Biomaterials Science
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2022
·Vol. 10
·期 16
·4549-4560
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IF 7.59
Ying Qian,Jiarong Mao,Xuejiao Leng,Ling Zhu,Xue Rui,Zhetong Jin,Houzhe Jiang,Heng Liu,Fengguang Zhang,Xiaolin Bi,Zhipeng Chen,Jingjing Wang
Immunological checkpoint inhibitors provide a revolutionary method for cancer treatment. However, due to low tumor mutations and insufficient infiltration of immune cells into the tumor microenvironment, 85% of colorectal cancer patients cannot respond to checkpoint blockade immunotherapy. In this study, tumor microenvironment-responsive deformable nanoparticles (DMP@NPs) were rationally designed to improve immunotherapy by synergistically modulating the immune tumor microenvironment. DMP@NPs self-assemble from a newly synthesized tumor acidity responsive polypeptide checkpoint inhibitor polymer (PEG–DMA–DPPA-1) with immunogenic cell death (ICD) enhanced combination drugs containing a certain proportion of mitoxantrone (MITX) and proanthocyanidins (PC). Upon tumor acidity-triggered cleavage of PEG–DMA–DPPA-1, DMP@NPs undergo special “sphere-ring deformation” dissociation, gradually releasing polypeptide checkpoint inhibitor DPPA-1, MITX and PC. MITX/PC in vitro synergistically triggers higher ICD with the release of the high mobility group box-1 (HMGB-1) and calreticulin (CRT). After intravenous injection of DMP@NPs, the local tumor microenvironment of CT26 tumor-bearing mice was reprogrammed, and dendritic cell activation and T cell infiltration were significantly increased. Most importantly, the synergistic immune nanodrug DMP@NPs improved the efficacy of colorectal cancer immunotherapy and reduced toxicity and side effects for the immune organs.
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高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2022
·
IF 10.319
Shaofeng Zhou,Jin Yan,Jialin Chen,Huimin Yan,Yin Zhang,Jin Huang,Guizhe Zhao,Qiaoxin Zhang,Yaqing Liu
To enhance the wear resistance of graphene oxide (GO) nano-filled epoxy resin (EP) coatings with excellent dispersion, GO were modified using a co-crosslinking strategy between polydopamine (PDA) and polyethyleneimine (PEI) through an environmentally friendly, simple and low-cost process. High-density amino-branched PEI and highly adhesive PDA formed covalent bond cross-links with GO (PDA/PEI-GO) through the Michael addition and Schiff base reactions. With the introduction of amino active sites, the PDA self-polymerization reaction time was significantly shorted from 24 to 6 h. The covalently cross-linked network increased the lamellar spacing of GO and enhanced the interfacial bonds between the PDA/PEI-GO lamellae and EP matrix. Due to the improved dispersion and surface activity of GO, the PDA/PEI-GO nano-filled EP coating exhibited excellent wear resistance. Reciprocating friction with GCr15 stainless steel ball, the average friction coefficient and wear rate of the coating were reduced by 31.9% and 62.7%, respectively, compared to the pure EP coating. In addition, the wear mechanism of the PDA/PEI-GO/EP coating changed from adhesive and fatigue wear to abrasive wear, and it maintained good wear resistance by forming a GO lubrication transfer film on the counterpart surface. Therefore, this study may provide a new strategy for improving the dispersion of graphene in wear-resistant polymer materials for practical applications.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2022
·Vol. 414
·期 23
·6791-6800
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IF 4.478
Zhou Zhen-Fan,Feng Xiao-Zhen,Zhan Tao,Han Guo-Cheng,Chen Zhencheng,Kraatz Heinz-Bernhard
Folic acid (FA) is essential for human health, particularly for pregnant women and infants. In this work, a glassy carbon electrode (GCE) was modified by a bimetallic layer of Cu/Co nanoparticles (CuNPs/CoNPs) as a synergistic amplification element by simple step-by-step electrodeposition, and was used for sensitive detection of FA. The proposed CuNPs/CoNPs/GCE sensor was characterized by differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and field emission scanning electron microscopy (FESEM). Then, under optimal conditions, a linear relationship was obtained in the wide range of 110.00–1750.00 μM for the detection of FA with a limit of detection (LOD) of 34.79 μM ( S/N = 3). The sensitivity was calculated as 0.096 μA μM −1 cm −2 . Some interfering compounds including glucose (Glc), biotin, dopamine (DA), and glutamic acid (Glu) showed little effect on the detection of FA by amperometry ( i-t ). Finally, the average recovery obtained was in a range of 91.77–110.06%, with a relative standard deviation (RSD) less than 8.00% in FA tablets, indicating that the proposed sensor can accurately and effectively detect the FA content in FA tablets.
