Carbon Neutralization
·
2025
·Vol. 4
·期 6
·e70064
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IF 12
Xueying Wang,Yaxin Xie,Jihai Cai,Rui Shu,Changchun Ai,Lijuan Shi,Huijuan Guo,Shangqing Chen,Qun Yi
Developing solid electrolytes that simultaneously ensure high-safety and electrochemical performance remains a critical challenge for next-generation high-energy-density batteries. Herein, we design a phosphorus-containing ionic liquid (POIL) and fabricate a flame-retardant composite solid electrolyte (PIL-SPEs) via in situ thermal polymerization. The incorporated POIL endows PIL-SPEs with exceptional self-extinguishing properties (< 1 s), and synergizes with the polymer matrix to facilitate Li + transport and salt dissociation. Consequently, PIL-SPEs achieve a high room-temperature ionic conductivity (3.50 × 10 −4 S cm −1 ) and Li + transference number (0.60). At 60°C, its conductivity rises to 1.28 × 10 −3 S cm −1 , coupled with a wide electrochemical stability window (4.7 V vs. Li + /Li). LiFePO 4 ||Li full cells employing PIL-SPEs demonstrate excellent cycling stability at 60°C, retaining 76% capacity (108.6 mAh g −1 ) after 200 cycles. The rational molecular design of POIL and its synergistic effects within the composite matrix provide a viable material strategy for developing safe, high-performance solid-state lithium batteries.
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Small
·
2025
·
IF 12.1
Guofeng Ji,Jian Guan,Leyi Gong,Hang Xu,Jiarong Shi,Shiqi Liu,Hongyu Chu,Haochen Yao,Jiongdi Lu,Jia Li
Radiofrequency ablation (RFA) can destroy hepatocellular carcinoma (HCC) through the thermal-killing effect and increase tumor immunogenicity by releasing tumor cell debris. However, insufficient RFA (iRFA) is frequently encountered and leaves behind malignant tissues in clinical settings. The immune responses induced by RFA are too weak to trigger an efficient immune response to eliminate residual tumors. Toll-like receptor (TLR) 7/8 agonists serve as potent immunological adjuvants in combinatorial cancer immunotherapy, capable of enhancing RFA-mediated immune responses. Nevertheless, the poor bioavailability and off-target toxicities compromised their clinical applications. To address this clinical challenge, mechanistic investigations is initially conducted and revealed that iRFA exacerbates tumor hypoxia and induces immune suppression. Building on these findings, azobenzene (Azo) is strategically utilized as a cleavable linker to prepare a novel hypoxia-activated TLR 7/8 agonist imidazoquinoline (IMDQ) prodrug nanoparticles (Azo-IMDQ-NPs) to enhance RFA-mediated antitumor immunity. Azo-IMDQ-NPs can be selectively reduced to IMDQ in aggravated hypoxic tumor microenvironments (TME) induced by iRFA, thereby reprogramming immunosuppressive TME, triggering potent antitumor immune responses to eliminate residual tumors, and establishing a long-term immunological memory effect to prevent tumor recurrence. This study proposed a novel strategy for engineering hypoxia-activated prodrug nanoparticles to potentiate RFA-mediated antitumor immunity against HCC and further extend its clinical value.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Wang Zhiqin,Li Wei,Xiao Ningyu,Wang Chenxing
Conductive hydrogels show great potential for flexible sensors, yet their applications are limited by low strength, poor freeze resistance, and easy dehydration. To address these issues, this paper developed a multifunctional PVA (polyvinyl alcohol)/CMC (carboxymethyl cellulose sodium)/PANI (polyaniline)/PA (phytic acid)/BA (boric acid)/Fe 3+ hydrogel (denoted as PMNF) with a double-network structure formed via the Hofmeister effect and in situ polymerization. The hydrogel exhibits excellent mechanical properties (tensile strength: 236 kPa; elongation: 541%), high conductivity (2 S/m), and improved antifreezing behavior. At −12°C, it retains a conductivity of 0.86 S/m and over 300% elongation. It also demonstrates strong water retention after 15 days and stability in acidic/alkaline salt environments. Based on these properties, PMNF-based sensors reliably detect both subtle and large human motions under various conditions. This work offers a practical strategy for developing robust wearable electronics suited for real-world use.
