IONICS
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2026
·
IF 3.4
Liu Zhuangzhuang,Yang Xiaobo,Li Shengting,Lu Guimin,Sun Ze
Iron impurities are among the most detrimental impurities in magnesium electrolysis because they can promote cathode passivation, reduce current efficiency, and contribute to Mg loss. This study systematically investigated the electrochemical reduction of Fe(Ⅲ) and the corresponding cathode passivation mechanism in an anhydrous carnallite melt composed of MgCl₂ and KCl with a molar ratio of 1:1 at 973 K. Based on cyclic voltammetry (CV), square wave voltammetry (SWV), chronoamperometry (CA), chronopotentiometry (CP), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS), the results show that Fe(Ⅲ) reduction is a single-step, diffusion-controlled, quasi-reversible process. Current reversal chronopotentiometry (CR-CP) measurements based on representative curves suggested a decrease in apparent current efficiency from 92.5% to 79.1% after 10 min of electrolysis. Morphological and electrochemical analyses further suggest the underlying passivation mechanism. During the initial stage of electrolysis, Fe(Ⅲ) is preferentially reduced and deposited on the cathode surface as a porous, sponge-like structure. The newly formed porous Fe deposits may adsorb MgO-containing species from the molten salt, suggesting the possible presence of an Fe/Mg/O-rich passivation layer on the cathode surface. Such a surface layer may reduce the wettability of the cathode toward liquid Mg and hinder the spreading and coalescence of Mg droplets, thereby promoting the deposition of Mg as fine, discrete, caviar-like particles with diameters below 1 mm. This process may contribute to Mg loss and the decrease in current efficiency during electrolysis. These findings provide fundamental insight into the role of Fe(Ⅲ) in cathode passivation during magnesium electrolysis.
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Nature Communications
·
2026
·
IF 18.1
Feng Doudou,Xie Yanchun,Shen Yinlin,Zhang Hao,Chen Xuan,Wang Peng-Fei,Qin Jiaqian,Jiao Yucong,Xu Jijian
Interfacial instability from polyiodide shuttling and zinc electrode degradation critically limits the reversibility of aqueous zinc–iodine batteries. Existing mono-valent organic cation strategies offer insufficient charge density and pose challenges in maintaining interfacial protection under dynamic electric field conditions. Here, we present an electrolyte design incorporating a high-valent organic cation (HVOC) —a tetravalent cation derived from 1,1,4,4,7,7,10,10-octaallyltetraazacyclodecane trifluoromethanesulfonate—that enables electrostatically engineered bipolar interfaces. The HVOC establishes a durable cationic positive electrode–electrolyte interphase on the iodine electrode that not only effectively immobilizes polyiodide species through strong electrostatic interactions under dynamic field reversals, but also facilitates iodine redox kinetics. Simultaneously, the HVOC drives the formation of a hybrid organic–inorganic solid electrolyte interphase on the zinc electrode that homogenizes zinc deposition and mitigates side reactions. This bipolar interfacial regulation enables zinc–iodine batteries with an N/P ratio of 2.43 to achieve 40.7% of zinc utilization and 95.4% of iodine utilization, with minimal capacity decay of 0.016% per cycle over 1,000 cycles at 0.4 A g –1 , and stable performance across a wide temperature range from –40 to 60 o C. This work presents a viable electrolyte design paradigm using HVOC chemistry for advanced aqueous battery systems.
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高影响因子
INTERNATIONAL UROLOGY AND NEPHROLOGY
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2026
·
IF 2.2
Chen Huihui,Zhang Guolei,Jin Jingjing,Cheng Mei Juan,Zhang Dongxue,Niu Zhezhe,Zhu Rongfang,Qian Yuetong,Liang Xiangnan,He Lei,Zhou Wei,Zhang Shenglei,Bai Yaling,Xu Jin Sheng
Purpose Vascular calcification (VC) is highly prevalent and a significant cardiovascular risk factor in patients with chronic kidney disease (CKD). Secreted frizzled-related protein 1 (SFRP1) is a secreted glycoprotein closely associated with the Wnt/β-catenin pathway which plays a crucial role in bone formation, but its function and mechanism in VC remain unknown. Methods Serum and radial artery tissues were collected from CKD patients with or without VC. The cellular model of VSMCs’ calcification was established under high-phosphate conditions in vitro. Western blot, qRT-PCR, and immunofluorescence were used to detect SFRP1 expression. The function of SFRP1 was identified by transfection with sh-SFRP1 and pCMV3-SFRP1 plasmid. Results Initially, bioinformatics analysis showed that SFRP1 expression was significantly elevated in high-phosphate-stimulated rat VSMCs. Subsequently, we discovered that the expression of SFRP1 was dramatically increased in the calcified arteries of CKD patients. Functionally, when SFRP1 was knocked down, the calcification process and the expression of Runx2 were attenuated. In contrast, SFRP1 overexpression exacerbated the β-GP-induced VSMCs’ calcification. Mechanistically, we confirmed the activation of Wnt/β-catenin signaling in the in vitro calcification model and this activation was inhibited by SFRP1 knockdown. Furthermore, when the Wnt/β-catenin signaling was enhanced with LiCl, the suppressing effect of SFRP1 knockdown on β-GP-induced osteogenic transdifferentiation of VSMCs was reversed, and calcification was promoted. Conclusion We identified that SFRP1 promoted vascular calcification in CKD partly by regulating the Wnt/β-catenin/Runx2 axis, suggesting that SFRP1 may be a potential biomarker and therapeutic target for VC in CKD.
