Materials Research Express
·
2015
·Vol. 2
·期 12
·125901
·
IF 0
Na Wu,Qun Luo,Xvsheng Qiao,Chang-Qi Ma
Recently, spectra conversion has been used to minimize energy loss in photovoltaic devices. In this work, we explore the development of a novel Eu3+-doped ZnO bi-functional layer for use in organic solar cells. The bi-functional layer acts as both a spectra conversion and an electron transporting layer. Compared to conventional spectra conversion layers, it has a simpler device structure, is easier to fabricate, and has a wider spectrum-sensitized region. A series of Eu3+-doped ZnO nanocrystals were synthesized using the simple solution route. X-ray powder diffraction patterns (XRD), transmission electron microscopy (TEM), and UV-visible absorbance spectra were used to characterize the obtained ZnO nanocrystals. The results reveal that the size and bandgap of ZnO nanocrystals can be controlled through regulation of the doping concentration of Eu3+ ions. The energy transfer of ZnO → Eu3+ is observed by photoluminescence (PL) spectra. At a bandgap excitation of around 300–400 nm, a typical emission band from the Eu3+ is obtained. By employing the Eu3+- doped ZnO nanocrystals as a buffer layer in a P3HT:PC61BM bulk heterojunction device, the obtained performance is similar to the undoped ZnO device, indicating that the electrical properties of ZnO are not affected by Eu3+ doping. Due to the down-conversion energy transfer between ZnO and Eu3+, the external quantum efficiency of the ZnO:Eu3+ device at 300–400 nm is higher than that of the pure ZnO device, which subsequently leads to an increase in short circuit current density (JSC). This work proves that it is possible to improve the solar spectrum response in the ultraviolet region of organic solar cells effectively by incorporating the bi-functional layer.
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Journal of Environmental Sciences
·
2013
·
IF 1.773
Kashif Naeem,Feng Ouyang
The photocatalytic degradation of phenol and 4-chlorophenol (4-CP) in aqueous suspensions with the use of titanium dioxide (TiO 2 ) under UV irradiation was examined. The effects of different supporting materials mixed physically with TiO 2 were studied to achieve maximum degradation efficiency. Among the three supports, namely activated carbon (AC), silica (SiO 2 ) and zeolite (ZSM-5), all exhibited paramount efficiency for degradation of phenol and 4-CP and was better than TiO 2 alone. The optimum concentration was found to be 50 mg for all supporting materials. The efficiency order of the three supports was as follows: AC > ZSM-5 > SiO 2 , respectively. Whilst, the degradation of phenol and 4-CP was improved from 70.6% to 87.6% and 80.6% to 89.7%, respectively, within 120 min photocatalysis in the presence of optimal amount of AC. The degradation was also comparatively enhanced in the presence of cheaper rice husk and the activity was closed to ZSM-5 and lower than AC.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Xing-Yan Fu,Hao Yin,Xi-Tong Chen,Jing-Fang Yao,Yan-Nan Ma,Min Song,Huan Xu,Qian-Yao Yu,Shan-Shan Du,Yun-Kun Qi,Ke-Wei Wang
Oncolytic peptides represent promising novel candidates for anticancer treatments. In our efforts to develop oncolytic peptides possessing both high protease stability and durable anticancer efficiency, three rounds of optimization were conducted on the first-in-class oncolytic peptide LTX-315. The robust synthetic method, in vitro and in vivo anticancer activity, and anticancer mechanism were investigated. The D-type peptides represented by FXY-12 possessed significantly improved proteolytic stability and sustained anticancer efficiency. Strikingly, the novel hybrid peptide FXY-30, containing one FXY-12 and two camptothecin moieties, exhibited the most potent in vitro and in vivo anticancer activities. The mechanism explorations indicated that FXY-30 exhibited rapid membranolytic effects and induced severe DNA double-strand breaks to trigger cell apoptosis. Collectively, this study not only established robust strategies to improve the stability and anticancer potential of oncolytic peptides but also provided valuable references for the future development of D-type peptides-based hybrid anticancer chemotherapeutics.