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MedComm
·
2025
·Vol. 6
·期 11
·e70450
·
IF 10.7
Yu Chun Wang,Shuai Ding,Ya Feng Wang,Han Xie,Shan Shan Liu,Hong Wei Chen,Dan Wu,Ying Xie,Xin Wen,Yi Zhun Zhu,Ling Yun Sun
Achieving clinical remission in rheumatoid arthritis (RA) remains a significant challenge in current therapeutic strategies. While transplantation of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) has shown promising outcomes, therapeutic responses vary considerably among patients. In this study, we characterized the immune profiles of nonresponders and identified elevated expression of inducible costimulator (ICOS) in peripheral immune cells as a critical barrier to effective treatment. This upregulation, combined with the presence of ICOS ligand (ICOSL) on UC-MSCs, activated T cells to secrete inflammatory cytokines through the Phosphatidylinositol 3-kinase / Protein kinase B / Mammalian target of rapamycin (PI3K/AKT/mTOR) pathway. To overcome this limitation, we identified silybin as a potential adjunctive agent. Further investigations demonstrated that silybin acts as a competitive binding inhibitor, effectively targeting the PI3K/AKT/mTOR pathway and reducing downstream cytokine release. The combined application of silybin and UC-MSCs significantly enhanced immunoregulatory effects, as validated through in vitro analyses with patient-derived samples and in vivo experiments using a collagen-induced arthritis mouse model. This study highlights a novel, personalized therapeutic approach for RA, offering insights into improving clinical outcomes through targeted interventions.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2025
·Vol. 39
·期 11
·e70403
·
IF 0
Yingxue Zhang,Qiang Wang,Jingwen Cao,Xinhao Zhang,Yongze Zhang,Yali Chen
Gas tracer technology plays a crucial role in enhancing oil recovery during oil and gas field development. However, the limited storage capacity and detection efficiency of current gas tracers hinder their broader application. In this study, Ni-MOF-74 was successfully synthesized through a solvothermal method and subsequently modified by grafting perfluoroalkyl chains. The results demonstrated that the crystal structure and morphology of the material remained stable following fluorination, while its thermal stability was significantly improved. Notably, the specific surface area decreased with the increasing length of the grafted perfluoroalkyl chains, accompanied by a reduction in surface free energy. Additionally, the number of Lewis acidic sites increased, while the number of Lewis basic sites decreased. Adsorption performance tests revealed that the modified Ni-MOF-74 exhibited high adsorption capacities for difluorochloromethane (R22) and tetrafluoroethane (R134a), with values of 2.623 mmol·g −1 and 2.385 mmol·g −1 , respectively. These capacities were significantly higher than those of conventional activated carbon adsorption tubes. This study offers a novel approach to efficient gas tracer storage/detection and provides theoretical insights into the potential application of metal–organic frameworks (MOFs) in oil and gas field development.
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Energy & Environmental Materials
·
2025
·
IF 14.1
Chuixiong Kong,Tingmin Di,Geming Wang,Quanrong Deng,Yuan Gao,Shenggao Wang
The antagonism between porosity and graphitization critically limits carbon supercapacitor performance. Here, we demonstrate a structural engineering strategy that converts Sargentodoxa Cuneata residue (SCR) into hierarchically porous graphitic carbons (SCR-HPCs). By precisely regulating biomass precursor porous architecture, this methodology decouples the antagonism between porosity development and graphitization progression in KOH-mediated activation, achieving simultaneous high specific surface area (2465.1 m 2 g −1 ) and graphitization (I D /I G of 0.73). In 6 m KOH electrolyte, the specific capacitance of the optimized SCR-HPC-900 electrode reaches 415.6 F g −1 at 0.5 A g −1 , with a capacitance retention of 75.1% even at an ultra-high current density of 200 A g −1 . The fabricated symmetric supercapacitor achieves an energy density of 8.5 Wh kg −1 at a power density of 37 803 W kg −1 , retaining over 100.8% of its capacitance after 100 000 cycles. Remarkably, in 1 m TEABF 4 /PC organic electrolyte, the supercapacitor achieves maximum energy and power densities of 45.6 Wh kg −1 and 41 750 W kg −1 , respectively. This study presents an effective methodology for decoupling the antagonism between porosity and graphitization in conventional processes, offering a new idea for converting biomass waste into high-performance energy storage materials.
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MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Wei Wang,Jinghang Li,Yaodong Di,Shuai Yang,Youfa Wang,Lesan Yan
Chemodynamic therapy (CDT) is an innovative cancer treatment strategy that leverages Fenton or Fenton-like reactions to convert hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment (TME) into highly cytotoxic hydroxyl radicals (•OH). However, the therapeutic efficacy of CDT against tumor cells is limited by two primary constraints: 1) insufficient H 2 O 2 levels in the TME, which restricts •OH generation; and 2) elevated concentrations of reduced glutathione (GSH) in the TME, which neutralizes excess reactive oxygen species (ROS). To address these challenges, this study developed a nanoplatform based on mixed micelles composed of two distinct polycarbonate materials. One polycarbonate is conjugated with cinnamaldehyde (CA) via side chains to form a polymeric prodrug, enabling pH-responsive release of CA. The other polycarbonate chelates Fe 3+ through side-chain carboxyl groups to initiate Fenton-like reactions. In the acidic TME, the mixed micelles release CA, which elevates intracellular H 2 O 2 levels, thereby overcoming the limitation of inadequate H 2 O 2 supply in tumor cells. Simultaneously, the Fe 3+ complex within the micelles depletes GSH, reducing it to Fe 2+ , which triggers Fenton-like reactions that amplify ROS production, thus enhancing CDT efficacy. Additionally, pH-triggered disassembly of the micelles in the acidic TME releases encapsulated doxorubicin (DOX), which induces tumor cell apoptosis by damaging DNA, further augmenting antitumor therapeutic outcomes. The nanocarrier developed in this study integrates a synergistic strategy of “H 2 O 2 elevation and Fenton-like reaction” with chemotherapy, significantly improving tumor cell eradication and demonstrating substantial potential for cancer treatment.
