Solar RRL
·
2020
·Vol. 4
·期 9
·2000220
·
IF 7.527
Kanghua Li,Yue Lu,Xiaoxing Ke,Sen Li,Shuaicheng Lu,Chong Wang,Siyu Wang,Chao Chen,Jiang Tang
Antimony chalcogenides (including Sb 2 S 3 , Sb 2 Se 3 , and Sb 2 (S,Se) 3 alloy) have emerged as promising solar absorber materials. Notably, the Sb 2 (S,Se) 3 alloy possesses continuously tunable bandgap from 1.1 to 1.7 eV, which covers the ideal bandgap for single-junction photovoltaics governed by the Shockley–Queisser theory. Moreover, the bandgap gradient provides effective ways for photogenerated carriers collection and has the potential for high-efficient Sb 2 (S,Se) 3 alloy solar cells. Herein, a V-shaped distributional bandgap in Sb 2 (S,Se) 3 solar cells is reported through a simple dual-source vapor transport deposition process, enabling the synergetic increase of the open-circuit voltage ( V OC ) and short-circuit current ( J SC ). Through careful optimization, a power conversion efficiency of 7.27% under AM1.5G illumination is obtained, with V OC and J SC of 0.46 V and 29.6 mA cm −2 , respectively. This V-shaped bandgap engineering provides an effective method to enhance the device performance and can be extended to other chalcogenide thin-film solar cells such as Sn–X, Ge–X, Cu–Sb–X (X = S and Se), and so on.
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JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2021
·
IF 2.369
Ke Cao,Ji Wu,Cai-Yan Zhang,Li-Fang Ding,Junxiao Yang
A palladium catalyzed intramolecular amination of B(7)-H for synthesis of o -carborane fused isoquinolinones has been developed. Kinds of o -carborane fused isoquinolinones decorated with active groups have been synthesized with good to excellent yields. A plausible mechanism involving palladium catalyzed electrophilic B-H activation/amination was proposed.
研究领域:
有机化学
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催化化学
·
硼化学
·
药物化学
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高影响因子
BMC Veterinary Research
·
2026
·
IF 3.1
Jing Yang,Xiaoli Zhang,Hao Wu,Wei Peng,Weiwei Su,Peibo Li
Background: Porcine reproductive and respiratory syndrome virus (PRRSV) poses a major threat to global swine production, with no clinically approved specific therapeutics. Archidendron clypearia (AC), a medicinal plant traditionally used for human upper respiratory infections, exhibits broad-spectrum antiviral activity. This study systematically evaluated the antiviral efficacy of AC against PRRSV, elucidated its pharmacodynamic material basis through comprehensive chemical profiling, and explored the targeted molecular mechanisms of its core active component, 7-GTDF. Results: Screening of 30 herbal ethanol extracts based on a PRRSV-EGFP fluorescence phenotype identified AC as possessing significant anti-PRRSV activity. In Marc-145 cells and porcine alveolar macrophages (PAMs), AC inhibited the replication of PRRSV-Li11 and PRRSV-CHR6 at both the mRNA and protein levels. Time-of-addition assays indicated that AC acts by inactivating the virus and interfering with early infection stages. Phytochemical analysis identified 40 constituents in AC, with 7-O-galloyltricetiflavan (7-GTDF) quantified via high-performance liquid chromatography (HPLC) as the predominant compound, accounting for 37.59% of the total peak area. Network pharmacology combined with experimental validation demonstrated that AC suppresses the PRRSV-induced overexpression of TNF-α, IL-1β, and IL-6 in PAMs by modulating the TLR4/NF-κB signaling pathway. Subsequent screening of the primary compounds in AC revealed that 7-GTDF exhibits significant anti-PRRSV activity. Molecular docking and molecular dynamics simulations indicated a stable interaction between 7-GTDF and the host CD163 receptor. Finally, cellular thermal shift assay (CETSA) confirmed this target engagement, demonstrating that 7-GTDF binds to the CD163 receptor and reduces its thermal stability. Conclusions: These data indicate that AC and its constituent 7-GTDF inhibit PRRSV infection through mechanisms involving CD163 targeting and inflammatory pathway modulation. These findings provide a pharmacological basis for evaluating AC as a potential antiviral candidate in swine health management.
