TALANTA
·
2026
·
IF 6.7
Yue Liu,Yu Wu,Lihan Feng,Xinyi Zhang,Jihui Lang,Qi Zhang,Naveen Reddy Kadasala,Wenshi Zhao,Yang Liu
Ciprofloxacin (CIP) is widely utilized for the treatment of bacterial infections due to its broad-spectrum antibacterial properties; however, excessive residues inevitably cause environmental pollution. Therefore, the development of sensitive and accurate analytical methods for CIP detection remains important. Herein, a novel self-cleaning surface-enhanced Raman scattering (SERS) sensor was fabricated for the ultrasensitive and specific detection of CIP. ZnFe 2 O 4 -Cu 2 O-Au@Ag (ZCAA) nanocomposites (NCs) were synthesized by decorating ZnFe 2 O 4 -Cu 2 O with various amounts of Au@Ag nanocrystals, thereby integrating dual functions of pollutant detection and photocatalytic degradation. Finite-difference time-domain (FDTD) simulation was adopted to elucidate the correlation between Au@Ag loading density and SERS performance. After modification with molecular imprinted polymers (MIPs), the prepared ZnFe 2 O 4 -Cu 2 O-Au@Ag-MIPs (ZCAA-MIPs) exhibited robust anti-interference capability, enabling specific detection of CIP even in the presence of structurally similar antibiotics such as tetracycline (TC) and oxytetracycline (OTC). A limit of detection (LOD) of 9.3 × 10 −11 M was achieved in aqueous media. Furthermore, the sensor successfully identified trace CIP on the epidermal surfaces of river snail, demonstrating its practical applicability in real-world samples. Time-resolved photoluminescence (TRPL) and X-ray photoelectron spectroscopy (XPS) analyses revealed that the synergistic interaction between the ZnFe 2 O 4 -Cu 2 O heterojunction and Au@Ag nanocrystals accelerated charge carrier migration and optimized interfacial charge transfer. Density functional theory (DFT) calculations further verified the superior degradation capacity of ZCAA substrate. Benefiting from its intrinsic magnetic properties, ZCAA-MIPs sensor was easily recycled under external magnetic field and retained stable SERS performance after five consecutive recycling cycles. This magnetic MIPs-SERS sensor provides a reliable and sustainable platform for monitoring CIP residues in complex water environments.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Zhenyu Wang,Bo Li,Peng Sun,Binhui Mao,Xinqiang Mao,Jingjie Dai,Zonghua Wang
Efficient generation, transport, and utilization of plasmon-induced hot carriers remain fundamental challenges in the development of photoresponsive electrocatalysts. Herein, a hierarchical Au nanoparticle (NP)-decorated NiFe layered double hydroxide/Ni(TCNQ) 2 heterostructure supported on copper foam (Au NPs–NiFe LDH–Ni(TCNQ) 2 /CF) with a rationally designed conductive Ni(TCNQ) 2 interlayer is engineered, and the Au NPs size is systematically optimized to maximize plasmon-enhanced electrocatalytic performance. The conductive Ni(TCNQ) 2 nanorods serve as both electron-transport pathways and structural scaffolds enabling the growth of ultrathin NiFe LDH nanosheets, while plasmonic Au NPs enable light-driven electronic modulation. The integration of these components establishes efficient pathways for charge generation, separation, and transfer, thereby improving the utilization efficiency of plasmon-generated carriers. Notably, a systematic size-dependent investigation identifies 5-nm Au NPs as the optimal plasmonic configuration, exhibiting the strongest localized surface plasmon resonance enhancement. Under light irradiation, the optimized catalyst achieves an additional overpotential reduction of 22 mV at 100 mA cm −2 and a decreased Tafel slope of 60.47 mV dec −1 , highlighting the critical role of NP dimensions in regulating hot-carrier generation and interfacial charge-transfer efficiency. Importantly, the synergistic interaction between plasmon-induced electronic excitation and conductive interlayer engineering effectively promotes charge transport across the heterointerface and enhances the overall electrocatalytic process. This study provides new insights into the rational design of plasmon-enhanced electrocatalysts and offers a versatile strategy for integrating hot-carrier modulation with conductive interface engineering in solar-driven energy conversion systems.
