FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Liyang Du,Zong Meng
Herein, a novel edible foam based on surfactant-free, gelled Pickering oil-in-water-in-oil (O/W/O) emulsion was developed using fat crystals as stabilizers of water-in-oil and air-in-oil interfaces while protein microgel as the stabilizer of oil-in-water interface, in which multi-chambered droplets and bubbles co-existed. The effects of fat crystals and fat amount, including palm oil (PO), anhydrous milk fat (AMF), and palm stearin (PS), on foam performance were evaluated. AMF-based foams exhibited a better aeration performance and a smoother cream-like sensation than PO, better interfacial stabilization on emulsion and foam were achievable by AMF crystals for greater diffusivity and a homogeneous spatial distribution, thereby allowing engaging in more interactions to support networks. Excessive PS was not conducive to the foam structure and led to a rough oral perception because more aggregated stiff PS crystals tended to destroy the water droplets. The introduction of gas greatly improved the rheological behaviors of O/W/O emulsions, and the viscous dissipation behavior for concentrated-droplets dominated foams was more pronounced at large deformation compared to bubble-filled foams. The microstructure and rheological behaviors further influenced the 3D printing properties of foamy systems as nutraceutical co-loading carriers for epigallocatechin gallate (EGCG) and lycopene. The tuneability of foam inks was permitted to improve printing accuracy, enhance the tolerance of printed objects to extrusion process through modulating the fat phase, thereby reducing the loss of EGCG and lycopene. This work is expected to provide a versatile soft foamy material with explicit and implicit multi-functionalities that finds interesting application in fat products.
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MOLECULES
·
2020
·Vol. 25
·期 2
·407
·
IF 3.267
Jiaguo Li,Dian Xiao,Lianqi Liu,Fei Xie,Wei Li,Wei Sun,Xiaohong Yang,Xinbo Zhou
In this article, we report the design, synthesis, photodynamic properties, and in vitro evaluation of photoactivatable prodrug for the poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor Talazoparib. In order to yield a photoactivatable, inactive prodrug, photoactivatable protecting groups (PPGs) were employed to mask the key pharmacophore of Talazoparib. Our study confirmed the good stability and photolytic effect of prodrugs. A PARP-1 enzyme inhibition assay and PARylation experiment showed that the inhibitory activity of the prodrug was reduced 380 times and more than 658 times, respectively, which proved that the prodrug’s expected activity was lost after PPG protection. InBRCA1- andBRCA2-deficient cell lines, the inhibitory activity of the compound was significantly restored after ultraviolet (UV) irradiation. The results indicate that the photoactivatable prodrug strategy is an interesting approach for studying PARP inhibitors. Meanwhile, the described photoactivatable prodrug also provided a new biological tool for the mechanism research of PARP.Keywords:Talazoparib;PARP inhibitor;prodrug;o-nitro-benzyl;photoactivatable protecting groups
研究领域:
药物化学
·
肿瘤学
·
生物化学
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JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Rui Sun,Junyi Wang,Haoran Liang,Shuo Li,Xiao Yang
A facile and novel N-heteroarenium iodide-catalyzed hydroalkoxylation of enamides has been described. The protocol provides easy access to N,O-acetals, which proved to be a versatile synthetic synthon. The hydrosulfonylation, hydroamination, and hydrophosphorylation products of enamide could be indirectly provided from N,O-acetals. The reaction mechanism was further investigated, which indicated that the hydroalkoxylation of enamides was driven by weak coordination between enamide and the contact ion pair of N-heteroarenium iodide.
研究领域:
有机化学
·
合成化学
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Keqing Wang,Yujie Hao,Yaru Duan,Xueqian Guo,Zhenyue Yang,Pierre Waffo-Téguo,Michaël Jourdes,Pierre-Louis Teissedre,Wen Ma
Esterified flavan-3-ols, prevalent in grapes and wine as monomers or subunits within condensed tannins, significantly influence the mouthfeel of wine. However, comprehensive knowledge of their molecular structures and transformations during vinification is still limited. This study investigated tannin derivatives, specifically vanillate and gallate forms, using UHPLC-Q-TOF to elucidate their distribution across four Vitis vinifera L. cultivars, their transformations during vinification, and their metabolic fate mediated by Oenococcus oeni and β -glucosidase activity. The taste responses of epicatechin-3- O -vanillate (ECV) and − 3- O -gallate (ECG) were evaluated using an electronic tongue. The results indicated that ECV was predominantly found as monomers and terminal units within the condensed tannins across all examined grape varieties. During early malolactic fermentation (MLF), ECV and ECG are hydrolyzed into epicatechin (EC), vanillic acid (VA), and gallic acid (GA) by O. oeni and β -glucosidase enzymes. This enzymatic cleavage is potentially correlated with reduction of esterified flavan-3-ols contentand perceptible bitterness in wine.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Chengduan Wang,Wan Gou,Changlu Liu,Dong Fu,Lvshan Zhou,Chuan Lai,Bin Xie,Shasha Zhu
The new corrosion inhibitor of S-benzyl-O,O'-bis( p -tert-butyl phenyl)dithiophosphate (SOBP) was synthesized and characterized by elemental analysis, FT-IR, 1 H NMR, 13 C NMR, 31 P NMR and single crystal X-ray diffraction. Meanwhile, the corrosion inhibition and mechanism of SOBP for Q235 steel in 1.0 M HCl were studied by weight loss and potentiodynamic polarization measurement, also the crystal structure of corrosion inhibitor was presented. The potentiodynamic polarization measurement result indicates that SOBP is a mixed-type inhibitor. The two methods all reveal that the inhibition efficiency increases with the concentration of SOBP, which is an effective corrosion inhibitor. The adsorption of SOBP on Q235 steel surface in 1.0 M HCl belongs both physisorption and chemisorption.