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DOI
PubMed
高影响因子
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2026
·Vol. 42
·期 10
·560
·
IF 4.7
Xia Ruhan,Han Pengxiang,Zhao Qiangbo,Yao Wenzhi,Jiang JingJing,Dong Miaoyin,Li Mengfei
Astragalus mongholicus is one of the most commonly traditional Chinese herbal medicines in China and other Asian countries. However, the root rot disease caused by Fusarium oxysporum can severely reduce root yield and quality, resulting in significant large economic losses. Although biological control has attracted widespread attention due to its safety, environmental friendliness and sustainability, the biocontrol efficiency and potential mechanism of Bacillus velezensis against root rot of A. mongholicus have been rarely investigated. In the present study, a rhizosphere bacterium GNB3-7 was isolated from the rhizosphere soil of wild A. mongholicus and possessed the strong broad-spectrum antagonistic activity on multiple pathogenic fungi, which was identified as B. velezensis on the basis of whole-genome sequence analyses. Further genomic analyses revealed that the B. velezensis GNB3-7 has 12 biosynthetic gene clusters encoding antifungal secondary metabolites (e.g., surfactin, bacillibactin, bacilysin). In addition, a total of 36 volatile organic compounds (VOCs) were detected by GC-MS, among which benzothiazole, disulfide-dimethyl and 2-nonanone showed the strongest antifungal activities, with an inhibition rate of 99.41%, 96.87% and 92.69%, respectively. In pot experiments, the treatment rate and prevention efficiency of B. velezensis GNB3-7 against A. mongholicus root rot achieved 44.44% and 72.22%, respectively. Notably, the genes involved in plant induced systemic resistance (ISR, e.g., AmNPR1 , AmCHI2 and AmCOI1 ) were significantly up-regulated in treatment and prevention plants, indicating the activation of ISR in A. mongholicus . These results indicated that B. velezensis GNB3-7 could efficiently control root rot by synergistic action involving the production of metabolites and VOCs, activation of plant ISR, which deepens our understanding on the biocontrol mechanism of B . velezensis against root rot in medicinal plant A. mongholicus .
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Materials Today Bio
·
2025
·
IF 10.2
Xiaoying Feng,Ling Dai,Yanfang Guo,Liuting Zhong,Yuxiu Zheng,Senling Feng,Liping Cao,Zhongwen Yuan
Intrahepatic cholestasis in pregnancy (ICP) is a characteristic disease during the perinatal period; however, its therapy remains unsatisfactory, and the pathogenesis remains unclear. The ameliorative effect of naturally occurring quercetin 7-rhamnoside (Q7R) in cholestasis has been established. In this study, we aimed to establish a nanoparticle-based peptide, A20FMDV2-modified liposome (t-QL), to encapsulate and deliver Q7R. Q7R bioavailability improved significantly when liposomes were used as carriers. This peptide A20FMDV2-modified nanosystem targeted integrin αvβ6 on biliary epithelial cells and improved stillbirth rates and liver function indicators better than free Q7R without a carrier. Q7R improved ICP by regulating mitochondrial function and bile metabolism. Our nanosystem provides a promising nanotherapeutic strategy for applying Q7R in ICP. We also elucidated a therapeutic mechanism underlying the action of ICP by simultaneously targeting mitochondrial structure and function, as well as bile acid metabolism.
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Ziheng Song,Quan Zhao,Jianyu Wang,Yong-Jun Tian,Wen Wang,Hanze Ma,Qianfeng Pan,Sheng Yuan,Shilin Guo,Da Zhang,Yanxiong Ren,Jing Ma,Guangwei He,Zhongyi Jiang
Metal organic framework (MOF) membranes represent one of the most promising materials for helium (He) separation membranes. However, conventional fabrication methods using high-boiling-point solvents often generate defects during activation. This work employs a mixed-solvent-assisted electrodeposition method for ZIF-7 membranes wherein the DMF solvent lowers the ligand deprotonation energy barrier and the methanol solvent increases the solution supersaturation, synergistically enhancing the nucleation rate and nucleation density. Concurrently, the introduction of methanol leads to reduced precursor solubility, thereby reducing the ZIF-7 growth rate. Additionally, the use of methanol allows activation of the ZIF-7 via mild conditions, suppressing the formation of defects. As a result, ultrathin (160 nm) ZIF-7 membranes with low crystallinity and reduced intercrystalline defects are fabricated for the first time, achieving efficient He separation. The membrane on anodic aluminum oxide (AAO) demonstrates a He/N 2 selectivity of 261.2, which is nearly an order of magnitude higher than other reported He-selective MOF membranes. Continuous operation exceeding 144 h confirms exceptional stability. Successful fabrication on porous ceramic substrates with maintained separation performance underscores application potential of our strategy.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ritong Wang,Zuozhu Yin,Xiangyu Han,Yining Zhang,Suhang Zhang,Xiangyu Lan,Yuhua Chen,Zhen Hong,Chan Xie,Jilin Xu,Mingshan Xue