研究领域:
癌症研究
·
药物化学
·
分子生物学
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.1
Jingxuan Qiu,Yunchun Guo,Huiliang Wang,Libo Wang,Cen Yao,Jing Lin,Cong Liu,Chaoqun Zhang
This work measured the solubility of tetramethylthiuram disulfide in methanol, ethanol, n-propanol, isopropanol, sec-butanol, n-pentanol, acetonitrile, acetone, 2-butanone, methyl acetate, ethyl acetate, and water by utilizing a static gravimetric method covering the temperature range from 283.15 to 323.15 K under atmospheric pressure. The results demonstrate that the solubility tends to increase monotonously with increasing temperature in each studied solvent. The highest solubility (52.17 × 10–3) is observed in acetone at 323.15 K, and the lowest value (0.1180 × 10–3) is found in sec-butanol at 283.15 K. The solubility of TMTD is roughly ranked as ethanol > sec-butanol > n-pentanol > n-propanol > methanol > isopropanol in alcoholic solvents and acetone > 2-butanone > acetonitrile > methyl acetate > ethyl acetate > water in nonalcoholic solvents. Moreover, the Apelblat and Yaws models were used to correlate the solubility data. The outcomes of deviations and AIC values suggest that the Yaws model could give better fitting effects compared with the Apelblat model. This investigation not only fills the gap in the essential data of solubility for TMTD but also provides a theoretical basis for optimization and solvent screening in its separation and purification process in the pharmaceutical industry.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2014
·
IF 5.03
Chun-Feng Gao,Li-Ping Wang,Qi-Feng Li,Chao Wang,Zhao-Dong Nan,Xiao-Zheng Lan
In practical use, latent heat storage system always faces a lack of phase change materials (PCMs) that have ideal performance at desirable temperature and high efficiency to treat thermal effects from various outer heat sources. To solve this problem, some new latent heat storage composites were prepared by incorporating those well-performed PCMs in porous materials. In doing this, the layered perovskite-type compounds, (1-C 10 H 21 NH 3 ) 2 ZnCl 4 (C 10 Zn) and (1-C 12 H 25 NH 3 ) 2 ZnCl 4 (C 12 Zn), were embedded in controlled porous glass (CPG), which can acquire size-dependent thermal properties. Heat storage nature, morphology and crystalline structures of the materials were characterized using differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and powder X-ray diffractions (XRD). Under confinement of the porous glass with nominal pore sizes of d =12–300 nm, the porous C n Zn compound gains a regulation window of around 10 °C in relation to the bulk by its solid–solid phase transition. The transition temperature ( T d ), depression of the transition temperature (∆ T trs ), and enthalpy change of the transition (∆ trs H d ) of the confined compound show a linear relation to the reverse pore size. A same stable thermal cycling property is observed in the pore compound as the bulk, which is consistent with similar diffraction patterns among them. The supercooling of the pore form becomes larger than the bulk. The retention of the layered structure and complete crystallization in the pore C n Zn is responsible for its reversible heat storage property.
研究领域:
材料科学
·
热能工程
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高影响因子
JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2022
·Vol. 61
·期 2
·103-109
·
IF 1.555
Zhao Shuang-Li,Fu Fei,Yu Bo-Yang,Li Ren-Shi
To evaluate the quality and quantify bioactive constituents in different parts of Angelicae Sinensis Radix, an efficient, high-speed, high-sensitivity high-performance liquid chromatography and triple quadrupole mass spectrometry method was used for simultaneous detection of 12 chemical compounds including L-tryptophan, chlorogenic acid, caffeic acid, ferulic acid, isoferulic acid, senkyunolide I, guanosine, proline, L-glutamine, γ-aminobutyric acid, glutamic acid, and arginine in 52 batches of Angelicae Sinensis Radix from Gansu, China. The established methods were validated by good linearity (R2≥0.9921), limits of detection (0.0001–0.0156 μg/mL), limits of quantitation (0.0006–0.0781 μg/mL), stability (RSD≤7.77%), repeatability (RSD≤6.79%), intra- and interday precisions (RSD≤6.00% and RSD≤6.39%, respectively) and recovery (90.90–107.16%). According to the quantitative results, the contents of the hydrophilic compounds were higher in the head, while the medium and weak polar components were mainly concentrated in the tail. Finally, principal component analysis results revealed that Angelicae Sinensis Radix could be divided into different medicinal sites based on polar components such as amino acids, nucleosides. The combination of liquid chromatography-tandem mass spectrometry and principal component analysis is a simple and reliable method for pattern recognition and quality evaluation of Angelicae Sinensis Radix.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Hangbiao Jin,Dan Yang,Yunbin Hao,Jinyang Zhang,Pengfei Wu,Weiping Liu,Meirong Zhao
The abuse of psychoactive substances has been increasing dramatically over the last few years, which is becoming a concern for human health and social stability. How to accurately estimate psychoactive substances' total consumption in certain areas is the key to manage such substances. In order to control psychoactive substances, 8 psychoactive substances' consumption within 12 wastewater treatment plants (WWTPs) service areas in a certain city of Guangxi, China was investigated in 2019. Firstly, a solid-phase extraction-liquid chromatography-tandem mass spectrometry method was used to determine the influent concentrations. Morphine (MOR), 3, 4-methylenedioxymethamphetamine (MDMA), methamphetamine (METH), ketamine (KET), and norketamine (NK) were detected, with the concentrations ranging from less than method detection limit (NK, MDMA) to 170.91 (METH) ng/L. Then, the back-estimation of consumption was conducted according to the objective and near real-time wastewater-based epidemiology (WBE). The results demonstrate that KET, MOR, and METH are the most abused psychoactive substances, with the mean consumption of 682.42, 167.81, and 44.56 mg/day/1000 inh, respectively. The psychoactive substance residues of WWTPs influent were analyzed to estimate such substances' consumption in specific areas, so as to provide support for risk prevention and control.