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Interdisciplinary Medicine
·
2025
·
IF 13.6
Muladili Mutailipu,Ran Cui,Tianxiao Mei,Zinan Zhao,Yongkun Wang,Chunxiu Dong,Bingdi Chen,Yihui Hu,Wenjun Le,Bo Chen
In recent years, magnetic hyperthermia therapy (MHT), recognized as a clinically promising anticancer treatment, has focused on enhancing therapeutic outcomes in tumor management, such as optimizing magnetic nanoparticle accumulation within tumor microenvironments and developing synergistic combination approaches with other therapies. Herein, we developed nanoengineered neutrophils (NE) by loading magnetic nanoparticles (FPP) onto healthy-derived NE, designated as FPPN. The combination of FPP's pronounced T 2 -weighted magnetic resonance imaging (MRI) and superior magnetothermal efficiency with the high tumor-targeting and cancer-killing activity of NE successfully achieved the synergistic implementation of MHT and NE. Under the guidance of T 2 -weighted MRI, the accumulation of FPPN within the tumor site demonstrated a significant enhancement compared with free FPP. Under exposure to alternating magnetic fields, the thermal energy produced by FPP and FPPN could ablate tumor cells directly. Intriguingly, mitochondria within NE exhibit significant reactive oxygen species (ROS) under magnetothermal activation, thereby enhancing therapeutic efficacy and enabling synergistic tumor treatment through the combination of MHT and NE-mediated ROS. This therapeutic strategy not only highlighted the significant potential of nanoengineered NE for highly efficient MHT but also established a novel therapeutic platform for precision-targeted treatment of deep-seated tumors.
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PLANT BIOTECHNOLOGY JOURNAL
·
2025
·
IF 10.5
Caiyun Tian,Chengzhe Zhou,Shengjing Wen,Cheng Zhang,Anru Zheng,Lele Jiang,Niannian Yang,Zhuo Tang,Xiaowen Hu,Zhendong Zhang,Jiaxin Fang,Zhong Wang,Yuqiong Guo
Drought priming is a critical agronomic strategy for enhancing plant drought tolerance, yet the optimal priming intensity and transcriptional regulatory mechanisms underlying subsequent drought responses in the tea plant ( Camellia sinensis ) remain poorly characterised. In this study, we systematically evaluated tea plants exposed to recurrent drought stress under varying priming intensities. Results demonstrated that moderate drought priming specifically conferred superior drought tolerance compared to non-primed controls. Integrated metabolomic and transcriptomic profiling identified flavonoid biosynthesis as the key pathway associated with priming-induced drought resilience. Exogenous flavonoid application and overexpression of six biosynthesis genes ( CsCHS , CsCHI , CsFLS , CsDFR , CsANS and CsANR ) functionally validated flavonoids' role in drought adaptation. Notably, transcriptional regulators CsYABBY1 and CsMYB114 were identified as hub transcription factors demonstrating transcriptional activation potential towards flavonoid biosynthesis. Combinatorial transient overexpression and silencing assays revealed that both CsYABBY1 and CsMYB114 coordinately upregulate flavonoid biosynthesis genes, redirecting metabolic flux towards flavonoid accumulation to enhance drought tolerance. Multimodal validation through yeast one-hybrid assays, dual-luciferase reporter systems and electrophoretic mobility shift assays, as well as molecular docking, confirmed or simulated direct binding of CsYABBY1 and CsMYB114 to promoter regions of flavonoid biosynthesis genes for transcriptional activation. These findings establish a synergistic regulatory model where CsYABBY1 and CsMYB114 cooperatively enhance flavonoid accumulation through transcriptional reprogramming, thereby conferring acquired drought tolerance. This study provides mechanistic insights for developing adaptive cultivation practices and advances molecular breeding strategies for drought-resilient tea cultivars.
