COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Huaqiang Luo,Bingjie Sun,Guitao Tan,Bingtian Tu,Jing Tu
Core-shell-shell PPH nanospheres were designed for antibiotic-free wound therapy. • Cationic PHMB and released Cu 2+ cooperatively eliminate bacteria and biofilms. • PDA layer regulates pH-responsive Cu 2+ release with favorable hemocompatibility. • PPH promotes HUVEC migration in vitro and neovascularization in vivo . • Accelerated wound remodeling was achieved with enhanced collagen deposition. Bacterial infection and biofilm formation pose major obstacles to wound healing. To address these challenges, we designed a core-shell nanocomposite, Cu-PBG@PDA@PHMB (PPH), consisting of a copper-doped phosphate glass (Cu-PBG) core, a polydopamine (PDA) interlayer, and a polyhexamethylene biguanide (PHMB) outer shell. The PPH nanospheres exert a complementary antibacterial effect via contact-killing and ion release: the cationic PHMB shell disrupts bacterial membranes through electrostatic interaction, whereas the PDA layer mediates pH-responsive Cu 2+ release. This combined effect is primarily driven by substantial contact-induced membrane damage, and the presence of released Cu 2 ⁺ ions further enhances this membrane-disruptive action, ultimately leading to efficient bacterial killing. In vitro evaluations demonstrated that PPH exhibited notable antibacterial activity against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ), markedly reduced mature biofilm biomass, and substantially disrupted biofilm integrity. Furthermore, the nanocomposite exhibited favorable biocompatibility and significantly promoted endothelial cell migration. In vivo experiments in a S. aureus -infected murine wound model demonstrated that PPH treatment was associated with accelerated wound closure, reduced bacterial burden, and improved angiogenesis and collagen deposition. This nanoplatform represents a promising therapeutic strategy for the clinical management of infected wounds.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·Vol. 14
·期 34
·15242-15253
·
IF 7.6
Hong Zhe,Miao Lei,Xiong Chuanfang,Zhu Li,Li Na,Chen Kaiyuan,Shen Hongxia,Gao Xianlong,Zhu Zhirong
The reaction of toluene side-chain alkylation with methanol represents a potential route to reduce the energy consumption in large-scale styrene production. In this study, we design a dual zeolite-based Cu–Cs catalytic system that constructs a catalytic enhancement path to produce styrene by leveraging the distribution of Cu–Cs sites. The reaction results demonstrate that the catalyst in the stacking model of a dual bed manner (Cu/NaX-CsX-DB) exhibits higher toluene conversion (8.1%), methanol utilization efficiency (60.2%), and styrene selectivity (84.3%), accompanied by an extended catalytic stability (>100 h), than conventional Cu-modified CsX (Cu/CsX) and parent CsX catalysts. The excellent catalytic performance is realized on the basis of the triple functions of the optimal catalyst: (i) the introduction of Cu sites and the original Cs sites synergistically facilitates the dehydrogenation of methanol to formaldehyde, thereby improving the utilization of methanol; (ii) meanwhile, the introduced Cu species act as a new Lewis acid site, which modulate the surface Lewis acid-base pairs; (iii) the oriented component distribution in the Cu/NaX-CsX-DB catalyst greatly promotes the transfer of the HCOO* intermediate and provides a directional spatial pathway to improve the reaction efficiency of toluene and methanol to styrene.
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INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 34
·19989-19997
·
IF 4.6
Yang Yuanyuan,Wang Xinyue,Zhang Chun-yang,Jia Henglei
Alloyed nanoframes (NFs), featuring high metal atomic
utilization
efficiency and large specific surface areas, have shown great promise
for electrocatalysis. However, the rational design and precise synthesis
of structurally stable NF catalysts remain considerable challenges.
