Molecular Catalysis
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2026
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IF 4.3
Dandan Zuo,Wuyu Wang,Miaojia Song,Peng Zheng,Sa Li,Qi Zhang,Xinghua Zhang,Longlong Ma
A ternary Cu-Nb/Al-MCM-41 catalyst achieves 99.60 % 2-methylfuran selectivity at 160 °C under atmospheric H2. • Al incorporation enhances metal dispersion and generates balanced Brønsted-Lewis acidity for controlled C O hydrogenolysis. • Nb promotion enables efficient H2 activation and strengthens Cu-Nb interfacial electronic coupling. • The catalyst exhibits excellent long-term stability and can operate continuously in a fixed bed for 500 h. The selective hydrodeoxygenation (HDO) of furfural (FAL) into 2-methylfuran (2-MF) is a crucial transformation for upgrading lignocellulosic biomass into liquid fuels. Herein, a series of Cu-Nb catalysts supported on mesoporous MCM-41 were developed. Over the optimized Cu-Nb/Al-MCM-41 catalyst, FAL was completely converted and the selectivity of 2-MF was 99.60 % at only 160 °C under ambient hydrogen pressure. Structural analyses revealed that Al incorporation reinforced metal-support interactions, enhanced Cu dispersion, and producing moderate Brønsted-Lewis acid sites, which synergistically facilitated hydrogen transfer and selective C O bond cleavage. In situ DRIFTS and XPS measurements confirmed a tandem hydrogenation-dehydration pathway proceeding via furfuryl-alcohol (FOL) intermediates, where Nb promoted H 2 activation and Al-derived acid centers accelerated dehydration at interfacial Cu-Nb-Al sites. The catalyst maintained high activity and selectivity during 500 h time-on-stream in a fixed-bed reactor, although slight deactivation was observed after prolonged operation. These findings establish a clear structure-function correlation between electronic modulation and acid-metal synergy, offering a sustainable strategy for efficiently producing furan-based biofuels under mild conditions. Download: Download high-res image (291KB) Download: Download full-size image
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Wu Qianmin,Li Cui,Wu Yuxuan,Liang Qing,Lv Xuyu,Li Yanhong,Wang Chang,Wu Mengjie,Kong Lichun,Lu Ji-Qing,Zhang Wei,Li Zhengquan,Chen De-Li,Zhou Jing,Yang Fa
Stabilizing metal oxides is a prerequisite for elucidating their intrinsic mechanistic roles and sustaining high electrocatalytic activity. Here, we synthesize a high-temperature-phase La 2 O 3 -socketed sub-2 nm δ-Bi 2 O 3 heterojunction (δ-Bi 2 O 3 /La 2 O 3 ) that suppresses Bi 3+ reduction to metallic Bi, achieving ≥95% formate Faradaic efficiency for ~200 hours in industrial-level electrolyzers. Electronic structure analyses reveal that strong electrostatic interactions between δ-Bi 2 O 3 and La 2 O 3 drive oxygen migration to the interface, contracting δ-Bi 2 O 3 domains and enhancing La–Bi d-p orbital hybridization. This structural relaxation stabilizes interfacial Bi–O–La linkages and electron-deficient Bi 2 O 3+x species under cathodic potentials, as confirmed by in situ X-ray absorption spectroscopy. Pourbaix diagrams and in situ infrared spectroscopy demonstrate that La 2 O 3 promotes water dissociation to form a hydroxylated δ-Bi 2 O 3 surface under working potentials, enhancing protonation propensity. Consequently, the energy barrier for the rate-determining step (*CO 2 → *HCOO) is lowered to +0.15 eV on δ-Bi 2 O 3 /La 2 O 3 , significantly lower than the +0.83 eV barrier on pristine δ-Bi 2 O 3 . This work establishes a sub-nanoscale oxide/oxide heterojunction strategy to stabilize high-valent metal sites, enabling sustainable electrochemical conversion.