The aviation industry's rapid development highlights aircraft metal corrosion, especially for parts like nacelle lips exposed to varying environments, greatly impacting flight safety. In this paper, we propose a “sandwich” superhydrophobic anticorrosive coating containing ZIF-7, which utilizes nanocontainer technology to achieve rapid environmental response. ZIF-7-encapsulated corrosion inhibitor releases during corrosion, preventing leakage and coating damage. In addition, a superhydrophobic coating has been added on top of the anticorrosive coating, which has been imparted with a surface water contact angle of up to 154 ± 3° and a water sliding angle of about 3°. It also has excellent physical/chemical stability, and it remains superhydrophobic even after repeated mechanical abrasion and acid/alkali immersion. The double-layer structure not only further enhances the ‘labyrinth effect’ and extends the path for corrosive media to reach the metal surface, but also successfully isolates water and oxygen from the surface of the coating, which significantly improves the coating's functionality and anticorrosion performance. The highest impedance modulus of 1.3931 × 10 11 Ω·cm 2 is 10 7 fold higher than that of the bare Al alloy sheet. After 30 days of salt spray experiments to accelerate the corrosion rate, the bare Al alloy sheet corroded significantly smaller on the fifth day, while the ZB/ZnO did not undergo significant changes, and healing occurred at the scratches. Our study introduces ZIF-7 to the field of corrosion protection by superhydrophobic coating, providing insights into practical applications and the field of aircraft lip corrosion protection.
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NATURAL PRODUCT RESEARCH
·
2020
·
IF 2.158
Qian-Qian Pang,Yu-Dan Mei,Yuan-Chu Zhang,Ling-Xian Liu,Dan-Feng Shi,Da-Bo Pan,Xin-Sheng Yao,Hai-Bo Li,Yang Yu
Ten cycloart-7-ene triterpenoid glycosides, including three new compounds (1–3), were isolated from the roots of Cimicifuga dahurica. Their structures were elucidated on the basis of extensive spectroscopic analyses, chemical methods and comparison with literatures. In addition, the isolates were evaluated for their inhibitory effects on the production of NO, as well as the expressions of iNOS and COX-2 in LPS-stimulated RAW 264.7 macrophages. The results showed that compounds 3, 5, 6, 7 and 8 can reduce the release of NO in a dose-dependent manner. Mechanistically, Western blot analysis indicated that the NO inhibitory effects relied on down-regulating the expression of iNOS, and partially associated with lowering the expression of COX-2.
研究领域:
药理学
·
植物化学
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高影响因子
RSC Advances
·
2021
·Vol. 11
·期 44
·27207-27214
·
IF 3.361
Hongmei Zhang,Yuxiang Chen,Shichao Xu,Jing Wang,Huanhuan Dong,Zhendong Zhao,Jianxin Jiang
In this study, a series of novel p-menthane type secondary amines (sec-p-menthane-7-amine derivatives 3a–3y) were synthesized and then characterized by FTIR, 1H NMR, 13C NMR, and HRMS. The post-emergence herbicidal activities of these amines against barnyard grass and rape were evaluated by the culture dish method. Most of the sec-p-menthane-7-amine derivatives showed excellent herbicidal activities equivalent to or even higher than either diuron or glyphosate. The alkyl-substituted derivatives were more active than the phenyl-substituted derivatives. The herbicidal activities of compounds 3p, 3r, 3u, and 3w against the root growth of barnyard grass were 404% higher, respectively, than those of glyphosate. The herbicidal activities of compounds 3q, 3v, 3w, and 3x against the root growth of rape were 561%, 494%, 491%, and 544% higher, respectively, than those of diuron, and 484%, 760%, 423%, and 665% higher respectively, than those of diuron against shoot growth of rape. In addition, compounds 3p, 3u, and 3v are almost harmless to rice, wheat, sorghum, maize, and peanuts at a concentration of 100 mg L−1. Most of the compounds are nontoxic to HUVEC-C and BALB/c 3T3 cells. It is indicated that the title compounds could be utilized as botanical herbicides for future weed control.
