CHEMICAL ENGINEERING JOURNAL
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2020
·
IF 10.652
Yaoyao Huang,Huaili Zheng,Hong Li,Chun Zhao,Rui Zhao,Siqi Li
The separation and recovery of uranium resources from nuclear waste solutions is important for achieving uranium reuse and environmental protection. In this study, a novel adsorbent, 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTCA)-decorated chitosan-coated magnetic silica nanoparticles, was fabricated and applied to the highly selective adsorption of uranium from aqueous solution. Selective sorption in a multi-ion solution (pH 4.0) containing 14 coexisting cations resulted in CoFe 2 O 4 @SiO 2 @CS-PBTCA showing an excellent uranium adsorption capacity of up to 83.16 mg g −1 , which was much higher than that of ungrafted CoFe 2 O 4 @SiO 2 @CS (29.99 mg g −1 ). The adsorbent also exhibited higher acid resistance than uncoated silica adsorbent under pH 1.0 conditions, with CoFe 2 O 4 @SiO 2 @CS-PBTCA showing barely any iron and cobalt leaching, while CoFe 2 O 4 @CS-PBTCA showed iron and cobalt leaching amounts of 2.97 and 0.93 mg L −1 , respectively. The desorption experiment used 0.2 M PBTCA (pH 1.0) as eluent, with the results showing that uranium ions were readily and rapidly desorbed. Furthermore, CoFe 2 O 4 @SiO 2 @CS-PBTCA maintained outstanding stability and adsorption performance after five reuse cycles. The mechanism for U(VI) removal was investigated by X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy, with the results suggesting that the adsorbent binds to uranium mainly though oxygen atoms of carboxyl groups and phosphonic groups in PBTCA. This strategy shows strong potential for developing a variety of novel, highly active, acid resistance, and reusable immobilized functional magnetic materials for effective separation of uranium from a multi-ion solution.
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CARBOHYDRATE POLYMERS
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2020
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IF 7.182
Yupei Li,Jiameng Li,Zhenqiang Shi,Yilin Wang,Xin Song,Liya Wang,Mei Han,Heyue Du,Chao He,Weifeng Zhao,Baihai Su,Changsheng Zhao
Here, we describe a green approach to fabricate genipin crosslinked chitosan-kappa-carrageenan composite hydrogels (C-K hydrogels) aiming at reducing endotoxin level and bacteria burden in septic blood synchronously. The chemical compositions and morphologies of the developed C-K hydrogels were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and scanning electron microscopy. The C-K hydrogels significantly inhibited adverse blood-material interactions such as hemolysis, complement activation, platelet activation and contact activation, and exhibited better anticoagulant properties than raw chitosan hydrogels. Most importantly, the optimized C 2 -K 1 hydrogels were competent to eliminate 63.3 % of endotoxin in septic blood with a maximum adsorption capacity of 95.0 EU/g during a 3-h simulative hemoperfusion procedure. Bacteria cleansing experiments further demonstrated that the optimized C 2 -K 1 hydrogels effectively decreased 46.0 % of E. coli and 68.7 % of S. aureus load, respectively. It is believed that the C-K hydrogels are promising hemoperfusion sorbents to treat severe septic patients.
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ACS Applied Polymer Materials
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2020
·
IF 0
Xinran Wei,Ke Ma,Yongbin Cheng,Leyun Sun,Daijun Chen,Xiaoli Zhao,Hao Lu,Botao Song,Kewu Yang,Pengxiang Jia
In addition to conductivity, recent evidence suggests that adhesive, self-healing, and antibacterial properties are also important aspects of wearable force sensors. However, preparation of hydrogel with these combined aspects in a facile strategy is still a challenge. In this paper, a simple method is proposed to obtain adhesive, conductive, self-healing, and antibacterial chitosan–polyoxometalate (POM) hydrogel. First, silicotungstic acid (SiW) was added into a chitosan solution to form a chitosan–silicotungstic acid (CS/SiW) physical cross-link network. Second, the CS/SiW–poly(acrylamide) (PAM) double-network hydrogels were fabricated by the in situ polymerization of acrylamide (AM). The CS/SiW-PAM hydrogel indicated excellent repeatable adhesive capacity on the surface of various materials. The CS/SiW-PAM hydrogel also displayed highly sensitive conductivity upon strain. Moreover, the CS/SiW-PAM hydrogel had outstanding self-healing and antibacterial properties. As a result, it is envisioned that the present work will broaden the path for development of POM-based functional soft materials for various applications.
