SOLID STATE SCIENCES
·
2026
·
IF 3.6
Feng-Jun Zhang,Zi-Chen Wang,Jun-Jie Zhang
MoS 2 and LDH were successfully integrated into a two-dimensional/two-dimensional (2D/2D) structure. • PMA with electron-capturing capability was successfully intercalated into the two-dimensional nanosheet layers. • 10% LDH-PMA/MoS 2 shows superior light harvesting capacity, 6.45-fold higher than ZnAl-LDH. Addressing urgent environmental remediation and sustainable energy needs, this study enhances photocatalytic H 2 evolution via rational design of an efficient composite catalyst. In-situ synthesis controllably grew MoS 2 onto LDH-PMA surface, constructing ZnAl-PMA/MoS 2 photocatalytic system. Photocatalytic tests show 10% MoS 2 -loaded composite exhibits optimal light harvesting, achieving 4498.59 μmol g −1 h −1 H 2 evolution, 6.45 times pristine ZnAl-LDH and 3.1 times LDH-PMA, and retaining 3890 μmol g −1 h −1 after six cycles (24 h total), confirming excellent stability. This enhanced performance arises from 2D/2D heterostructure and intercalated PMA's electron trapping capability, facilitating photogenerated carrier separation, suppressing recombination, and boosting. Download: Download high-res image (346KB) Download: Download full-size image
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2013
·Vol. 31
·期 4
·691-701
·
IF 1.27
Tan Lin,Xing Jin-xing,Cao Fu-hu,Chen Li-juan,Zhang Chong,Shi Rong-hua,Wang Yan-mei
A series of double-hydrophilic double-grafted PMA- g -PEG/PDMA copolymers, which contained poly(methacrylate) (PMA) as backbone, poly(ethylene glycol) (PEG) and poly( N,N -dimethylacrylamide) (PDMA) as side chains synthesized successfully by using reversible addition-fragmentation chain transfer (RAFT) polymerization and atom transfer radical polymerization (ATRP), were used as physical coatings for the evaluation of protein-resistant properties by capillary electrophoresis (CE). Electroosmotic flow (EOF) measurement results showed that the PMA- g -PEG/PDMA copolymer coated capillaries could suppress electroosmotic mobility in a wide pH range (pH = 2.8–9.8) and EOF mobility decreased with the increase of copolymer molecular mass and PDMA content. At the same time, protein recovery, theoretical plate number of separation and repeatability of migration time demonstrated that antifouling efficiency was improved with the increase of molecular mass and PEG content.
研究领域:
高分子化学
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生物医学工程
·
材料科学
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Dong Wang,Feng Yuan,Xuliang Deng,Haoyang Li,Siyang Nie,Qingda Liu,Xun Wang
Therapy based on heat and reactive oxygen species (ROS) generation have attracted increasing attention, while the weak photothermal ability and low ROS production have severely limited the efficiency of the tumor treatment. Here, 2D ultrathin CuS-phosphomolybdic acid (PMA) nanosheets are synthesized at sub-nanoscale. Typically, the improved second near-infrared light (NIR-II) light absorption, small bandgap, fast hot carrier response, abundant oxygen vacancies, and the electron delocalization between closely connected PMA and CuS units in sub-nanoscale result in the notably enhanced NIR-II photothermal therapy (PTT) performance of CuS-PMA. The reversible redox of Mo active sites in PMA provides basis for glutathione (GSH) depletion while triggering chemodynamic therapy (CDT) in the tumor microenvironment (TME), and the heat produced by the PTT greatly promotes the CDT and GSH depletion, where CuS-PMA presents sevenfold more ROS generation and fourfold more GSH depletion under PTT. In addition, the ROS generation/GSH depletion can downregulate heat shock proteins, weakening the heat resistance of tumor cells and thereby amplifying the killing effect of PTT. Moreover, the combination of antiprogrammed death-ligand 1 (αPD-L1) with the treatment of CuS-PMA promote the immunotherapy, resulting in the suppression of untreated abscopal tumors.
