Nanoscale
·
2018
·Vol. 11
·期 3
·1111-1122
·
IF 7.233
Chunmei Li,Zhihui Chen,Weiyong Yuan,Qing-Hua Xu,Chang Ming Li
Photoelectrochemical (PEC) water splitting represents a promising strategy to convert solar energy into chemical energy in the form of hydrogen, but its performance is severely limited by the sluggish water oxidation reaction. Herein, for the first time, we report the direct assembly of an ultrathin, uniform, and dense layer of Co3O4 on wormlike nanostructured hematite (WN-α-Fe2O3) to form a large-area and high-density WN-α-Fe2O3@Co3O4 core–shell nanoarray via in situ hydrothermal growth followed by calcination, in which the electrostatic force between WN-α-Fe2O3 and the reactants, pH- and temperature-controlled structures of WN-α-Fe2O3, and ultralow nucleation rate of Co3O4 precursors all play critical roles. The obtained heteronanostructure array shows a photocurrent density of 3.48 mA cm−2, which is 4.05 times higher than that of pristine WN-α-Fe2O3 (0.86 mA cm−2), an onset potential of ∼0.62 V, 60 mV lower than that of α-Fe2O3 (∼0.68 V), and a photoconversion efficiency of 0.55%, 3.93 times higher than that of WN-α-Fe2O3 (0.14%). This is among the highest performances reported for Fe2O3-based photoanodes for water splitting. It is discovered that the Co3O4 shells can significantly enhance the charge separation, accelerate the charge transport and transfer, and reduce the charge transfer resistance from the photoelectrode to the electrolyte for a fast water oxidation reaction, thereby greatly promoting the PEC water oxidation performance of pristine WN-α-Fe2O3. This work not only creates a novel low-cost and Earth-abundant WN-α-Fe2O3@Co3O4 photoelectrode with superior PEC water oxidation performance and provides scientific insights into the enhancement mechanism, but also offers a general strategy for the in situ growth of water oxidation catalysts on various photoelectrodes with 3-D complex geometries for PEC water splitting.
研究领域:
材料科学
·
能源转换与存储
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Yawen Jiang,Xiaoxiao Li,Tjaard Pijning,Yuxiang Bai,Lubbert Dijkhuizen
Limosilactobacillus reuteri 121 4,6-α-glucanotransferase (Lr121 4,6-α-GTase), belonging to the glycosyl hydrolase (GH) 70 GtfB subfamily, converts starch and maltodextrins into linear isomalto/malto polysaccharides (IMMPs) with consecutive (α1 → 6) linkages. The recent elucidation of its crystal structure allowed identification and analysis of further structural features that determine its reaction and product specificity. Herein, sequence alignments between GtfB enzymes with different product linkage specificities (4,6-α-GTase and 4,3-α-GTase) identified amino acid residues in GH70 homology motifs, which may be critical for reaction and product specificity. Based on these alignments, four Lr121 GtfB-ΔN mutants (I1020M, S1057P, H1056G, and Q1126I) were constructed. Compared to wild-type Lr121 GtfB-ΔN, mutants S1057P and Q1126I had considerably improved catalytic efficiencies. Mutants H1056G and Q1126I showed a 9% decrease and an 11% increase, respectively, in the ratio of (α1 → 6) over (α1 → 4) linkages in maltodextrin-derived products. A change in linkage type (e.g., (α1 → 6) linkages to (α1 → 3) linkages) was not observed. The possible functional roles of these Lr121 GtfB-ΔN residues located around the acceptor substrate-binding subsites are discussed. The results provide new insights into structural determinants of the reaction and product specificity of Lr121 GtfB 4,6-α-GTase.