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TALANTA
·
2020
·
IF 5.339
Shi-En Chen,Jingwen Hu,Ping Yan,Jing Sun,Wenhui Jia,Shuyun Zhu,Xian-En Zhao,Huwei Liu
Urinary sarcosine was considered to be a potential biomarker for prostate cancer (Pca). In this work, an integrated strategy of multiplex tags chemical isotope labeling (MTCIL) combined with magnetic dispersive solid phase extraction (MDSPE), was proposed for specific extraction and high-throughput determination of sarcosine by ultra high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). In the past three months, we have developed 8-plex MTCIL reagents with excellent qualitative and quantitative performance. In this work, the multiplexing capacity of MTCIL reagents (MTCIL360/361/362/363/364/365/366/375/376/378/379/381) was increased 1.5-fold from 8-plex to 12-plex. MTCIL359 was prepared and used to label sarcosine standard as internal standard (IS). The structural analogue derivative (MTCIL373-sarcosine) of all targeted MTCIL-sarcosine derivatives was synthesized and used as a novel dummy template to prepare dummy magnetic molecularly imprinted polymers (DMMIPs). The integration of MTCIL and DMMIPs procedures were extremely favorable to excellent chromatographic separation and efficient mass spectrometric detection. The labeling efficiency, chromatographic retention and mass spectrometry responses of MTCIL reagents were consistent for sarcosine. In a single UHPLC-MS/MS run (2.0 min), this method can simultaneously quantify sarcosine in 12-plex urine samples and achieve unbiased concentrations comparison between different urine samples. Analytical parameters including linearity (R 2 0.989–0.997), detection limits (0.02 nM), precision (2.6–11.5%), accuracy (96.1–107.4%), matrix effect, labeling and extraction efficiency were carefully validated. The proposed method was successfully applied for urinary sarcosine determination of healthy male individuals and Pca patients. It was found that the sarcosine concentrations in these two groups were statistically extremely significantly different ( P < 0.001). The developed method was a powerful analytical tool to substantially promote the analysis throughput and large-scale experiments about the potential biomarker research.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xue Bai,Jiangdong Dai,Yue Ma,Weibai Bian,Jianming Pan
It is highly desirable to develop an efficient adsorbent with large capacity, high selectivity and fast kinetics to recovery virtually inexhaustible lithium ion (Li + ) resources from salt lake brine. In this work, 2-(allyloxy) methylol-12-crown-4 ether (2AM12C4) functionalized polymer brushes (PVBC-g-PCE) from macroporous polymeric high internal-phase emulsion (PolyHIPE) using UV-initiated surface polymerization are synthesized for selectively recovery of Li + . PVBC-g-PCE possesses the advantages of strong physical strength, high density of accessible binding sites, and the size of highly permeatable voids and interconnecting pores is about 8.0–18 µm and 3.3–4.8 µm, respectively, which is a favorable adsorbent for specific capture Li + . PVBC-g-PCE has a maximum capacity at pH 6.0, and the pH-dependent adsorption amount suggests the grafted polymer brushes of 2AM12C4 is the driving force to enhance binding performance. PVBC-g-PCE has a fast adsorption equilibrium within 45 min, and the kinetic results are well-described by the pseudo-second-order model, indicating the specific host-guest interaction between functionalized 2AM12C4 and Li + is the main adsorption mechanism. Moreover, the maximum monolayer binding amount of PVBC-g-PCE is 4.43 mg g −1 , and the strong affinity in the presence of four kinds of interfering ions (i.e. Na + , K + , Mg 2+ , and Ca 2+ ) is also observed, which can also be proved by the high relative selectivity separation coefficient ( α r ) between 3.16 and 7.98. It is expected that this PVBC-g-PCE with abundant easy-to-access specific recognition sites can be applied as a promising adsorbent for effective separation of Li + .
