Nature Communications
·
2025
·Vol. 16
·期 1
·1-20
·
IF 15.7
Xu Zihan,He Xiujing,Gui Yu,Tang Lingkai,Zhao Yuxin,Song Linlin,Xu Tianyue,Chen Meixu,Zhao Yujie,Du Peixin,Wang Xin,Chen Siyi,Luo Yong,Luo Feng,Meng Huan,Hu Jianping,Zhuo Wei,Jing Jing,Shi Hubing
Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O 3 P@LPYU), which can be triggered by physiological intrapleural pressure during breath. Under the gently alterative pressure, the piezoelectric nanoparticles with notable peroxidase-like activity effectively produce a burst of reactive oxygen species and induce immunogenic cell death by catalysis of carried ozone as well as peroxide in interstitial fluid. A clear and sustained biodistribution is observed in thorax effusion and tumors upon intrapleural administration of particle. Remarkably, due to the abundant substrates in oxygen-rich environment of pleural cavity, O 3 P@LPYU particle provides a potent reduction of MPE volume and durable inhibition of tumor growth in thorax. Our work not only develops a bio-responsive piezoelectric nano-system, but also provides a strategy for persistent suppression of MPE in clinics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2025
·Vol. 155
·期 5
·1-14
·
IF 2.4
Wang Juping,Zhu Fengfan,Qin Yu,Zhu Yuan-Hao,Zhou Jiancheng,Li Naixu
This research is centered on the design and synthesis of a highly efficient heterogeneous catalyst, 1%Ru-MgO- 400 °C, for the hydrogenation of pyrrole to pyrrolidine. As a key intermediate in pharmaceutical manufacturing and fine chemical production, pyrrolidine synthesis poses significant challenges in terms of efficiency. In this work, MgO was synthesized via the calcination of Mg(OH) 2 , followed by the deposition of Ru onto MgO- 400 °C through a sodium borohydride reduction approach to produce the 1%Ru-MgO- 400 °C catalyst. The catalyst demonstrated exceptional performance under conditions of 170 °C and 3.5 MPa H 2 pressure, achieving complete conversion of pyrrole and a 100% yield of pyrrolidine. Advanced characterization methods such as XRD, TG, BET, SEM and HR-TEM were used to analyze the catalyst, revealing that the ruthenium nanoparticles were uniformly loaded on the MgO carrier to form a highly dispersed active site, while the crystal structure of MgO remained intact with excellent thermal stability, providing a structural basis for the efficient performance of the catalyst. Additionally, the catalyst exhibited remarkable stability and retained high activity over multiple reaction cycles, highlighting its suitability for industrial-scale applications. The findings of this study contribute novel perspectives to the development of robust and efficient hydrogenation catalysts and present a sustainable approach for the environmentally friendly synthesis of pyrrolidine. Graphic
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale Research Letters
·
2014
·Vol. 9
·期 1
·1-6
·
IF 2.481
Li Xiaolin,Zhou Zhihua,Lu Dejiong,Dong Xinwei,Xu Minghan,Wei Liangming,Zhang Yafei
We examined the toxicity of four carbon-based nanomaterials (unmodified) by using carbon quantum dots (CQDs), graphene quantum dots (GQDs), graphene oxide (GO), and single-walled carbon nanotubes (SWCNTs) to cultivate bean sprout. Results showed that the toxicity of these four carbon nanomaterials increases with the increasing of concentration and cultivating time. In addition, pH test was applied to study the effect of carbon-based nanomaterials on water. pH of culture solution displayed unconspicuous dose-dependent, but nanomaterials indeed have a considerable impact on the pH even at low concentration.