Herein, we report a template-guided strategy for constructing alloyed
Cu x Rh y NFs
via the selective etching of Cu atoms from the low-energy facets of
Cu nanocubes (NCs) using a Cl – /O 2 pair,
followed by the galvanic replacement of Cu atoms with Rh at the frame
edges and vertices. Notably, the Cu 24 Rh 76 NFs
deliver outstanding electrocatalytic performance toward the nitrite
reduction reaction (NO 2 RR), achieving an NH 3 Faradaic efficiency (FE) of 99.6% at 0 V (vs the reversible hydrogen
electrode (RHE)) and an NH 3 yield rate of 676.7 mmol h –1 g –1 at −0.4 V. Such remarkable
electrocatalytic performance for NH 3 production arises
from not only the unique three-dimensional (3D) ultrathin frame architecture
but also a tandem catalytic mechanism. During the NO 2 RR
process, Cu sites adsorb and activate NO 2 – to produce the *NO intermediate, while Rh sites generate *H species
that migrate to the *NO intermediates adsorbed on Cu sites, effectively
promoting the subsequent hydrogenation steps toward NH 3 generation.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 34
·18223-18234
·
IF 3.9
Ji Xianxian,Lin Hui,Faraj Yousef,Xie Ruzhen
Electrochemical nitrate reduction to ammonia (NO 3 RR)
is a sustainable strategy that integrates environmental remediation
with ammonia resource recovery. Current NO 3 RR studies mainly
focus on high nitrate concentrations under idealized electrolyte conditions
to achieve high ammonia yields. Under realistic water conditions,
low NO 3 – concentrations, neutral media,
and competing side reactions often result in sluggish kinetics, low
removal efficiency, and undesirable nitrite accumulation. Herein,
we report a facile strategy for constructing an interface-tunable Cu/Cu 2 O@CoO-P heterojunction
through one-step regulation of the growth of CoO nanoneedles on copper
mesh by tuning the phosphorus concentration. Phosphorus incorporation
effectively modulates the electronic structure of the Co active sites
and tunes the heterojunction interface, thereby optimizing the generation
of adsorbed hydrogen (*H) and suppressing the hydrogen evolution reaction.
This enables a well-matched two-step tandem pathway, where Cu/Cu 2 O facilitates the conversion of NO 3 – to NO 2 – , and the P-modulated CoO sites
rapidly hydrogenate NO 2 – to NH 4 + , thus effectively preventing excessive NO 2 – accumulation. The optimized Cu/Cu 2 O@CoO-P achieves a high Faradaic efficiency
(FE) of 97.11% for NH 4 + - N and an ammonia yield
of 36.09 mg h –1 cm –2 at 10 mA
cm –2 under neutral-pH conditions, along with excellent
stability, retaining 98.45% of its performance after 20 cycles. Notably,
the catalyst demonstrates exceptional practical applicability for
ammonia recovery from real aquaculture tailwater in both batch mode
and continuous-flow mode. This work offers new insights into the design
of tunable heterojunction interfaces to achieve a well-matched and
efficient tandem catalytic process, enabling effective remediation
of low-concentration nitrate contamination and high ammonia recovery
in real wastewater environments.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124771
·
IF 7.5
Xiaoyang Zhang,Mengyuan Ding,Julio Romano Meneghini,Xungang Diao,Mingze Jia,Song Guo,Jinlei Guo,Juan Wang
Traditional photocatalytic alcohol reforming often suffers from uncontrolled deep oxidation, leading to undesirable greenhouse gas (CO 2 ) emissions and the loss of valuable carbon resources. To address this environmental and engineering bottleneck, a highly dispersed, sub-nanometer Cu + cluster/TiO 2 catalyst with engineered oxygen vacancies was constructed via a scalable, one-step molten-salt strategy. The highly polarized liquid flux provides a localized salt-thermal microenvironment that thermodynamically stabilizes the highly active Cu + state and effectively prevents cluster agglomeration under ambient air calcination. The optimized catalyst delivers a promising photocatalytic hydrogen evolution rate of 181.89 mmol g-1 over 4 h, achieving an apparent quantum yield (AQY) of 27.1% at 365 nm. Notably, this non-noble-metal system outperforms highly active noble-metal benchmarks under identical conditions. Crucially, detailed characterizations indicate that the highly dispersed Cu + clusters significantly modulate surface adsorption configurations rather than relying on macroscopic plasmonic effects. This robust sub-nanoscale interfacial coupling selectively drives targeted dehydrogenation and dehydration pathways. Consequently, the catalyst suppresses parasitic C-C bond cleavage, keeping CO and CO 2 emissions below the detection limit of GC-TCD while maximizing active hydrogen extraction and co-producing value-added chemicals (e.g., highly selective production of formaldehyde from methanol, alongside valuable C 2 products from ethanol). This work presents a sustainable, easily scalable engineering paradigm for waste alcohol valorization, effectively bridging green hydrogen production with carbon-neutral chemical synthesis.