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ACS Sustainable Chemistry & Engineering
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2020
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IF 7.632
Jianli Zhou,Xiaobo Liu,Fang Yuan,Bin Deng,Xiaobin Yu
Chitosanase (EC3.2.1.132) can be used to selectively produce partially acetylated chitosan oligosaccharides (COSs), which are functional biopolymers that can widely be utilized as environmentally friendly agents, due to their bioactive, nontoxic, nonallergenic, and biodegradable properties. Different chitosanases can give rise to hydrolysates with diverse functions, making the development of novel chitosanases of great importance in applied biotechnologies. Here, we successfully expressed a novel chitosanase derived from Aspergillus fumigatus CJ22-326 in Pichia pastoris GS115, which could controllably produce chitosan oligosaccharides with desirable polymeric degrees. After glycosylation, the sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) analysis of the recombinant enzyme Csn75 showed two specific protein bands with sizes of 25.5 and 23.5 kDa individually. The activity of the glycosylated Csn75 was 3.6-fold of that of the deglycosylated Csn75, indicating that glycosylation can greatly increase the activity. Km and Vmax values of the purified Csn75 were 0.46 mg/mL and 6.03 μmol·mL–1·min–1 separately, revealing a good affinity and high catalytic efficiency to the substrate. Moreover, biochemical tests confirmed that Csn75 had the highest activity from 55 to 65 °C when pH ranged from 5.0 to 6.0 and exhibited 4-fold activity in the presence of 1 mM Mn2+. Interestingly, the hydrolysis rate of the crude Csn75 (30 U/mL) can reach up to 90.65% in 4 h when using 2% chitosan as the substrate, producing a mixture of COS with desirable degrees of polymerization (DP), which significantly inhibited the mycelium growth of phytopathogenic fungi. This study proved Csn75 to be a promising chitosanase for the preparation of desirable chitosan oligosaccharides that are green biocides applicable for sustainable agricultural production and environmental protection.
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FOOD CHEMISTRY
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2020
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IF 6.306
Bing Xie,Xingzhong Zhang,Xiaogang Luo,Yixiang Wang,Yan Li,Bin Li,Shilin Liu
In this work, novel edible coating films based on beeswax-in-water (O/W) Pickering emulsions had been investigated. The Pickering emulsions were stabilized with cellulose nanofibrils (CNFs)/carboxymethyl chitosan (CCS). The emulsions with a droplet diameter of around 10 μm had uniform particle size distribution, and the creaming stability was improved with the increasing the contents of CNFs in the complexes, rheological analysis demonstrated that the Pickering emulsions had an elastic gel-like network. Furthermore, free-standing films were obtained when the emulsions were dried at ambient condition, the tensile strength of the coating films could be 5.0 MPa at a strain of 2.2%, and the water vapor permeability (WVP) value was lower than 2 × 10 −7 g∙h −1 ∙m −1 ∙Pa −1 . Moreover, the coating films could inhibit the growth of typical spoilage organisms such as S. aureus or E. coli, it indicated that the coatings films would have promising applications in antiseptic and fresh keeping for berry fruits.