✓ 已验证
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 5
·1-12
·
IF 4
Liu Xiaoqing,Dong Xiaoling,Peng Zhen,Wang Cuihong,Wan Jianwei,Chen Min,Zheng Chunli
In this study, a quercetin-loaded liposome system modified with collagenase was developed to increase QU penetration in the ECM and improve IPF treatment. Quercetin-loaded long circulation liposome (QU-LP) and quercetin-loaded liposome modified with collagenase type I (QU-CLP) were prepared, followed by characterization of the encapsulation efficiency, particle size, morphology, and in vitro drug release. Their effect on the cytotoxicity of A549 cells was detected by the Cell Counting Kit-8, and the cellular uptake was investigated using cellular fluorescence imaging and flow cytometry. TGF-β1 induced A549 cell model was established to mimic pulmonary fibrosis to explore further the anti-pulmonary fibrosis effect of QU-CLP by CCK8 experiment. QU-CLP significantly improves the solubility and bioavailability of QU by encapsulating it in the internal cavity with a high encapsulation efficiency (EE%) of 92.86 ± 1.03%. Liposomes alleviate the influence of QU on normal A549 cell growth. Enhanced fluorescence intensity was observed in A549 cells treated with coumarin 6-labeled and collagenase-modified nanoliposomes (C6-CLP) after 4 h of incubation on the collagen matrix, confirming that collagenase-loaded liposomes could penetrate the collagen barrier and cells internalized more hydrophobic drug. The mean fluorescence intensity (MFI) of the C6-CLP group was 2.88 times that of the C6-labeled nanoliposomes (C6-LP). Moreover, QU-CLP significantly (** P < 0.01) inhibited the proliferation of A549 cells stimulated by TGF-β1. QU-CLP has excellent potential for delivering QU with enhanced bioavailability, high cellular uptake efficiency, and improved therapeutic efficacy in IPF. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Tungsten
·
2025
·
IF 11.2
Zhou Jie,Zhang Yu-Hang,Mao Qin-Zhong,Xu Xing,Reng Zi-Rui,Yao Zhu-Jun,Xia Yang,Lu Xiao-Xiao
Ultra-high Ni layered cathodes are considered leading candidates for next-generation lithium-ion batteries due to their high energy density. However, their practical application is hindered by structural instability, rapid capacity degradation, and sluggish lithium-ion kinetics. To overcome these challenges, a synergistic modification strategy combining gradient Nb doping with in situ formation of a LiNbO 3 surface layer is proposed. The radially distributed Nb dopant effectively mitigates internal lattice strain and suppresses the formation of microcracks, while the LiNbO 3 coating enhances interfacial stability and facilitates Li-ion transport. As a result, the optimized sample (0.5%Nb-NCM) delivers a high specific capacity of 222.2 mAh·g −1 at 0.1C, retains 94.7% of its capacity after 200 cycles at 1C, and achieves 147.7 mAh·g −1 at an ultra-high rate of 20C. This work highlights the effectiveness of combining compositional and interfacial engineering to develop structurally robust and electrochemically stable ultrahigh-Ni cathodes for advanced Li-ion battery applications. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOM
·
2025
·
IF 2.3
Wang Zhen,Zeng Zhaoyubo,Lu Zhixiang,Liu Can,Dai Wenjie,Hua Nengbin,Liu Zhiqiang,Wu Hecan
The sensitivity of the stress-induced tetragonal to monoclinic (t → m) phase transformation in zirconia ceramics is significantly affected by the addition of rare-earth dopants, which subsequently influences its mechanical properties. However, how to achieve zirconia with varying rare-earth ion distributions and investigate their properties is difficult. Based on the co-precipitation, coating, and ball milling methods, this work successfully achieved a uniform distribution of rare-earth ions and systematically studied the effect of yttrium oxide distribution on the microstructure and mechanical properties of zirconia. The t → m transformation sensitivity during the fracture was assessed through X-ray diffraction, scanning electron microscopy, and Raman spectroscopy, and the results show that both the fracture toughness and flexural strength of zirconia are positively correlated with the increase in sintering temperature. The coated zirconia demonstrated superior fracture strength, and the co-precipitated zirconia exhibited enhanced flexural strength. The enhanced mechanical properties of the coated zirconia are attributed to the non-uniform distribution and un-aggregation of rare-earth dopants within the matrix. Additionally, the high stress-induced phase transformation rate (~ 33.3%) and the significant transformation depth (~ 35 μm) in rare-earth-deficient regions contribute to the material's improved toughness.