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ACS Nano
·
2025
·
IF 16
Xiaohui Zhan,Yujia Jiang,Zhiyu Li,Xiaoqin Hu,Fang Lan,Binwu Ying,Yao Wu
The screening and monitoring of microRNAs as cancer molecular biomarkers is clinically significant, but traditional methods lack sufficient sensitivity, accuracy, and convenience. The CRISPR-colorimetric lateral flow assay (CLFA) integration offers a promising and efficient solution; however, cumbersome preamplification and poor quantification hinder clinical adoption. In this study, we developed a one-step isothermal CRISPR-Cas cascaded sensing system that is preamplification-free. At its core is a designed and selected split DNA tetrahedron activator, employing spatiotemporal-hierarchy mechanisms to precisely bidirectionally drive the kinetics of two Cas enzymes, accelerating the activation of Cas13a while delaying the initiation of Cas12a, to achieve optimal balance. This system enables ultrasensitive, single-step, single-tube, and rapid detection of a cervical cancer relative biomarker, microRNA-21, achieving a limit of detection of 38 aM with a broad linear range. The CRISPR system is further integrated with CLFA enhanced by ultrathin platinum-protected gold nanolabels (Au@Pt, also named Au@s-Pt), along with a smartphone equipped with dual convolutional neural network models (YOLO v5 and MobileNet v3), enabling more precise, rapid quantification of target miRNA. Using this integrated platform, miRNA-21 levels in cervical cancer and precancerous samples can be accurately quantified with approximately 30 min at low cost and without the need for large, sophisticated instruments, with results showing good concordance with quantitative real-time polymerase chain reaction. This platform provides an efficient, highly sensitive, user-friendly, and quantifiable point-of-care testing solution.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xinyu Lan,Tingting Liu,Jianjun Li,Jian Zhu,Junwu Zhao,Guojun Weng
Silver coated gold nanobipyramids (Au NBPs@Ag) have opened up a wide range of applications in sensing based on the etching, due to the fact that a tiny change in shape or composition could directly lead to optical changes. Here, we developed an ultrasensitive surface-enhanced Raman scattering (SERS) method for S 2− sensing by using Au NBPs@Ag as nanoprobes. This strategy was revealed to be related to the redox reaction between S 2− and the silver nanoshell of the Au NBPs@Ag. The silver nanoshell was gradually etched as the S 2− concentration was gradually increased. Meanwhile, the generated Ag 2 S was secondary deposited on the surface of etched Au NBPs@Ag. Thus, the etching of silver shell and secondary deposition of Ag 2 S induced SERS decrease of the nanoprobes, which was not only highly selective toward S 2− but also showed a linear logarithmic dependence on S 2− concentrations from 10 −5 to 10 −8 M, with a limit of detection (LOD) of 4.7 × 10 −8 mol/L. Spike recovery tests in tap water demonstrated recoveries of 104.00%, 98.86%, and 105.32% with relative standard deviations (RSD) between 2.52% and 3.98%, validating high accuracy for S 2− detection. This approach provided a novel SERS strategy for trace sulfide monitoring in drinking water systems.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Yi Ma,Yuanyuan Du,Ying Chen,Chenjie Gu,Tao Jiang,Guodong Wei,Jun Zhou
Aiming to realize a reliable quantification multiphase surface-enhanced Raman scattering (SERS) detection, we designed and synthesized a novel flexible and transparent SERS substrate based on PDMS film modified with forest of Ag/Au nanowires (NWs) through two steps of seed-mediated growth and magnetron sputtering coating. Owing to the flexibility of the polymer matrix, the SERS activity of the Ag/Au NWs/PDMS film was improved by a mechanical stretch strategy, showing a remarkable enhancement factor of 6.74 × 10 6 . Moreover, the versatile hybrid SERS substrate could be utilized to trace pesticides under various conditions. The monitoring of 2-naphthalenethiol with limit of detection (LOD) of 10 −9 M in atmosphere, the detection of methyl parathion (MP) with LOD of 10 −6 mg/mL on the surface of tomato, and the identifying of MP with LOD of 10 −5 mg/mL in soybean oil were all effectively realized. Particularly, the poor linear relationships in the three detections were significantly corrected to guarantee the quantitative analysis by using the intrinsic SERS peak of PDMS as internal standard. The multifunctional Ag/Au NWs/PDMS film developed here is expected to find great potential practical applications in rapid and sensitive on-site monitoring of food and environmental security.