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高影响因子
Nature Communications
·
2026
·Vol. 17
·期 1
·3422
·
IF 18.1
Cao Hongxuan,Tu Jie,Chen Jiahui,Chen Bingzhang,Huang Zeyue,Wang Yingjie,Shen Jing,Hu Xiuqi,Bo Jialin,Rao Li,Liu Zheng,Makunga Nokwanda P.,Hameed Muhammad Salman,Su Chen,Wan Jian,Chang Wenqiang,Sheng Chunquan,Ren Yanliang
The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis -fumaramidmycin-derived analogs inhibiting the interactions of ribosome assembly factor Mrt4 with rRNA to combat fungal infections. Through antifungal screening, we identified a promising lead 20 with strong efficacy against various drug-resistant fungi, including notorious super-fungus Candida auris . A comprehensive approach combining active-and-inactive-based protein profiling (AIBPP), chemical-genetic profiling, and fluorescence polarization revealed that the antifungal activity of 20 is primarily due to selectively inhibiting essential Ca Mrt4-rRNA interaction by conjointly covalent engaging C96&C189 on Ca Mrt4 but inactive for Hu Mrt4-rRNA interaction, thereby disrupting fungal ribosomal assembly. Therapeutic efficacy of 20 in both Galleria mellonella larvae and murine candidiasis models validate this antifungal strategy. Collectively, our studies provide a potential and much needed therapeutic strategy to address the rapidly rising burden of drug-resistant fungal infections.
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npj Heritage Science
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2026
·
IF 0
Yang Guan,Yang Ruofan,Guo Ning,Guo Jingyang,Chen Jiawei,Ma Haomeng,Qi Yunpeng,Li Yuhu,Zhou Yajun,Luo Yujia
Lead white blackening is a common deterioration in traditional Chinese paintings that severely undermines their artistic and cultural value. This study proposes a two-step preventive treatment involving sequential application of phosphotungstic acid-phosphoric acid-acetone (PPA) and barium hydroxide-ethyl cellulose-methanol (BCM) solutions. Accelerated H₂S aging tests showed that the treated lead white only exhibited localized blackening after 20 days of aging, whereas the untreated control turned completely black within 1 day. Comprehensive characterizations (EDS, SEM, XRD, XPS, FTIR) demonstrated that phosphotungstic acid chelates Pb(II) to inhibit H₂S-induced blackening, while barium hydroxide neutralizes residual acid and forms a protective barrier. Mechanical tests confirmed no adverse impact on paper substrates. This method offers a promising reference for lead white blackening prevention, though its on-site applicability and long-term stability require further validation.