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CARBOHYDRATE POLYMERS
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2020
·
IF 7.182
Zhao Zhao,Mei Ji,Qianqing Wang,Nannan He,Yue Li
Off-target drug delivery, together with multidrug resistance (MDR), are two keys obstacles that account for the disappointing outcome in clinical chemotherapy of cancer. To solve these dilemmas, Herein, we constructed cancer cell membrane (CCM) modified silica (CS) nanoparticles (CCM/CS) to co-deliver Ca 2+ channel siRNA with doxorubicin (DOX) to construct a platform (CCM/CS/R-D) for the efficient therapy of cervical cancer. It was demonstrated that the optimal CCM/CS/R-D was spherical nanoparticles with size at 122.39 ± 4.69 nm and the surface charge of -27.76 ± 3.12 mV. In addition, the CCM/CS/R-D showed acid responsive drug release while high stability under physiological conditions with negligible hemolysis. The CCM/CS/R-D showed CCM mediated cellular uptake and efficient endosomal escape as well as siRNA transfection potential (comparable to that of PEI 25 K) on MDR cervical cancer cells (HeLa/DOX). Most importantly, the MDR of cancer cells was conquered through modulation of T-type Ca 2+ (Cav) channels. It was observed that the Cav channel siRNA could negatively regulate the level of cytosolic Ca 2+ concentration which triggered G0/G1 phase cell cycle arrest and elevated intracellular drug retention in HeLa/DOX cells without significantly affect the expression of P-glycolprotein (P-gp). The in vitro and in vivo experiments revealed that CCM/CS/R-D exerted greatly enhanced tumor targetability and therapeutic effect on HeLa/DOX, which was superior than CS/R-D or mono delivery system (CCM/CS/R or CCM/CS/D).
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Food and Bioprocess Technology
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2020
·Vol. 13
·期 6
·1024-1034
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IF 3.356
Wang Qian,Zhang Li,Ding Wu,Zhang Dequan,Reed Kevin,Zhang Boce
This study aimed to develop self-assembled gelatin-chitosan (Gel-CS) nanocapsules as a water-soluble delivery system for alcohol-soluble compounds. Eugenol (Eug) selected as the model molecule for its high solubility in alcohol and insolubility in water. The study also examined different reaction conditions and reagent loading ratios to optimize eugenol-embedded gelatin-chitosan nanocapsules (Eug-Gel-CS NPs) formation. The optimal loading ratio of Gel, CS, and Eug was 3:1:2, which yielded an average particle size of 229.09 nm and an encapsulation efficiency of 50.69%. The morphological characteristics of Eug-Gel-CS NPs were further demonstrated by transmission electron microscopy. The prepared Eug-Gel-CS NPs also exhibited potential controlled-release properties in aqueous phase with the in vitro release percentage of 69.47 ± 1.24% over 36 h. This nanocapsule system may provide a platform to expand the potential applications of Eug in food and nutrition.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2020
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IF 4.389
Wenzhong Dai,Chengcheng Ruan,Yue Sun,Xueling Gao,Jin Liang
In order to investigate the influence of different embedding methods on the properties and function of polyphenols, the Epigallocatechin gallate (EGCG) loaded chitosan nanoparticles prepared with or without β-lactoglobulin (β-Lg) were obtained by ionic cross linking method. The average particle sizes of EGCG loaded chitosan nanoparticles (EGCG-CS NPs) decreased from 190 nm to 157 nm after adding with β-Lg, whereas the encapsulation efficiency (EE) increased from 59.79 % to 76.29 %. The results of transmission electron microscopy (TEM) showed that the obtained nanoparticles had obvious core-shell structure. The results of simulated gastrointestinal digestion showed that the release rate of EGCG in CS/β-Lg NPs was much lower than that of CS-NPs. Compared with free EGCG, the DPPH and FRAP assay showed that EGCG-CS NPs and EGCG-CS/β-Lg NPs had slow-controlled antioxidant activity. Meanwhile, the study of cellular antioxidant activity (CAA) showed that the EC 50 values of EGCG-CS NPs and EGCG-CS/β-Lg NPs were decreased by 8.56 % and 18.35 %, respectively.
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ACS Applied Materials & Interfaces
·
2021
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IF 9.229
Jing Cong,Zhiwei Fan,Shaoshan Pan,Jie Tian,Weizhen Lian,Shan Li,Sijie Wang,Dongchang Zheng,Chunguang Miao,Weiping Ding,Taolin Sun,Tianzhi Luo
Hydrogel-based electronics have received growing attention because of their great flexibility and stretchability. However, the fabrication of conductive hydrogels with high stretchability, excellent toughness, outstanding sensitivity, and low-temperature stability still remains a great challenge. In this study, a type of conductive hydrogels consisting of a double network (DN) structure is synthesized. The dynamically cross-linked chitosan (CS) and the flexible polyacrylamide network doped with polyaniline constitute the DN through the hydrogen bonds between the hydroxyl, amide, and aniline groups. This type of hydrogels displays excellent mechanical performance, striking conductivity, and remarkable freezing tolerance. The flexible electronic sensors based on the double-network hydrogels demonstrate superior strain sensitivity and linear response on various deformations. Additionally, the good antifreezing property of the hydrogels allows the sensors to exhibit excellent performance at −20 °C.