研究领域:
分析化学
·
纳米材料
·
传感器
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食品安全
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环境监测
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ANALYTICAL CHEMISTRY
·
2026
·
IF 6.7
Longxue Yu,Yao Zhou,Xin Wang,Lingyun Xue,Shuo Wang,Yi Liu,Xuezhen Gao,Xunyong Liu
Cysteine (Cys) is essential in human physiological processes, and its abnormal levels are linked to various diseases, necessitating real-time monitoring in biological samples. Conventional detection methods, however, are often limited by the operational complexity and susceptibility to interference. To overcome these issues, we developed a chitosan–gold nanoparticle (CS–Au NP) gel sensor for dual-mode visual detection of Cys via gel–sol transition and colorimetry. This approach significantly reduces false positives that are common in single-signal methods. The sensor utilizes chitosan as an in situ reductant to form Au NPs, which together with chitosan amine groups and hydrogen bonding construct a 3D gel network. In the presence of Cys, its thiol groups competitively bind to Au NPs, disrupting cross-linking and triggering a gel–sol transition. Quantitative analysis based on the coverage ratio (Cr) on paper substrates showed high sensitivity with a detection limit of 2.08 μM and strong linearity (R2 = 0.9981). Concurrently, Au NPs released from the gel assemble into nanoaggregates, causing a red-to-blue-gray color shift due to SPR changes. This allows both visual qualitative assessment and smartphone-based RGB quantification, achieving a linear range of 20–1000 μM and an LOD of 2.23 μM. The dual-mode design ensures high selectivity, with minimal response to 19 interfering amino acids. Practical tests in human urine and bovine serum yielded recoveries of 100.24%–125.80%, confirming accuracy in complex matrices. Integrated with smartphone imaging, this portable system is ideal for point-of-care testing, offering a reliable and cost-effective platform for Cys monitoring and precision medicine.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Zijie Qu,Shihan Yu,Miao Li,Yumeng Chen,Xia Liu,Xia Zhang,Guodong Zhang,Xiufeng Wang,Fang Wang,Zhiqing Zhang,Ting Zhou
This study designed and synthesized a Fe 3 O 4 @PDA@Ag-Au NPs nanocatalyst featuring a “core-shell-satellite” structure, aimed at efficiently reducing 4-nitrophenol through photothermal catalysis. Under 808 nm near-infrared laser irradiation, the material demonstrated exceptional photothermal performance and catalytic activity. The reduction rate of 4-nitrophenol reached 90.35 %, with a reaction rate constant of 0.1397 min −1 , significantly surpassing that of a water bath heating system at the same temperature. The high efficiency was attributed to two synergistic effects: the photothermal conversion facilitated by the polydopamine shell and the unique resonance effect exhibited by Ag-Au bimetals. This synergy elevated the system’s equilibrium temperature to 50.7 °C (12.8 °C higher than that of pure water) and generated active site pairs on the Ag-Au interface. These sites enhanced critical reaction steps, thereby reducing the activation energy to 13.8 kJ·mol −1 ,a reduction of 24.0 % compared to that observed in the water bath system (18.3 kJ·mol −1 ). This catalyst could be easily recovered using magnets and maintained over 90 % efficiency after seven cycles. By integrating photothermal catalysis, bimetallic synergy, and magnetic separation, this study presents a novel strategy for developing efficient and recyclable catalysts with significant potential for addressing nitroaromatic organic pollutants.
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NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 40
·期 2
·1685-1692
·
IF 3.086
Min Hong,Lidan Xu,Fangli Wang,Shuling Xu,Haibo Li,Chen-zhong Li,Jifeng Liu
Graphene oxide-supported hollow Au–Ag alloy nanocages (AuAgNC/GO) with tunable shell composition were in situ fabricated by employing a galvanic replacement reaction (GRR) between HAuCl4 and Ag nanoparticles loaded on graphene oxide nanosheets (AgNP/GO). AgNPs on the graphene oxide nanosheets were first synthesized as sacrificial templates by the microwave method. The as-synthesized hybrid materials were characterized by TEM, EDX, HAADF-STEM, XRD and XPS. On the well-known 4-nitrophenol (4-NP) reduction to 4-aminophenol (4-AP) in the presence of excess borohydride, AuAgNC/GO as a solid phase heterogeneous catalyst has been investigated, which exhibited a short induction time, high catalytic activity and good stability against agglomeration for the reduction.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Jing Tang,Guangping Qin,Qiuhui Wen,Wenhao Li,Liuci Huang,Jian Liang,Zhijiao Tang,Zhengyi Chen,Yumin Wang
The development of a simple-yet-practical and accurate sensing strategy for rapid detection of Alzheimer's disease (AD)-related miRNA in biofluids holds great promise for early diagnosis and monitoring of AD. Herein, a colorimetric/portable Raman dual-mode nanoprobe was proposed for quantification of AD-related miRNA-574-5p in biological fluids. The MOF-818@Au NPs@ssDNA nanoprobe was prepared by step-by-step loading of gold nanoparticles (Au NPs) and ssDNA onto the surface of MOF-818. Strikingly, the adsorbed ssDNA was capable of greatly improving the intrinsic peroxidase-like activity of MOF-818@Au NPs. In the presence of miRNA-574-5p, the ssDNA onto MOF-818@Au NPs will specifically hybridized with miRNA-574-5p, resulting in the desorption of ssDNA from MOF-818@Au NPs and the decrease of nanoenzyme activity for H 2 O 2 -mediated TMB oxidation. Based on this feature, visualization and quantitative analysis of miRNA-574-5p can be successfully realized by observing and measuring changes in output colorimetric/Raman signal from blue TMB oxide (oxTMB) with portable Raman spectrometer. Experimental results demonstrated that the colorimetric/portable Raman dual-mode nanoprobe can be utilized for fast, sensitive and accurate detection of AD-related miRNA-574-5p in complex human serum samples, providing a universal, valuable and practical tool for AD biomarkers detection and AD early diagnosis.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Bofei Zhang,Ke Zhao,Baozhong Zhang,Boxu Chen,Kunfeng Zhang,Hanyu Chen,Baoshan He
