ORGANIC ELECTRONICS
·
2020
·
IF 3.31
Jiaji Duan,Yuning Liu,Xiaohong Chen,Sumei Huang,Wei Ou-Yang,Guang Zhu,Sanjun Zhang,Zhuo Sun
A p-type poly(9-vinylcarbazole) (PVC) was inserted into the interface between perovskite and mesoporous TiO 2 electron transport layers. The ultrathin PVC modified TiO 2 layer can obviously improve the crystallinity of perovskite layer with less pinholes, passivate the interface and inhibit hole carriers transport into the interface of perovskite/TiO 2 electron transport layers. The perovskite film modified with PVC shows larger grain sizes and more compact films, which helps to increase photocurrent and reduce the leak current of cells. The passivating interface with less hole carrier accumulation and hydrophobicity can greatly reduce carrier recombination, improve carrier transport and extraction abilities and cells stability. Therefore, perovskite solar cells (PSCs) with PVC modified TiO 2 layer exhibited a power conversion efficiency (PCE) of 19.02%, which is remarkably higher than that (16.09%) of the reference cells. Furthermore, PSCs without and with PVC modification respectively retained 20% and 55% of the initial PCE values aging for 30 days at the relative humidity 15% in air without encapsulation. For thermal stability test, the pervoskite layers were heated for 10 h at 100 °C before further spin-coating Spiro-OMeTAD, PSCs with PVC modification were still remained 70% of the original PCEs, which is greatly higher than that (30%) of the reference cells. These results indicate that PSCs with PVC modified TiO 2 layer can effectively improve PCEs and show better moisture resistance and thermal stability.
研究领域:
材料科学
·
能源科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF ONCOLOGY
·
2019
·Vol. 55
·期 5
·988-1002
·
IF 3.571
Pei Yan,Zijie Su,Zhenhua Zhang,Teng Gao
Anaplastic thyroid carcinoma (ATC) has a poor prognosis due to its resistance to all conventional treatments. The long non‑coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) serves a critical role in cancer chemoresistance; however, whether NEAT1 is associated with chemoresistance of ATC remains unclear. In the present study, reverse transcription‑quantitative PCR assays were performed to detect the expression levels of NEAT1, microRNA (miR)‑9‑5p and sperm‑associated antigen 9 (SPAG9). Western blot analysis was conducted to assess the protein expression levels of p62, microtubule‑associated proteins 1A/1B light chain 3B and SPAG9. Cell proliferation was detected using the Cell Counting kit‑8 assay, and cell apoptosis was determined by flow cytometry. Dual‑luciferase reporter and RNA immunoprecipitation assays were performed to verify the interaction between NEAT1 and miR‑9‑5p, or miR‑9‑5p and SPAG9. Furthermore, an animal model was used to investigate the regulatory effects of NEAT1 on cisplatin (DDP)‑resistance in tumors in vivo. The present results demonstrated that NEAT1 was upregulated in ATC tissues and cell lines, and NEAT1 silencing resulted in decreased DDP‑resistance of ATC cells. In addition, NEAT1 suppressed miR‑9‑5p expression by binding to miR‑9‑5p and SPAG9 was a direct target of miR‑9‑5p. miR‑9‑5p overexpression sensitized ATC cells to DDP. Notably, NEAT1 silencing exerted its inhibitory effect on DDP‑resistance of ATC via the miR‑9‑5p/SPAG9 axis in vitro and in vivo. In conclusion, the present study demonstrated that NEAT1 silencing ameliorated DDP‑resistance of ATC, at least in part by reducing miR‑9‑5p sponging and regulating SPAG5 expression; therefore, NEAT1 may be considered a potential therapeutic target of ATC.
