INORGANICA CHIMICA ACTA
·
2021
·
IF 2.545
Ping-Ping Sun,Yi-Ming Li,Yu-Hang Zhang,Hongwei Shi,Fa-Nian Shi
Herein, we designed and prepared a one-dimensional (1-D) cobalt-based metal organic coordination polymer (2,4-pdc-Co) by hydrothermal method. 2,4-pdc-Co has the molecular formula of Co 4 (H 2 O) 10 (2,4-pdc) 4 and possesses orthorhombic symmetry Pna 2 1 space group. In the same synthesis method, we added urea as a template. On the premise of maintaining this 1-D microstructure, we modified the block-shape 2,4-pdc-Co into a 1-D wire (2,4-pdc-Co-W). As an electrode material for supercapacitors, compared with 2,4-pdc-Co, the modified 2,4-pdc-Co-W shows better electrochemical performance. The specific capacitance of the optimized electrode material can reach 325 F g -1 at 1 A g −1 . 2,4-pdc-Co-W is also assembled with activated carbon to form a battery-type hybrid supercapacitor. As the positive material for the device, an assembled hybridcapacitor delivers an energy density of 17.7 Wh kg −1 at power density of 400 W kg −1 .
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
·
2025
·
IF 4.9
Zhenni Liu,Ruoyun Tang,Qiurong Qi,Siting Lin,Ping Liu,Gaofeng Cai,Zhanhong Zheng,Xiaoquan Guo,Xiaona Gao
Naringenin, a flavonoid extract, possesses anti-inflammatory, antioxidant, hepatoprotective, antitumor, and antineurotoxic properties. This study investigated the anti-heat stress effects in broilers by adding 200mg/kg naringenin to the diet of Ningdu yellow chicken under heat stress conditions. Heat stress conditions was controlled at 37 ± 2°C (7:00 a.m. to 7:00 p.m.) and 24 ± 2°C (7:00 p.m. to 7:00 a.m.) at humidity maintained at 60-65%. The results suggest that naringenin elevated the body weight and the ratio of liver mass to weight of Ningdu yellow chicken significantly. Additionally, naringenin significantly reduces heat stress level, improves liver function and antioxidant capacity. Meanwhile, the levels of necroptosis indexes (CYLD, RIPK1, RIPK3 and MLKL) and oxidative stress indexes (PDC, PYGL, GLUL and GLUD1) are downregulated by naringenin. Naringenin mitigated liver damage by decreasing inflammatory indexes caused by heat stress, including NF-κB, IL-1β, IL-18 and HMGB1. This anti-inflammatory effect arose through the downlink binding of the necroptosis index (RIPK3) and the oxidative stress index (PDC) as shown in results of fluorescence co-localization and co-immunoprecipitation. The use of naringenin in poultry may be a possible feed additive to address clinical heat stress.
研究领域:
动物科学
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分子生物学
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营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2017
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IF 3.151
Xingwen Huang,Bangren Fang,Zehang Xu,Zhaoyu Cao,Rong Zeng,Mei Tu,Jianhao Zhao
Cationic polymers possess significant potential in various biomedical applications due to their favorable interactions with biocomponents in aqueous media, which is related to their inherent structure and associated water structure. This work presents the development of a novel biodegradable cationic polymer with specific associated water structure and unique interactions with biocomponents. Bioinspired branched dicationically-charged phosphodicholine-chitosan (PdCCs) with different substitute degree were synthesized via Atherton-Todd reaction. As compared with monocationically charged N -(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC), thermal analysis confirmed the existence of the freezing bound water surrounding PdCCs due to the introduction of branched dicationically-charged PdC moiety. Fluorescence spectra revealed that PdCCs induced much less conformational change of bovine serum albumin than HTCC. Antibacterial and hemolysis assay showed that PdCCs and HTCC displayed high antibacterial activities against Escherichia coli and Staphylococcus aureus with different bacterial-type selectivity, and PdCCs showed higher selectivity to kill bacteria over red blood cell than HTCC. Furthermore, PdCCs-immobilized antibacterial surfaces exhibited better hydrophilicity and less protein adsorption than HTCC-immobilized antibacterial surfaces. These results indicated that branched dicationic PdC with capacity to restrain the freezing bound water may provide a good choice for developing cationic polymers for therapeutic applications.