✓ 已验证
产品关联
DOI
高影响因子
NPG Asia Materials
·
2025
·Vol. 17
·期 1
·1-14
·
IF 8.3
An Jiahao,Li Lin,Wu Tingting,Lin Zudong,Ren Ruohan,Fujita Toyohisa,Liu Qian
General wound management requires innovative strategies that simultaneously promote effective healing while minimizing patient discomfort and reducing the risk of infection. Herein, we report a photothermal self-gelation sponge dressing based on 3-Aminobenzeneboronic acid (BA) -modified sodium alginate doped with polydopamine nanoparticles (Alg-BA@PDA) that promotes wound repair. This in-situ self-gelation sponge ensures a precise fit to the wound contours within 5 s of rapid fluid absorption, significantly enhancing the therapeutic effect. Dynamically reversible borate ester bonds are formed between the sodium alginate network and PDA-NPs, which enhances the mechanical robustness of the sponge dressing and its adaptability to wound irregularity while maintaining good biocompatibility. Moreover, the sponge dressing shows good antibacterial activity and ROS scavenging capacity, attributed to the photothermal effect of doped PDA-NPs. The RT-qPCR testing and immunofluorescent staining revealed that the Alg-BA@PDA significantly enhances angiogenesis by upregulating the expression of VEGF, HIF-1α, bFGF, eNOs, and CD31 in endothelial cells, and inhibits the inflammatory response by downregulating the expression of IL-6, IL-1β, iNOS, TNF-α, and CD68, all of which promotes wound healing in a mice full-thickness skin wound model in vivo. This outstanding ability makes the self-gelation sponge an ideal dressing to accelerate wound healing with wide potential applications in biomaterials and clinical treatment.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Tan Hao,Zhou Peng,Gu Yu,Liu Youxing,Chen Wenxing,Guo Hongyu,Lin Fangxu,Luo Heng,Cao Xiaoqing,Zeng Lingyou,Luo Mingchuan,Guo Shaojun
Solar-driven artificial photosynthesis of hydrogen peroxide and high-value chemicals from oxygen and biomass is promising but is hindered by poor light absorption, sluggish kinetics of biomass dehydrogenation, and low oxygen reduction selectivity. Herein, we develop a resorcinol-formaldehyde resin/carbon-supported Ta-N 2 O 2 single-atom catalyst (RF/C-TaSA) that enables broad-spectrum light harvesting (> 932 nm) and selective biomass conversion in a solid-organic-aqueous three-phase system. RF/C-TaSA achieves a high 3.0% quantum yield at 635 nm, with Ta-N 2 O 2 sites stabilizing intermediates and reducing the energy barrier for biomass conversion. We further demonstrate that RF/C-TaSA enables efficient artificial photosynthesis of H 2 O 2 and value-added chemicals from more available thatch, pine needles and wastepaper. Combining catalyst innovation and system engineering, we build a solar-powered RF/C-TaSA-based photocatalytic device for directly producing commercially viable H 2 O 2 at a high concentration of 3 wt% and high-value-added chemical without requiring energy-intensive separation processes for 70-day operation. Furthermore, the produced crude concentrated H 2 O 2 can also be readily converted to solid H 2 O 2 powder (Na 2 CO 3 ∙ 1.5 H 2 O 2 ) for ease of storage and transport with high sterilization activities even after 6 months.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Chen Jiawei,Liu Xiangyu,Cai Bo,Cheng Yuanzhuang,Wen Hao,Zhu Danlei,Xiong Yaonan,Dai Linjie,Yan Xinghua,Xiang Baixu,Luo Xiyu,Feng Wenjing,Du Jiuyao,Dong Shuyue,Shan Qingsong,Chen Shulin,Zeng Haibo,Xiong Qihua,Duan Lian,Ma Dongxin
Perovskite quantum dot light-emitting diodes have rapidly achieved high external quantum efficiencies of over 25%; however, hindered by limited operating stability originating from surface defects or ion migration in quantum dots. Here, we design a lattice-matched anchoring molecule, tris(4-methoxyphenyl)phosphine oxide (TMeOPPO- p ), to anchor the multi-site defects and stabilise the lattice. The target quantum dots exhibit high exciton recombination features with near-unity photoluminescence quantum yields (97%), and the as-fabricated quantum dot light-emitting diodes present a maximum external quantum efficiency of up to 27% at 693 nm, a low efficiency roll-off (over 20% at a current density of 100 mA cm −2 for the typical device) and an operating half-life of over 23,000 h. Besides, the air-processed devices maintain a maximum external quantum efficiency of over 26% with good storage stability. We expect this work to exert a profound influence on rational and on-demand molecule design for perovskite QDs, indicating great promise in optoelectronic applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
He Jiaxing,Deng Youzhi,Han Junwei,Xu Tianze,Qi Jiangshan,Li Jinghong,Zhang Yibo,Zhao Ziyun,Li Qi,Xiao Jing,Zhang Jun,Kong Debin,Wei Wei,Wu Shichao,Yang Quan-Hong