研究领域:
肿瘤学
·
分子生物学
·
癌症研究
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DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Yuan-Bin Chen,Xiuyuan Su,Ruxuan Tang,Ling Tang
Building upon the Ln 2 Zr 3 (MoO 4 ) 9 (Ln = La, Pr, Sm, Eu, Gd) molybdate system, this study strategically employs (Bi 0.5 Ta 0.5 ) 4+ co-substitution at Zr 4+ sites to achieve a enhancement in quality factor ( Q×f ), concurrently reducing optimal sintering temperatures for La- (725 °C) and Sm-based (725 °C) systems compared to their pristine counterparts. Comprehensive structural characterization through X-ray diffraction, Raman spectroscopy, and electron microscopy confirms the formation of phase-pure solid solutions with enhanced densification (relative density >95%), while bond valence analysis reveals that Ln-O bonds predominantly govern ionic characteristics ( f i >78%), whereas Mo-O interactions critically determine lattice energy and thermal expansion coefficients. The engineered Ln 2 [Zr 0.89 (Bi/Ta) 0.11 ] 3 (MoO 4 ) 9 ceramics exhibit microwave dielectric properties tailored by lanthanide ionic radii: La-system demonstrates εᵣ = 10.97,Q×f = 135,333 GHz,τf = −29.74 ppm/°C; Sm-system achieves εᵣ = 11.46, Q×f = 157,465 GHz, τf = -30.96 ppm/°C; Gd-system yields εᵣ = 11.63, Q×f = 157,280 GHz, τf = −30.60 ppm/°C.Notably, sintering temperature reduction is particularly pronounced in Eu-system (675 °C, εᵣ = 11.49, Q×f = 87,850 GHz, τf = −35.59 ppm/°C), attributed to the synergistic effects of bond polarizability enhancement and lattice energy optimization. These results establish a universal ion-substitution paradigm for developing advanced ULTCC materials with simultaneously improved Q×f and reduced processing temperatures (<725 °C), demonstrating significant potential for millimeter-wave communication applications. Through ion substitution, these materials all have low sintering temperatures and high Q×f values, making them ideal candidates for low-temperature co-fired ceramics (LTCC).
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DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.4
Shiya Wang,Wei Huang,Shanshan Ma,Peng Chen,Juan Li,Miaojun Xu
The thermal conductivity of PA56 composites is 283% higher than that of PA56. • Surface modification enhances the flame retardancy of PA56. • Nickel phosphomolybdate improves the flame-retardant efficiency of PA56. • PA56 with good thermal conductivity and flame retardancy are achieved. Flame retardancy of polymer is often deteriorated when its thermal conductivity (TC) is increased. In this paper, alumina (Al 2 O 3 ) and boron nitride (BN) were modified and applied to increase the performance of polyamide 56 (PA56). The 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide derivative (DiDOPO) and nickel phosphomolybdate (PMoNi) were compounded as a flame-retardant system for PA56. The TC for PA56 samples is increased to 0.92 W/(m·K) which is 283% higher than the TC of PA56. 6 wt% DiDOPO endows PA56 with a UL-94 V-2 rating, while the PA56 containing the same amount of DiDOPO/PMoNi (5:1) obtains the UL-94 V-0 and a limiting oxygen index of 34.2 vol%. The char layer generated by PA56 and the thermal conductive fillers show some blocking effect, effectively inhibiting the release of heat, smoke from PA56 during combustion. DiDOPO works in gas and condensed phase, and the former dominates; PMoNi helps PA56 to form char layer with high quality, which enhances the scavenging effect and improves the flame-retardant efficiency. PMoNi improves the flame retardancy of thermally conductive PA56 by enhancing the scavenging effect. Download: Download high-res image (180KB) Download: Download full-size image
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DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·455
·
IF 5.4
Zhao Zhenghong,Xu Yue,Xu Shuzhen,Zhang Lianming,Li Jianping
The detection of carbohydrate antigen 19 − 9 (CA19-9), a critical serum marker for gastrointestinal malignancies, is particularly challenging because of its typically low concentration and substantial matrix interference, creating a critical demand for improved detection technologies. Herein, we rationally designed and synthesized a nanozyme with dual-ligand cerium-organic framework (Ce-MOF-BN) nanozyme for glycosyl-imprinted colorimetric biosensing via a one-pot method. The crystalline porous framework is densely functionalized on its surface with spatially accessible amino and boronic acid groups, enabling the recognition and oriented immobilization of imprinting templates. A well-defined core–shell molecularly imprinted composite was successfully fabricated through the systematic optimization of the ligand ratio. The composite exhibits intrinsic oxidase-like activity without requiring H 2 O 2 , and the molecularly imprinted polymer (MIP) shell supplies specific cavities for the highly selective recognition of CA19-9. Under optimized assay conditions, the sensor achieves the quantitative detection of CA19-9 across a broad linear range of 0.0001–100 U/mL, with a limit of detection as low as 2.7 × 10 − 5 U/mL. This work provides valuable insights for designing next-generation high performance biomimetic sensing materials and advancing their clinical diagnostic applications. Graphical The alternative text for this image may have been generated using AI.