研究领域:
酶学
·
分子生物学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2019
·
IF 7.467
Yunzhao Liu,Xiaowei Chi,Qi Han,Yuexiu Du,Jiaqi Huang,Yu Liu,Jianhua Yang
Rechargeable Zn-ion batteries (ZIBs) have attracted extensive attention, but their practical application is hindered by the limited cycling life and complicated preparation process of cathode materials . Here, we develop a facile yet scalable chemical precipitation/spray-granulation combined methodology for the fabrication of α-MnO 2 nanofibers/carbon nanotubes hierarchically assembled microspheres (α-MnO 2 /CNT HMs) as the cathode material for aqueous ZIBs . The α-MnO 2 evenly anchoring to the CNTs-based framework shows significantly increased tap density compared with pristine α-MnO 2 , which can effectively enhance the electrochemical stability. Owing to the synergistic merits of highly conductive carbon nanotubes network and α-MnO 2 nanofibers with desirable structure features, within our knowledge, the highest areal energy density of 0.98 Wh cm −2 at 0.2 A g −1 and the record cycling stability with 96% capacity retention over 10000 cycles at 3 A g −1 among the reported cathodes for ZIBs are achieved. Zn 2+ and H + co-insertion reaction mechanism with high reversibility is further revealed. Fast kinetic of the H + insertion/extraction process renders the cell excellent cycling stability. Facile preparation of nanofibrous α-MnO 2 based micro-composite, cost benefit of the source materials, and the superior battery performance provide new approaches for the practical applications of ZIBs.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Junliang Fan,Li Xiao,Yuantao Qin,Hao Yan,Xiaolin Qu,Zhenzhen Li,Hengxiang Gong
There is little research on α-Ga 2 O 3 single crystal film because it is a metastable phase of Ga 2 O 3 crystal and difficult for controllable fabrication. In this paper, highly crystallized Ga 2 O 3 thin films of poly-crystalline, α-Ga 2 O 3 and β-Ga 2 O 3 were prepared by modulating the growth temperature from 400 °C to 700 °C by mist-assisted CVD (Mist CVD) method. The results show that films grown at 525 °C owes the best crystalline quality of α-Ga 2 O 3 film. To further improve the crystallinity of α-Ga 2 O 3 thin film, a systematic simulation revealing the distribution changes of aerosol particle size, flow field, and temperature gradient in the reaction chamber were explored. The optimal growth region C with uniform particle size, well-distribute temperature gradient and stable flow field is determined. Meanwhile, the experimental results of α-Ga 2 O 3 thin films grown at different positions in the reaction chamber was proved to consistent with the simulation results. Furthermore, the optimal single crystallized α-Ga 2 O 3 thin films with smooth surface morphology and optical property were obtained. The PL spectrum operated at room temperature show the α-Ga 2 O 3 film with low defect density and high crystalline quality. It shows that the single crystallized α-Ga 2 O 3 is orientated grown on sapphire substrate with epitaxial relationship of α-Ga 2 O 3 (0006)//c-Al 2 O 3 (0006). Although, slight lattice mismatch is observed on the selected area electron diffraction pattern of the interface between sapphire and α-Ga 2 O 3 film, it is ideal for further application in devices. This work reveals the key point for α-Ga 2 O 3 single crystal film growth by mist CVD is to construct a steady and orderly environment through controlling aerosol particle state.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
Chinese Medicine
·
2019
·Vol. 14
·期 1
·1-11
·
IF 2.265
Guo Shangxin,Lin Xiaotong,Wang Yi,Gong Xingchu
Background The discovery of bioactive compounds in traditional Chinese medicine (TCM) has become an important field in TCM modernization. Ligand fishing is a suitable method for discovery of bioactive compounds in complex mixtures such as TCM with high selectivity. Because of unique advantage of low cost and convenience, paper-based microdevices can be good carriers for enzyme immobilized ligand fishing. Methods As an important enzyme for glucose metabolism, α-glucosidase was immobilized on polycaprolactone–chitosan-modified paper to prepare the microdevice with unique microfluid structure generated by 3D printing technology, which can be easily applied to screen active compounds in herbal extracts. The preparation conditions of the paper microarray were optimized. The activity of immobilized α-glucosidase was verified by colorimetric reactions which can be easily monitored by cellphone. The paper microarray with α-glucosidase immobilized was used to screen active compounds in the water extracts of mulberry leaves and lotus leaves. Results Several key parameters including Na 2 CO 3 solution concentration, Na 2 CO 3 solution volume, glutaraldehyde concentration, crosslinking time of glutaraldehyde and time of α-glucosidase immobilization were optimized. The proposed paper-based microarray was successfully applied in screening active compounds in two herbal extracts. Four compounds including chlorogenic acid, quercetin-3- O -glucuronide, isoquercetin, and quercetin were identified as α-glucosidase inhibitors. The compounds with significant non-specific adsorption caused by chitosan, such as isoquercitrin, astragalin, quercetin, were also found to be active compounds. Conclusions An enzyme immobilized paper microarray was designed and fabricated in this work. Polycaprolactone and chitosan were used to modify filter paper to prepare paper microarrays. Parameters of paper device preparation were optimized. Our findings suggested that 3D-printing paper-based microarrays can be a simple and low-cost approach for discovery of active compounds of TCM.
