ARCHIVES OF TOXICOLOGY
·
2026
·
IF 10.9
Zhao Tong,Zhao Yichen,Mao Tingting,Da Weixuan,Qin Lina,Liu Li,Liu Huan,Cheng Bolun,Wen Yan,Zhang Feng,Jia Yumeng
Kashin-Beck disease (KBD) is a multifactorial endemic osteoarthropathy that has been associated with nutritional and environmental factors, including selenium deficiency and T-2 toxin exposure. However, whether combined selenium deficiency and T-2 toxin exposure affects hepatic xenobiotic metabolism has not been systematically investigated. Male C57BL/6 mice were fed a selenium-adequate or selenium-deficient diet for 4 weeks, followed by another 4 weeks with or without daily oral T-2 toxin (0.2 mg/kg). Plasma selenium and glutathione peroxidase (GPx) activity were measured. Hepatic histology, activities of major mouse cytochrome P450 (Cyp450) isoforms, and corresponding mRNA and protein expression were assessed. RNA sequencing was performed using liver samples from four biological replicates per group to identify differentially expressed genes (DEGs) and enriched pathways. Selenium deficiency was confirmed by significantly reduced plasma selenium levels and GPx activity. Histological examination revealed marked hepatic steatosis. Transmission electron microscopy further showed prominent ultrastructural alterations including endoplasmic reticulum dilation. The activities of five hepatic Cyp450 isoforms, Cyp1a2, Cyp2b10, Cyp2c29, Cyp2c50, and Cyp3a11, were significantly increased to 1.64–2.51 times the control levels, consistent with increased mRNA and protein expression. Combined selenium deficiency and T-2 toxin exposure was associated with increased hepatic Cyp450 enzyme activity and expression, identifying the liver as a responsive target of KBD-related exposures. These findings suggest the need to further evaluate hepatic xenobiotic metabolism in populations from KBD-endemic areas.
✓ 已验证
DOI
高影响因子
Carbohydrate Polymer Technologies and Applications
·
2026
·
IF 7.6
Haoyang MIAO,Zhuangzhuang WANG,Chi ZHANG,Mingru CUI,Qun YANG,Han ZHANG,Mei YIN,Xuefeng YANG,Xuehan LIU,Qinggong HAN,Xiaojing XIA,Zhixing AN
Type 2 diabetes mellitus (T2DM) is a major global health burden. Chlorogenic acid (CGA) shows antidiabetic potential by improving glucose/lipid metabolism, insulin sensitivity, and inflammatory/oxidative status, but its use is limited by poor solubility, low gastrointestinal stability, extensive first-pass metabolism, and low oral bioavailability. Here, we developed an oral multilayer nanodelivery system (CGA@CDs-HA-TMC) comprising cyclodextrin inclusion cores (CDs) and hyaluronic acid (HA) plus trimethyl chitosan (TMC) outer layers. The nanocomposites displayed a uniform nanoscale size, positive ζ-potential, and favorable colloidal dispersion characteristics. Spectroscopic and X-ray diffraction analyses confirmed CGA amorphization and stable encapsulation within the cyclodextrin–polysaccharide network. CGA@CDs-HA-TMC reduced burst release in simulated gastric fluid and enabled sustained release in simulated intestinal fluid. In high-fat diet/streptozotocin-induced T2DM mice, CGA@CDs-HA-TMC lowered fasting blood glucose and OGTT AUC, improved insulin resistance (HOMA-IR), and partially restored β-cell function (HOMA-β). It also improved dyslipidemia, decreased ALT, AST, serum creatinine, BUN, 24-h urinary protein, and reduced circulating TNF-α, IL-6, IL-1β, and IL-18, generally outperforming free CGA. Histology further showed alleviation of hepatic steatosis, renal glomerular/tubular injury, and pancreatic islet damage. Overall, CGA@CDs-HA-TMC is a promising cyclodextrin–polysaccharide nanoplatform for enhancing oral delivery and antidiabetic efficacy of CGA and other poorly bioavailable polyphenols.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.2
Chaoxuan Wang,Zeqi Liu,Hao Wang,Ying Sha,Jianshu Wang,Junhan Jia,Yi Du,Wuzhao Li,Lei Qian
With its special one-dimensional tunnel structure, VO₂ stands out as a highly promising cathode material for aqueous zinc-ion batteries (AZIBs). However, its intrinsically low electronic conductivity and pronounced structural degradation hinder its practical application. In this work, controllable doping of VO₂ with I⁻ was successfully achieved via a one-step hydrothermal method. It was found that I⁻ induced the evolution of VO₂ from disordered clusters to highly ordered nanoflower-like spheres. Meanwhile, lattice incorporation of I⁻ leaded to an expansion of the tunnel spacing and induced the enrichment of oxygen vacancies. The resulted amorphous hybrid structure accommodated the local strain associated with repeated Zn²⁺ insertion and extraction. In addition, I⁻ doping facilitated the valence transition from V⁴⁺ to V³⁺, optimizing the intrinsic electronic structure and charge-transfer kinetics of the material.The multiscale routes including morphology, crystal structure, and electronic states synergistically enhanced the electrochemical performance of the VO₂ cathode. The optimized IVO-30 electrode delivered a high specific capacity of 543.6 mAh g⁻¹ at 0.5 A g⁻¹, retained 87.3% of its capacity even at a high rate of 10 A g⁻¹ and exhibited near-100% Coulombic efficiency along with excellent structural stability. This work provides new insights for design of high-performance cathode materials for AZIBs.