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高影响因子
BMC Pulmonary Medicine
·
2025
·Vol. 25
·期 1
·1-11
·
IF 2.8
Luo Jun,Liu Min,Ai Wen,Zheng Xiaoling,Han Lu,Huang Kuo,Zhang Changlin,Wang Peng,Fan Jinhong,Li Qianyuan,Luo Chunhua
Background Timely detection of viable Staphylococcus aureus (MSSA)/ methicillin-resistant Staphylococcus aureus (MRSA) and antimicrobial resistance are crucial for the treatment of patients with pulmonary infection. Methods In the current study, we have developed and evaluated the potential clinical applicability of the PMA TaqMan-based real-time PCR (PMA-TaqMan qPCR) assay for detection of viable MSSA/MRSA and antimicrobial susceptibility directly from bronchoalveolar lavage fluid. Results The PMA-TaqMan qPCR assay demonstrated high sensitivity with a detection limit of 800 CFU/mL within 115 min. Furthermore, the assay required only 45 min of antibiotic exposure and completed antimicrobial susceptibility testing within 160 min. Upon detection of 10 spiked bronchoalveolar lavage fluid samples treated by clindamycin after 24 h, the PMA-TaqMan qPCR assay showed better agreement with culture-based methods in detecting viable bacteria. Subsequent antimicrobial susceptibility results of bronchoalveolar lavage fluid samples spiked by 16 MRSA isolates and 11 MSSA isolates based on the current assay, compared with the standard broth microdilution method, showed an overall agreement of 100% (95% confidence intervals [CI]: 80.64 to 100) for MRSA and 90.91% (95% CI: 62.27 to 98.38) for MSSA. Conclusions Our findings demonstrate that the PMA-TaqMan qPCR assay is a highly sensitive and specific method for the direct detection of viable MSSA/MRSA and antimicrobial susceptibility testing from bronchoalveolar lavage fluid.
研究领域:
微生物学
·
分子诊断
·
感染性疾病
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抗菌耐药
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PubMed
高影响因子
JOURNAL OF NUCLEAR MATERIALS
·
2019
·
IF 2.547
Hui Dan,Qiang Xian,Li Chen,Tianheng Xiong,Zhengdi Jiang,Facheng Yi,Yi Ding
Mesoporous ammonium molybdophosphate/SBA-15 (AMP/SBA-15) was considered as an excellent adsorbent to remove Cs + from radioactive wastewater. However, AMP/SBA-15 obtained from two-step method suffers from poor stability and low reuse ability. Herein, we reported a facile one-step method to fabricate AMP/SBA-15 using Phosphomolybdic acid (PMA) as acid media. The effect of PMA content on the properties of the resultant AMP/SBA-15 was investigated in detail. And the Cs + adsorption performance of the developed AMP/SBA-15 adsorbents was also evaluated. It was found that the PMA content had a strong influence on the structure and morphology of AMP/SBA-15. The mesoporous structure order of the AMP/SBA-15 decreased with increasing PMA content. The AMP particles were mainly incorporated into the framework of SBA-15. Furthermore, the AMP incorporation rate obtained from one-step method is much higher than that of two-step method. The developed AMP/SBA-15 with AMP in the framework of SBA-15 exhibited good stability and high reuse ability for the removal of Cs + .
研究领域:
材料科学
·
环境科学
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高影响因子
ACS Omega
·
2020
·
IF 2.87
Zelong Mei,Kun Zhang,Ge Qu,Jun-Kuan Li,Baoyan Liu,Jun-An Ma,Ran Tu,Zhoutong Sun
Ketones are of great importance as building blocks in synthetic organic chemistry and biocatalysis. Most ketones cannot easily be quantitatively assayed due to the lack of visible photometric properties. Effective high-throughput assay (HTA) development is therefore necessary for ketone determination. Inspired by previous works of an aldehyde assay based on 2-amino benzamidoxime derivatives, we developed a colorimetric method for rapid a HTA of structurally diverse ketones by using para-methoxy-2-amino benzamidoxime (PMA). This PMA-based method is characterized by high sensitivity manner (μM) with low background, as checked by gas chromatography (GC). It can be used for quantitatively monitoring ketones by fluorescence screening in microtiter plates. Furthermore, this HTA method was employed in mining alcohol dehydrogenases (ADHs), and in directed evolution aimed at enhancing ADH activity in the catalytic transformation of alcohols to ketones. This work provides a general tool for ketone detection in biocatalyst development.