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ENERGY & FUELS
·
2026
·Vol. 40
·期 33
·18068-18080
·
IF 6
Fu Zong-Pin,Zhao Yun-Peng,Wu Yu-Fa,Qiu Le-Le,Liu Fang-Jing,Zhong Mei,Liang Jing,Cao Jing-Pei
Efficient depolymerization of lignite remains challenging
owing
to both its structural complexity and the high stability of oxygen-containing
bridge linkages. Herein, low-temperature pyrolysis and oxidative pretreatments
were employed to regulate oxygen-containing structures and enhance
the hydrogenolysis reactivity of Zhaotong lignite (ZT). These pretreatments
promoted the structural evolution of lignite, activated oxygen-containing
bridge structures, and suppressed the recondensation of reactive intermediates,
thereby facilitating subsequent depolymerization reactions. A CuCoOx
catalyst capable of dynamic in situ reconstruction was introduced
for catalytic hydrogenolysis. Under reaction conditions, partial reduction
of CuCoOx generated reconstructed Cu 0 -CoOx interfacial
active sites, where the synergistic interaction between metallic Cu
and defect-rich CoOx promoted H 2 activation and selective
C–O bond cleavage. Density functional theory (DFT) calculations
further revealed that interfacial electron redistribution at the Cu
cluster/Vo-Co 3 O 4 (311) interface facilitated
H 2 activation and stabilized reactive hydrogen species.
These findings provide new mechanistic insights into pretreatment-regulated
and interface-controlled hydrogenolysis pathways for the efficient
valorization of low-rank coal.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2026
·
IF 3.3
Xu Ying-Yu,Wang Shuang,Zhu Han-Dong,Wang Shuo,Feng Xiao-Qian,Wang Huan,Zhao Yong-Hua
Photo-thermal synergistic catalysis offers a promising route for low-temperature and efficient hydrogen production, in which the design of catalysts is crucial. In this study, a series of promoter-modified Cu supported on ZnO (M-Cu/ZnO, M = Al, Zr, Co, Ce) were designed and prepared via a controllable hydrothermal synthesis strategy, and their catalytic performance in photo-thermal methanol steam reforming (MSR) for hydrogen production was systematically investigated. By varying the type of promoter, precise modulation of the catalyst's textural properties, metal-support interactions, and distribution of active sites was achieved. Characterization results revealed that the introduction of Al promoters significantly enhanced the dispersion of Cu species on the ZnO surface and strengthened metal-support interactions, thereby effectively suppressing the sintering and deactivation of active components during the reaction. Under photo-thermal MSR conditions of 240 °C, 0.1 MPa, and a space velocity of 17 300 mL·g −1 ·h −1 , the Al-Cu/ZnO catalyst exhibited the optimal catalytic performance, achieving a methanol conversion of 97.08% and an H 2 yield of 99.14 mL·g −1 ·min −1 , with only an 11% decrease in conversion after 10 h of continuous operation, demonstrating excellent stability. This work elucidates the structure–activity relationships in multicomponent Cu/ZnO catalysts for photo-thermal MSR from the perspective of promoter engineering, providing both experimental evidence and design insights for the development of efficient and stable solar-driven hydrogen production catalyst systems.
