GIANT
·
2022
·
IF 0
Yifan Jia,Weiwen Yuan,Mengmeng Xu,Congyi Yang,Lei Chen,Shuo Wang,Paul D. Topham,Guoxuan Luo,Mo Wang,Yong Zhang,Guihua Jiang,Qianqian Yu,LinGe Wang
Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T 1 positive MRI visibility, MRI contrast agent (CA), Gd(OH) 3 , is introduced in a new, extremely convenient method. Crucially, GdCl 3 is reacted with NaOH in situ during electrospinning, with flexibility to deliver both well-dispersed and aggregated Gd(OH) 3 clusters within a poly(ethylene terephthalate) (PET) matrix. T 1 and T 2 relaxivities of Gd(OH) 3 in PET nanofibers are studied. Well-dispersed Gd(OH) 3 (sub-nanometer in size) exhibits 34 times higher T 1 relaxivity than aggregated nanoparticles when embedded within the fibers. The morphology, structure, magnetic properties, tensile properties, imaging performance and biosafety of the PET/Gd(OH) 3 composite fibers are evaluated to identify the optimum conditions to produce new materials with balanced properties, excellent in vivo positive contrast and approximately 139 days imaging lifetime. Comparing this sample with a commercial CA, only 0.32 wt.% Gd loading is needed to attain similar MRI signal intensity. In summary, PET/Gd(OH) 3 long-term MRI-active fibers show great potential for future biomedical applications and the study also provides a promising new general strategy to enhance the MRI T 1 positive contrast of electrospun fibers of a whole host of other systems.
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International Journal of Minerals Metallurgy and Materials
·
2024
·Vol. 31
·期 7
·1651-1658
·
IF 5.6
Zhang Peixiong,Wang Enhui,Liu Jingjing,Yang Tao,Wang Hailong,Hou Xinmei
Thermal insulation materials play an increasingly important role in protecting mechanical parts functioning at high temperatures. In this study, a new porous high-entropy (La 1/6 Ce 1/6 Pr 1/6 Sm 1/6 Eu 1/6 Gd 1/6 )PO 4 (HE (6RE 1/6 )PO 4 ) ceramics was prepared by combining the high-entropy method with the pore-forming agent method and the effect of different starch contents (0–60vol%) on this ceramic properties was systematically investigated. The results show that the porous HE (6RE 1/6 )PO 4 ceramics with 60vol% starch exhibit the lowest thermal conductivity of 0.061 W·m −1 ·K −1 at room temperature and good pore structure stability with a linear shrinkage of approximately 1.67%. Moreover, the effect of large regular spherical pores (>10 µm) on its thermal insulation performance was discussed, and an optimal thermal conductivity prediction model was screened. The superior properties of the prepared porous HE (6RE 1/6 )PO 4 ceramics allow them to be promising insulation materials in the future.
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Nano-Micro Letters
·
2020
·Vol. 12
·期 1
·1-14
·
IF 12.264
Fang Hanyi,Li Mengting,Liu Qingyao,Gai Yongkang,Yuan Lujie,Wang Sheng,Zhang Xiao,Ye Min,Zhang Yongxue,Gao Mingyuan,Hou Yi,Lan Xiaoli
A biomimetic nanoprobe was built with cancer cell membrane-coated and Gd 3+ -doped upconversion nanoparticles.
The nanoprobe could be applied to in vivo UCL/MRI/PET multimodality precise imaging and successfully differentiated MDA-MB-231 tumor models through in vivo tri-modality imaging, which may be used for breast cancer molecular classification.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
医学成像
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PubMed
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 7
·1364-1373
·
IF 1.474
Zhang Yumei,Pei Ruina,Luo Tao
ABSTRACT
The development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2
oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards
to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic
origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution.
When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression.
During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body
and further used for the early diagnosis of abdominal tumors.