A dual-mode (colorimetric/electrochemical) aptasensor was developed for ZEN detection. • Au@Ti 3 C 2 T x MXene@MoSe 2 was synthesized to enhance electrode conductivity and surface area. • RCA was integrated to generate G-quadruplexes for both electrochemical and colorimetric readouts. • Electrochemical mode achieved 1.23 fg/mL LOD; colorimetric mode enabled convenient visual screening. • The sensor exhibited excellent selectivity, stability, and recoveries (89.6–106.2%) in real samples. Zearalenone (ZEN), a nonsteroidal mycotoxin produced by Fusarium fungi, widely contaminates cereals and their derived products, posing a serious threat to human health. In this study, a highly sensitive dual-mode (colorimetric and electrochemical) aptasensor for ZEN was constructed. The sensor employs rolling circle amplification (RCA) to efficiently generate long single-stranded DNA rich in G-quadruplex sequences, combined with an electrode modified with an Au@Ti 3 C 2 T x MXene@MoSe 2 nanocomposite, thereby achieving synergistic signal amplification and dual readout. In the electrochemical mode, the RCA product is anchored through hybridization between the primer and the capture probe on the electrode surface, where it adsorbs abundant methylene blue to produce a square wave voltammetry (SWV) response. In the colorimetric mode, the G-quadruplex structures self-assemble with hemin to form peroxidase-mimicking DNAzymes, which catalyze the TMB chromogenic reaction to generate a visual signal. Experimental results showed that the electrochemical mode achieved a detection limit as low as 1.23 fg/mL (detection range: 10 −3 -10 4 pg/mL), while the colorimetric mode exhibited a detection limit of 64.89 fg/mL (detection range: 1 pM-10 μM). The aptasensor demonstrated excellent selectivity, good stability, and satisfactory reproducibility for ZEN, with spiked recoveries ranging from 89.6% to 106.2% in real corn flour and beer samples. This dual-mode sensing platform effectively eliminates single-mode interferences through signal cross-validation, providing a reliable technical means for the accurate and rapid detection of trace ZEN in food safety. Download: Download high-res image (117KB) Download: Download full-size image
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MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Yanqiu Zhang,Sai Xu,Xiangping Li,Jinsu Zhang,Jiashi Sun,Haiping Xia,Ruinian Hua,Baojiu Chen
Novel nanoplatform with excellent photothermal conversion and temperature feedback are preferable in clinical photothermal therapy (PTT). In this work, a hybrid of NaYF 4 :Er 3+ ,Yb 3+ @NaYF 4 upconversion nanoparticles (UCNPs) conjugated with gold nanorods (GNRs) was fabricated in order to achieve effective photothermal conversion and excellent temperature detection. In this nanoplatform, the GNRs as photo-activated nano-heaters could effectively convert the 808 nm photoenergy into heat, meanwhile UCNPs as 980 nm triggered temperature probe could read the temperature in an exact microdomain where the nanocomposite was located at. The effects of excitation source, GNRs concentration and power density on photothermal conversion were investigated. In addition, the difference between eigen temperature of nanoparticles and solution temperature, and the potential for temperature feedback were analyzed under double lasers excitation. Moreover, the photothermal conversion efficiency was experimentally confirmed from thermodynamic analysis. It was found that the nanocomposite can be an excellent nanoplatform for potential application in advanced PTT.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤治疗
·
光热疗法
·
分子影像
·
热疗监测
·
转化医学
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高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Ying Yu,Xiaodan Wang,Mingyang Li,Dengyong Liu
5′-Guanosine monophosphate (5′-GMP) is one main source of freshness in broths. Herein, an electrochemical platform based on a novel ternary nanocomposite glassy carbon electrode modified with advantageously-united gold nanoparticles, 2,2′-bipyridine hydrated ruthenium (Ru(bpy) 2 Cl 2 ) and sulfonated multi-walled carbon nanotubes (SMWCNTs)was prepared and used to detect 5′-GMP. After conditions optimization, the best performance of the electrochemical sensor was found in acidic media, including high specificity, sensitivity and selectivity. The electrochemical sensor exhibited a wide linear range under the optimal conditions. The enhanced sensitivity of this sensor was attributed to the Ru(bpy) 2 Cl 2 and functionalized SMWCNTs that provided high electrical conductivity and electrocatalytic properties during electrochemical reaction . Precise analysis of 5′-GMP in actual broth samples showed satisfactory recovery. Thus, the sensor can be used in the market and food enterprises.
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高影响因子
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