JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2019
·
IF 4.027
Yu-Heng Hu,Jie Yang,Yun Zhang,Ke-Chun Liu,Teng Liu,Jie Sun,Xiao-Jing Wang
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 ± 0.011 µM and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 ± 0.017 µM. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.
研究领域:
药理学
·
神经科学
·
药物设计
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Mengru Zhao,Minghui Sun,Qi Kang,Xuemei Ma,Dazhong Shen
Herein, we report a differential strategy to enhance the anti-interference ability of the electrochemical molecularly imprinted polymers (MIP) based sensors for the determination of 4-acetamidophenol (AP) and sulfamerazine (SMR). Polypyrrole MIP membranes for AP or SMR were grown independently on the surface of Ni 2 P/GCE, with the imprinting factors of 6.13 for MIP AP and 5.82 for MIP SMR . At the potentials of 0.42 V and 0.89 V (vs. Ag/AgCl), MIP AP /Ni 2 P/GCE and MIP SMR /Ni 2 P/GCE exhibit sensitive current responses to AP and SMR, respectively. However, the non-specific adsorption of various interferents on the surface of MIP suppresses the selectivity of the MIP sensors. For example, 20 μM ascorbic acid (AA) and sulfamethoxazole (SMZ) were determined falsely as 5.2 μM AP and 4.7 μM SMR, respectively. In the proposed differential strategy using the current differences between MIP AP /Ni 2 P/GCE and MIP SMR /Ni 2 P/GCE as the signal indicators, 20 μM of AA and SMZ are equivalent only to 0.25 μM AP and 0.33 μM SMR, respectively, enhancing significantly the anti-interference ability of MIP sensors. Moreover, the limit of detection for AP and SMR are 0.011 and 0.019 μM, respectively. AP and SMR in actual urine samples were determined with the recoveries from 94% to 105%.
研究领域:
分析化学
·
电化学传感器
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2020
·
IF 7.489
Qiao Yan,Xiao-Yu Wang,Jiu-Ju Feng,Li-Ping Mei,Ai-Jun Wang
Water pollution caused by organic pollutants has aroused great concern to earth sustainability in the last several decades. Herein, a facile one-pot solvothermal approach was developed to construct bimetallic platinum-rhodium alloyed nano-multipods (PtRh ANMPs) in oleylamine (OAm) by adopting creatinine and cetyltrimethylammonium chloride (CTAC) as the co-structure-directing agents. The as-fabricated nanocatalyst exhibited extraordinary catalytic behaviors towards 4-nitrophenol (4-NP) and rhodamine B (RhB) reduction by sodium borohydride (NaBH 4 ). Impressively, the resultant catalyst showed highly facilitated rate constant ( k : 0.209/0.354 min −1 ) and turnover frequency (TOF: 1.0 × 10 −3 /0.44 × 10 −3 mol g −1 min −1 ) towards 4-NP and RhB reduction in comparison with commercial Pt black under the same conditions. This research offers some valuable insights for facile preparation of advanced nanostructures as efficient and recyclable catalyst in environmental remediation field.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 6
·066512
·
IF 3.721
Nannan Dou,Jianying Qu
A novel highly sensitive nanoelectrochemical sensor was prepared using graphene oxide/titanium dioxide/gold nanoparticles composites (GT@AuNPs) modified glassy carbon electrode (GCE) to measure paracetamol (PA) and 4-aminophenol (4-AP) simultaneously. It can be found that PA and 4-AP could be completely separated on the GT@AuNPs/GCE using cyclic voltammetry and differential pulse voltammetry technique. Under the best conditions, the linear responses for PA from 0.10 to 300.00 μM with the detection limits of 0.78 nM. And the linear responses for 4-AP from 0.10 to 150.00 μM with the detection limits of 2.36 nM. This sensor can be used to detect acetaminophen in pharmaceutical formulations with satisfactory results, indicating that the electrochemical sensor has potential application value.
研究领域:
分析化学
·
材料科学
·
药物分析
✓ 已验证
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2020
·Vol. 27
·期 6
·1639-1648
·
IF 2.183
Zhang Tiantian,Li Bin,Zhang Xiaoli,Wang Jiao,Wei Longhui,Zhao Binxia,Li Binglin
N,N′-dimethyl-N-(4-pyridyl)-1,2-ethanediamine (DMPE) as a special N-alkylation precursor of 4-dimethylaminopyridine (DMAP) was grafted on the surface of γ-chloropropylated functionalized mesoporous silica MCM-41 to prepare immobilized DMAP. Characterization results of small angle X-ray diffraction, thermogravimetry and derivative thermogravimetry, Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray and transmission electron microscopy indicated that DMAP was successfully covalently bound to the surface of MCM-41. The highest loading of DMAP reached 0.9 mmol/g, which was 2.5 times higher than that of DMAP immobilized on the normal silica gel. The prepared immobilized DMAP as nucleophilic heterogeneous catalysts was successfully used for the acetylation reaction to produce α-tocopherol acetate. The highest yield reached 90.1% under the optimal condition which was summarized as follows: immobilized DMAP 100 mg, substrates mole ratio (acetic anhydride/α-tocopherol) 3:1, reaction temperature 50 ℃, stirring intensity 500 rpm, reaction in toluene for 12 h. The recyclability and stability of the DMAP grafted MCM-41 were excellent, as demonstrated by its use 20 times during batch operation without any loss of productivity.