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Junbo Chen,Shanquan Liang,Dan Liu,Shaoqing Yang,Qiaojuan Yan,Zhengqiang Jiang
2′-Fucosyllactose (2′-FL) shows promise in ameliorating metabolic disorders. However, the role of 2′-FL in metabolic hypertension (MH) remains unclear. This study aimed to evaluate the effects of 2′-FL on MH and explore its underlying mechanisms. 2′-FL treatment (1000 mg/kg) reduced systolic blood pressure (SBP) by 16.6% and alleviated dyslipidemia, microglial activation, and neuroinflammation in MH mice. 2′-FL markedly increased short-chain fatty acids (SCFAs)-producing beneficial bacteria, e.g., Akkermansia and Bifidobacterium by 3.9-fold and 19.5-fold, accompanied by increased fecal acetate and butyrate. Notably, the benefits of 2′-FL for MH were transferable via fecal microbiota transplantation (FMT). Particularly, 2′-FL-mediated attenuation of vascular dysfunction was associated with the inhibition of the lipopolysaccharide/toll-like receptor 4 (LPS/TLR4) signaling, a protective effect that could be transferred via FMT. The antihypertensive and metabolic benefits of 2′-FL in mice were accompanied by gut-brain axis modulation. These findings suggest that 2′-FL represents a promising dietary strategy for preventing hypertension-associated complications.
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Yunpeng Xue,Lu Li,Yuren Wang,Yuchen Xiong,Min Deng,Kang Song
Abstract Lake biofilms are microbial habitats for nitrogen transformation, but how carrier type and elevation influence N2O dynamics remains unclear. We examined abiotic- and biotic-carrier biofilms from 12 lakes spanning 4–4272 m using anoxic incubations, 15N tracing, selective inhibition, isotopocule analysis, and metagenomics. Net N2O emission potential increased with elevation in both carrier types, with the largest carrier contrast at high elevation, where biotic-carrier biofilms showed the highest net N2O emission potential. 15N partitioning showed a marked shift in emission sources. At low elevation, heterotrophic nitrification dominated abiotic-carrier biofilms (∼91%), whereas denitrification contributed ∼57% in biotic-carrier biofilms. At high elevation, denitrification accounted for 67–97% of net N2O emission across both carriers, and bacterial denitrification dominated the total denitrification rate potential. Metagenomic profiles provided mechanistic support: high-elevation biotic-carrier biofilms showed higher relative representation of genes for dissimilatory nitrate reduction to ammonium and nitrogen fixation, but had few nosZ-carrying genomes, indicating weak terminal N2O reduction capacity. Overall, carrier type and elevation jointly shape nitrogen transformation pathways. High-elevation lake ecosystems, particularly those with abundant biotic substrates, may harbor disproportionately important biofilm N2O hotspots under global change.
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Qiaozhi Han,Chengxu Li,Yunshu Wang,Ziwei Ma,Chengyu Duan,Yucong Yin,Zichen Bao,Yonghao Shen,Chenwen Yin,Zhuofeng Hu,Qiming Sun
Abstract The direct synthesis of hydrogen peroxide (H2O2) from H2 and O2 provides a sustainable route for decentralized oxidant production, but its practical use is limited by inefficient Pd utilization, undesired H2O2 decomposition, and the need for high noble-metal loadings. Here, we report a Ni(OH)2-promoted Pd@S-1 catalyst that integrates zeolite confinement with interfacial electronic modulation for efficient aqueous H2O2 synthesis. The optimized Pd4Ni1@S-1-H catalyst delivers an H2O2 productivity of 3.39 mol gPd–1 h–1 under acidic conditions, representing the highest value among reported semibatch glass reactor systems and a 10-fold improvement in Pd utilization efficiency relative to a commercial Pd/C catalyst. Advanced spectroscopic analysis and density functional theory calculations reveal that Ni(OH)2 donates electrons to Pd, lowering the average Pd valence state from 1.83 to 1.39, and serves as a hydrogen-transfer bridge that promotes hydrogen migration to the *O–O intermediate. Meanwhile, hydrophobic silicalite-1 (S-1) zeolite micropores enrich dissolved H2/O2 and suppress secondary H2O2 decomposition by facilitating product desorption. The resulting in situ H2O2 generation system enables efficient Cr(VI) reduction, highlighting its potential for sustainable water remediation.