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高影响因子
Insect Science
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2026
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IF 3.7
Kang-Kang Xu,Yang-Fan Zhou,Wen-Jia Yang,Fang-Hao Wan,Guy Smagghe,Can Li
Laccase-2 (Lac2) is a key phenoloxidase that catalyzes cuticular sclerotization and pigmentation, which are processes essential for insect molting and metamorphosis. Although the alternatively spliced isoform Lac2A is known to function in cuticular tanning, the physiological role of Lac2B has remained largely unresolved. Here, we identified and functionally characterized two Lac2 isoforms, LsLac2A and LsLac2B , from the cigarette beetle Lasioderma serricorne , a globally important stored-product pest. Both isoforms are highly expressed during the pupal and eclosion stages, with transcripts localized mainly in the cuticle and wing tissues, and are transcriptionally induced by 20-hydroxyecdysone (20E), linking their activity to endocrine regulation of development. Functional analyses revealed that LsLac2A and LsLac2B have distinct and complementary roles in molting and metamorphosis. During larval molting, LsLac2A promotes the synthesis of new cuticle by regulating genes involved in cuticular protein and chitin biosynthesis, whereas LsLac2B facilitates degradation of the old cuticle through modulation of chitinolytic and cuticular protein-degrading genes. In the pupal stage, both isoforms influence elytral pigmentation, sclerotization, and wing morphogenesis via the coordinated regulation of wing development-related and yellow family genes. These results reveal isoform-specific functions of LsLac2 in cuticle renewal and morphogenesis, uncovering a novel mechanism of hormonal and genetic integration during insect development. This work provides new insight into the molecular specialization of Lac2 and identifies promising RNAi-based targets for the sustainable control of L. serricorne .
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高影响因子
JOURNAL OF RARE EARTHS
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2026
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IF 9.6
Yuejia Wu,Li Li,Lina Su,Ling Huang
The elemental doping strategy was widely adopted to improve the ion transport of lanthanum silicate apatites (La 9.33 Si 6 O 26 , LSO), a very promising electrolyte for solid oxide fuel cells (SOFCs). Specifically, La 9.33 Si 5.5 (Ga 1/2 V 1/2 ) 0.5 O 26 , i.e., LSGV 0.5 is obtained through (Ga 1/2 V 1/2 ) 4+ doping, which leads to not only a 4-fold oxygen ion conductivity (15.8 mS/cm at 800 °C) improvement, but also a 150 °C reduced sintering temperature compared with that of LSO. The as-such fabricated SOFC achieves a peak power density of 0.357 W/cm 2 at 800 °C using LSGV 0.5 as the electrolyte, demonstrating the effective complex ion doping towards enhanced performance for apatite-based electrolytes.
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Advanced Science
·
2026
·
IF 14.1
Sidi Yang,Kun Li,Lihong Liu,Linsen Zeng,Qifeng Deng,Jiacheng Huang,Xiaoran Dong,Xin Wang,Jianwei Liang,Hongchao Liu,Hong Peng,Yuxin Lin,Xiaolu Xie,Yuzhen Ye,Tiefeng Xu,Zhaohuan Wang,Chun-Mei Li,Deyin Guo
SARS-CoV-2 accessory protein ORF3a contributes to viral pathogenesis through membrane remodeling, immune evasion, and inflammation induction. However, the molecular mechanisms underlying ORF3a-mediated pathogenesis remain poorly characterized, and no therapeutic strategies targeting ORF3a currently exist. Here, we demonstrate that palmitoylation, a post-translational modification, governs ORF3a-mediated viral pathogenesis. Specifically, ORF3a undergoes ZDHHC18-mediated palmitoylation at evolutionarily conserved Cys130/Cys133 residues, which stabilizes the protein by masking an intrinsic proteasomal degradation signal. This palmitoylation competitively inhibits tripartite motif-containing 16 (TRIM16)-dependent K27-linked polyubiquitination, thereby preventing ORF3a degradation and enhancing viral replication and inflammatory responses. A designed ORF3a-mimicking palmitoylation-inhibitory peptide (OPIP) blocked ORF3a palmitoylation, promoted its degradation, and significantly reduced SARS-CoV-2 pathogenicity. Collectively, these findings establish ZDHHC18-mediated palmitoylation as a central regulator of ORF3a stability and virulence, revealing a potentially druggable axis for disrupting SARS-CoV-2 pathogenesis.