研究领域:
分析化学
·
生物化学
·
生物催化
·
蛋白质工程
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuanchan Yu,Fangxiang Song,Maofa Yang,Shuang Tian,Xiangyu Ji,Xiaofei Yu,Jianfeng Liu,Feng Zhu,Yan Li
The utilization of highly efficient and ecofriendly stimulus-responsive delivery systems for pesticides represents a powerful strategy for enhancing their efficacy and environmental safety. In this study, the application of emamectin benzoate (EB)-loaded amino-functionalized rough mesoporous silica (KMSNs)@poly(glycidyl methacrylate-co-acrylic acid) (PMA) composites (KMSNs@PMA@EB, 6.52 % loading capacity for EB) to control efficacy for Spodoptera frugiperda was investigated in detail. The results showed that, KMSNs@PMA@EB rapidly released EB under acidic and high-temperature conditions. compared with EB and commercial formulations, a solution of KMSNs@PMA@EB with the agricultural organosilicon additive exhibited excellent wetting. Compared with MSNs, KMSNs@PMA significantly enhanced the effective deposition. Moreover, the photostability of KMSNs@PMA@EB was improved by 1.87-fold and 2.25-fold compared to EB and an EB suspension concentrate (EB SC). S. frugiperda larvae preferred corn leaves with low concentrations (0.125 mg/L) of KMSNs@PMA@EB than EB-treated. Bioassays revealed that KMSNs@PMA@EB maintained > 37 % control efficiency after 21 d of spraying, KMSNs@PMA@EB exhibited significantly greater insecticidal activity and persistence against S. frugiperda than commercial formulations. After 21 days of application, the final deposition rates of KMSNs@PMA@EB were lower than the maximum residual limit of EB, spraying KMSNs@PMA@EB has a lower impact on corn plants. Furthermore, biological safety assessments confirmed that KMSNs@PMA@EB did not affect the maize seed germination and growth and posed a low risk to Microplitis manilae . Those results highlight that the advantages of KMSNs@PMA@EB nanoparticles multidimensional enhancement of pesticide efficacy, persistence, and safety to parasitic wasps and has great potential to be used in pest control combining parasitoid and nanopesticides.
研究领域:
农业科学
·
纳米技术
·
害虫管理
·
环境科学
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高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Dong Hu,Wenfang Lin,Jie Zeng,Heng Zhang,Yating Wei,Xin Yu
Secondary water supply systems (SWSSs) are widely used to supply water to high-rise households in urban residential buildings. A special mode of double tanks with one used while another was spared was noted in SWSSs, which would facilitate microbial growth due to longer water stagnation in the spare tank. There are limited studies on the microbial risk of water samples in such SWSSs. In this study, the input water valves of the operational SWSSs consisting of double tanks were artificially closed and opened on time. Propidium monoazide-qPCR and high-throughput sequencing were performed to systematically investigate the microbial risks in water samples. After closing the tank input water valve, it may take several weeks to replace the bulk water in the spare tank. The residual chlorine concentration in the spare tank decreased by up to 85 % within 2–3 days compared with that in the input water. The microbial communities in the spare and used tank water samples clustered separately. High bacterial 16S rRNA gene abundance and pathogens-like sequences were detected in the spare tanks. Most antibiotic-resistant genes (11/15) in the spare tanks showed an increase in their relative abundance. Moreover, when both tanks within one SWSS were in use, the water quality of the used tank water samples deteriorated to varying degrees. Overall, running SWSSs with double tanks will reduce the replacement rate of water in one storage tank, and consumers who use taps served by the presented SWSSs may have a higher microbial risk.
研究领域:
环境科学
·
微生物学
·
水质管理
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PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 47
·22849-22859
·
IF 6.97
Jin Cheng,Qian Zhang,Sisi Fan,Amin Zhang,Bin Liu,Yuping Hong,Jinghui Guo,Daxiang Cui,Jie Song
Inorganic nanoparticles (NPs), particularly iron oxide (IO) and gold (Au) NPs, are widely used in a variety of biomedical applications, such as diagnosis and cancer therapy. As an important component of host defense in organisms, macrophages play a crucial role in responding to foreign substances, such as nanoparticles. Thus, it is of utmost importance to understand the nanotoxicity effects on the immune system by investigating the influences of such nanoparticles. In this study, we found that macrophages can take up large amounts of amphiphilic polymer (PMA)-modified Au and IO NPs, which will induce macrophage cell vacuolization and enhance macrophage polarization. This mechanism is an essential part of the immune response in vivo. In addition, we report that smaller-sized nanoparticles (ca. 4 nm) show more significant effects on the macrophage polarization and caused lysosomal damage compared to larger nanoparticles (ca. 14 nm). Moreover, the amount of NP uptake in macrophages decreases upon trapping the PMA with PEG, resulting in reduced vacuolization and a reduced immune response. We hypothesize that vacuoles are formed in large amounts during NP uptake by macrophages, which enhances the immune response and induces macrophages toward M1 polarization. These findings are potentially useful for disease treatment and understanding the immune response when NPs are used in vitro and in vivo.