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Lei Jiang,Chunli Mao,Gaojie Cheng,Hongbo Yang,Jiawen Yin,Qinghui Jin
An integrated three-electrode non-enzymatic urea sensor is developed. • The sensor exhibits a wide linear range (1–200 mg/L) and a fast response (10.8 s). • Detection potential dynamically regulates the contributions of the two urea oxidation pathways. Rapid and accurate monitoring of urea concentration in swimming pool water is critical for protecting swimmers' health and optimizing water quality management. However, traditional techniques are either expensive or operationally complex, whereas enzyme-based sensors suffer from enzyme deactivation, limiting their applicability for online monitoring. In this paper, a nickel hydroxide/nickel oxyhydroxide (Ni(OH) 2 /NiOOH) nanonetwork electrochemical sensor for non-enzymatic urea detection is proposed, which is mass-produced on a platinum electrode using microelectromechanical systems (MEMS). The electrode was activated and optimized via cyclic voltammetry by varying the scan rate. The sensor demonstrates a high sensitivity of 1.43 μA/(mg·L −1 ·cm 2 ), a wide detection range of 1–200 mg/L, a fast response time (<12 s), good repeatability with a relative standard deviation (RSD) of 1.24%, and an excellent linearity ( R 2 = 0.9988). In addition, the proposed sensor exhibits excellent anti-interference performance toward coexisting species such as creatinine, uric acid, residual chlorine, and lactic acid. Practical applications in swimming pool water samples yielded recovery rates of 92.5–100.4%, validating the sensor's robustness. Two distinct oxidation mechanisms for urea on the electrode were observed by electrochemical impedance spectroscopy (EIS). The direct pathway was further found to be potential-tunable, with its charge-transfer resistance decreasing by 35.6% upon raising the working potential from 0.45 V to 0.50 V. This work offers a promising route toward non-enzymatic urea sensors for swimming pool water monitoring. Download: Download high-res image (140KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Ling Yu,Fengkai Qiu,Yumin Hu,Tingting Liao,Mengqian Zhai,Ronghua Wu,Qianhui He,Huilin Hu,Shuiwei Xia,Junguo Hui,Zufei Wang,Yang Yang,Rongfang Qiu,Minjiang Chen,Weiqian Chen,Jianfei Tu,Jiansong Ji,Chenying Lu
Because of the high incidence and mortality of cancer, there is an urgent need for more effective tumor diagnostic imaging and treatment strategies. Single-molecule therapeutics have emerged as a promising strategy to address the limitations of independent imaging and therapeutic modalities, thereby significantly reducing adverse side effects for patients. For the first time, we successfully synthesized NaGd(MoO4)2 nanoparticles via a homogeneous precipitation method in polyol media, which serve as a single-molecule agent for MRI imaging and metallic immunotherapy. With the addition of iRGD, we obtained iRGD-NaGd(MoO4)2. The iRGD-NaGd(MoO4)2 nanoparticles exhibit excellent tumor-targeting capability and significantly enhance T1-weighted MRI contrast with a longitudinal relaxivity of 4.95 mM–1 s–1. In terms of antitumor immunotherapy, iRGD-NaGd(MoO4)2 not only directly activates the cGAS-STING pathway but also induces ferroptosis in tumor cells, resulting in the generation of aberrant dsDNA and thereby indirectly activating the STING pathway. The dual pathway elicits a tumor-specific immune response, plays a significant role in promoting the maturation of DC cells, activates DC and T cells to secrete high levels of TNF-α, IL-6 and other cytokines, and regulates the polarization of macrophages from M2 phenotype to M1 phenotype. This mechanism significantly suppresses tumor growth. Beyond the metallic immunotherapy induced by Mn2+, Zn2+, and Co2+, this study provides robust validation of MoO42– as an effective cGAS-STING agonist. Moreover, this study achieved the synergy of multiple disciplines including biomaterials, tumor immunotherapy and medical imaging. This not only promotes the innovative integration in various fields, but also provides new treatment strategies and imaging tools for cancer treatment, which has important clinical application prospects.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Wenjing Qian,Yumei Chen,Hongliang Liu,Yankai Liu,Chao Liang,Xifang Zhu,Enping Liu,Aiping Wang,Jingming Zhou