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npj Science of Food
·
2026
·
IF 9.7
Xu Jingyi,Luo Peida,Xie Mingji,Liu Cheng,Li Xin,Zhao Jianping,Zheng Murong,Chen Changhui,Sun Bo,He Chunlei,Bian Jinlin,Du Xiao
Mengding bud yellow tea (MDBYT) is a renowned Chinese yellow tea characterized by its mellow, umami, and sweet taste. This study integrated flavoromics and metabolomics to investigate dynamic changes in non-volatile metabolites and sensory attributes during traditional “three yellowings and three fryings” processing. Sensory evaluation revealed progressive quality improvement, with the yellowing critical for enhancing umami and sweetness. Untargeted metabolomics identified 156 differentially abundant compounds. Theanine glucoside emerged as a potential contributor to the characteristic taste. KEGG pathway analysis highlighted amino acid biosynthesis and flavonoid metabolism as significantly enriched. Comparative metabolomic analysis with green tea identified 19 potential biomarkers, prominently including N-ethyl-2-pyrrolidinone-substituted flavan-3-ols (EPSFs), which were the most prominent. Correlation analysis between biomarkers and sensory attributes revealed distinct patterns in yellow and green teas, supporting their potential functional roles. These findings provide systematic and novel insights into the taste characteristics and underlying formation mechanisms of yellow tea.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·480
·
IF 5.4
Yang LingFeng,Fu Zuyao,Shuaibu Abubakar,Xie Jing,Ding Zhaoyang
A zirconium-based MOF-on-MOF hybrid nanostructure (AIE-MOF@PCN-222, average size 3860 nm) was synthesized and characterized by SEM, TEM, XRD, XPS, FTIR, BET and TGA, which displays excellent peroxidase-like activity and stable aggregation-induced emission (AIE) properties. The dual-mode colorimetric-fluorescent sensing of formaldehyde relies on the synergistic mechanism of specific Schiff-base condensation, nanozyme catalysis and fluorescence resonance energy transfer (FRET). After parameter optimization, the sensor presents a linear response of 4–40 µM, with detection limits of 14.5 nM (colorimetric) and 1.78 nM (fluorescent). A 3D-printed portable device integrated with PDMS microfluidics was developed for on-site detection. In spiked shrimp and fish samples, the sensor achieves recoveries of 97.60-103.50% (colorimetric, RSD ≤ 2.95%) and 98.20-102.40% (fluorescent, RSD ≤ 3.12%), with relative errors below 1.51% relative to HPLC. This strategy provides a promising dual-mode platform with potential for portable HCHO screening in food matrices for HCHO detection in food matrices. Graphical The alternative text for this image may have been generated using AI.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Wang Yunfan,Zheng Zihao,Ren Lele,Du Yifeng,Guo Jinming,Zhang Shujun,Nan Ce-Wen,Li Bao-Wen
Sodium niobate (NaNbO 3 ), traditionally recognized as an antiferroelectric material, has garnered significant attention for its potential in energy storage, electromechanical devices, and electrocaloric applications. Central to unlocking its full potential is precise control over its ferroic orders, particularly the transition between antiferroelectric and ferroelectric phases. In this study, we propose a topochemical conversion strategy for fabricating pure ferroelectric NaNbO 3 membranes with a P 2 1 ma orthorhombic phase regardless of membrane thickness. Using Scanning transmission electron microscopy, we identify two distinct regions with large ( > 10°) or small ( < 1°) octahedral tilts in the ferroelectric NaNbO 3 membranes. Polarization analyses in these regions reveal that the ferroelectricity originates from the out-of-plane displacement of Nb 5+ cations. Additionally, the pure ferroelectric NaNbO 3 membranes demonstrate thickness-dependent piezoelectric enhancement, achieving a d 33 value of 93.7 pm/V at 30 nm thickness, as well as pronounced resistance switching behaviors. This study introduces an innovative molten salt environment-controlled synthesis strategy, enabling efficient production of high-quality pure ferroelectric NaNbO 3 membranes, and advancing their integration into next-generation functional devices.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·482
·
IF 5.4
Zhu Yun,Luo Tianshu,Niu Jingge,Cao Jie,Pang Yizhuo,Hou Xiaohong
A novel two-dimensional metal-organic framework (2D MOF), 2D Co-MOF@MnO 2 , with oxidase-like activity was successfully prepared via a solvothermal method, and its mimetic oxidase-like activity was investigated in detail. Its kinetic parameters K m and V max were determined to be 0.048 mM and 5.897 × 10 − 7 Ms − 1 , respectively. Taking advantage of the material’s ability to catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) and the inhibitory effect of uric acid (UA) on this oxidase-like activity, we designed and constructed a portable colorimetric sensing device for the rapid detection of UA. This device enabled UA detection within 3 min at room temperature. The proposed system showed a linear response in the concentration range 5-200 µM with a detection limit of 4.98 µM, which was comparable to or even better than several previously reported colorimetric methods. This proof-of-concept study presented a novel and efficient approach that had potential for future point-of-care (POCT) applications for uric acid detection, and may offer new insights into early disease diagnosis, health monitoring, and biomedical research. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
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IF 4.4
Guo Xiurong,Zheng Kaiwen,Liu Zexin,Qiao Lulu,Sun Chaowei,Du Danfeng
The rapid advancement of new energy vehicles presents numerous challenges, among which the growing incidence of battery overheating-related accidents highlights the urgent need for effective thermal insulation materials for battery thermal management. To address this demand, microencapsulated phase-change materials (MEPCMs) comprising a titanium dioxide (TiO 2 ) shell and an n-hexadecane core were synthesized through interfacial polymerization. Incorporation of the MEPCMs into SiO 2 aerogels (SA) prepared by ambient drying yielded a novel phase-change aerogel composite material (MSA). The composite demonstrated a slightly higher thermal conductivity, 0.041 W/m·K, than both pristine silica aerogels and those directly loaded with n-hexadecane. Its latent heat reached 91.39 J/g, thereby combining thermal insulation with energy storage to achieve dynamic thermal regulation. Overall, this simple and scalable fabrication approach underscores the aerogel composite’s promise in battery thermal management and other thermal regulation uses. Graphical
The alternative text for this image may have been generated using AI.
