ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2021
·
IF 6.291
Min Kang,Jie Luo,Ling Zhao,Fei Shi,Gang Ye,Xiaoli He,Suqi Hao,Dan Yang,Helin Chen,Hongrui Guo,Yinglun Li,Huaqiao Tang
Nano-copper (nano-Cu) is widely used in the pharmaceutical field as well as a feed additive for animals owing to its unique physicochemical characteristics and bioactivities. In our previous study, nano-Cu was found to hamper fetal development; however, the toxicity of nano-Cu and its effects in placental function have not been elucidated. Therefore, we investigated the toxic effects of nano-Cu using rat placenta. Pregnant Sprague-Dawley rats were orally exposed to different copper sources from the third day of gestation (GD 3) to GD 18. We found that nano-Cu (180 mg/kg) and CuCl 2 .2 H 2 O increased the accumulation of copper. Besides, nano-Cu and CuCl 2 .2 H 2 O disrupted the placental morphology and induced oxidative stress. Micro-copper (micro-Cu) caused similar toxicity in the placenta, but its effects were weaker than that of nano-Cu and CuCl 2 .2 H 2 O. In addition, exposure to nano-Cu (180 mg/kg) and CuCl 2 .2 H 2 O induced inflammation in the rat placenta. Furthermore, nano-Cu, micro-Cu, and CuCl 2 .2 H 2 O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62. Moreover, nano-Cu, micro-Cu, and CuCl 2 .2 H 2 O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. Taken together, our data indicated that prenatal exposure to nano-Cu induced autophagy via the PI3K/AKT/mTOR and AMPK/mTOR pathways, which associated with oxidative stress and inflammation in rat placenta.
研究领域:
毒理学
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药理学
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生殖生物学
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产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2017
·
IF 2.466
Huanan Wang,Wenqing Xu
Due to higher transmembrane potential of tumor cells, enhanced accumulation of cationic drugs in tumor mitochondria has been attributed to a higher (more negative inside) mitochondrial transmembrane potential compared with normal cells, emerging researchers are focus on developing mitochondria-targeted antitumor drugs. Coumarins showed great potential on antitumor, but mitochondria-targeted coumarin derivatives have not been reported. In the present study, we synthesized mitochondria-targeted-methyl coumarin (mito-methyl coumarin) through coupling 6-methyl coumarin to TPP. We confirmed that mito-methyl coumarin inhibited HeLa cells proliferation selectively, induced ROS generation, reduced mitochondrial membrane potential , promoted mitochondria Ca 2+ accumulation, decreased mitochondria mass and induced HeLa cells apoptosis, but methyl coumarin did not. These results demonstrate that we succeed in synthesizing a novel mitochondria-targeted drug, mito-methyl coumarin, which is effective in inhibiting HeLa cells proliferation and inducing HeLa cells apoptosis through promoting ROS generation and mitochondria Ca 2+ accumulation.
研究领域:
药理学
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肿瘤学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Zhi Song,Yu-Long Ma,Cong-Er Li
The object of this study was to remove the tetracycline (TC) residue in pharmaceutical wastewater after flocculation treatment. MnO 2 /graphene nanocomposite was synthesized by an in situ hydrothermal method and its TC removal rate was up to 99.4%. This nanocomposite had excellent water solubility. More importantly, the introduction of MnO 2 nanorods allowed the avoidance of excessive stacking of treated graphene sheets during the adsorption process, which made the TC molecules to have more opportunities to make contact with the adsorbents. In order to eliminate the interference factors, the adsorption isotherm, kinetics, thermodynamics and mechanism were all studied in TC aqueous solution. The influence of solution pH, contact time, MnO 2 loading amount, temperature and solution concentration on the adsorption process were also assessed. The main adsorption mechanism contributed to the complexation of Mn(IV) and π-π interactions of the benzene ring structure on treated graphene sheets with TC molecules.