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DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Fang Fang,Yuxin He,Jutang Zhao,Yanli Zhang,Chunhua Chen,Huijun He,Quanyong Wu,Mengwei Hu,Shaoping Nie,Mingyong Xie,Jielun Hu
Whole grains (WGs) are considered as the representative sources of dietary fiber (DF). Thermal treatments can change the properties of DF, and potentially affecting the gut microbiota as well as human health. In this study, DF content and in vitro fermentation characteristics of 9 kinds of WGs (highland barley, barley, buckwheat, proso millet, quinoa, sorghum, coix seed, foxtail millet, and oats) after boiling and steaming treatments were compared. It was found that boiling and steaming treatments could both increase DF content in these grains, except for barley and foxtail millet. Processed WGs could regulate beneficial microbial genus, such as Bifidobacterium , Prevotella, Megamona and Megasphaera. Oats, quinoa, highland barley, and buckwheat after boiling treatment can produce more total short-chain fatty acids (SCFAs) than steaming treatment ( p < 0.05), while barley, foxtail millet and coix seed showed opposite results. This study can provide data support for the design of WGs diets and the development of WGs products which are beneficial for gut health.
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产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Wanyi Zhou,Zhiguang Duan,Jing Zhao,Rongzhan Fu,Chenhui Zhu,Daidi Fan
Chronic diabetic wounds are an important healthcare challenge. High concentration glucose, high level of matrix metalloproteinase-9 (MMP-9), and long-term inflammation constitute the special wound environment of diabetic wounds. Tissue necrosis aggravates the formation of irregular wounds. All the above factors hinder the healing of chronic diabetic wounds. To solve these issues, a glucose and MMP-9 dual-response temperature-sensitive shape self-adaptive hydrogel (CBP/ [email protected] &INS) was designed and constructed with polyvinyl alcohol (PVA) and chitosan grafted with phenylboric acid (CS-BA) by encapsulating insulin (INS) and gelatin microspheres containing celecoxib ( [email protected] ). Temperature-sensitive self-adaptive CBP/ [email protected] &INS provides a new way to balance the fluid-like mobility (self-adapt to deep wounds quickly, approximately 37 °C) and solid-like elasticity (protect wounds against external forces, approximately 25 °C) of self-adaptive hydrogels, while simultaneously releasing insulin and celecoxib on-demand in the environment of high-level glucose and MMP-9. Moreover, CBP/ [email protected] &INS exhibits remodeling and self-healing properties, enhanced adhesion strength (39.65 ± 6.58 kPa), down-regulates MMP-9, and promotes cell proliferation, migration, and glucose consumption. In diabetic full-thickness skin defect models, CBP/ [email protected] &INS significantly alleviates inflammation and regulates the local high-level glucose and MMP-9 in the wounds, and promotes wound healing effectively through the synergistic effect of temperature-sensitive shape-adaptive character and the dual-responsive system.
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产品关联
DOI
PubMed
高影响因子
ANALYST
·
2023
·Vol. 148
·期 23
·5905-5914
·
IF 4.2
Tingting Zhang,Yan Ma,Yuzhong Zhang
In this work, label-free electrochemical immunosensing of the cancer biomarker carbohydrate antigen 19-9 (CA19-9) is reported using [Fe(CN)6]3−/4− as a signal probe and a copper organic framework (Cu-BTC) nanocomposite for the amplification of the signal. The immunosensor was fabricated by the following process. First, the Cu-BTC nanomaterial with a larger surface area and good biocompatibility was synthesized to improve the dispersion of gold nanoparticles (Au NPs). Then, nitrogen-doped graphene (N-GR) was combined with Cu-BTC to form the nanocomposite. The synthesized Cu-BTC@N-GR@AuNPs@CS nanocomposite was employed to modify the surface of the immunosensor to accelerate the electron transfer rate and improve the immobilization amount of CA19-9 antibodies (Ab). Various techniques, including TEM, SEM and XPS were used to characterize Cu-BTC and nanocomposites. Differential pulse voltammetry (DPV) was used to measure the electrochemical response of the immunosensor in [Fe(CN)6]3−/4−. The signal intensity of the immunosensor was linearly changed upon increasing the concentration of CA19-9 antigen from 10 μU mL−1 to 100 U mL−1, and a detection limit of 4.2 μU mL−1 was achieved. Furthermore, the immunosensor showed good stability, reproducibility and specificity, indicating its potential application in clinical analysis.