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MATERIALS & DESIGN
·
2026
·
IF 8.2
Hongbao Hou,Xu Li
Introduction Esophageal cancer (EC) is the most malignant tumor posing great threat to human health. Chemotherapy, as the first-line treatment for EC, can not yield expected outcome due to chemo-resistance, low efficacy of monotherapy and off-target toxicity. Hence, it is imperative to develop one novel therapeutic strategy that can realize anti-drug resistance, tumor microenvironment response drug release, and integrated multi-modal therapy. Objectives Currently, treatment of EC faces great challenges. One pH-responsive nanoplatform, CDs-DOX-GOx@PEG (CDG@PEG), composed of copper-doped carbon dots (Cu-CDs), doxorubicin (DOX), glucose oxidase (GOx), and polyethylene glycol (PEG), was fabricated to realize better treatment of EC via multi-modal synergistic and targeted therapy. Methods Microscopy. The physicochemical properties of CDG@PEG were determined via TEM, XPS, XRD, FTIR and so on. The anti-tumor capacity was assessed with KYSE-30 cells and xenograft mice models. Moreover, the therapeutic mechanism was assessed by transcriptome, immunofluorescence and immunohistochemical analysis. Results Physiochemical characterization results showed that as designed nanoplatform was successfully fabricated and was endowed with outstanding pH-responsive and O 2 /ROS-generation capacities. In vitro , CDG@PEG exhibited excellent cell uptake and potent tumor cell-killing effect. In vivo, CDG@PEG displayed superior anti-tumor effect accompanied by good biocompatibility. Mechanistically, CDG@PEG realized the EC therapy by down-regulating drug-resistant genes (such as HIF-1α related genes), inducing mitochondria dysfunction, triggering cell apoptosis. Conclusion One multifunctional nanoplatform, CDG@PEG, was successfully prepared and it exhibited excellent in vitro and in vivo anti-tumor effect, which open new venues for developing novel therapeutic strategies for chemo-resistance cancer.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Wenxin Lai,Pengfei Xu,Molly Meng-Jung Li,Biao Xu
Layered n-type SnSe2 is a promising eco-friendly thermoelectric (TE) material, yet its practical application is constrained by low carrier concentration and the inherent coupling of electronic-thermal transport. Herein, a CuCl annealing strategy is developed to leverage Cu interstitial intercalation for the precise modulation of electronic band structures and phonon dispersions in SnSe2. By synergizing with the Cu-induced formation of SnSe heterojunctions, this approach effectively decouples electron and phonon transport. Consequently, the SnSe2-2 mol% CuCl sample achieves a maximum power factor (PF) of 0.74 mW m-1 K-2 and surpasses pristine SnSe2 by 8-fold. Furthermore, the κL is reduced to 0.53 W m-1 K-1 at 723 K, marking a 31% decrease relative to pristine SnSe2. This translates to a dimensionless figure of merit (zT) of 0.88 at 723 K parallel to the spark plasma sintering direction. Notably, we fabricate the first SnSe2-based single-leg thermoelectric generator (TEG), which delivers an energy conversion efficiency of about 2% under a ΔT of 340.8 K. By effectively decoupling electronic and thermal transport, this work unlocks the full potential of eco-friendly SnSe2, providing a sustainable and high-performance paradigm for green energy harvesting without relying on toxic elements.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zixuan Xu,Yiming Wang,Rufeng Zhang,Anmin Liu,Yumin Zhang,Gaohong He,Yixiang Huang,Qiulin Li,Yuheng Wang,Min Li,Wenjun Zhang
In situ coordination assembly of Cu 2 O/Cu-TCPP(Fe) bimetallic nanozyme. • Intermetallic Cu + /Fe 3+ electron transfer accelerates the peroxidase-like activity. • ML-integrated dual-channel array distinguishes six antioxidants with 100% accuracy. • Precise quantification of antioxidant mixtures in biofluids via RF. Accurate identification and quantitative analysis of antioxidants in complex biological fluids are the keys to the early detection of severe diseases. The single-channel sensors suffer from weak specificity and critical multi-component signal crosstalk, which hardly meet the accurate analytical requirements. Herein, an intelligent colorimetric sensing platform of bimetallic mixed-valence nanozyme was integrated with machine learning (ML) to improve the