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高影响因子
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2026
·Vol. 42
·期 7
·356
·
IF 4.7
Zhang Junshun,Wang Maoyu,Lu Suwan,Zhi Yuhui,Bi Luchen,Wang Yuxian,Yin Linlin,Wang Yi,Chen Zhina
Ginseng rootlets, an underutilized by‑product of ginseng processing, are abundant in bioactive ginsenosides. This study investigated the antibacterial activity of ginsenosides derived from ginseng rootlets against four foodborne pathogens including Staphylococcus aureus , Escherichia coli , Salmonella enterica serovar Typhimurium, and Bacillus subtilis , and their preservative potential in minced beef. The results demonstrated that ginsenosides exerted potent, strain‑specific antibacterial activity, with the strongest effect against Escherichia coli . The inhibition zone diameter (DIZ) for Escherichia coli was 10.25 ± 0.12 mm, its minimum inhibitory concentration (MIC), was 2.85 ± 0.025 mg/mL, and its MBC was 3.3 ± 0.067 mg/mL. Besides, ginsenosides exhibited strong free radical-scavenging activity at 16 mg/mL. The scavenging rate for ABTS⁺· was 77.1%, the scavenging rate for DPPH· was 80.4%, and the scavenging rate for ·OH was 75.0%. The control group of minced beef exhibited a shelf life of 4 days, and treatments with 2% and 4% ginsenosides extended the shelf life by 2 and 4 days, respectively, compared with the control group. Ginsenosides significantly inhibited the growth of mesophilic bacteria, attenuated the increases in TBARS, acid value (AV), and pH, and effectively maintained the redness ( a* value) and lightness ( L* value) of beef. Consequently, ginsenosides from ginseng rootlets simultaneously suppressed microbial proliferation and oxidative deterioration, thereby extending the shelf life of minced beef. This study provided a theoretical basis for the high‑value utilization of ginseng rootlet by‑products and the development of natural dual‑functional preservatives for meat products.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·293
·
IF 5.4
Pan Yi,Wang Li,Chen Shouhui,Wei Xinlin
In response to the coexistence of multiple heavy metals and their complex interactions, this study developed an integrated microfluidic chip that combined a fluorescence sensor array with an electrochemical aptasensor. Various metal nanoclusters stabilized by different ligands were synthesized as fluorescence signal probes with six distinguishable emission wavelengths to form the fluorescence sensor array. Six heavy metal ions (Pb 2+ , Cd 2+ , Hg 2+ , As 3+ , Cr 6+ , and Cu 2+ ) exhibited different influence on the fluorescence intensities and achieved in a variant data matrix for linear discriminant analysis. The quantification of specific heavy metal ions was realized thorough the electrochemical aptasensor, which was constructed using nucleases exonuclease-assisted and nucleic acid amplification technique. The rapid and sensitive detection of Pb 2+ , Cd 2+ , and Hg 2+ was achieved with detection limits as low as 3.327 pg/mL, 7.975 pg/mL, and 1.228 pg/mL, respectively. The above two sensing strategies were successfully assembled into the microfluidic chip, in which the fluorescence sensor array realized the preliminary identification of various heavy metal ions while the electrochemical aptasensor provided a quantitative signal to improve sensitivity. This integrated microfluidic chip could successfully detect Pb 2+ , Cd 2+ , and Hg 2+ in the tea sample. Therefore, the integrated device designed in this study exhibited excellent potential in the screening and quantification of multiple heavy metal ions in complex matrices.
Section
Graphical
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危险品化学品经营许可证（带存储）