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高影响因子
MINERALS ENGINEERING
·
2026
·
IF 6
Suofeiya Ba,Junjie Zhang,Jiehong Liu,Zhe Liu,Yibo Li,Chengchao Liu,Shouxing He,Yaoguo Huang,Wen Tan
5-methyl isobutylxanthate-1,3,4-oxadiazole-2-thione (MIXODT) was designed. • Ionic MIXODT exhibits enhanced electron-donating ability. • Stronger adsorption on chalcopyrite than galena was confirmed. • Cu–S/N orbital hybridization governs selective chemisorption. • Flotation tests agree well with theoretical predictions. To achieve highly selective separation of chalcopyrite (CuFeS 2 ) from galena (PbS), we introduced a xanthate ester group into the 1,3,4-oxadiazole-2-thione skeleton based on a synergistic coordination design strategy and synthesized a collector, 5-isobutyl xanthate methyl ester-1,3,4-oxadiazole-2-thione (MIXODT), with 5-heptyl-1,3,4-oxadiazole-2-thione (HPODT) lacking this group as a control. Density functional theory (DFT) calculations revealed that the ionized form (MIXODT − ) is the predominant reactive species. MIXODT⁻ exhibited significantly higher adsorption energy on the chalcopyrite (0 0 1) surface than on the galena (1 0 0) surface, and outperformed HPODT − . Density of states (DOS) and charge analysis revealed that MIXODT⁻ formed multi-site Cu–S/Cu–N coordination bonds with surface Cu atoms through S and N active sites, leading to pronounced orbital hybridization and electron transfer, while only weak interactions occurred at Pb sites. Flotation experiments confirmed this selective interfacial bonding and achieved a distinct “high Cu, low Pb” separation window under low-alkaline conditions. The core innovation of this work lies in the multi-site synergistic coordination mechanism at the interface, which establishes an inherent link among molecular design, interfacial coordination chemistry, and selective flotation behavior, providing theoretical guidance for the rational design of collectors for copper-lead sulfide ores. Combining quantum chemical calculations with flotation experiments, this work systematically elucidated the multi-site coordination mechanism and selective flotation behavior of oxadiazole-2-thione-based collectors in chalcopyrite-galena separation. Download: Download high-res image (132KB) Download: Download full-size image
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Dandan Chen,Bin Yin,Zhirun Ji,Zhiqi Liu,Jiahao Li,Fei Liu,Xuping Wu
Amplification-free digital detection of SARS-CoV-2 via CRISPR/Cas12a. • Pneumatically actuated droplet microfluidics enables uniform ∼30 μm droplets. • Rapid detection of SARS-CoV-2 with demonstrated performance in clinical samples. • Offers a simple, portable method for rapid virus detection. Outbreaks of respiratory viruses, including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), Influenza A (IAV), and Influenza B (IBV) viruses, present a formidable challenge to global public health, driving the urgent need for rapid, sensitive, and deployable diagnostic tools. Here, we present an amplification-free digital nucleic acid detection platform that synergistically integrates a pneumatically actuated droplet microfluidics platform (PADMP) with CRISPR/Cas12a. PADMP enables the precise generation of highly uniform, monodisperse microdroplets (∼30 μm), within which an optimized Cas12a reaction is compartmentalized. This digital partitioning strategy exponentially increases the local target concentration and facilitates single-molecule detection without pre-amplification. Through systematic optimization of droplet stability, surfactant formulation, and Cas12a assay kinetics, the PADMP-Cas12a platform achieves a detection limit (LOD) of 100 pM for synthetic SARS-CoV-2 N gene targets within 40 min. It demonstrates exceptional specificity, showing no cross-reactivity with non-target respiratory viruses (IAV, IBV, SARS-CoV, MERS-CoV, HRSV). The platform successfully detected SARS-CoV-2 in clinical positive samples, with mean droplet fluorescence intensity negatively correlated with Ct values. By combining the advantages of droplet microfluidics with the programmable recognition and trans -cleavage activity of CRISPR/Cas12a, this platform provides a rapid, amplification-free, and highly specific digital detection pathway for RNA viruses, marking an important advance toward high-throughput and point-of-care testing (POCT) for molecular diagnostics. Download: Download high-res image (127KB) Download: Download full-size image
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高影响因子
Journal of Materials Chemistry B
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2026
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IF 6.2
Xiaoyu Ma,Zhuang Zhang,Dandan Yang,Hui Wang,Hao Zhang,Yue Yang,Siying Li,Yuping Shan