✓ 已验证
产品关联
DOI
高影响因子
Inorganic and Nano-Metal Chemistry
·
2017
·
IF 0
Jiaxing Li,Meng Ni,Chaoyi Fan,Yan Li,Xiuqing Zhang
A new cobalt complex [Co3(SIP)2(4-PP)8(H2O)6]·4H2O·2(4-PP) (1) with 5-sulfoisophthalic acid sodium (NaH2SIP) and 4-phenyl pyridine (4-PP) as ligands has been synthesized in the mixed solvents of ethanol and water. It crystallized in monoclinic, space group P21/c, with a = 20.9642(9) Å, b = 15.6091(5) Å, c = 20.0126(8) Å, α = 90.00°, β = 115.493(6)°, γ = 90.00°, V = 5911.2(4) Å3, Z = 2, Dc = 1.346 g/cm−3, F(000) = 2494, the final GOOF = 1.038, Rint = 0.0258 and wR2 = 0.1793. The complex (1) was characterized by single-crystal X-ray diffraction, magnetic susceptibility and IR spectroscopy analyses. Single-crystal X-ray diffraction shows that complex (1) is trinuclear based on cobalt units. Magnetic susceptibility measurement indicates that complex (1) shows an antiferromagnetic coupling between the Co(II) ions.
研究领域:
无机化学
·
材料科学
✓ 已验证
DOI
JOURNAL OF CHEMICAL RESEARCH
·
2021
·
IF 0.782
Fangmin Chen,Chichi Zhou,Yan Li,Xiuqing Zhang
Three coordination polymers—{[Ag2(SIP)(4-pp)]·[Ag(4-pp)2]·H2O}n, [Pb4(SIP)2(μ3-OH)2(H2O)2]n, and {[Zn2(SIP)2(4-pp)4][Zn(4-pp)2(H2O)4]·4H2O}n (SIP = 5-sulfoisophthalic acid anion, 4-pp = 4-phenylpyridine)—are constructed under hydrothermal or solvothermal conditions using sodium m-phthalate 5-sulfonate (NaH2SIP) and 4-phenylpyridine as ligands. The structures of the three complexes are determined by single-crystal X-ray diffraction, powder X-ray diffraction, thermogravimetric analyses, Fourier-transform infrared analysis, and photoluminescence. The fluorescent properties of the complexes in the solid state are investigated at room temperature, and the results indicate that they all show photoluminescent properties.
研究领域:
无机化学
·
材料科学
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF STRUCTURAL CHEMISTRY
·
2022
·Vol. 63
·期 10
·1610-1615
·
IF 1.004
Wang G. -F.,Sun S. -W.
Abstract Two coordination polymers, {[Co 2 (L 1 ) 2 (adc) 2 ]·5H 2 O} n ( 1 ) and {[Ni(L 1 ) 2 (Hadc) 2 ]} n ( 2 ) (L 1 = bis(4-(1 H -imidazol-1-yl)phenyl)methanone, H 2 adc = adamantane-1,3-dicarboxylic acid), have been synthesized and structurally characterized. In 1 , Co1 is five-coordinated by three oxygen atoms of two adc 2– and two nitrogen atoms from two L 1 ligands. The neighboring [Co(adc)] 2 dimers are linked through four L 1 ligands to form a 1D ladder structure. In 2 , Ni1 is six-coordinated by two oxygen atoms from two Hadc – ligands, four nitrogen atoms from four distinct L 1 ligands to give a slight distorted octahedral geometry. The [Ni(Hadc) 2 ] units are bridged by L 1 ligands to form 1D looped chains.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOLOGICAL CHEMISTRY
·
2019
·Vol. 294
·期 8
·2628-5268
·
IF 4.106
Ailin Yang,Haitao Fan,Yanan Zhao,Xiaonan Chen,Zhixiang Zhu,Xiaojun Zha,Yunfang Zhao,Xingyun Chai,Jun Li,Pengfei Tu,Zhongdong Hu
Trametes robiniophila Murr. (Huaier) is a mushroom with a long history of use as a medicinal ingredient in China and exhibits good clinical efficacy in cancer management. However, the antitumor components of Huaier and the underlying molecular mechanisms remain poorly understood. Here, we isolated a proteoglycan with a molecular mass of ∼5.59 × 104 Da from Huaier aqueous extract. We named this proteoglycan TPG-1, and using FTIR and additional biochemical analyses, we determined that its total carbohydrate and protein compositions are 43.9 and 41.2%, respectively. Using biochemical assays and immunoblotting, we found that exposing murine RAW264.7 macrophages to TPG-1 promotes the production of nitric oxide (NO), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) through Toll-like receptor 4 (TLR4)-dependent activation of NF-κB and mitogen-activated protein kinase (MAPK) signaling. Of note, the TPG-1 treatment significantly inhibited the tumorigenesis of human hepatoma HepG2 cells likely at least in part by increasing serum levels of TNFα and promoting leukocyte infiltration into tumors in nude mice. TPG-1 also exhibited good antitumor activity in hepatoma H22-bearing mice and had no obvious adverse effects in these mice. We conclude that TPG-1 exerts antitumor activity partially through an immune-potentiating effect due to activation of the TLR4–NF-κB/MAPK signaling cassette. Therefore, TPG-1 may be a promising candidate drug for cancer immunotherapy. This study has identified the TPG-1 proteoglycan as an antitumor agent and provided insights into TPG-1’s molecular mechanism, suggesting a potential utility for applying this agent in cancer therapy.