研究领域:
药理学
·
生物技术
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Xiang-Yi He,Qian-Wen Shen,Chao-Jie Zhu,Shuo Hao,Kai-Yu Tan,Qing Li
This study presents a novel crosstalk-free dual-mode biosensing platform based on a single cerium-incorporated metal-organic framework (UiO-66-NH 2 (Ce)) for sensitive detection of α-glucosidase activity and inhibitor screening. Unlike traditional dual-mode systems affected by signal interference, this monolithic MOF platform intrinsically produces orthogonal colorimetric and fluorescent responses. Upon α-glucosidase-mediated generation of hydroquinone, simultaneous signal transduction occurs through independent pathways: colorimetric attenuation via suppression of the oxidase-like catalytic process, and fluorescence recovery due to ligand-to-metal charge transfer modulation. Rigorously optimized for clinical application, the platform achieves ultra-low detection limits of 0.0166 U/L in colorimetric mode and 0.0094 U/L in fluorescent mode, surpassing existing methods. The platform demonstrates selectivity against potential interferents and successfully quantifies α-glucosidase in human serum with satisfactory recovery rates. Furthermore, the system facilitates precise inhibitor screening with IC 50 values of 8.13 μM for fluorescence-based detection and 10.06 μM for colorimetric detection of acarbose. By integrating self-validating detection and drug evaluation within a single-material architecture, this work establishes a paradigm for designing robust MOF-based biosensors equipped with built-in cross-validation capabilities.
研究领域:
生物传感器
·
分子生物学
·
药物代谢
·
临床检验
·
纳米医学
·
酶学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Kaixin Feng,Zhongkun Zhang,Jingjing Zhang,Xiaohan Xia,Siyu Yao,Yufei Wang,Min Wu
Doxorubicin (DOX) is limited by its clinical toxicity as a breast cancer therapy. Traditional liposomal formulations improve the tumor delivery of DOX but suffer from inadequate controlled release and low encapsulation efficiency of DOX. To address these, we developed a photo-responsive liposomal formulation DTTPL by co-encapsulating DOX and TiO 2 nanostructures (TiO 2 ) within D-α-tocopheryl succinate (α-TOS)-PEG liposomes. DTTPL successfully facilitated the release of DOX through the light-sensitive catalysis mechanism of TiO 2 , exhibiting 4.6 times greater cytotoxicity against MCF-7 cells compared to free DOX. Transcriptional analysis revealed synergistic DOX/DTTPL dysregulation of key genes (Brca1, Bcl-2, Bax, Caspase-3), aligning with cytotoxicity. Eventually, light-triggered DOX/DTTPL formulation resulted in 70.09% of tumor growth inhibition (TGI) in mice with no significant organ toxicity. This photo-responsive nanoformulation enables efficient controlled release of DOX, offering an alternative strategy for small molecule delivery to treat triple negative breast cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 33
·期 7
·2313-2324
·
IF 3.348
Zhiyi Huang,Tingting Liao,Xiaochun Liu,Jianyu Wu,Zilun Tang,Guoyi Pan,Huameng Liu,Xiaofeng Lin,Wenjing Lin,Yong Li,Yuxin Gu,Guobin Yi
Thermoplastic elastomer ethylene/α-octene co-polymer (POE) is a special polymer material with both elasticity and thermoplasticity. However, the nonpolarity and low-tensile strength of POE limit its application in polar materials and high-strength materials fields. In this study, we synthesized a specific molecule with C═C bonds and N H bonds, which was introduced into POE to construct hydrogen bonding network, and the prepared modified POE is further blended with carboxyl terminated polystyrene nanospheres as toughening agent to prepare modified POE elastomer composites. Based on such dual toughening strategy containing chemical modification and physical toughening, the modified POE elastomer composites possess improved mechanical properties. The composites achieve a tensile strength of 21.4 MPa, elongation at break of 1268%, fracture energy of 109.6 MJ∙m −3 and exhibit improved thermal stability. Impressively, the tensile strength of reprocessed composites is restored to more than 90% of their original tensile strength even after four times of reprocessing steps, demonstrating excellent reusability.
