WORLD JOURNAL OF GASTROENTEROLOGY
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2026
·Vol. 32
·期 2
·114057
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IF 5.4
Yi-Qing Zhao,Yu Zhang,Yan Qin,Rui-Ya Zhang,Jun-Ping Wang
BACKGROUND Ulcerative colitis (UC) is a chronic and treatment-resistant disorder requiring potent therapeutics that are effective and safe. Cedrol (CE) is a bioactive natural product present in many traditional Chinese medicines. It is known for its suppression of inflammation and mitigation of oxidative stress. Its therapeutic efficacy and mechanistic underpinnings in UC remain uncharacterized. AIM To investigate the therapeutic potential and mechanisms of CE in UC. METHODS The anti-inflammatory activity and intestinal barrier-repairing effects of CE were assessed in a dextran sulfate sodium-induced murine colitis model. Network pharmacology was employed to predict potential targets and pathways. Then molecular docking and dynamics simulations were utilized to confirm a stable interaction between CE and the toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD2) complex. The anti-inflammatory mechanisms were further verified using in vitro assays. Additionally, the gut microbiota composition was analyzed via 16S rRNA gene sequencing. RESULTS CE significantly alleviated colitis symptoms, mitigated histopathological damage, and suppressed inflammation. Moreover, CE restored intestinal barrier integrity by enhancing mucus secretion and upregulating tight junction proteins (zonula occludens 1, occludin, claudin-1). Mechanistically, CE stably bound to MD2, inhibiting lipopolysaccharide-induced TLR4 signaling in RAW264.7 cells. This led to suppression of the downstream mitogen-activated protein kinase and nuclear factor kappa B signaling pathways, downregulating the expression of tumor necrosis factor-alpha, interleukin-1β, and interleukin-6. Gut microbiota analysis revealed that CE reversed dextran sulfate sodium-induced dysbiosis with significant enrichment of butyrogenic Christensenella minuta . CONCLUSION CE acted on MD2 to suppress proinflammatory cascades, promoting mucosal barrier reconstitution and microbiota remodeling and supporting its therapeutic use in UC.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2026
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IF 2.2
Jianjun Chen,Jian Ma,Jichao Hu,Pan Zhang,Dong Fu,Lemeng Wang
In this study, we investigated the viscosity data of carbonated aqueous blends of 1-dimethylamino-2-propanol (DMA2P) and piperazine (PZ) over a temperature range of 303.2 to 323.2 K at atmospheric pressure. The concentration of DMA2P and PZ ranged from 30 wt% to 50 wt% and 2.5 wt% to 7.5 wt%, respectively. The experimental viscosities were calculated and predicted using the Weiland equation. The calculations showed good agreement with the experimental results, yielding an average relative deviation of 2.18%. Furthermore, the viscosity activation energy ( E a) and the estimated diffusion coefficient of CO 2 ( D CO2 ) into the carbonated DMA2P-PZ aqueous blends were derived using the Arrhenius-type expression and the modified Stokes-Einstein equation, respectively. The results indicate that the DMA2P-PZ absorbent exhibits promising potential for industrial application in CO 2 capture processes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Yuan Chen,Yanchen Sun,Gaojie Fang,Wenyao Huang,Quan Wang
The performance of energetic hydrogels—a promising class of water-resistant explosives—is often related to the internal microstructure and chemical reactivity. This study introduces a modification strategy employing copper (II) nitrate trihydrate (Cu(NO 3 ) 2 ·3H 2 O) to simultaneously tailor the hydrogel’s microstructure and enhance its chemical reactivity. The additive functions dually: by acidifying the system, it accelerates cross-linking kinetics and refines sensitized microbubbles; concurrently, it lowers the thermal decomposition barrier of the gel matrix. At an optimal content of 0.75 wt%, the proportion of effective microbubbles (diameter ≤ 100 µm) is maximized to 42.2 %, establishing a dense hotspot network. This microstructural and chemical optimization synergistically boosts detonation performance, increasing velocity by 15.34 % to 4610 m·s⁻¹ and reducing the minimum initiation charge from 50 g to 30 g. Thermal analysis confirms a reduced apparent activation energy and reveals a possible low-temperature exothermic pathway, providing direct evidence for the enhanced reactivity. Crucially, this enhancement does not compromise handling safety, as the initial decomposition temperature remains above 244 °C for all formulations. This work establishes additive-mediated modification as an effective route to engineer energetic materials by concurrently optimizing the microstructure and accelerating the reaction kinetics.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2012
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IF 2.098
Sheng-Gui Liu,Lin-Ping Zhang,Jian Liu,Wen-Yi Su,Xiao-Bo Shi
Two cadmium complexes, Cd(bpbp)Cl 2 (complex 1 ) and [Cd(bpbp) 2 ](ClO 4 ) 2 (complex 2 ), based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine (bpbp), were synthesized and characterized by X-ray single crystal structure analyses. For complex 1 : crystal system, monoclinic, space group, C2/c, a = 27.427(3) Å, b = 13.4495(15) Å, c = 14.8381(17) Å, β = 106.635(2)°, V = 5244.4(10) Å 3 , Z = 8. It is a neutral complex. The Cd(II) ion distorted trigonal bipyramidal geometry is five-coordinated by three nitrogen atoms from ligand (bpbp) and two chlorine ions. For complex 2 : crystal system, triclinic, space group, P-1, a = 13.4791(15) Å, b = 13.8506(16) Å, c = 16.5839(19) Å, α = 94.202(2)°, β = 106.948(2)°, γ = 94.872(2)°, V = 2935.3(6) Å 3 , Z = 2. It is an ionic complex. The Cd(II) ion octahedral geometry is six-coordinated by six nitrogen atoms from two ligand (bpbp). Both complexes emit blue luminescence with emission peaks at 420 and 430 nm in solid state and with emission peaks at 415 and 425 nm in DMF solution. In complex 1 absorption spectra, there is not only the free ligand absorption peak at 310 nm, but also shows strong Cd–Cl charge transfer peak at 350 nm in DMF solution.