Ideal silicon negative electrodes for high-energy lithium-ion batteries are expected to feature high capacity, minimal expansion, long lifespan, and fast charging. Yet, engineered silicon materials face a fundamental paradox associated with particle deformation and charge transfer, which hinders the industrial use of advanced silicon electrode materials. Here we show a sieving-pore design for carbon supports that overcomes these mechano-kinetic limitations to enable stable, fast (de)alloying chemistries of silicon negative electrodes. Such a sieving-pore structure features an inner nanopore body with reserved voids to accommodate high-mass-content silicon deformation and an outer sub-nanopore entrance to induce both pre-desolvation and fast intrapore transport of ions during cycling. Importantly, the sieving effect yields inorganic-rich solid electrolyte interphases to mechanically confine the in-pore silicon, producing a stress-voltage coupling effect that mitigates the formation of detrimental crystalline Li 15 Si 4 . As a result, this design enables low electrode expansion (58% at the specific capacity of 1773 mAh g − 1 and areal capacity of 4 mAh cm − 2 ), high initial/cyclic Coulombic efficiency (93.6%/99.9%), and minimal capacity decay (0.015% per cycle). A practical pouch cell with such a sieving-pore silicon negative electrode delivers 80% capacity retention over 1700 cycles at 2 A as well as a 10-min fast charging capability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Protocols
·
2025
·
IF 16
Liu Yang,Niu Rui,Wang Yinghui,Zhang Hongjie,Zhao Yanli
Nanocatalysts, including nanozymes, photocatalysts and sonocatalysts, have been investigated to trigger catalytic reactions in vivo to regulate biological microenvironments and stimulate therapeutic effects. Compared with lower metal atom utilization rate and catalytic activity of conventional nanocatalysts, single-metal atom catalysts (SACs) usually possess higher catalytic activity and selectivity owing to their well-defined structures and maximized atom utilization. Their properties are, however, strongly dependent on their composition and the preparation procedure. Here we describe the design, preparation and functionalization of SACs with single-metal atoms positioned within nitrogen-doped carbon supports. The SACs are prepared by pyrolysis of zeolitic imidazolate framework-8 (ZIF-8) or polydopamine-derived materials. Their properties depend on, for example, the metal chosen and atoms available for coordination; four example procedures are described: Cu–N 4 from Cu–ZIF-8, Ir–N 5 from Ir@ZIF-8 plus melamine, Co–PN 3 from triphenylphosphine@Co-ZIF-8 and Cu–SN 3 from ZnS@Cu-polydopamine. These SACs need to be functionalized to, for example, reduce aggregation and in vivo corona formation before they can be used in biological applications. In this Protocol, functionalization with the proteins (that is, cholesterol oxidase and pyruvate oxidase) is used as an example. The Protocol provides advice regarding physicochemical and functional characterization, as well as for performing experiments in tumor-bearing mice. The functional experiments were designed with the aim of identifying nanocatalysts with peroxidase-like activity that generate reactive oxygen species within areas of the tumor microenvironment that have increased levels of hydrogen peroxide. SAC synthesis takes 3–4 days, functional modification requires one extra day and the most basic and essential in vitro and in vivo assays require 2–3 months.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Collagen and Leather
·
2025
·Vol. 7
·期 1
·1-13
·
IF 9.2
Cai Zhenpeng,Xiang Yujia,Cong Boyi,Liu Yang,Yang Shuai,Wang Ningruo,Zhang Heng,Wang Yuzhong,Lai Bo
Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) is commonly used as a preservative and fungicide in leather production that leads to its presence in tannery wastewater. As a typical organic phosphorus pollutant, THPS poses potential threats to both the ecological environment and human health. Herein, this investigation used the microscale zero-valent iron (mZVI)/O3 process to eliminate THPS from aquatic environments. The mZVI/O3 system demonstrated superior removal performance, achieving high removal efficiencies of total phosphorus (TP), organic phosphorus (OP), and chemical oxygen demand (COD) compared to traditional systems (i.e., mZVI alone, O3 alone, Fe2+/O3, and Fe3+/O3). Moreover, batch experiments were conducted to optimize the key operational parameters (such as initial pH, mZVI dosage, O3 concentration, and stirring rate). The TP, OP, and COD removal efficiencies in the mZVI/O3 system reached 97.10%, 97.31%, and 81.56% within 20 min, respectively, under optimized conditions. Based on the experimental results and characterization analysis, the THPS degradation mechanism by the mZVI/O3 system was primarily a combination of oxidation (60.37% ± 7.41%) and flocculation (39.63% ± 7.41%). Furthermore, the mZVI/O3 system demonstrated unprecedented removal performance in various actual wastewater samples. The system eliminated organic pollutants and improved biodegradability of actual wastewater. This study not only establishes the mZVI/O3 process as a robust, cost-effective, and environmentally sound approach for OP degradation but also offers substantial promise for practical wastewater treatment applications.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）