研究领域:
环境科学
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材料科学
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药学
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产品关联
DOI
PubMed
高影响因子
Geoenergy Science and Engineering
·
2023
·
IF 0
Xuening Feng,Shi Liu,Hanjun Liu,Xuebin Jiang,Weiyang Wang,Ying Yang,Liwei Shen,Zejun Zhang,Fan Ye,Yuanzhu Mi
A demulsifier (PEDA) with double hydrophobic chain structure was synthesized using polyethylene glycol diglycidyl ether (PEDGE) and dodecyl amine (DA) as starting materials by a one-step method. The PEDA was characterized by FT-IR, 1 H NMR and thermogravimetric analysis (TGA). It was used for the demulsification of two water-in-crude oil (W/O) emulsions (m water :m oil = 70:30 and m water :m oil = 10:90). The effect of PEDA concentration, settling time, demulisification temperature, pH value and salinity on the demulsifying efficiency (DE) were detailly discussed in the W/O emulsions. The results showed that the DE of PEDA could reach 91.78% and 100% in the 70:30 and 10:90 emulsion at 50 °C for 240 min, respectively. Also, PEDA had excellent acid, alkaline and salt resistance. In addition, some commercial demulsifiers were used for comparison to evaluate the demulsification ability of PEDA. The dynamic interfacial tension (IFT), three-phase contact angle (CA), zeta potential and optical microscopic observation were used to investigate the demulsifying mechanism. The current study not only develops a new PEDA demulsifier with excellent performance at lower temperature but also provides a simple synthesis method for the demulsifier using less variety of raw materials, so it is more conducive to the industrial applications.
研究领域:
化学工程
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石油工程
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DOI
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Guoping Yu,Xingyu Huo,Jun Wang,Qiuyu Wang,Kangzheng Li,Ziwen Wang,Zhe Yin,Huanyu Chen,Binglin Tang,Bo Lv
Photocatalytic reforming of glucose can simultaneously produce hydrogen (H 2 ) and high value-added biochemicals, which can alleviate energy shortages and environmental crises. In this study, a powder photocatalyst of 1.5 % Pt supported titanium dioxide (1.5 %Pt/TiO 2 ) was employed for the photoreforming of glucose to generate H 2 . The H 2 evolution is only 2.03 mmol/g/h. This is primarily attributed to the sluggish delivery of reactants, challenges in recovery, and inadequate utilization of light energy within the traditional photocatalytic system. These issues not only impede the efficiency of photocatalytic reactions but also pose obstacles to large-scale practical applications. To overcome these drawbacks, we designed a recyclable hydrophilic floating hydrogel device that 1.5 %Pt/TiO 2 was used as filler and floating sodium alginate (SA) hydrogel was self-assembled into a composite material 1.5 %Pt/TiO 2 /SA, and the gas-solid-liquid three-phase interface (TPI) was formed in the process in glucose photoreforming to produce H 2 . The results show that the H 2 evolution of 1.5 %Pt/TiO 2 /SA is 6.16 mmol/g/h from the glucose aqueous solution, which is ∼154-fold and∼3.0-fold those of TiO 2 and 1.5 %Pt/TiO 2 , respectively. This is mainly because the unique TPI can enhance the temperament transport ability and photogenerated carrier separation. In addition, photocatalytic mechanism studies have shown that in the process in glucose photoreforming, glucose is first oxidized to arabinose by holes, and then arabinose is converted to lactic acid and acetic acid. Finally, the composite material with TPI proposed by us also lays a certain foundation for the future photocatalytic reforming of glucose.
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产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2024
·Vol. 28
·期 8
·2669-2677
·
IF 2.6
Xia Xiaohong,Duolihong Bawurejiang,Ma Xiangdong,Yue Shan,Liu Rui
Electrochemical biosensor based on horseradish peroxidase (HRP) modified gold nanoparticle/sulfur-doped graphene (AuNP/SG) has been developed for the quantification of trans -resveratrol (Res). Gold nanoparticle (AuNP) was selected as the carrier for HRP due to its excellent electrochemical catalytic activity, biocompatibility, and conductivity, while sulfur-doped graphene (SG) was selected as the support for AuNP due to the defects introduced in the carbon network by sulfur doping can facilitate the high dispersion state of AuNP and HRP. The results show that the excellent sensing performance of the HRP/AuNP/SG is attributed to the high charge polarization of material after sulfur dropping and the co-catalysis of HRP and AuNP. For the detection of Res, linear response can be observed with high sensitivity and low detection limit (4 × 10 −8 M). Further, this electrochemical biosensor presents strong reproducibility, stability, and anti-interference capability in detecting Res. These unique properties make it an excellent choice for Res reliable detection.