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ACTA MATERIALIA
·
2026
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IF 10.7
Zhengniu Pan,Sijing Zhu,Yi Wang,Zhen Fan,Jisheng Liang,Shiyuan Zhao,Jun-Liang Chen,Zhongwei Zhang,Zhixiang Zhang,Qi Zhou,Jie Gao,Huaizhou Zhao,Lei Miao
The n-type Mg 3+δ (Sb,Bi) 2 ‐based system has recently emerged as a breakthrough class of thermoelectric (TE) materials, drawing considerable interest for its eco‐friendly composition and potential to replace conventional commercial counterparts. However, the precise regulation of grain boundaries in Mg-based materials—akin to wielding an accurate scalpel—so as to extremely optimize thermoelectric performance and device properties remains ill-defined. In this study, the incorporation of Ga into the Mg 3 (Sb,Bi) 2 matrix via high‐energy ball milling (HBM) and spark plasma sintering (SPS) yielded an ultralow lattice thermal conductivity of 0.41 W m -1 K -1 at 300 K, a superior figure of merit ( ZT ) exceeding 1.84 at 673 K, and a high average ZT ( ZT avg ) of 1.55 across 300—773 K. The lattice thermal conductivity of Ga‐modified Mg 3+δ (Sb,Bi) 2 is markedly reduced over the entire temperature range, primarily due to the enhanced Kapitza thermal resistivity (ρ Kapitza ) resulting from the introduction of a liquid‐like phase at grain boundaries (GBs), which strengthens phonon scattering. while, Ohmic-like metal–semiconductor junctions form at the interfaces between the Ga/Bi secondary phases and the Mg 3+δ (Sb,Bi) 2 matrix lead to superior power factor. The high performance of Ga‐Mg 3+δ (Sb,Bi) 2 enabled a two‐pair module based on Mg 3.2 Ga 0.04 Sb 1.5 Bi 0.49 Te 0.01 / MgAgSb to achieve a conversion efficiency ( η ) of ∼6.0% at ΔT = 300 K. As a result, this work demonstrates significant theoretical and practical value in areas such as thermal management and thermoelectric material design.
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BIOMASS & BIOENERGY
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2026
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IF 7
Yahui Zhang,Haowen Cui,Haian Xia
The selective oxidation of furfural (FF) to 2-furoic acid (FA) represents a significant route toward sustainable chemical production. However, existing catalytic systems often suffer from limitations such as low substrate concentrations, harsh reaction conditions, and inadequate selectivity. In this study, a series of Ag/ZrO 2 catalysts with varying Ag loadings were prepared via a deposition–precipitation method and were used for the aerobic oxidation of FF to FA under mild conditions. The effects of metal loading, catalyst mass, reaction temperature, reaction time, and oxygen pressure on FF conversion and FA selectivity were systematically investigated. Under optimized conditions, nearly 100% FA was achieved under 10 wt% FF concentration at low-temperature (ca. 5 °C), while a high selectivity of 90.3% toward FA was maintained even at 20 wt% FF. The catalysts also exhibited excellent recyclability, retaining over 85% FA selectivity after five consecutive cycles. Comprehensive characterization techniques, including XRD, XPS, and HRTEM, were employed to elucidate the structure-activity relationship of the catalysts. The experimental and characterization findings propose a possible reaction mechanism involving synergistic effects of Ag 0 sites for dehydrogenation and ZrO 2 oxygen vacancies for O 2 activation. This work represents a notable advance in the field, as it develops the high efficient catalytic system under high FF concentrations and low-temperature conditions for the first time.