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TALANTA
·
2019
·
IF 4.916
Chaofan Rui,Juan He,Yuanyuan Li,Yutao Liang,Liqin You,Lijun He,Kai Li,Shusheng Zhang
In this work, a highly selective surface molecular imprinted polymers (FDU-12@MIPs) were prepared using structural analogues of aflatoxins as the template molecule and mesoporous silica FDU-12 as the carrier. The resulting polymers were characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction and attenuated total reflection Fourier transform infrared spectrometer. A highly ordered mesoporous nanostructure was observed in the fabricated polymer. Results showed that the adsorption capacity of FDU-12@MIPs for aflatoxins were higher than that of non-imprinted mesoporous silica polymer (FDU-12@NIPs). FDU-12@MIPs were successfully used as a solid-phase extraction sorbent coupled with HPLC for aflatoxin G2, G1, B2 and B1 determination in food samples. Under optimized conditions, recoveries from the spiked cereals were found to be 82.6%–116.7%, with relative standard deviations ranging from 2.73 to 4.21. The detection limits of aflatoxin G2, G1, B2 and B1 were estimated to be 0.05 μg kg −1 , 0.06 μg kg −1 , 0.06 μg kg −1 and 0.05 μg kg −1 , respectively. Limits of quantifications were estimated to be 0.15 μg kg −1 , 0.2 μg kg −1 , 0.2 μg kg −1 and 0.15 μg kg −1 , respectively. The developed method exhibited a favorable linear response toward aflatoxin G2, G1, B2 and B1 in the range of 0.1 μg kg −1 -50 μg kg −1 , R 2 is 0.9992–0.9996. These results indicated that FDU-12@MIPs could be used as an efficient adsorbent of solid phase extraction for enrichment of aflatoxins in real samples.
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JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 40
·期 8
·1651-1659
·
IF 2.557
Tong Wang,Hai-Long Wu,Li-Xia Xie,Li Zhu,Zhi Liu,Xiao-Dong Sun,Rong Xiao,Ru-Qin Yu
In this work, a smart chemometrics-enhanced strategy, high-performance liquid chromatography, and diode array detection coupled with second-order calibration method based on alternating trilinear decomposition algorithm was proposed to simultaneously quantify 12 polyphenols in different kinds of apple peel and pulp samples. The proposed strategy proved to be a powerful tool to solve the problems of coelution, unknown interferences, and chromatographic shifts in the process of high-performance liquid chromatography analysis, making it possible for the determination of 12 polyphenols in complex apple matrices within 10 min under simple conditions of elution. The average recoveries with standard deviations, and figures of merit including sensitivity, selectivity, limit of detection, and limit of quantitation were calculated to validate the accuracy of the proposed method. Compared to the quantitative analysis results from the classic high-performance liquid chromatography method, the statistical and graphical analysis showed that our proposed strategy obtained more reliable results. All results indicated that our proposed method used in the quantitative analysis of apple polyphenols was an accurate, fast, universal, simple, and green one, and it was expected to be developed as an attractive alternative method for simultaneous determination of multitargeted analytes in complex matrices.
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MOLECULES
·
2024
·Vol. 29
·期 10
·2306
·
IF 4.2
Danyang Zhang,Xiaoshi He,Ting Wang,Yan Xing,Zhilong Xiu,Yongming Bao,Yuesheng Dong
Methylglyoxal-induced ROS elevation is the primary cause of neuronal damage. Metformin is a traditional hypoglycemic drug that has been reported to be beneficial to the nervous system. In this study, flavonoids were found to enhance the protective effect of metformin when added at a molar concentration of 0.5%. The structure–activity relationship (SAR) analysis indicated that ortho- substitution in the B ring, and the absence of double bonds between the 2 and 3 position combined with the gallate substitution with R configuration at the 3 position in the C ring played crucial roles in the synergistic effects, which could be beneficial for designing a combination of the compounds. Additionally, the mechanism study revealed that a typical flavonoid, EGCG, enhanced ROS scavenging and anti-apoptotic ability via the BCL2/Bax/Cyto C/Caspase-3 pathway, and synergistically inhibited the expression of GSK-3β, BACE-1, and APP in PC-12 cells when used in combination with metformin. The dose of metformin used in the combination was only 1/4 of the conventional dose when used alone. These results suggested that ROS-mediated apoptosis and the pathways related to amyloid plaques (Aβ) formation can be the targets for the synergistic neuroprotective effects of flavonoids and metformin.
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