研究领域:
生物化学
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材料科学
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分析化学
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 141
·期 5
·e54873
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IF 3
Ze Liang,Lin Lu,Tingting Gao,Qinze Liu,Zhizhou Yang,Ruoyao Zhou,Guofeng Peng,Jinshui Yao,Changbin Zhang
Wastewater containing dyes is frequently discharged by industrial processes and needs separation and recycling. To solve this problem, it is important to research and develop environmentally friendly, efficient adsorbent materials for pollutant separation and recovery. In this study, a poly(PEI-catechol-tetraethylenepentamine) (PPCT) adsorbent was synthesized using a simple catecholamine reaction. This adsorbent exhibited high adsorption capacity and excellent removal efficiency for Reactive Red 195 (RR-195) in wastewater. The material was characterized using SEM, FT-IR, TGA, EA, and XPS. Its performance was optimized by varying the type of polyethyleneimine and the amount added during the preparation process. The effects of temperature, pH, contact time, and salt concentration on the adsorption were systematically investigated. Additionally, the experimental data showed consistency with both the Langmuir and pseudo-second-order kinetic models, simultaneously. The maximum adsorption capacity can reach 1754 mg g −1 at 303 K, with a retention rate of 86.6% after two cycles. The removal rate exceeds 98% at a concentration of 400 mg g −1 or lower. Additionally, the protonated amine group in PPCT carries a positive charge under acidic conditions, enabling selective adsorption of the anionic dye RR-195. Consequently, PPCT exhibits an excellent adsorption effect on RR-195 and holds promising applications in pollutant removal.
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DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Jinmin Zhao,Juanli Chen,Liting He,Youhua Cao,Chengqiang Peng,Jing Fang,Zhongyu Duan,Hao Li
Polyvinylidene fluoride membranes (PVDFMs) are frequently used in oil-water separation due to their stable properties, high porosity, and modification easily. However, the pollution, low separation efficiency, and low recovery rate of PVDFMs have limited the oil sewage treatment. This work is based on dopamine-modified PVDFMs, which prepared hydrophilic separation membranes by attaching hydroxymethylated lignin (HAL) to PVDFMs. Lignin was hydroxymethylated to improve its hydrophilicity. Additionally, HAL was assembled on the surface of PVDFMs with the effect of dopamine (DA) and 3-aminopropyltriethoxysilane (KH550). The effect of the ratio of DA and KH550 (D: K) and HAL concentration on the hydrophilic effect was explored. The modified membranes exhibited considerable separation efficiency (>99 %) for several kinds of oil-water emulsions and could be recycled multiple times. This green modification method using lignin provides an environmentally friendly solution for modifying PVDFMs.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiuqi Niu,Xiyu Zhang,Yang Wu,Chuanzhi Sun,Xiong Zheng,Min Long,Yinguang Chen
The escalating global production of waste activated sludge (WAS) presents both environmental challenges and opportunities for resource recovery through anaerobic fermentation (AF) to volatile fatty acids (VFAs). However, the ubiquitous presence of emerging contaminants (ECs, e.g., tribromophenol (TBP)) in WAS, resulting from extensive industrial applications, raises critical concerns about potential impacts on fermentation process. This study systematically investigated dose-dependent effects of TBP on VFA production during WAS fermentation, focusing on organic matter (OM) transformation, microbial metabolism, and adaptive mechanisms. Results demonstrated that low-dose TBP (10 mg/g TSS) enhanced VFA yield by 30.4 % (from 1288 to 1680 mg COD/L), while high-dose TBP (100 mg/g TSS) inhibited production by 8.0 % (to 1185 mg COD/L). Spectroscopic analysis confirmed TBP addition significantly attenuated amide I/II band intensities (1656/1546 cm −1 ) in FTIR and reduced amino acid-associated organic C=O/C-O XPS peak areas in the solid phase, while proportionally increasing amino acids in the liquid phase. This dissolution of solid-phase proteins by TBP thereby enhanced substrate bioavailability for fermentation. The improved substrate availability stimulated the growth of Firmicutes (increased by 53.52 %) and protein-degrading genera (e.g., Proteocatella ), while upregulating key metabolic pathways including amino acid metabolism (e.g., hisC and maiA ), glycolysis (e.g., HK and apgM ), and pyruvate metabolism (e.g., porA and korA ). Moreover, low-dose TBP enhanced microbial adaptability through quorum sensing (e.g., lsrB increased by 43.9 %) and two-component systems (e.g., rstB increased by 14.0 %). However, these beneficial effects were reversed at high TBP concentrations, leading to decreased microbial activity and VFA production. This work provides a comprehensive insight into ECs impacts on WAS fermentation, highlighting the critical need for dose-dependent process control to ensure safe resource recovery.