研究领域:
生物材料学
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药剂学
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分子生物学
✓ 已验证
产品关联
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Yueyue Zhang,Hua Zhao,Yifei Gong,Haiyang Shen,Wei Chen,Xianbiao Wei,Congliang Cheng,Ping Li
Anion exchange membranes were prepared by a simple method on the basis of polyvinyl alcohol (PVA) and 1,4-Piperazinedicarboxaldehyde (PDC). A network structure was formed in the membranes by cross-linking between PVA and PDC. The mechanical stability and acid stability the prepared membranes was tested. The TS value was tested as 17.5–37.8 MPa, E b was 120.4–54.7% and the mass retention in the acid environment was 98.4–97.2%. Meanwhile, the physicochemical properties of membranes, such as thermogravimetric analysis (TGA), water absorption (W R ), ion exchange capacity (IEC) and linear expansion rate (LER). W R was 106.9–136.7%, IEC was 1.03–1.55 mmol/g, and LER was 37.93–33.33%. In practical application, diffusion dialysis (DD) performance of membranes were tested. In DD test, the acid dialysis coefficient (U H + ) was 17.5–27.9 × 10 −3 m/h, and the separation factor (S) was 31.25–23.38. The U H + and S were all higher than commercial membrane DF-120 (U H + is 9 × 10 −3 m/h and S is 18.00). Results were shown that the comprehensive properties of membranes were good. Therefore, the prepared membranes had broad application prospects for acid recovery by diffusion dialysis.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2020
·
IF 5.573
Xin Deng,Ruiyao Mai,Chenyu Zhang,Dianbao Yu,Yichang Ren,Gang Li,Binbin Cheng,Ling Li,Zhiqiang Yu,Jianjun Chen
To ameliorate the deficiencies (e.g. solubility, membrane permeability and non-selective cytotoxicity) of paclitaxel (PTX), we synthesized a “smart” PDC (peptide-drug conjugate), by linking PTX with a multifunctional peptide consisting of a tumor targeting peptide (TTP) and a cell penetrating peptide (CPP), to construct the TTP-CPP-PTX conjugate , LTP-1. LTP-1 could intelligently deliver PTX into LHRH receptor-overexpressed MCF-7 cells, showing 2 times higher cellular uptake than PTX, and enhanced cytotoxicity with IC 50 of 3.8 nM (vs 6.6 nM for PTX). LTP-1 exhibited less cytotoxicity to normal cells and the ability to overcome PTX-resistance. Furthermore, LTP-1 had higher in vivo antitumor efficacy than PTX (TGI of 83.4% and 65.7% for LTP-1 and PTX, respectively, at 12 mmol/kg) without apparent toxicities. In summary, we proposed and testified the concept of constructing a novel PDC molecule, which can potentially conquer the drawbacks of PTX. LTP-1 represents a new class of antitumor PDC deserving further investigation.
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Tiping Wei,Liguo Wang,Jiajun Zhang,Yan Cao,Xiang Hui,Jianhui Shi,Shuang Xu,Liyan Zhao,Peng He,Huiquan Li
Bio-based pentamethylene dicarbamate (PDC) belongs to N-substituted carbamates, which are important fine chemicals and organic intermediates. In this work, well-defined CeO2 rods, cubes, and octahedrons were successfully prepared to catalyze the synthesis of PDC by carbonylation of 1,5-pentanediamine (PDA) with methyl carbamate (MC). Among them, CeO2 rods with higher amounts of acid–base sites and abundant oxygen vacancies showed superior intrinsic activity in the PDA carbonylation reaction. In situ FTIR results showed that intermediate polyureas were readily formed in the reaction, and then, CeO2 rods promoted the alcoholysis of polyureas to PDC. In situ DRIFTS results indicated that the surface of CeO2 rods is more favorable for the adsorption and activation of the reactants. CeO2 rods can also be used for the efficient synthesis of a series of N-substituted carbamates. We believe that this work will contribute to the efficient, green, and sustainable production of N-substituted carbamates.