analytical precision. Fe/Cu nanosheets of mixed valence were successfully acquired through Cu 2 O-coordinated anchoring in situ into iron porphyrin (TCPP(Fe)). This mixed-valence strategy effectively promoted the synergistic catalysis and valence cycling among the metal active sites, thereby significantly enhancing the peroxidase (POD)-like activity of the Cu 2 O/Cu-TCPP(Fe) ( V max as high as 8.107 × 10 −7 M·s −1 and K m as low as 0.913 mM). DFT calculations indicated that the introduction of Cu 2 O promoted strong Cu 3d and Fe 3d orbital hybridization and an upshift of the Cu d-band center, accelerating interfacial electron transfer and Fe/Cu valence cycling, thereby revealing the intrinsic mechanism underlying the enhanced catalytic activity. Taking the differential catalytic responses of the nanozyme with two different substrates, a highly sensitive dual-channel sensor array was designed with machine learning. Combined with algorithms of artificial neural network (ANN), random forest (RF), and support vector machine (SVM), etc., 100% accurate qualitative discrimination of six antioxidants was remarkably completed. Relying on the outstanding capability of the Random Forest (RF) algorithm to remarkable robustness in handling high-dimensional sample datasets, the sensor array successfully established a precise quantitative model for multiple antioxidants in complex samples, remarkably and intelligently sensing the diverse components in urine and serum. This work paved a new way for highly active bimetallic nanozymes to construct a trustworthy sensing platform as a diagnostic tool for the intelligent profiling of multi-component biomarkers in complex matrices. Download: Download high-res image (150KB) Download: Download full-size image
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Nanomaterials
·
2025
·Vol. 15
·期 12
·893
·
IF 4.3
Danyang Li,Can Liu,Shu Zhao,Fujie Li,Hao Li,Chao Wang,Xiu Song Zhao
Na-layered Li-containing Mn-based cathodes (NaxLiyMn1-yO2, NLMOs) with additional Na+storage ability resulting from the anionic redox reaction (ARR) hold great promise for sodium-ion batteries (NIBs). However, practical applications of NLMOs encounter challenges, such as migration of transition metal Mn, loss of lattice oxygen, and voltage decay during cycling. Here, we show that Cu plays an important role in enhancing the ARR via the reductive coupling mechanism (RCM). Results shows that a Cu2+/Fe3+modified NLMO sample delivers a Na+storage capacity as high as 174 mA h g−1at 0.2C, higher than that of a Zn2+/Fe3+modified NLMO sample (130 mA h g−1) and NLMO (154 mA h g−1). Both in situ and ex situ characterization results indicate that the obvious improvement in the electrochemical performance of the Cu2+/Fe3+modified NLMO is due to the additional overlaps between the Cu 3d and O 2p orbitals, which is beneficial for the RCM. As a result, the ARR is enhanced so as to increase the Na+storage capacity.
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Molecular Catalysis
·
2025
·
IF 4.9
Min Yang,Shuang Sheng,Ziyi Wan,Yaoyao Xu,Rui Qi,Xiaofeng Luo,Weiyu Pan,Kunshan Yang,Ziqing Zhang,Guowei Deng
Hydrogen evolution reaction (HER) is a key step in the production of hydrogen (H 2 ) by overall water splitting, which is of great significance for the storage and conversion of renewable energy. Nevertheless, the elevated excess potential and insufficient stability of catalysts constrain their industrial applicability. Due to the poor catalytic activity of NiWO 4 in alkaline solution, this study investigated the effect of IB metal (IB=Au, Ag, Cu) ion doping and its interaction with different concentrations of IB x /NiWO 4 ( X = 1,2,3,4 mmol) on catalytic activity to achieve stable H 2 in alkaline media. In 1.0 M KOH solution, the current density is 10 mA cm −2 , the Au 3 /NiWO 4 exhibits a low overpotential is 86.11 mV, the slope of Tafel is 115.16 mV dec −1 , and the overpotential of Ag 3 /NiWO 4 is 168.41 mV, with a Tafel slope of 64.32 mV dec −1 , the catalyst also showed long term stability for 150 h, the Au 3 /NiWO 4 NF‖Au 3 /NiWO 4 NF catalysts achieved a low voltage of 1.45 V at 10 mA cm −2 current density for 100 h. The synergistic interactions of bimetals present a novel approach for enhancing catalyst design and optimizing performance.
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