研究领域:
植物学
·
药理学
·
农业化学
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PROPELLANTS EXPLOSIVES PYROTECHNICS
·
2025
·Vol. 51
·期 2
·170-181
·
IF 2
Kai Yin,Wenyu Wu,Xiaoyan Chen,Wenjie Liu,Xiaodong Li
Modifying the microforms of energetic materials can greatly improve their safety performance and energy release efficiency. This study spherical RDX/FOX-7 composite crystals with high energy density and low sensitivity were created using an independently constructed modular microreaction system combined with solvent-nonsolvent and crystallization technology. The effects of four distinct solution concentrations on the morphology and particle size distribution of RDX/FOX-7 composite crystals were investigated, and the formation mechanism of the composite crystals was analyzed. Meanwhile, the crystal structure, molecular structure, and thermal properties of RDX/FOX-7 composite crystals were characterized, and the mechanical sensitivity and combustion performance of the composite samples at the optimal concentration were tested. The results show that when the solution concentration is 0.35 g/mL, spherical-like composite crystals with an average particle size of 1.83 µm and uniform particle size distribution can be obtained. The thermal performance analysis indicates that the average activation energy of thermal decomposition of the composite crystals at this concentration has increased to 232.31 kJ⋅mol −1 , which is 48.84 kJ⋅mol −1 higher than that of the raw RDX. The mechanical sensitivity test shows that the composite crystals' impact force and friction load are 17.5 J and 288 N, respectively, 94% and 125% higher than raw RDX. Meanwhile, the combustion performance test confirmed that the RDX/FOX-7 composite crystals can release energy efficiently during combustion and have better stability. Its overall performance is better than that of the raw materials. This study provides important theoretical support for designing and preparing new energetic materials.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jun Zhu,Jingjing Chen,Congcong Wang,Dehong Yu,Minghao Chao,Hanrong Yan,Ruqi Huang,Zhenxin Wang,Bin Pan,Fenglei Gao
Insufficient generation of reactive oxygen species and the highly active cholesterol metabolism of tumors are two major barriers limiting the efficacy of conventional ferroptosis-based cancer therapies. Here, we engineered a single-atom iron nanozyme (Fe-NC@TASIN-30@FA, abbreviated as FTF) to overcome ferroptosis resistance and sensitize tumors to apoptosis-coupled catalytic therapy by simultaneously delivering a distal cholesterol synthesis inhibitor and catalytically amplifying ROS production. FTF is constructed by loading a selective 7-dehydrocholesterol (7-DHC) synthesis inhibitor, TASIN-30, onto an iron single-atom nanozyme and further functionalizing it with folate-modified polyethylene glycol (SH-PEG-FA) to confer tumor-targeting capability. Notably, TASIN-30 is incorporated with a drug-loading rate of 22.5%, providing efficient payload delivery without compromising nanozyme activity. The iron active centers in FTF exhibit dual enzyme-mimetic activities. One of them is peroxidase-like activity that breaks down H 2 O 2 into hydroxyl radicals, and the other is glutathione peroxidase-like activity that catalyzes the oxidation of reduced glutathione to oxidized glutathione, thereby increasing intracellular ROS levels and consuming antioxidants to achieve a coordinated iron apoptosis effect. In addition, by inhibiting 7-DHC and cholesterol biosynthesis, FTF accelerates the consumption of excess intracellular cholesterol in tumor cells, disrupts the integrity of lipid rafts, and consequently suppresses tumor cell proliferation. In 143B tumor-bearing nude mice, FTF achieves an in vivo tumor inhibition rate of approximately 82.5%, while exhibiting a maximum tolerated dose of 7.5 mg/kg. Overall, this study proposes a new therapeutic strategy that integrates cholesterol metabolic interference with catalytic nanozyme therapy, providing a potent ferroptosis-apoptosis synergistic modality for tumors refractory to conventional treatments.
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OPTICAL MATERIALS
·
2020
·
IF 2.779
Hua Yu,Fengping Ruan,Leifeng Chen,Degang Deng
Ca 9 Zn 1.5 (PO 4 ) 7 : Eu 2+ /Eu 3+ phosphors had been synthesized via conventional high temperature solid-state reaction. Based on the different thermal quenching characteristics between 4f-5d transition of Eu 2+ ions and 4f-4f transition of Eu 3+ ions, the fluorescence intensity ratio (FIR) of Eu 3+ to Eu 2+ exhibits temperature dependence at the temperature from 293 to 473 K. The maximum absolute and relative temperature sensitivity of Ca 9 Zn 1.5 (PO 4 ) 7 : Eu phosphor can reach up to 0.0034 K −1 and 1.4% K −1 at 453 K, respectively, when used as thermometric material. These results indicated that our study opens up an effective approach for developing other high-performance self-calibrated optical thermometers.
研究领域:
材料科学
·
光学传感器
·
发光材料
·
测温技术
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危险品化学品经营许可证（带存储）