研究领域:
催化
·
化学工程
·
绿色化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2024
·
IF 3.7
Zhaorui Qi,Xurui Li,Yueming Zhu,Li Li,Yu Liu
Metal–organic framework (MOF) is a porous material composed of metal ions/clusters and organic ligands. It has attracted much attention due to its high specific surface area, good biocompatibility, chemical modifiability, and diversity of components. Among many MOFs, zirconium-based MOFs are particularly suitable for biological applications due to their optimal stability and low toxicity to hydrolysis. However, due to the weak coordination bonds between many metal clusters and organic ligands, most MOFs are prone to collapse in acidic environments, and the stability of MOFs as drug carriers cannot be guaranteed so that they cannot be widely used as oral drug carriers. This study synthesized the three MOFs using metal Zr ion clusters as the center and different nitrogen-containing organic ligands, which are stable in gastric acid, namely, UiO-66-PDC, UiO-66-NH 2 , and UiO-66-NO 2 . The anionic drug loxoprofen (LOX) was loaded and characterized using scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, and x-ray diffraction. The adsorption and release behaviors of LOX and the three MOFs were studied from the molecular point of view by computer simulation. A series of behaviors and mechanisms of pH-responsive nitrogen-containing MOFs as oral drug carriers were further explored through rat pharmacokinetic experiments, the everted gut sac experiments, and intestinal absorption mechanism experiments. The experimental results show that there is a strong electrostatic interaction between anionic drug LOX and UiO-66-PDC under simulated gastric acid environment, which prolongs the half-life of the drug, proving that LOX@UiO-66-PDC is a promising new oral drug delivery system.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Yongzhao Hou,Bo Xiao,Zhiyuan Sun,Wen Yang,Songsong Wu,Shuai Qi,Guangwu Wen,Xiaoxiao Huang
With the rapid development of high power electromagnetic (EM) equipment and high-speed aircraft, the powerful and high oxidation-resistance absorbers are fundamentally desirable for the EM field. Herein, a novel high temperature anti-oxidative SiC/Fe 3 Si/CNTs composite is synthesized by a facile polymer derived ceramic (PDC) route from a Fe-containing polysilyacetylene (PSA). The microstructure of as-prepared SiC/Fe 3 Si/CNTs composite absorber is featured by micro-sized SiC ceramic grains with spherical Fe 3 Si nanoparticles and carbon nanotubes (CNTs) attached to. The vector network analyzer tests show a tunable wave-absorbing performance by adjusting the thickness of layer, and the effective bandwidth (the reflection loss < −10 dB) is 3.3–16.8 GHz for the sample S-1400 (heat treatment at 1400 °C in nitrogen flow). The minimal RL value is −41.2 dB at 10.5 GHz at a thickness of 2 mm and an effective bandwidth is nearly 4 GHz (12.9–16.9 GHz) at the thickness of only 1.5 mm. Moreover, after the oxidation treatment at 800 °C in the air, this absorber maintains the main structure and shows a good high temperature oxidation resistance . This absorber still remains excellent wave absorption property, in view of a minimal RL value of −40 dB at the thickness of 3 mm and a bandwidth of 4.8 GHz (10.4–15.2 GHz) at the thickness of 2.5 mm. The mechanism of high EM wave absorption performance is studied and attributed to the impendence matching, polarization, and the magnetic properties . Thus, the SiC/Fe 3 Si/CNTs composite is a promising EM absorber for high-temperature EM wave-absorbing applications.
研究领域:
材料科学
·
电磁工程
·
复合材料
·
陶瓷
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）