Beyond the canonical angiotensin-converting enzyme 2 (ACE2)-mediated entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells, basigin (BSG) and dipeptidyl peptidase 4 (DPP4) may also act as alternative receptors that can facilitate viral attachment and subsequent endocytosis. Herein, we analyzed the binding efficiency and binding dynamics of SARS-CoV-2 virus-like particles (VLPs), mediated by BSG and DPP4 at the single-particle level, by combining super-resolution direct stochastic optical reconstruction microscopy (dSTORM) and single-molecule force spectroscopy (SMFS). dSTORM imaging demonstrated that DPP4 exhibits higher surface expression levels than BSG on HepG2 cells. However, SARS-CoV-2 VLPs display a distinct preference for BSG-dependent cellular entry. Using SMFS, we further probed the binding dynamics between the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD) and these two receptors. The results demonstrated that RBD-BSG exhibits greater stability and a more rapid formation rate compared to RBD-DPP4. Subsequently, a real-time force tracing technique was used to show that BSG-mediated VLP entry requires lower force and faster speed compared with DPP4-mediated entry. In particular, we confirmed that the structural integrity of intramolecular disulfide bonds within the RBD is indispensable for mediating high-affinity receptor binding. These findings elucidate the distinct receptor-mediated endocytic dynamic mechanisms underlying SARS-CoV-2 entry mediated by BSG and DPP4, expanding our understanding of viral invasion beyond the ACE2 pathway and providing insights into potential intervention strategies targeting viral infection.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2026
·Vol. 46
·期 14
·118532
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IF 6.3
Jingdan Lei,Xiaoyun Yang,Mengxiang Wu,Xiwei Zhang,Di Yuan,Huijuan Geng,Chong Han,Zhaoyang Han,Zhenjie Tang,Chao Wang
Mg 3 (Sb, Bi) 2 is a promising mid- to low- temperature thermoelectric material owing to its earth-abundant composition. However, its performance is limited by low intrinsic carrier concentration and the inherent trade-off among thermoelectric parameters. Herein, large-grain sized Mg 3.01 Sb 1.3 Bi 0.69 Te 0.01 Ho 0.07 are fabricated via melting method at 1423 K using a tantalum-sealing technique. A high peak zT of 1.6 at 700 K is realized, along with a peak power factor of 24 μW cm −1 K −2 and a low κ L of 0.41 W m −1 K −1 . The superior performance originates from synergistic manipulation of electron and phonon transport. Ho doping optimizes carrier concentration up to 7.2 × 10 19 cm −3 due to its small electronegativity difference with Mg, while the large grain ensures high carrier mobility. Simultaneously, atomic-scale alloy disorder suppresses phonon propagation, resulting in a substantial reduction in lattice thermal conductivity. This work highlights the great potential of synergistic transport engineering for high-performance Mg 3 (Sb, Bi) 2 -based thermoelectric materials.
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Xin Xin,Qi Zhang,Sujun Yan,Zilong Chen,Xinhai Zhu
Background Monosaccharides and disaccharides are central components of carbohydrate metabolism, and fluctuations in their abundances are closely associated with disease onset, progression, and diagnostic outcomes. However, accurate analysis of trace-level saccharides in complex biological matrices remains challenging due to their limited chromatographic retention, modest ionization efficiency, and limited MS/MS fragmentation. Derivatization has been widely explored to improve analytical performance in LC-MS-based saccharide analysis; nevertheless, further development of simple, sensitive, and broadly applicable strategies is desirable, particularly for small-volume and low-abundance biological samples. This work presents an efficient derivatization-LC-MS approach enabling ultrasensitive quantification of saccharides under microscale analytical conditions. Results A derivatization strategy based on 2-hydrazinyl-6-methoxy-1,3-benzothiazole (HMBT) was developed to enhance LC-MS analysis of monosaccharides and disaccharides. The mild reaction generated stable derivatives directly compatible with LC-MS. HMBT tagging significantly improved chromatographic retention and separation on conventional C18 columns and markedly enhanced ionization efficiency. The derivatives produced high-intensity precursor ions and a dominant, highly responsive product ion, enabling ultrasensitive MRM detection on a triple-quadrupole system. Using nine representative saccharides, the method achieved excellent quantitative linearity down to 10 pg·mL −1 . Application to mouse serum enabled the quantification of glucose at single-cell-equivalent levels, and spiked galactose showed a linear range of 0.05–100 ng·mL −1 . Importantly, the workflow enabled quantification of five endogenous saccharides in individual HeLa cells. Significance The HMBT derivatization workflow provides an ultrahigh-sensitivity LC-MS platform for saccharide analysis, enabling robust MRM-based quantification at pg·mL −1 levels. Its operational simplicity, minimal sample handling, and full compatibility with conventional LC-MS instrumentation facilitate practical implementation. The demonstrated applicability to true single-cell measurements highlights its potential for glycometabolic studies in microscale biological systems.
