4,4′,4″-s-triazine-2,4,6-triyl-tribenzoate). On this basis, a hybrid metal–organic framework of PCN-222(Co)@MTTB was further synthesized by combining two-dimensional (2D) MTTB MOLs and three-dimensional (3D) PCN-222(Co) MOFs (metal–organic frameworks) via a one-step method. When applied to the cycloaddition reaction of carbon dioxide (CO2) and epoxides, PCN-222(Co)@MTTB was found to exhibit excellent synergistic catalytic performance under mild conditions. The unique catalytic activity of the composite is due to the combination of the exposed acidic sites (Co2+, Zr4+) and basic sites (−N– groups) within the matrix of the MOF structure, thereby providing a new method for the exploration of effective catalysts for the conversion of CO2 to value-added chemicals under mild conditions.
研究领域:
材料科学
·
催化
·
化学工程
·
环境化学
✓ 已验证
产品关联
DOI
FOOD CONTROL
·
2022
·
IF 6.652
Chengyuan Wu,Xiangchuan Wu,Fan Hou,Lina Wu,Guangxia Liu
An ultrasensitive electrochemical aptasensor was established based on metalloporphyrin metal organic frameworks ( [email protected] ) with peroxidase-like activity and exonuclease III-assisted recycling magnification for the detection of ochratoxin A (OTA). [email protected] showed well peroxidase-like activities due to Fe-tetrakis (4-carboxyphenyl) porphyrin (Fe-TCPP) as a heme-like ligand and in situ supported with palladium nanoparticle, which could be used for the label of ssDNA instead of nature enzyme. The designed exonuclease III-assisted recycling magnification further improve the sensitivity for the detection. Based on this, the proposed aptasensor showed a well linear relationship within the scope of 1 × 10 −5 ng mL −1 to 10 ng mL −1 and a low detection limit of 6.79 fg mL −1 . Additionally, the application in the real spiked oil samples confirmed the dependability and veracity of the aptasensor. Hence, the designed aptasensor has comprehensive application prospects for the detection of OTA in food .
研究领域:
食品安全
·
分析化学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 1
·526-537
·
IF 4.682
Xu Lin-Wei,Qian She-Liang,Dong Bao-Xia,Feng Li-Gang,Li Zong-Wei
Molecular complexes with active metal centers exhibit high activity and selectivity for electrochemical CO 2 reduction reaction (CO 2 RR), which represents a promising method for transforming greenhouse gas into valuable chemicals and feedstock. Using metal–organic frameworks (MOFs) to load the active molecular complexes then employing the combination with the carbonic conducting material may exhibit a beneficial effect for CO 2 RR. Herein, we obtained a composite catalyst named PCN-222(Fe)/CNTs, which was in situ synthesized through the solvothermal method that loads iron porphyrin-centered PCN-222(Fe) molecules onto CNTs. The catalyst PCN-222(Fe)/CNTs exhibits excellent electrocatalytic performance for CO 2 RR with a FE CO of 95.5% (m(Fe-TCPP):m(CNTs) = 1:30, written as PCN-222(Fe)/CNTs-30) and an overpotential ( η ) of 494 mV. In addition, the turnover frequency (TOF) is high as 448.76 h −1 (3.011 site −1 s −1 ) and the hydrogen evolution reaction (HER) is indistinctive. After long-term electrocatalysis of 10 h at −0.6 V vs. RHE, PCN-222(Fe)/CNTs-30 remained its high catalytic performance with average FE CO = 90%. This work provides a solid foundation for further research in the high-efficiency transformation of CO 2 to CO. Graphical abstract
研究领域:
电化学
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材料科学
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催化
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CATALYSIS
·
2021
·
IF 7.92
L.J. Zhang,J.C. Yuan,L.J. Ma,Z.Y. Tang,X.M. Zhang
Zirconium-based porphyrinic MOFs (PMOFs, MOF = metal-organic framework) have gained considerable attention in the field of electric/thermo/photo-catalysis as heterogeneous single-site catalysts; however, the study on multisite synergistic catalysis of PMOFs are rare. Herein, we have successfully developed a highly regio- and stereo-selective synthetic method of ( E )- β -vinylboronates through hydroboration of alkynes using PCN-222 (Cu, PCN = porous coordination network) as multifunctional heterogeneous catalyst. Compared with homogeneous catalytic system, high TOF value is achieved in the developed method, originating from the synergistic effect of central Cu(II) ions, N atoms of porphyrin rings and terminal –OH groups on Zr-nodes. Notably, density functional theory (DFT) study reveals that five-membered “Cu-N-B-C-C” ring is the key species responsible for the hydroboration process with specific selectivity.
研究领域:
化学
·
材料科学
·
催化反应
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）