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DOI
PubMed
高影响因子
Journal of Environmental Sciences
·
2023
·
IF 6.9
Shuhui Zhang,Xiang Zuo,Jialu Luan,Huijuan Bai,Zhenhua Fu,Mingzhu Sun,Xin Zhao,Xizeng Feng
Increasing evidence indicates that disturbance of the clock genes, which leads to systemic endocrine perturbation, plays a crucial role in the pathogenesis of metabolic and liver diseases. Fluorene-9-bisphenol (BHPF) is utilized in the manufacturing of plastic materials but its biological effects on liver homeostasis remain unknown. The impacts and involved mechanisms of BHPF on the liver diseases, metabolism, and circadian clock were comprehensively studied by zebrafish and mouse models. The therapeutic effect of melatonin (MT) was also verified. Zebrafish and mouse models with either acute exposure (0.5 and 1 µmol/L, 1-4 days post-fertilization) or chronic oral exposure (0.5 and 50 mg/(kg·2 days), 30 days) were established with various BHPF concentrations. Herein, we identified a crucial role for estrogenic regulation in liver development and circadian locomotor rhythms damaged by BHPF in a zebrafish model. BHPF mice showed chaos in circadian activity through the imbalance of circadian clock component Brain and Muscle Aryl hydrocarbon receptor nuclear translocator-like 1 in the liver and brain. The liver sexual dimorphic alteration along with reduced growth hormone and estrogens played a critical role in damaged glucose metabolism, hepatic inflammation, and fibrosis induced by BHPF. Besides, sleep improvement by exogenous MT alleviated BHPF‐related glucose metabolism and liver injury in mice. We proposed the pathogenesis of metabolic and liver disease resulting from BHPF and promising targeted therapy for liver metabolism disorders associated with endocrine perturbation chemicals. These results might play a warning role in the administration of endocrine-disrupting chemicals in everyday life and various industry applications.
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Jiale Wang,Guang Yao,Dong Hu,Sheng Huang,Junqi Liu,Quan Zhu
In order to investigate the interactive effect on the density of two-component mixtures, six mixtures of methylcyclohexane(1) + n-dodecane(2)/n-tetradecane(2)/n-hexadecane(2) and ethylcyclohexane(1) + n-dodecane(2)/n-tetradecane(2)/n-hexadecane(2) were measured by using the Anton Paar DMA 4200 M densimeter and a hand-operated pressure pump in the temperature and pressure ranges of T = 280 to 423.15 K and P = 0.1 to 9 MPa, respectively. Additionally, the combined standard uncertainty in the density of binary mixtures with n-hexadecane is uc(ρ) = 1.543 kg/m3, and for other mixtures, it is uc(ρ) = 1.541 kg/m3. The experimental data were successfully correlated with the empirically modified Toscani–Szwarc equation of state with a maximum regression deviation of less than 1.0630 kg/m3 for all the binary mixtures. On the basis of the experimental data and parameters of the regression model, isobaric thermal expansivity and isothermal compressibility were calculated and exhibited nonlinear behavior against the mole fraction, which is due to different molecular interactions between the two components.
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 8
·51688
·
IF 3.125
Qibin Xu,Shengchang Zhang,Zexi Su,Dazhe Li,Shuheng Liang,Bo Li,Tingting Lian,Xiangpu Qin,Mengjin Jiang,Pengqing Liu
9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and DOPO derivatives had always been regarded as main candidates for improving the flame retardancy of epoxy resin (EP). In this paper, a novel reactive flame retardant DOPOMAH was synthesized from the reaction between DOPO and cis-butenedioic anhydride (MAH), thereafter acted as a co-curing agent for EP to remarkably improve the flame retardancy of matrix. The effects of DOPOMAH and DOPO on comprehensive performance of EP were systematically investigated and compared through dynamic mechanical analysis, mechanical performance testing, limiting oxygen index (LOI), vertical burning (UL-94), and cone calorimetry test. These results indicated that the excellent dispersion of DOPOMAH in EP makes the EP modified by DOPOMAH has good mechanical properties. When the content of phosphorus is 2.0 wt%, compared with the EP modified by DOPO (ED), the LOI of the EP modified by DOPOMAH (EDM) increased from 30.6% to 32.8%, and the UL-94 was also improved from no rating to V-0. Meanwhile, the peak heat release rate of EDM was only 51% of that of pure EP, which was slightly less than that of ED. Finally, a flame-retardant mechanism comparison between DOPOMAH and DOPO was discussed in detail to reveal the reasons why the flame reatardant effect of DOPOMAH was better than that of DOPO.
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DOI
高影响因子
ORGANIC ELECTRONICS
·
2020
·
IF 3.31
Min Yang,Qin Zhang,Wenjing Zhang,Zhongqi Hao,Yuancheng Qin,Xia Hai,Fangfang Li,Dan Zhou,Yubao Zhang
Improving the hole carrier mobility of organic hole-transporting materials is critical for the development of advanced quantum dot light-emitting diodes (QLEDs). Here, a simple method is reported for enhancing the hole-charge mobility in poly(9-vinylcarbazole), PVK. Doping of the PVK using the molecular Lewis acid tris(pentafluorophenyl)borane as a dopant is shown to have a powerful effect on the hole-charge mobility, and the performance of the QLEDs. By adjusting the amount of dopant, the p-type Hall mobility can be increased up to 3.3-fold, and thereby, the external quantum efficiency and current efficiency of QLEDs are improved by 132% and 249%, respectively.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）