研究领域:
免疫学
·
肿瘤学
·
药理学
·
真菌学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Plant Science
·
2022
·
IF 6.627
Lei Wenli,Song Yuyang,Long Ai,Que Yanyan,He Shuzhong,Zhong Hang,Chen Yang
The medicinal plants were wildly library of natural products in drug discovery. The most active molecules with seven-membered rings skeleton represent a challenge for construction. A stereoselectivity (4 + 3) cycloadditions between allenyl ethers and substituted furans induced by chiral auxiliaries has been investigated. And the results showed significant stereoselectivities and regioselectivities. The optical cycloadducts with an oxygen-substituted seven-membered ring framework were generated by removing chiral auxiliaries under acidic conditions. The antiproliferative activity of the novel compounds displayed moderate antiproliferative effects toward T47D cells.
研究领域:
有机化学
·
药物化学
·
癌症研究
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Sefiu Abolaji Rasaki,Chunlei Zhao,Rui Wang,Jiacheng Wang,Heng Jiang,Minghui Yang
In this work, Ag/ZnO nanorods are prepared via simple and cost-saving liquid precipitation citrate reduction process (LPCR). The system shows appreciable catalytic activity for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) wherein NaBH 4 is used as electron sacrificer at ambience. It is found out that ZnO nanorods can effectively prevent Ag NPs agglomeration; a problem normally reduces active sites density. The coupling effect between the Ag NPs and ZnO greatly enhances electron transfer rate. This gives rise to high reduction rate constant ( k app ) of ˜3.97 × 10 −3 s −1 for the catalytic reduction of 4-NP. The result is about 1.9times better than that of Ag NPs (2.07 × 10 −3 s −1 ). The k app is well fitted into pseudo-first order kinetics with high correlation coefficient (R 2 ) of about 0.994, indicating chemisorptive reduction process. The remarkable performance obtained here is attributed to strong coupling effect between Ag NPs and ZnO nanorods derived from LPCR synthesis method.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 23
·4005-4013
·
IF 3.117
Baolin Liu,Yizhao Li,Shaojun Qing,Kun Wang,Jing Xie,Yali Cao
Highly dispersed surface Cu species and oxygen vacancies are important for CuOx–CeO2 catalysts in many reactions, but it is difficult to increase the concentrations of highly dispersed Cu species and oxygen vacancies simultaneously by only adding a Cu component. Herein, CuOx–ZrO2–CeO2 (CZC) nanocatalysts with different ratios of Cu/Zr have been effectively produced by a simple solvent-free synthetic strategy. The effect of Zr doping on the structure and reactivity of the CuOx–CeO2 catalysts has been investigated with the help of carbon monoxide (CO) oxidation and 4-nitrophenol (4-NP) reduction as model reactions. It is revealed that the introduction of Zr relieved the agglomeration of surface Cu species, produced more oxygen vacancies in the interior and Cu+ species on the surface of the catalyst, and increased the reducibility of CuOx–CeO2. The CZC catalysts show remarkably enhanced catalytic activity due to the abundant surface active sites and the improved redox properties provided by the suitable doping of Zr into CuOx–CeO2. This work not only offers a practicable way to reconstruct the distribution of active metals on the metal oxide support but also provides a high-efficiency strategy to prepare oxide catalysts with excellent catalytic performance.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
高影响因子
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