研究领域:
医学影像学
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纳米生物学
·
肿瘤学
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Materials
·
2023
·Vol. 16
·期 20
·6667
·
IF 3.4
Yukun Li,Svenja Hanson,Cheng Heng Pang,Peng Lyu,Jun Jiang
In order to attain phosphor ceramics with a high Color-Rendering Index (CRI), samples with the composition of Y0.997−xRexCe0.003)3(Al0.9748Mn2+0.024Cr3+0.0012)5O12(Rex= 0, Gd0.333, Gd0.666, Gd0.997, Tb0.333, Tb0.666, Tb0.997and Lu0.997were prepared by solid-state reaction and vacuum sintering, and exhibited potential for high-quality, solid-state lighting. Doping with Cr3+and Mn2+effectively enhanced the red component of Ce3+spectra through the intense energy transfer from Ce3+ions to Mn2+/Cr3+ions. The crystal field splitting of [GdO8] and [TbO8] was more extensive than that of [YO8], causing a massive redshift in the Ce3+emission peaks from 542 to 561 and 595 nm, while [LuO8] had an opposite effect and caused a blueshift with a peak position at 512 nm. White LED devices incorporating Ce/Mn/Cr: (Gd0.333Y0.664)3Al5O12phosphor ceramic exhibited a high CRI of 83.97, highlighting the potential for enhancing the red-light component of white LED lighting.Keywords:garnet phosphor;laser lighting;full spectrum;spectral modulation;Ce/Mn/Cr: (Re,Y)3Al5O12
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PubMed
高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 152
·期 12
·3772-3784
·
IF 2.936
Zhou Shuyu,Chen Zezhi,Gong Huijuan,Chen Lu,Yu Huiqiang
Nickel (Ni)-based catalyst is widely adopted for tar removing in the process of biomass gasification. In order to improve low-temperature catalytic activity of Ni-based catalyst, three-dimensional ordered macro/mesoporous (3DOM/m) Ce 0.8 Zr 0.1 M 0.1 (M = Gd, Pr and La) ternary solid solutions were prepared and used as the carriers of Ni/Ce 0.8 Zr 0.1 M 0.1 catalysts. The obtained catalysts were employed to catalyze the steam reforming of toluene (SRT). The results demonstrated that all the Ni/Ce 0.8 Zr 0.1 M 0.1 showed excellent low-temperature catalytic activity and presented higher toluene conversion than Ni/Ce 0.8 Zr 0.2 . Among the catalysts, Ni/Ce 0.8 Zr 0.1 Pr 0.1 exhibited the highest toluene conversion, reaching 96.1% at 550 ℃ (toluene = 185 μmol min −1 , S/C = 3). The characterization results of catalysts showed that all the catalysts presented ordered three-dimensional morphology containing interconnected periodic macropores with abundant mesopores existing on the wall. The rare earth dopants were incorporated into the lattice of cerium-zirconium solid solution. As a result, the thermal stability of the carrier was improved, which made the BET specific surface area of the carrier increase and the dispersion of active component of Ni increase. Moreover, the incorporation of dopants produced more oxygen vacancies, thus improved reactive oxygen mobility. These superior properties of 3DOM/m Ce 0.8 Zr 0.1 M 0.1 led to their excellent catalytic activity in SRT. Graphical Abstract
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高影响因子
TALANTA
·
2020
·
IF 5.339
Xing-Hui Ren,Hai-Yan Wang,Si Li,Xi-Wen He,Wen-You Li,Yu-Kui Zhang
Early and accurate detection of breast cancer plays an important role in improving the survival rates of patients. In this work, we designed and synthesized the Gal-NAc-imprinted nanoparticles (GIPs) via boronate-affinity glycan-oriented surface imprinting strategy. Molecularly imprinted polymers (MIPs) were hybridized with fluorescent silicon nanoparticles (SiNPs) to target Tn antigens. However, the single fluorescent imaging mode is not conducive to obtaining accurate diagnosis, due to its poor tissue penetration. To resolve this obstacle, doping gadolinium (Gd) into SiNPs was adopted to emerge an extra significant magnetic resonance (MR) signal, achieving highly sensitive fluorescence imaging and magnetic resonance imaging (MRI) with high spatial resolution. GIPs had uniform particle size around 31.8 nm, and exhibited satisfactory fluorescence stability. The maximum adsorption capacity of GIPs was 1.15 μM/g with a high imprinting factor (IF) of 7.5. Confocal laser scanning microscope imaging revealed that the GIPs had excellent specific recognition ability with a low cytotoxicity. GIPs also showed an outstanding MR performance on cancer cells. Therefore, the synthesized nanoparticles had desirable performance in dual-model imaging to specifically target recognition cancer cells. It may have a tremendous potential in real biological samples.