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JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Ji-Hao Zuo,Yi-Hang Gu,Chao Wei,Xi Yan,Yan Chen,Wan-Zhong Lang
Janus membrane is an emerging separation material due to its unique separation performance. The asymmetric surface wettability on its two surfaces is crucial for a Janus membrane. In this work, robust Janus polyvinylidene fluoride (PVDF) membranes were prepared via thermal induced phase separation (TIPS) accompanied with spray-coating method. The two surfaces of TIPS-prepared PVDF membranes were rapidly deposited with polydopamine/polyethyleneimine (PDA/PEI) and micro-/nano-scale silica particles crosslinking with diphenyldichlorosilane respectively. The spray-coating endows the Janus membranes with superhydrophilicity and superhydrophobicity on its opposite surfaces. The optimized membrane of M-A0.9B0.2 presents an asymmetric surface wettability. Its hydrophilic surface has a water contact angle (WCA) of 11.2°, while the hydrophobic surface has a WCA of 169.9° as well as a sliding angle of <1°. The superhydrophilic surface allows water to quickly pass through the membrane and oil phase is trapped; while oil can penetrate through the membrane and water is rejected by the superhydrophobic surface. The Janus membranes show excellent separation performance with the highest permeation of 2060.5 L m −2 h −1 ·bar −1 accompanied with above 94.0% oil rejection for toluene-in-water emulsion and the highest permeation of 1769.0 L m −2 h −1 ·bar −1 accompanied with above 97.0% water rejection for water-in-toluene emulsion using the opposite surfaces.
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Cell Death Discovery
·
2025
·
IF 7
Rui Ma,Chen Peng,Wenjuan Chen,Yizhen Zhang,Yangfeng Ding,Xin Wang,Yuling Shi
The skin barrier is crucial for protecting against environmental challenges, preventing water loss, and regulating immune responses. This study aims to investigate the roles and mechanisms of SERPINB7 in skin barrier maintenance. We found that SERPINB7 deficiency disrupts tight junctions of keratinocytes in vitro, and specific knockout of Serpinb7 in keratinocytes impairs skin barrier function in vivo. SERPINB7 deficiency leads to reduced expression of O-GalNAc regulatory proteins and structural abnormalities in the Golgi apparatus, ultimately impairing protein O-GalNAc glycosylation. Legumain acts as a critical mediator in the maintenance of normal biological functions and O-GalNAc glycosylation regulated by SERPINB7. O-GalNAc inhibition exhibits biological effects analogous to those induced by SERPINB7 deficiency, leading to weakened tight junctions, reduced cell adhesion, and compromised skin barrier integrity in keratinocytes and mouse skin, respectively. Consequently, O-GalNAc deficiency exacerbates inflammatory skin diseases such as psoriasis and atopic dermatitis. Mechanistically, O-GalNAc deficiency primarily affects the glycosylation of calcium-related and cell adhesion-related proteins, disrupting calcium signaling and compromising cell adhesion, ultimately leading to skin barrier dysfunction. In summary, this study demonstrates that SERPINB7 maintains skin barrier through protein O-GalNAc glycosylation. These findings not only deepen our understanding of skin barrier biology but also provide new insights for developing therapeutic strategies for skin barrier-related diseases.
研究领域:
皮肤病学
·
分子生物学
·
糖生物学
·
细胞生物学
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JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2019
·
IF 2.066
Ke Cao,Cai-Yan Zhang,Tao-Tao Xu,Ji Wu,Li-Fang Ding,Linhai Jiang,Junxiao Yang
The palladium catalyzed/counter ion tuned selective methylation of 9-amide- o -carboranes on B(4) and B(12) has been developed, and a series of o -carborane derivatives decorated with various groups have been synthesized with moderate yields. The in situ formed palladium species via counter ion exchange was proposed for the tunable B–H activation.
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CARBOHYDRATE POLYMERS
·
2011
·Vol. 85
·期 4
·832-837
·
IF 3.463
Dongke Zhao,Jun Huang,Sheng Hu,Jianwei Mao,Lehe Mei
Chitosan was prepared by alkaline N -deacetylation of squid cartilage β-chitin and carboxymethylated derivatives with different degrees of substitution (DS) were synthesized. The DS of the derivatives calculated by pH titration were 0.64, 0.81, 1.0, 1.33 and 1.59. The antioxidant properties and bile acid binding capacity of the derivatives were studied in vitro . The carboxymethylation of chitosan caused enhancement of bile acid binding capacity. At 1 mg/mL, carboxymethyl chitosan (CMCS) showed a stronger scavenging effect than chitosan towards DPPH radicals. The CMCS scavenging effect on superoxide radicals was stronger than that of chitosan, and EC 50 values were below 5.6 mg/mL. The effectiveness of reducing power correlated with the DS of CMCS. At 1.2 mg/mL, the ability of CMCS to chelate ferrous iron was 100%, whereas that of chitosan was only 22.34%. This suggested that carboxymethylation is a possible approach to obtain chitosan derivatives with desirable biological properties.