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JOURNAL OF RARE EARTHS
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2026
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IF 9.6
Yuejia Wu,Li Li,Lina Su,Ling Huang
The elemental doping strategy was widely adopted to improve the ion transport of lanthanum silicate apatites (La 9.33 Si 6 O 26 , LSO), a very promising electrolyte for solid oxide fuel cells (SOFCs). Specifically, La 9.33 Si 5.5 (Ga 1/2 V 1/2 ) 0.5 O 26 , i.e., LSGV 0.5 is obtained through (Ga 1/2 V 1/2 ) 4+ doping, which leads to not only a 4-fold oxygen ion conductivity (15.8 mS/cm at 800 °C) improvement, but also a 150 °C reduced sintering temperature compared with that of LSO. The as-such fabricated SOFC achieves a peak power density of 0.357 W/cm 2 at 800 °C using LSGV 0.5 as the electrolyte, demonstrating the effective complex ion doping towards enhanced performance for apatite-based electrolytes.
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ELECTROCHIMICA ACTA
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2026
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IF 5.8
Xiaojun Tang,Wenhao Lv,Song Lv
Customized Co(OH) 2 interface layer designed by electrodeposition. • The NF@[Co] 120 /Mn/[Co] 60 composite electrode integrates "conduction-adhesion-protection" functions. • Achieves high volumetric capacitance and excellent cycling stability. • Provide a novel design strategy for next-generation flexible and wearable energy storage devices. The in-situ synthesized nickel foam(NF)/manganese dioxide(MnO 2 ) electrode shows great promise for flexible supercapacitors owing to its high theoretical capacity, abundance, and eco-friendliness. However, the practical application of MnO 2 is hindered by poor conductivity, significant volume expansion, dissolution in electrolytes, and weak adhesion to smooth NF. To address these challenges, this work leverages the advantages of high conductivity and interface modification offered by Co(OH) 2 to precisely construct a sandwich-structured composite electrode(NF@[Co] 120 /Mn/[Co] 60 ) at the MnO 2 interface layer, which integrates conductive, adhesive, and protective functions. Benefiting from the advanced structure, the composite electrode exhibits outstanding electrochemical performance. NF@[Co] 120 /Mn/[Co] 60 achieves a capacitance of 340.31 F g −1 at 1 mA cm −2 , with a capacitance retention of 196.05 F g −1 when the current density increases to 20 mA cm −2 , and a capacity retention rate of 86.68% after 9000 cycles. Moreover, by utilizing the smooth and continuous macroscopic interface of the outermost Co(OH) 2 nanosheets, we integrated it with hydrogel electrolyte to assemble flexible supercapacitor (NF@[Co] 120 /Mn/[Co] 60 //PAA//AC). This device delivers an energy density of 74.95 Wh kg –1 at a power density of 994.94 W kg –1 and demonstrates excellent mechanical flexibility. This novel structural design provides a new electrode system strategy for the development of flexible wearable energy storage systems. Download: Download high-res image (197KB) Download: Download full-size image
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Infectious Diseases and Clinical Microbiology
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2026
·Vol. 8
·期 2
·165
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IF 1.1
Jingping Yang,Dan Liu,Xiyuan Xu,Na Meiri,Dezhi Yang
Objective This study aimed to develop a sensitive and reliable method for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various environmental samples using nano–liquid chromatography–tandem mass spectrometry parallel reaction monitoring (nanoLC-MS/MS PRM), targeting sequences of the viral spike (S) and nucleocapsid (N) proteins. Materials and Methods A synthetic peptide screening approach was employed to systematically evaluate candidate sequences as surrogates for protein quantification. The process began with the digestion of purified SARS-CoV-2 proteins. The candidate sequences were then refined to a subset of target peptides, and stable isotope-labeled heavy peptides were used as standards in a PRM workflow. The detection limits were determined using the nanoLC-MS/MS PRM method. Results The developed method achieved limits of detection in the 1 fmol/µL (2–8 × 10-15 viral copies/L) range on-column. This demonstrates high sensitivity for detecting SARS-CoV-2 in environmental samples using the PRM method. Conclusion The study successfully developed a sensitive and reliable peptide probe-based approach for detecting SARS-CoV-2 in various environmental samples. The use of the PRM method targeting the S and N proteins of SARS-CoV-2 provides a robust approach for virus detection, particularly given the potential persistence of the virus on surfaces. Graphic Graphic . Open in a new tab
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Liao Zixin,Zhong Rui,Li Wan jing,Wong Yee Shan,Liu Jiaxin,Venkatraman Subbu S.,Wang Hong,Cao Ye