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CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Jieyi Long,Zhonghui Qiao,Yuan Wang,Andong Zhou,Yibing Wang,Mengshan Zhang,Yong Zhou,Kevin H. Mayo,Lin Sun,Yifa Zhou
β-1,3-Glucans are widely used in food and pharmaceuticals, such that testing for them is crucial to their appropriate application. Using the aniline blue method is a convenient way to test for β-1,3-glucans. However, the conditions used to detect them are quite varied and need to be standardized for all investigators. Here, we established a protocol that optimizes key parameters, including NaOH concentration (0.6 M), depolymerization temperature (40°C), reaction time (10 min), and dye-binding temperature (30°C) using curdlan as a reference. We found that the fluorescence intensity of aniline blue binding was negatively correlated with branching in β-1,3-glucans and positively correlated with molecular weight. A correction factor CF = −0.471 + 0.163·ln( a ) × (1 − 0.550 b ), with a for molecular weight and b for branching degree, was developed to correct for structural diversity. This enabled accurate quantification among structurally different β-1,3-glucans. Overall, our results will greatly improve the accuracy and precision to detect β-1,3-glucans and provide a reliable method for their analysis. Graphical A protocol was established to optimizes key the parameters, including NaOH concentration, depolymerization temperature, reaction time, and dye-binding temperature using curdlan as a reference. The results showed that the fluorescence intensity of aniline blue binding was negatively correlated with branching in β-1,3-glucans and positively correlated with molecular weight.
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Small
·
2025
·
IF 12.1
Fan Zhou,Lingyu Zhong,Qing Hu,Ling Tang,Youxian Li,Yichen Chen,Yingfei Wang,Yuxi Tian,Jianping Lei,Qing Hao,Hong Liu
Covalent organic frameworks (COFs) regulated by molecular engineering are successfully employed as “thermal barriers” to construct motion-enhanced photothermal nanomotors, realizing the direct experimental observation of steep asymmetric thermal gradients and precise motion regulation. The COF thermal barriers, strategically implanted between a spherical SiO 2 core and an Au hemispherical shell, effectively inhibit the isotropic diffusion of photothermal energy from the asymmetric Au shell, resulting in a 4-fold amplification of the local thermal gradient. The step thermal gradient achieved a steep 320% increase in motion speed compared to nanomotors without thermal barriers, with the remarkable highest speed up to ≈88 µm s −1 . Benefiting from the amplified thermal gradient, the asymmetric thermal field generated by COF barriers is directly observed experimentally using high-resolution photothermal microscopy. Notably, the thermal conductivity of COFs can be precisely modulated through pore engineering, enabling accurate control of nanomotor speed at the molecular level. Leveraging the robust drug-loading capacity of COF, motion-enhanced COF nanomotors exhibit exceptional tissue penetration and drug delivery performance. Overall, the COF thermal barriers combine designable drug-loading pore structure with tailored thermal conductivity properties, endowing the nanomotors with potent synergistic therapeutic effects for venous thrombosis via enhanced local photothermal ablation and heat-triggered drug delivery.
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Small
·
2025
·
IF 12.1
Zhenlong Liu,Jiayuan Zhang,Liping Jiang,Ruiyan Zheng,Zunyuan Xie,Jizhen Li,Guofang Zhang
Nanoconfined composites exhibit outstanding catalytic performance for the thermal decomposition of ammonium perchlorate (AP). However, it remains a formidable challenge to construct nanoconfined catalysts when the restricted species are insoluble precipitates that form rapidly at room temperature. Herein, a general precursor-based stepwise confined strategy is proposed to encapsulate M 3 [Fe(CN) 6 ] 2 ·xH 2 O (M-Fe-PBA) (M = Fe, Co, Ni, Cu, Zn) within N-doped hollow carbon nanospheres (NHCs), resulting in yolk-shell structured composites, M-Fe-PBA@NHCs. Catalytic tests reveal that 5 wt.% Co-Fe-PBA@NHCs show the highest catalytic activity among the M-Fe-PBA@NHCs composites, significantly lowering the high-temperature decomposition peak of AP and increasing its heat release. Electrochemical analysis confirms that fast electron transfer of Co-Fe-PBA@NHCs facilitates AP combustion. TGA-FTIR-MS measurements further elucidate an accelerated decomposition pathway. Density functional theory calculations indicate that NH 3 and O 2 released during AP degradation are preferentially adsorbed on the in situ formed Co 3 O 4 /CoFe 2 O 4 , promoting O 2 reduction to O 2 − species and facilitating the deeper oxidation of NH 3 into higher-valence NO 2 . Crucially, this confinement strategy enables the efficient incorporation of instantly formed insoluble species into any hollow host material with accessible voids, providing a versatile platform for the development of multifunctional nanoconfined catalysts and the rational design of high-performance confined catalysts with potential applications.
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