研究领域:
免疫学
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纳米医学
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生物医学工程
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毒理学
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Yu Hou,Jiawei Lin,Yichao Chen,Jianbin He,Zhe Su,Qinhua Zheng,Xiujuan Zhao,Xiaodan Lv,Xiuping Tang,Changren Zhou
Monitoring hydroxyl radical (•OH) fluctuation is of great importance to study some relative pathological processes and to predict early diagnosis of diseases. Efficient •OH-responsive fluorescent sensors based on carbon dots (CDs) have been reported, but most researches have focused on the new strategies for the synthesis and doping of the CDs. Herein, a kind of biomass CDs (F-CDs) with Flammulina velutipes ( F. velutipes ) as the carbon source was prepared by a one-step hydrothermal method without any additional modification. The prepared F-CDs have remarkable sensitivity and selectivity and there is a good linear relationship from 0 to 12 μM with a low detection limit of 95 nM for quantitative •OH assay. With excitation-independent emission, favourable biocompatibility and low toxicity, the F-CDs can penetrate cell membranes as •OH-responsive fluorescent sensors to detect intracellular •OH in A549 cells stimulated by phorbol 12-myristate 13-acetate (PMA) and successfully monitor the •OH concentration levels by the corresponding fluorescence change. Given the combined benefits of the green and eco-friendly approach, the F-CDs show promise as novel theranostics tools for early detection and treatment of related diseases.
研究领域:
化学
·
材料科学
·
生物材料
·
生物医学工程
·
分析化学
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PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2016
·
IF 2.326
Wenjuan Yao,Lei Huang,Qinju Sun,Lifeng Yang,Lian Tang,Guoliang Meng,Xiaole Xu,Wei Zhang
Macrophage foam cell formation triggered by oxLDL is an important event that occurs during the development of atherosclerosis . 2,3,5,4′-Tetrahydroxystilbene-2- O -β- d -glucoside (TSG) exhibits significant anti-atherosclerotic activity. Herein we used U937 cells induced by PMA and oxLDL in vitro to investigate the inhibitory effects of TSG on U937 differentiation and macrophage foam cell formation. TSG pretreatment markedly inhibited cell differentiation induced by PMA, macrophage apoptosis and foam cell formation induced by oxLDL. The inhibition of vimentin expression and cleavage was involved in these inhibitory effects of TSG. The suppression of vimentin by siRNA in U937 significantly inhibited cell differentiation, apoptosis and foam cell formation. Using inhibitors for TGFβR1 and PI3K, we found that vimentin production in U937 cells is regulated by TGFβ/Smad signaling, but not by PI3K-Akt-mTOR signaling. Meanwhile, TSG pretreatment inhibited both the expression of TGFβ1 and the phosphorylation of Smad2 and Smad3, and TSG suppressed the nuclear translocation of Smad4 induced by PMA and oxLDL. Furthermore, TSG attenuated the induced caspase-3 activation and adhesion molecules levels by PMA and oxLDL. PMA and oxLDL increased the co-localization of vimentin with ICAM-1, which was attenuated by pretreatment with TSG. These results suggest that TSG inhibits macrophage foam cell formation through suppressing vimentin expression and cleavage, adhesion molecules expression and vimentin-ICAM-1 co-localization. The interruption of TGFβ/Smad pathway and caspase-3 activation is responsible for the downregulation of TSG on vimentin expression and degradation, respectively.
研究领域:
心血管疾病
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药理学
·
细胞生物学
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PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2023
·Vol. 195
·期 11
·6537-6556
·
IF 3
Chen Xue-fang,Shen Zhi-jie,Ji Xu-ran,Yao Shi-miao,Wang Can,Li Hai-long,Zhang Hai-rong,Xiong Lian,Chen Xin-de
The efficient and economical removal of fermentation inhibitors from the complex system of biomass hydrolysate was one of the basics and keys in bio-chemical transformation. In this work, post-cross-linked hydrophilic-hydrophobic interpenetrating polymer networks (PMA/PS_pc IPNs and PAM/PS_pc IPNs) were proposed to remove fermentation inhibitors from sugarcane bagasse hydrolysate for the first time. PMA/PS_pc and PAM/PS_pc IPNs can obviously enhance the adsorption performance towards fermentation inhibitors due to their higher surface area and hydrophilic-hydrophobic synergetic surface properties, especially PMA/PS_pc IPNs has higher selectivity coefficients of 4.57, 4.63, 4.85, 16.0, 49.43, and 22.69, and higher adsorption capacity of 24.7 mg/g, 39.2 mg/g, 52.4 mg/g, 9.1 mg/g, 13.2 mg/g, and 144.9 mg/g towards formic acid, acetic acid, levulinic acid (LA), 5-hydroxymethylfurfural (HMF), furfural, and acid-soluble lignin (ASL), respectively, in a lower total sugar loss of 2.03%. The adsorption kinetics and isotherm of PMA/PS_pc IPNs were studied to elucidate its adsorption behavior towards fermentation inhibitors. In addition, the cyclic utilization property of PMA/PS_pc IPNs was stable. Synthesizing PMA/PS_pc IPNs is a new strategy to provide an efficient adsorbent for the removal of fermentation inhibitors from lignocellulosic hydrolysate.
研究领域:
生物化工
·
环境科学
·
高分子科学
·
生物技术
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）