A novel electrochemical immunosensor was proposed for rapid determination of virginiamycin M1 (VIR M1). To enhance the sensitivity, anti-VIR M1 monoclonal antibody (mAb) and silver nanoparticles-Zinc 2-methylimidazole MOF (AgNPs-ZIF-8) nanocomposite were used as bio-recognition element and electrode modification material for signal amplification, respectively. The characterization of nanocomposite was performed using ultraviolet visible spectrophotometry (UV–Vis), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Under optimal conditions, proposed immunosensor achieved quantitative detection of VIR M1 in range from 0.4 to 20 ng/mL, with a detection limit (LOD) of 0.32 ng/mL. The immunosensor was applied to feed and food of animal origin with recoveries ranging from 90.51 % to 101.17 %, featuring RSDs within 2.8 % to 8.8 %. Therefore, the immunosensor could be a promising tool for determining VIR M1 levels in feed and residues in food of animal origin.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBON
·
2025
·
IF 11.6
Bingze Liu,Jin An Wang,Dongfang Niu
Nitrogen-doped carbon nanotubes for CO 2 electroreduction (CO 2 ER) to CO usually perform a low reaction activity due to weak adsorption and high activation energy of CO 2 . Herein, 2-chloropyridine molecules (2-PyCl) as co-catalysts were grafted onto nitrogen-doped carbon nanotubes (NCNT) to prepare a composite electrocatalyst (PyCl-NCNT). The structural characterization and electrochemical tests confirmed that chlorine atoms in 2-PyCl synergized with pyridine molecules, substantially enhancing the CO 2 adsorption capacity, thereby accelerating the CO 2 ER rate. PyCl-NCNT achieved a CO faradaic efficiency (FE CO ) of 91.3% and a CO partial current density (j CO ) of -26.8 mA cm -2 at -1.2 V vs. RHE, maintaining a FE CO above 90% in a wide electrochemical potential window (-0.7 ∼ -1.2 V).
✓ 已验证
产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Chonghui Niu,Mingjie Dan,Yi Yu,Xiurong Zhu,Yixin Fu,Yeqing Wang,Wang Zhao,Kenneth R. Poeppelmeier
In this study, a series of novel Eu3+-activated NaLu(MoO4)2 (NLMO) red phosphors were synthesized for the first time using hydrothermal, sol–gel, and microemulsion methods with varying active agents. The properties of these phosphors, including phase purity, crystal structure, DFT calculations, morphology, luminescence characteristics, thermal stability, and internal quantum efficiency, were comprehensively characterized. The results indicate that the ethylenediaminetetraacetic acid disodium salt (EDTA-2Na)-assisted hydrothermal method is the most suitable approach for the preparation of the phosphor. This method yields phosphors with a regular morphology, outstanding luminescence performance, relatively good thermal stability, and significantly high internal quantum efficiency. The internal quantum efficiency reaches 96.45%, and the phosphor exhibits good thermal stability, with the emission intensity at 423 K remaining about 73% compared to the initial temperature. The CIE chromaticity coordinate of the NLMO/0.13Eu3+ sample (0.667, 0.333) is very close to the standard chromaticity coordinate value (0.670, 0.330) from the National Television Standards Committee (NTSC). Remarkably, the color purity of the NLMO:0.13Eu3+ phosphor is an impressive 97%. Furthermore, Tb3+ was cointroduced in the NLMO:0.13Eu3+ phosphor, and its positive effects are discussed. Ultimately, a warm white light-emitting diode (W-LED) was fabricated using the studied NLMO:0.13Eu3+ phosphor with a 394 nm near-ultraviolet-emitting LED chip as the excitation source. The W-LED exhibits excellent properties such as high color purity, excellent correlation color temperature, and high color rendering index. Considering all of the results, the NLMO/Eu3+ red phosphor obtained by the EDTA-2Na-assisted hydrothermal method is an ideal red component for W-LEDs in various lighting applications.
✓ 已验证
产品关联
DOI
高影响因子
THERMOCHIMICA ACTA
·
2025
·
IF 3.5
Jian Ma,Yixiao Wang,Jichao Hu,Gaoqi Han,Lemeng Wang,Huiying Gao,Pan Zhang,Kangrui Li,Dong Fu
This study determined and correlated the density and viscosity of the 2-(methylamino)ethanol (MAE) - dimethyl sulfoxide (DMSO) non-aqueous solution over a temperature range of 298.15 to 323.15 K at atmospheric pressure. The effects of the mass fraction of MAE ( w 1 ), temperature ( T ) and CO 2 loading ( α ) on viscosity and density were demonstrated based on of experimental data and calculations. The excess molar volume ( V m E ) and viscosity deviation ( Δη ) were derived from the experimental data. Furthermore, the V m E and Δη were correlated by using the Redlich-Kister equation. The viscosity activation energy and CO 2 diffusion coefficient were calculated and analyzed by utilizing viscosity data. The activation parameters activation enthalpy (Δ Η* ) and activation entropy (Δ S* ) were determined using the measured viscosity and density data. This combined study provides insights into intermolecular interactions and transportation characteristics through the observed changes in viscosity and density with composition.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）