研究领域:
材料科学
·
高分子科学
·
机械工程
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jinmei Xu,Senqi Xu,Shangqing Tang,Luyao Wang,Kui Wan,Chuqiao Wang
The widespread use and release of 2,4,6-Trichlorophenol (TCP) poses a significant risk to water bodies and ecosystems. Designing efficient and stable catalysts for photocatalytic degradation of TCP remains a great challenge. In this paper, a Z-scheme α-MnO 2 /Bi 2 S 3 (Mn/Bi) composite enriched with oxygen (O Vs ) and sulfur (S Vs ) vacancies is designed for photocatalytic degradation of TCP. 60-Mn/Bi achieved 88 % degradation efficiency for 20 mg/L TCP solution. The reaction rate ( k ) of 60-Mn/Bi is 6.46 and 4.41 times higher than that of α-MnO 2 and Bi 2 S 3 , respectively. The catalyst exhibited high catalytic activity in a wide pH range and high resistance to anion. In addition, the cycling performance of 60-Mn/Bi is relatively stable, and the ion leaching rate is low. The Z-scheme mechanism is confirmed by characterization and DFT, which effectively retained the strong redox capacity. The abundant vacancy structure enhances the adsorption of TCP and promotes the migration of photogenerated carriers. In addition, the rod-shaped Bi 2 S 3 provides a carrier for α-MnO 2 nanoparticles, which effectively alleviates agglomeration and thus exposes more active sites. Three possible degradation pathways were explored by LC-MS and DFT. This study provides a facile method and guidance for the preparation of Z-scheme catalysts to improve photocatalytic degradation performance.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Zheng Fang,Wei He,Tao Tu,Niuniu Lv,Chuanhong Qiu,Xin Li,Ning Zhu,Li Wan,Kai Guo
α-Fe 2 O 3 nanoparticles were prepared by using a continuous precipitation method with a valve assisted micromixer in the presence of iron (III) sulfate and ammonia water. The resulting nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM). Meanwhile, CaCO 3 nanoparticles were synthesized in a tube-in-tube flow reactor AF-2400. The acylation process catalyzed by modified lipophilic α-Fe 2 O 3 and CaCO 3 nanoparticles in the flow reactor were systematically investigated. Under the optimal conditions, a yield of 97.8% was obtained. Addition of CaCO 3 nanoparticles resulted in higher catalytic efficiency compared with pure modified α-Fe 2 O 3 nanoparticles. Moreover, this novel acylation also worked well for other substrates.
研究领域:
化学工程
·
材料科学
·
绿色化学
✓ 已验证
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2017
·
IF 2.084
Xiaowei Mu,Bihe Yuan,Ying Pan,Xiaming Feng,Lijin Duan,Ruowen Zong,Yuan Hu
A layer-by-layer (LBL) assembly coating composed of α-cobalt hydroxide (α-Co(OH) 2 ) and sodium alginate (SA) is deposited on flexible polyurethane (FPU) foam to reduce its flammability . Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) are employed to prove the LBL assembly process. It is obvious from SEM results that a uniform and rough coating is deposited on FPU foam compared with that of untreated one. The peak intensity of methylene of SA in FITR spectra and typical (003) diffraction peak of α-Co(OH) 2 nanosheets at 11.0° in XRD patterns increases gradually with increment of bilayer number. Combustion behavior and toxicity suppression property of samples are characterized by cone calorimeter (under an irradiance of 35 kW m −2 ) and Thermogravimetry/Fourier transform infrared spectroscopy. The one and two bilayers (BL) coating on FPU foam can achieve excellent flame retardancy. Compared with untreated sample, the peak heat release rate of the coated FPU foam containing only one BL coating is reduced by 58.7%. The content of gaseous toxic substances during pyrolysis of FPU foam deposited with a single bilayer coating, such as CO and NCO-containing compounds, are reduced by 20.0% and 9.2%, respectively. Besides, the flame retardant mechanism of the coated FPU foam is also revealed.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Zhizhong Han,Min Luo,Li Chen,Jinghua Chen,Chunyan Li
In this work, a novel label free photoelectrochemical (PEC) immunosensor has been developed for the detection of α-fetoprotein (AFP). The immunosensor was based on Au-ZnO flower-rods (FRs) heterostructure, where Au nanoparticles (NPs) were firstly electrodeposited by cyclic voltammetry methods. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Mott-Schottky plot (MS), UV–vis diffuse reflectance spectrum and fluorescence emission spectrum were used for the characterizations of Au-ZnO FRs. The results demonstrated that Au NPs not only obviously enhanced the visible light absorption of ZnO FRs due to surface plasmon resonance (SPR) but also improved the separation of photo-generated electron-hole pairs. Therefore, the photocurrent of Au-ZnO FRs was increased under simulated sunlight. The photocurrent was reduced after the specific antibody-antigen immune reaction. And the photocurrent decrement was linear with the logarithm of AFP antigen concentration in the range from 0.005 ng mL −1 to 50 ng mL −1 with a low detection limit of 0.56 pg mL −1 (S/N = 3). The PEC immunosensor also exhibited high anti-interference property and acceptable stability. This work would provide a promising photoelectrochemical strategy for the detection of other proteins in clinical diagnosis.
研究领域:
生物医学工程
·
分析化学
·
肿瘤学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）