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Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 15
·3679-3691
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IF 7.779
Lei Fan,Lianming Zhao,Yuchao Lv,Tinghu Wang,Yupeng Tian,Jianye Fu,Xinmei Liu
The synthesis of highly-dispersed non-noble metal based catalysts and their application in hydrogenation/dehydrogenation still remain challenging. Therefore, it is of great importance to protect metals from aggregation in both calcination and reduction processes. In this research, density functional theory (DFT) calculations were used to elucidate the stabilization effect of ionic liquid [Bmim][BF4] on Ni in the reduction process, showing that [Bmim][BF4] could efficiently inhibit Ni aggregation on the support. By further analysis combined with theoretical calculations, we found that the degree of metal dispersion before reduction directly determines the effect of [Bmim][BF4]. Guided by the DFT results, the method of co-assisted preparation of Ni/SAPO-11 using [Bmim][BF4] and lysine was adopted. Lysine forms a coordination compound with nickel oxides. The steric hindrance generated by the Ni–lysine complex can effectively inhibit the aggregation of nickel oxides during the calcination process. The DFT calculations revealed that during the reduction process, [BF4−] plays a dominant role in stabilization and electronic modulation by directly interacting with Ni on the support. The combination effects of [Bmim][BF4] and lysine effectively inhibit metal aggregation, leading to ultra-small nickel particles with a mean size of 4.4 nm over the obtained catalyst. Furthermore, the presence of [Bmim][BF4] also tunes the electronic state of Ni species. Using hexane isomerization as a probe reaction, the result indicates the excellent catalytic activity of the obtained catalyst (≈93.7% isomer selectivity at 63.5% conversion), much superior to that of Ni/SAPO-11 obtained from the traditional impregnation route (≈75.8% isomer selectivity at 64.6% conversion). This work provides a new method for the preparation of highly effective non-noble metal supported catalysts.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Hui Yang,Wei Shuai,Xinwei Zhu,Lei Lai,Jie Liu,Changwei Li,Jie Yang,Guangjin Wang,Yingxi Chen
The exploration of high-efficiency non-noble metal catalysts for improving the intrinsic activity and active sites for overall water splitting persists as a bottleneck issue. Herein, a facile heterogeneous molten salt strategy has been proposed to fabricate CoP/Co nanosheets array that is vertically attached to a carbon matrix. Such a hierarchical structure endows the hybrid with abundant active sites and favorable reaction kinetics. Experimental results reveal that the molten salt determines the final shape of metallic Co, which is not sensitive to the organic sources. After optimization of the molten salt mass, the CoP/Co/C-6 shows the best bifunctional performance, requiring an overpotential of 132 mV and 320 mV at 10 mA cm −2 for hydrogen evolution reaction and oxygen evolution reaction, respectively. Theoretical simulation results manifest the CoP/Co heterostructure alters the electronic structure of Co and CoP , and reduces the adsorption free energy of intermediates, thus further boosting the electrocatalysis activity. This work proposes a molten salt-assisted method for the rational design of novel two-dimensional nano-hybrids for energy conversion applications.
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RESOURCES CONSERVATION AND RECYCLING
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2022
·
IF 13.716
Longgong Xia,Shuheng Cao,Qihou Li,Xingwu Lu,Zhihong Liu
Copper smelting slag and gypsum residue are by-products in copper making processes, and both contain valuable elements, such as copper, sulfur, etc. However, there is more than 0.25 wt% Cu in the smelting slag, which cannot be recovered with present technologies. A sulfidation process, which used the gypsum residue as the sulfur resource, was proposed and studied in treating copper smelting slag. Obtained results showed: 1) CaSO 4 transformed to CaS under reductive decomposing conditions, and reactions between CaS and slag components occurred spontaneously during the slag cooling process; 2) the Fe/SiO 2 mass ratio of the slag, the CaS excess coefficient (α), and the cooling rate (v) had an influence on the terminal phase composition, sulfide particle size, etc.; 3) under optimized conditions (Fe/SiO 2 =1.0: α=5, v = 1.00°C/min; Fe/SiO 2 =1.3: α=4, v = 0.25°C/min; Fe/SiO 2 =1.8: α=5, v = 0.25°C/min), the Cu contents in non-sulfide phases were lower than 0.08 wt%, and the mean particle size of sulfides were 37- 40 μm, which were feasible for flotation recoveries. TCLP (Toxicity Characteristic Leaching Procedure) tests indicated that the co-treatment process improved the stability of these starting materials. Based on samples characterization and thermodynamic analysis, a corresponding reaction mechanism was proposed.