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高影响因子
JOURNAL OF PROTEOME RESEARCH
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2026
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IF 3.8
Xue Li,Zhanxuan Emily Wu,Xinyuan Wang,Fengming Luo,Cheng Deng,Yu Chen,Huajing Wan,Xiaoju Tang,Yabin Zhang,Peiliang Shi,Zhengzhong Wu,Chunyou Ning,Wenxiang Yang,Hao Yang,Jia Liu,Fei Li
Age is a key risk factor for morbidity in coronavirus disease 2019 (COVID-19). This study investigates how “inflammaging” predisposes older hosts to severe SARS-CoV-2 outcomes through systemic and localized metabolic shifts. SARS-CoV-2 infection experiments were conducted respectively on 8 week-old mice and 16 week-old mice. An integrated multiomics approach was employed to delineate age-dependent molecular signatures and metabolic-immune crosstalk. 16 week-old mice exhibited significantly exacerbated weight loss and pulmonary pathology, successfully recapitulating age-related susceptibility. Multiomics integration revealed a “systemic bioenergetic gap”: suppressed plasma TCA cycle metabolites correlated with depleted pulmonary nucleotide pools (AMP, GMP, UMP and uracil). This metabolic failure led to a paradoxical proteomic profile: despite interferon pathway activation, key antiviral effectors (RSAD2, ISG15, IFIT3B) were downregulated, while stress markers (CYP1A1, MAPK8) increased. Furthermore, threonic acid, betaine, and d-ribose were identified as robust, age-dependent biomarkers of infection severity. Our findings suggest that COVID-19 severity in the aging host is driven by the failure of a systemic-to-local metabolic-immune axis. The exhaustion of circulating energetic precursors constrains localized pulmonary nucleotide metabolism, thereby impairing essential antiviral responses and tissue repair. This study identifies the “systemic bioenergetic gap” as a novel therapeutic target, suggesting that systemic metabolic resuscitation may improve clinical outcomes in elderly populations.
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高影响因子
ACTA MATERIALIA
·
2026
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IF 10.7
Zhengniu Pan,Sijing Zhu,Yi Wang,Zhen Fan,Jisheng Liang,Shiyuan Zhao,Jun-Liang Chen,Zhongwei Zhang,Zhixiang Zhang,Qi Zhou,Jie Gao,Huaizhou Zhao,Lei Miao
The n-type Mg 3+δ (Sb,Bi) 2 ‐based system has recently emerged as a breakthrough class of thermoelectric (TE) materials, drawing considerable interest for its eco‐friendly composition and potential to replace conventional commercial counterparts. However, the precise regulation of grain boundaries in Mg-based materials—akin to wielding an accurate scalpel—so as to extremely optimize thermoelectric performance and device properties remains ill-defined. In this study, the incorporation of Ga into the Mg 3 (Sb,Bi) 2 matrix via high‐energy ball milling (HBM) and spark plasma sintering (SPS) yielded an ultralow lattice thermal conductivity of 0.41 W m -1 K -1 at 300 K, a superior figure of merit ( ZT ) exceeding 1.84 at 673 K, and a high average ZT ( ZT avg ) of 1.55 across 300—773 K. The lattice thermal conductivity of Ga‐modified Mg 3+δ (Sb,Bi) 2 is markedly reduced over the entire temperature range, primarily due to the enhanced Kapitza thermal resistivity (ρ Kapitza ) resulting from the introduction of a liquid‐like phase at grain boundaries (GBs), which strengthens phonon scattering. while, Ohmic-like metal–semiconductor junctions form at the interfaces between the Ga/Bi secondary phases and the Mg 3+δ (Sb,Bi) 2 matrix lead to superior power factor. The high performance of Ga‐Mg 3+δ (Sb,Bi) 2 enabled a two‐pair module based on Mg 3.2 Ga 0.04 Sb 1.5 Bi 0.49 Te 0.01 / MgAgSb to achieve a conversion efficiency ( η ) of ∼6.0% at ΔT = 300 K. As a result, this work demonstrates significant theoretical and practical value in areas such as thermal management and thermoelectric material design.
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