Triple-negative breast cancer (TNBC) bone metastasis remains a significant clinical challenge owing to limited drug across the blood - bone marrow barrier as well as the chemotherapy resistance. Overexpression of the anti-apoptosis protein B-cell lymphoma-2 (Bcl-2) and activation of ATP-binding cassette transporter-mediated drug efflux pathway contribute substantially to paclitaxel (PTX) resistance, leading to poor therapeutic outcomes. Herein, we developed a biomimetic bone-targeted nanotherapeutic by integrating neutrophil “hitchhiking” technology with hyaluronic acid (HA)-modified lipid nanoparticles co-loaded with PTX and Bcl-2 small interfering RNA (siRNA) (BP-HLNP@NEs) for the therapy of TNBC bone metastasis. Leveraging neutrophil-mediated bone marrow homing and HA-CD44 receptor-mediated active targeting, BP-HLNP@NEs efficiently traversed the blood-bone marrow barrier, enhanced accumulation within metastatic bone lesions, and reduced off-target toxicity in the liver and spleen. Following cellular internalization, the co-delivered PTX and Bcl-2 siRNA synergistically suppressed tumor growth by silencing Bcl-2 expression, inhibiting the NF-κB/P-glycoprotein resistance pathway, restoring chemosensitivity, and activating caspase-mediated apoptosis. In orthotopic bone metastatic TNBC models, BP-HLNP@NEs markedly inhibited tumor progression, reduced secondary lung metastasis, preserved bone architecture, and elicited antitumor immune responses. Collectively, this biomimetic delivery platform overcomes both biological delivery barriers and chemoresistance, providing a promising therapeutic strategy for the treatment of TNBC bone metastasis. Graphical
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高影响因子
Chinese Physics B
·
2026
·Vol. 35
·期 1
·017801
·
IF 1.6
Mengyu Zhang,Shujing Pan,Haitang Hu,Wenzhi Su,Yong Zou,Shoujun Ding,Qingli Zhang
Conventional Tb3+-doped phosphors typically suffer from concentration quenching once the doping level exceeds a critical threshold. Consequently, the development of Tb3+ phosphors with intrinsic resistance to concentration quenching has become a key research focus. In this work, we successfully synthesized KBi(MoO4)2: xTb3+ (x = 0–100 at%) (denoted as KBM: xTb3+) phosphors via a high-temperature solid-state reaction. Remarkably, no concentration quenching was observed across the entire doping range. This anti-quenching behavior originates from the large Tb3+–Tb3+ interionic distance (> 5 Å) inherent to the quasi-layered crystal structure, which effectively suppresses multipole-interaction-mediated energy migration. At full Tb3+ substitution (x = 100 at%), the material undergoes a structural phase transition from the monoclinic KBM phase to the triclinic α-KTb(MoO4)2 (α-KTM) phase. The α-KTM phosphor exhibits excellent thermal stability (activation energy = 0.6129 eV) and a single-exponential decay profile, whereas KBM: xTb3+ (x < 100%) display double-exponential decay behaviors, attributed to dual energy transfer pathways. These findings provide new insights into the luminescence mechanisms of high-concentration rare-earth-doped systems and offer guidance for designing next-generation anti-quenching phosphors.
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Environmental Science & Technology Letters
·
2025
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IF 8.8
Lingjun Zeng,Mengyan Huang,Chongli Shi,Chen Wang,Jin Zhang,Yi Peng,Yang Zheng,Susu Wang,Jiawei Hong,Yangzhizhe Gao,María Dolores Hernando,Amadeo R. Fernández-Alba,Damià Barceló,Hui Li
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP), a widely used chlorinated flame retardant, is ubiquitous in dust, water, and biota. Parental exposure of Caenorhabditis elegans to environmentally relevant TDCPP (0.1–10 μg/L) reduced mean lifespan by 14.9–20.9% in parental nematodes and 8.07–28.2% in offspring. Multiomics analyses (transcriptomics and lipidomics) uncovered a previously unrecognized lipid-centered mechanism by which TDCPP impaired organismal health. Specifically, TDCPP suppressed the expression of daf-16 and downstream fatty acid desaturase (fat-5/6), leading to depletion of unsaturated lipid species, including triglycerides, diacylglycerols, lysophospholipids, and glycosphingolipids. This disruption was corroborated by phenocopy experiments showing that genetic deletion of fat-5/6 or dietary supplementation with saturated fatty acids (positive control) mimicked TDCPP-induced aging phenotypes. Moreover, TDCPP downregulated aak-2 and cpt-1, impairing mitochondrial β-oxidation and energy metabolism. These findings identified a novel daf-16–fat-6–AMPK–CPT-1 signaling axis, providing mechanistic insight into how the environmental pollutant TDCPP disrupts lipid homeostasis to promote aging and transgenerational toxicity.
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危险品化学品经营许可证（带存储）