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LANGMUIR
·
2022
·
IF 4.331
Shuhong Li,Fan Yang,Kailing Xiang,Jiacheng Chen,Ye Zhang,Jincheng Wang,Jibo Sun,Yuan Li
A multifunctional microspheric soil conditioner based on chitosan-grafted poly(acrylamide-co-acrylic acid)/biochar [CS-g-P(AM-co-AA)/BC] was prepared. First, the P(AM-co-AA) was synthesized and successfully grafted onto CS, and the three-dimensional network structure of microspheres was formed with N,N-methylenebis(acrylamide) as the cross-linking agent according to the inverse suspension polymerization method. Meanwhile, BC and urea were encapsulated into the body of microspheres during the polymerization. The structure of the microspheres was analyzed by Fourier transform infrared spectroscopy, polarized optical microscopy, and scanning electron microscopy, and the mechanism of adsorption of Cu2+ on the microspheres was investigated by X-ray photoelectron spectroscopy. Furthermore, the experimental results demonstrated the excellent water absorption and retention capabilities of microspheres, and the release rate of urea was dramatically reduced. Importantly, the introduction of BC significantly enhanced the adsorption performance of the microspheres with respect to heavy metal ions. Consequently, the multifunctional soil conditioner held promise for use in soil improvement and agricultural production.
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Advanced Optical Materials
·
2022
·Vol. 10
·期 11
·2102848
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IF 10.05
Xiaoxiao Xu,Ting Zhu,Ke Xiao,Yu Zhu,Jiaming Chen,Dongke Li,Ling Xu,Jun Xu,Kunji Chen
The preparation of high-efficiency perovskite light-emitting devices (PeLEDs) in the air-ambient has always been a challenge. Herein, the authors propose a Si-based near-infrared air-processed PeLED through the anti-solvent engineering. Two materials, poly(methyl methacrylate) (PMMA) and tetrabutylammonium hexafluorophosphate (TBAPF 6 ) are co-doped into the anti-solvent, the former protects the perovskite from degradation in a high-humidity atmosphere, and the latter passivates the defects on perovskite surface and increases the conductivity. Through the anti-solvent engineering, the efficiency of PeLEDs has been significantly enhanced and obtains a maximum external quantum efficiency (EQE) of 10.4%, which is the highest among similar devices. This work shows that it is possible to prepare high-efficiency near-infrared PeLEDs in air-ambient through a simple method.
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JOURNAL OF NANOBIOTECHNOLOGY
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2022
·Vol. 20
·期 1
·1-18
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IF 9.429
Chen Youlu,Chen Zuoguan,Duan Jianwei,Gui Liang,Li Huiyang,Liang Xiaoyu,Tian Xinxin,Liu Kaijing,Li Yongjun,Yang Jing
Peripheral vascular disease (PVD) is a common clinical manifestation of atherosclerosis. Vascular endothelial growth factor (VEGF) gene therapy is a promising approach for PVD treatment. However, due to single-gene therapy limitations and high H2O2 pathological microenvironment, VEGF gene therapy are not as expectations and its clinical application are limited. Synergistic effects of Nerve factors and vascular factors in angiogenesis have attracted attention in recent years. In this study, VEGF and nerve growth factor (NGF) genes co-delivery nanoparticles (VEGF/NGF-NPs) were prepared by using H2O2 responsive 6s-PLGA-Po-PEG as a carrier. 6s-PLGA-Po-PEG could react with H2O2 specifically due to the internal peroxalate bond. Angiogenic effects of VEGF/NGF-NPs has been evaluated in cells and hindlimb ischemia mice model. Results showed that VEGF/NGF-NPs promoted VEGF and NGF co-expression simultaneously, eliminated excessive H2O2, strengthened reactions between SH-SY5Ys and HUVECs, and finally enhanced migration, tube formation, proliferation and H2O2 damage resistance of HUVECs. VEGF/NGF-NPs also recovered blood perfusion, promoted the expression of VEGF, NGF, eNOS and NO, and enhanced vascular coverage of pericytes. Treatment effects of VEGF/NGF-NPs may related to VEGF/eNOS/NO pathway. Altogether, VEGF/NGF-NPs eliminated excessive H2O2 while achieving gene co-delivery, and promoted stable angiogenesis. It’s a promising way for PVD treatment by using VEGF/NGF-NPs.Graphical Abstract
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Biosensors-Basel