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PubMed
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2020
·Vol. 37
·期 4
·2000044
·
IF 3.099
Kehan Xu,Na Xu,Yanchao Zhu,Mengsi Zhang,Weijun Tang,Yun Ding,Aiguo Hu
Conformity of two biological imaging entities, magnetic resonance imaging (MRI) and fluorescence imaging, is achieved through co-assembly of a Gd(III)-based metallosurfactant, conjugated polymeric nanoparticles, and amphiphilic block copolymer F127 (PEO 106 PPO 70 PEO 106 ) followed by crosslinking with organosilica. The cross-linked micelles with a size around 100 nm exhibit outstanding dispersion stability in aqueous and phosphate buffered saline solutions, bright fluorescence emission, and high relaxivities, providing a new approach to synthesize highly efficient bimodal contrast agents. The relaxivities of the co-assembled micelles are synergistically enhanced by incorporation of Gd(III) complexes with high hydration number ( q = 3) and elongation of rotation correlation time to achieve r 1 values up to 105.37 m m −1 s −1 (at 1.5 T), which is over 20 times that of clinically used MRI contrast agents and among the highest values of all the nanoparticular MRI contrast agents. The external PEO layer endows these micelles with very low cytotoxicity for both in vitro and in vivo imaging. Meanwhile, thanks to the enhanced permeability and retention effect originating from their nanoscale sizes, the bimodal contrast agents show a prolonged blood circulation time in vivo and targeted accumulation at tumor regions to display outstanding MRI imaging performance.
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高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Nan Zhang,Shan-Shan Han,Yun Xie,Da-Li Chen,Wen-Dong Yao,Xiao Huang,Wenlong Liu,Sheng-Ping Guo
Rare-earth (RE) chalcogenide borates are very rarely discovered in view of the difficulties in synthesis though they have demonstrated attractive physical performances. Here, the first mixed RE chalcogenide borates Eu5.4Sm3.6MgS2B20O41 (1) and Eu3Gd6MgS2B20O41 (2) are synthesized by combining RE, sulfur, and borate ions into one structure. They crystallize in the centrosymmetric hexagonal space group P63/m, and their 3D honeycomb-like {[B20O41]22–}∞ open frameworks are built by [B6O9(O0.5)6]6– and [B7O13(O0.5)3]8– polyanionic clusters and consolidated by Mg2+ ions; both of which are formed by BO4 tetrahedra and BO3 planar triangles. The coordination modes of RE ions are rare REO6S2 bicapped trigonal prisms and REO8S irregular polyhedra, and their band gaps are determined to be 2.25 and 2.22 eV, respectively. They exhibit antiferromagnetic interactions and distinct photocurrent responses. The corresponding theoretical calculations are also performed. The study of 1 and 2 perhaps stimulates interest in exploring new functional RE chalcogenide borates.
研究领域:
无机化学
·
材料科学
·
固态化学
·
功能材料
·
晶体学
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2013
·Vol. 97
·期 3
·990-995
·
IF 2.107
Kuo Jiang,Songbai Liu,Yuan Li,Yaofei Li
Powders of zirconia doped with 8 mol% REO 1.5 (RE = Yb, Y, Gd, and Nd) were synthesized by using the sol–spray pyrolysis method. The effects of RE 3+ ionic radius on monoclinic (m) phase content of powders were investigated. The XRD results showed that the metastable tetragonal (t′) phase underwent a complete phase change to form m and cubic (c) phases after a heat treatment of 50–100 h at 1450°C. A cation size-dependent reduction in the m phase content of the REO 1.5 partially stabilized ZrO 2 powders was observed. The SEM–EDS analysis of the powders revealed that the RE 3+ concentrations in the c phases decreased with decreasing the RE 3+ ionic radius. These results indicate that the stabilizer concentration of the c phase can be attributed to RE 3+ ionic radii, resulting in different m phase contents. Compared to the REO 1.5 single doped ZrO 2 , the m phase contents of 8 mol% (RE 0.5 Yb 0.5 )–ZrO 2 (RE = Y, Gd, and Nd) powders were significantly reduced. The results prove that the stabilizer with a lower RE 3+ size is effective in reducing the m phase content of partially stabilized ZrO 2 after annealing at high temperatures.