研究领域:
环境科学
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生物技术
·
微生物学
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化学工程
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废弃物管理
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分析化学
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生物化学
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产品关联
DOI
高影响因子
Applied Materials Today
·
2026
·
IF 7
Jian Li,Wenbin Luo,Yi Yu,Ruichen Xu,Zisheng Chao,JinCheng Fan
CNSeCNC was designed as cathode for aluminum batteries. • The CNSeCNC cathode exhibits superior electrochemical performance. • Dual-carbon modification and interface design strategies enhanced the performance. A porous CoSe 2 /NiSe 2 @C@NC cubic nanobox composite material is designed as a cathode material for aluminum batteries. This composite material consists of CoSe 2 /NiSe 2 anchored onto a three-dimensional porous carbon framework forming the core, and is coated with a nitrogen-doped carbon layer on its outer shell. The CNSeCNC cathode has an initial discharge capacity of 356 mAh/g and exhibits excellent capacity retention, retaining 217 mAh/g after 200 cycles. The Coulombic efficiency approaches 100% during prolonged cycling. Even at a high current density of 2.0 A/g, the material still maintains a capacity of 100 mAh/g. The CoSe 2 /NiSe 2 heterojunction generates interfacial lattice distortion that promotes efficient ion transfer. Meanwhile, the internal carbon network, external carbon coating and N-doping significantly boost electronic conductivity. Additionally, the carbon coating layer mitigates framework collapse and aggregation, ensuring superior structural stability throughout cycling. Owing to the improvements introduced through the double-carbon modification, CNSeCNC exhibits remarkable electrochemical performance as a cathode for ABs. Download: Download high-res image (158KB) Download: Download full-size image
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Bo Tian,Yuanjie Sun,Na Zhou,Zhigang Li,Jinfeng Li,Nan Zhang,Hongtao Zhao
Under the global impact of the COVID-19 pandemic, the demand for melt-blown polypropylene (PP), a crucial material in the manufacture of protective equipment, has seen a significant surge. During the melt-blowing process, PP melts exhibit a sharp decline in viscosity and exhibit poor thermal aging properties. In this study, melt-blown PP composites were prepared through radiation and melt blending techniques. By adjusting the proportions of the constituents, an investigation was conducted into the melt flow rate, FTIR spectra, rheological behavior, crystallization characteristics, surface morphology, surface charge, dielectric properties, and aging properties of these composites. The melt flow rate analysis revealed that the irradiated composites meet the melt-blowing standard of 1500 cm 3 /10 min. Infrared analysis shows that the chemical crosslinking network is formed by oxidative degradation-grafting reaction in melt-blown PP modification. Rheological studies demonstrated that flake graphite - lignin (GNP-LS) interactions promote heterogeneous network formation in composites. Four models-phase angle versus complex modulus, complex viscosity versus complex modulus, Han's plot, and Cole-Cole plot-provided evidence that the melt structure of PP undergoes a ‘liquid-to-solid’ transition. Differential scanning calorimetry (DSC) results indicated that flake graphite exhibits heterogeneous nucleation effects. Scanning electron microscopy (SEM) and transmission electron microscope(TEM) analysis showed that the interaction between flake graphite and lignin enhances the compatibility of the blend system. Zeta potential and dielectric properties tests show that the electrochemical environmental adaptability of melt-blown PP can be controlled by the gradient addition of lignin and flake graphite. Additionally, a large number of hindered phenol structures in GNP and LS enhance aging resistance. Thermogravimetric analysis (TG) indicated that GNP increased PP's heat resistance. Oxidation induction analysis further demonstrated that the oxidation induction time can reach 99.29 min upon the addition of flake graphite.
研究领域:
高分子材料科学
·
辐射化学
·
功能材料
·
聚合物加工
·
介电材料
·
热分析
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产品关联
DOI
PubMed
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Chaoliang Wang,Xiaoyang Zhao,Yongjun Li,Dehu Yang,Fuyang Liu,Feng Liu,Li Li,Ping Ke
A series of simple and low-cost Ca-doped g-C 3 N 4 (Ca/CN-X) photocatalysts were fabricated through a two-step calcination method for photodegradation of methylene blue (MB) simulated dyeing wastewater. The results showed that the photodegradation efficiency of Ca/CN-15 % on MB removal under visible light was 97.7 %, and the degradation rate constant was 4 times that of CN, showing the best photocatalytic performance. This was attributed to the fact that the doping of Ca expanded the absorption band edge, reduced the band gap, and suppressed the photogenerated electron-hole recombination, thereby increasing its corresponding photocatalytic activity. A possible photodegradation mechanism was explored, and it was found that h + was the main active species during the process. The above indicated that Ca/CN-X can be regarded as a promising catalyst for dyeing wastewater treatment.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）