·
2022
·Vol. 12
·期 5
·350
·
IF 5.743
Chunyang Wei,Chengzhuang Yu,Shanshan Li,Tiejun Li,Jiyu Meng,Junwei Li
Cell culture plays an essential role in tissue engineering and high-throughput drug screening. Compared with two-dimensional (2D) in vitro culture, three-dimensional (3D) in vitro culture can mimic cells in vivo more accurately, including complex cellular organizations, heterogeneity, and cell–extracellular matrix (ECM) interactions. This article presents a droplet-based microfluidic chip that integrates cell distribution, 3D in vitro cell culture, and in situ cell monitoring in a single device. Using the microfluidic “co-flow step emulsification” approach, we have successfully prepared close-packed droplet arrays with an ultra-high-volume fraction (72%) which can prevent cells from adhering to the chip surface so as to achieve a 3D cell culture and make scalable and high-throughput cell culture possible. The proposed device could produce droplets from 55.29 ± 1.52 to 95.64 ± 3.35 μm, enabling the diverse encapsulation of cells of different sizes and quantities. Furthermore, the cost for each microfluidic CFSE chip is approximately USD 3, making it a low-cost approach for 3D cell culture. The proposed device is successfully applied in the 3D culture of saccharomyces cerevisiae cells with an occurrence rate for proliferation of 80.34 ± 3.77%. With low-cost, easy-to-operate, high-throughput, and miniaturization characteristics, the proposed device meets the requirements for 3D in vitro cell culture and is expected to be applied in biological fields such as drug toxicology and pharmacokinetics.Keywords:microfluidics;droplet arrays;3D cell culture;co-flow step emulsification;lab on a chip
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Qiuyu Cheng,Xin Chen,Peng Jiang,Qiuying Wang,Zhiwei Wang,M.A. Subramanian
Novel blue pigments based on Ba 0.956 Mg 0.912 Al 10.088- x Ni x O 17 (0 ≤ x ≤ 0.3) and Ba 0.956 Mg 0.912 Al 10.088- x Co x O 17 (0 ≤ x ≤ 0.3) solid solutions were successfully synthesized by solid state method. The XRD results confirmed the structure of the as-synthesized sample belongs to hexagonal β -alumina structure with the space group of P 6 3 / mmc. The d-d electron transitions in Ni 2+ /Co 2+ tetrahedral sites in the visible light range are the reason for the blue colors. Then, the as-prepared blue oxides were sintered with ZrO 2 powders at 1400 °C to prepare blue zirconia ceramic materials. Based on XRD and SEM analysis, the pigment phase is stable after high-temperature sintering with ZrO 2 , and a clear grain boundary is observed. The XCT results indicate the prepared blue ceramics are dense and very small pores are rarely distributed inside the blue zirconia ceramic body. Additionally, the mechanical properties of the fabricated blue ceramics were maintained compared to pure ZrO 2 ceramic.
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ACS Applied Energy Materials
·
2022
·
IF 6.959
Guangzhou Hu,Wenying Fu,Yuxiao Lin,Yuanchao Yue,Maosen Wang,Pengbo Liu,Yinwei Li,Jianwei Li,Lu Wei,Xinsheng Zhao,Yongsheng Wei
Electrochemical water splitting to produce clean hydrogen (H2) and oxygen (O2) has emerged as an advanced technology to build a sustainable society. Low-cost electrocatalysts with excellent performance are required to improve the energy efficiency in overall water splitting. Here, a Co-W-B-P/CF catalyst with a nanoflower-like structure consisting of microspheres and nanoflakes was successfully synthesized using a one-step double-pulse electrodeposition approach. When used as a bifunctional electrocatalyst for overall water splitting, Co-W-B-P/CF presented the potentials of 1.57 and 1.86 V at current densities of 10 and 100 mA cm–2 in 1.0 M KOH solution, respectively. This was even comparable to that of the high-cost commercial catalyst Pt/C(−)//IrO2(+). Detailed electrochemical tests also showed that the kinetics, electron transfer, and intrinsic electrocatalytic activity of Co-W-B-P/CF in the HER (hydrogen evolution reaction) and the OER (oxygen evolution reaction) were dramatically improved due to the synergetic effect of co-doped B and P elements. Considering the excellent electrocatalytic performance of Co-W-B-P/CF, along with the simple synthesis method and low cost, bifunctional electrocatalyst Co-W-B-P/CF for overall water splitting is promising.
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