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高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Fei-Fei Lu,Jia-Hong Li,Qi Ma,Changjiu Li,Venkataraman Thangadurai,Chengxin Li
Metal-supported solid oxide fuel cells (MS-SOFCs) exhibit numerous advantages, including thermal cycle stability, rapid start-up and lower costs. However, the slow oxygen reduction reaction (ORR) at the cathode, especially at intermediate-low temperatures, poses a critical challenge to the development of MS-SOFCs. Here, we report a synergistic effect of co-doping in a cation-ordered double perovskite type material, Sm(Ba0.5Sr0.5)Co2-xFexO5+δ (SBSCFx), which has enhanced catalytic activity for ORR and chemical compatibility with Ce0.9Gd0.1O2-δ (GDC). X-ray photoelectron spectroscopy and thermogravimetric analysis were used to examine how Fe-doping in SBSCFx impacts the functional properties. A composite cathode with GDC was further prepared to enhance thermal compatibility with GDC, which effectively reduces the thermal expansion of the SBSCFx cathode from 23.35×10-6 K-1 to 15.04×10-6 K-1. The electrochemical results of symmetrical cells and the DRT fitting analysis demonstrate that the SBSCFx-GDC composite cathode exhibits strong ORR activity. Notably, the SBSCF10-GDC composite cathode achieves a remarkably low polarization resistance of 0.05 Ω·cm² at 650°C. The metal-supported single cell with SBSCF10-GDC cathode exhibited an open-circuit voltage of 0.85 V and showed a peak power density of 833 mW cm-² at 650℃. Furthermore, its stability during long-term cell operation highlights its potential as a cathode for intermediate-low temperature metal-supported SOFCs.
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高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Yaochen Si,Lingfeng Li,Ruida Wang,Songting Zhang,Yingnan Cao,Hongyu Li,Shixian Zhao,Hongxia Li,Jing Feng
With the development of high power and high thrust-weight ratio aeronautics and astronautics, aircraft engines and gas turbine technology, the development of thermal barrier coating (TBCs) material is an enormous challenge, which requires both high temperature stability and resistance to molten calcium-magnesium-aluminosilicate (CMAS) corrosion. In this study, five high-entropy rare-earth tantalate (5RE 0.2 )TaO 4 (Re=Y, Gd, Dy, Ce, Sm, La, Yb) ceramics were prepared by high temperature solid state reaction. The phase composition, microstructure, thermophysical and mechanical properties and CMAS corrosion resistance of the obtained high-entropy (5RE 0.2 )TaO 4 ceramics were systematically investigated. The as-prepared five high-entropy rare-earth tantalate (5RE 0.2 )TaO 4 ceramics had monoclinic structure and uniform composition. The five (5RE 0.2 )TaO 4 ceramics all had lower Young’s modulus (135.06∼158.63 GPa), Vickers hardness (3.7∼6.2 GPa), fracture toughness (2.30-2.80 MPa·m 1/2 ) and brittleness index (1.45-2.53 μm –1/2 ) than that of YSZ. The thermal expansion rate and thermal expansion coefficients of the five (5RE 0.2 )TaO 4 ceramics were close to each other but showed higher value than that of single RETaO 4 (RE= Gd, Dy, Sm or Y) and lower value than that of YSZ. The thermal diffusivities and thermal conductivity of the five (5RE 0.2 )TaO 4 ceramics were lower than that of YSZ, YTaO 4 and GdTaO 4 at all temperature. During molten CMAS corrosion, CMAS melt diffused into the (5RE 0.2 )TaO 4 ceramics and then corroded (5RE 0.2 )TaO 4 grains, thereby forming a corrosion area composed of reaction layer and penetration layer. The CaO in penetrated CMAS melt could react with Ta element in (5RE 0.2 )TaO 4 ceramics to generate Ca 2 Ta 2 O 7 in the reaction layer and reduce the content of CaO in the penetrated CMAS melt, which increased the viscosity of the CMAS melt and inhibited the further penetration of CMAS into the ceramics. Based on the obtained results, the CMAS corrosion of (5RE 0.2 )TaO 4 ceramics was primarily controlled by the Ca 2 Ta 2 O 7 formation and the CMAS penetration.
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