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BIOMACROMOLECULES
·
2021
·
IF 6.988
Panpan Song,Nannan Song,Li Li,Minghao Wu,Zhongxia Lu,Xia Zhao
Glioblastoma (GBM) is a fatal brain tumor with poor prognosis. Blood–brain barrier (BBB) prevents the effective delivery of chemotherapeutic agents to GBM. Herein, we developed a pH/reduction-sensitive carboxymethyl chitosan nanogel (CMCSN) modified by targeting peptide angiopep-2 (ANG) and loaded with doxorubicin (DOX). The multifunctional nanogel (DOX-ANG-CMCSN) exhibited good pH and reduction sensitivity, ideal stability, and biocompatibility. Its hydrodynamic diameter was 190 nm, drug loading was 12.7%, and the cumulative release rate of 24 h was 82.3% under the simulated tumor microenvironment. More importantly, the modification of ANG significantly enhanced BBB penetration and tumor targeting ability both in vivo and in vitro. DOX-ANG-CMCSN achieved 2–3-fold higher uptake and an enhanced antitumor activity compared with nontargeted DOX-CMCSN. Therefore, the targeted nanogels with the pH/reduction dual-stimuli response may provide a promising platform for GBM-targeted chemotherapy.
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Scientific Reports
·
2021
·Vol. 11
·期 1
·1-15
·
IF 4.38
Eltaweil Abdelazeem S.,El-Monaem Eman M. Abd,Mohy-Eldin Mohamed S.,Omer Ahmed M.
An efficient composite was constructed based on aminated chitosan (NH 2 Cs), attapulgite (ATP) clay and magnetic Fe 3 O 4 for adsorptive removal of Cr(VI) ions. The as-fabricated ATP@Fe 3 O 4 -NH 2 Cs composite was characterized by Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analyzer (TGA), Scanning Electron Microscope (SEM), Zeta potential (ZP), Vibrating Sample Magnetometer (VSM), Brunauer–Emmett–Teller method (BET) and X-ray photoelectron spectroscope (XPS). A significant improve in the adsorption profile was established at pH 2 in the order of ATP@Fe 3 O 4 -NH 2 Cs(1:3) > ATP@Fe 3 O 4 -NH 2 Cs(1:1) > ATP@Fe 3 O 4 -NH 2 Cs(3:1) > Fe 3 O 4 -NH 2 Cs > ATP. The maximum removal (%) of Cr(VI) exceeded 94% within a short equilibrium time of 60 min. The adsorption process obeyed the pseudo 2nd order and followed the Langmuir isotherm model with a maximum monolayer adsorption capacity of 294.12 mg/g. In addition, thermodynamics studies elucidated that the adsorption process was spontaneous, randomness and endothermic process. Interestingly, the developed adsorbent retained respectable adsorption properties with acceptable removal efficiency exceeded 58% after ten sequential cycles of reuse. Besides, the results hypothesize that the adsorption process occurs via electrostatic interactions, reduction of Cr(VI) to Cr(III) and ion-exchanging. These findings substantiate that the ATP@Fe 3 O 4 -NH 2 Cs composite could be effectively applied as a reusable adsorbent for removing of Cr(VI) ions from aqueous solutions.
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MOLECULES
·
2021
·Vol. 26
·期 13
·4037
·
IF 4.412
Xushan Chen,Huimin Zhang,Xin Yang,Wuhong Zhang,Ming Jiang,Ting Wen,Jie Wang,Rui Guo,Hanjiao Liu
Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate[email protected]/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The[email protected]/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.Keywords:infected burn wound;antibacterial hydrogel;silver nanoparticles
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