研究领域:
生物化学
·
海洋生物技术
·
食品科学
·
高分子化学
·
功能生物材料
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Chem & Bio Engineering
·
2026
·
IF 8.4
He Qin,Cheng Shuai,Yue Jianqing,Zong Shu,Li Congyu,Qi Xuerong,Liu Lipei,Zhang Zhidan,Sun Jun,Cheng Jian,Lu Xiaoyun,Jiang Huifeng
3 ′ -O-amino-deoxyribonucleoside
triphosphates (3 ′ -ONH 2 -dNTPs) are crucial reversible
terminators for template-independent
DNA synthesis. Owing to the structural complexity of purine bases,
here we propose a chemo-enzymatic process for the synthesis of purine-type
3 ′ -ONH 2 -dNTPs. First, the aminoalkoxyl group was
introduced into commercially available dA and dG via a chemical catalytic
process, affording yields of 24.9% and 27.3%, respectively. Subsequently,
to establish a green and scalable enzymatic cascade for phosphorylation
of the substrates, we engineered two key phosphorylation enzymes (Dm-dNK
and MrPPK2), improving the rate-limiting monophosphorylation of 3 ′ -ONH 2 -dG from 26% to 97.8% and achieving 59.9% conversion to the
corresponding triphosphate. Lastly, the produced nucleotides exhibit
performance equivalent to commercial counterparts in terminal deoxynucleotidyl
transferase (TdT)-mediated DNA synthesis, supporting the construction
of 120-nt strands with ∼99.7% stepwise accuracy. This work
establishes an efficient and generalizable catalytic platform for
producing modified dNTPs, advancing the practical application of enzymatic
DNA synthesis technologies.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Yanhui Guo,Ruiqi Zhang,Weiju Hao,Jiankan Zhang,Yanjing Yang
The development of efficient and non-noble catalyst is of great significance to hydrogen generation techniques. Three surface-oxidized cobalt borides of Co–B–O@Co x B (x = 0.5, 1 and 2) have been synthesized that can functionalize as active catalysts in both alkaline water electrolysis and the hydrolysis of sodium borohydride (NaBH 4 ) solution. It is discovered that oxidation layer and low boron content favor the oxygen evolution reaction (OER) activity of Co–B–O@Co x B in alkaline water electrolysis. And surface-oxidized cobalt boride with low boron content is more active toward hydrolysis of NaBH 4 solution. An alkaline electrolyzer fabricated using the optimized electrodes of Co–B–O@CoB 2 /Ni as cathode and Co–B–O@Co 2 B/Ni as anode can deliver current density of 10 mA cm −2 at 1.54 V for overall water splitting with satisfactory stability. Meanwhile, Co–B–O@Co 2 B affords the highest hydrogen generation rate of 3.85 L min −1 g −1 for hydrolysis of NaBH 4 at 25 °C.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2023
·
IF 3.6
XiaoNan Zhang,WenQin Xu,Xing Li,GuangHua Pan,NanChun Chen,QingLin Xie,XiuLi Wang
This experiment was done to study the zeolite molecular sieve as a drug-binding effector, the non-antibiotic drug potassium diformate uniformly disperse in the internal aqueous phase of the 'egg box' structure formed by pectin-calcium ions. With oil phase as the intermediate phase and Xanthan gum Chitosan as the external water phase, the W/O/W type sustained release bacteriostatic microcapsules with pH response were prepared and characterized by Fourier transform infrared, thermogravimetric, SEM, and TEM. It can be obtained through characterization experiments that the inner water phase, oil phase, and outer water phase were formed by observation, and W/O/W emulsion microcapsules were obtained and the bacteriostasis effect of microcapsules was verified by bacteriostasis experiment. The permeance experiment showed that the molecular sieve was successfully coated in the microsphere. Studying on drug release mechanism and sustaining release performance of composite emulsion microcapsules. In vitro drug release study showed that the encapsulation efficiency and drug loading rate of microcapsules were improved by adding molecular sieve, reaching 12.31% and 61.55%, respectively. At the same time, we observed that the drug release rate slowed down during the simulated intestinal release process, and the drug release kinetics were in line with the first-order kinetic model and Ritger-Peppas model equation. Experiments had proven that the drug-loaded microcapsules exerted a significant bacteriostatic effect on Escherichia coli, Staphylococcus aureus, and Bacillus subtilis, with the highest antibacterial rates of 97.25%, 94.05%, and 95.93%, respectively. Therefore, the composite emulsion microcapsules can be used as a new controlled-release drug delivery system in vivo.
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