TALANTA
·
2020
·
IF 5.339
Bo Song,Qi Liu,Hua Ma,Zhixin Tang,Chaolong Liu,Jinhua Zou,Mingqian Tan,Jingli Yuan
Bimodal photoluminescence-magnetic resonance (MR) imaging technique has attracted tremendous attention due to its great potential in biomedical researches and clinical practices. Herein a novel multifunctional magnetoluminescent nanocomposite, FA-Gd-Tb@SiO 2 , was found to serve as an effective probe for bimodal time-gated luminescence/MR imaging of cancer cells in vitro and in vivo . The nanoprobe was designed by integrating a luminescent Tb 3+ complex, a Gd(III)-based contrast agent and a tumor-targeting molecule, folic acid (FA), into a silica nanoparticle . The integration of these functional moieties allows the nanoprobe to be employed for specific imaging of cancer cells with background-free TGL and non-invasive MR imaging modes. In addition, the optical and magnetic properties were dramatically improved after implicating the newly synthesized nanoarchitecture. In vitro cellular TGL imaging demonstrated that the FA-Gd-Tb@SiO 2 nanoprobe could recognize and accumulate in cancer cells overexpressing FA receptor. Furthermore, in vivo study revealed that the as-prepared nanoprobe was able to effectively enhance T 1 -weighted MR contrast and TGL intensity in tumor tissue, which might contribute to the precise detection and tracing of cancer cells, as well as diagnosis and therapy of tumor in clinical.
研究领域:
生物医学工程
·
纳米技术
·
癌症研究
·
成像科学
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产品关联
DOI
PubMed
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2024
·Vol. 31
·期 7
·1651-1658
·
IF 5.6
Zhang Peixiong,Wang Enhui,Liu Jingjing,Yang Tao,Wang Hailong,Hou Xinmei
Thermal insulation materials play an increasingly important role in protecting mechanical parts functioning at high temperatures. In this study, a new porous high-entropy (La 1/6 Ce 1/6 Pr 1/6 Sm 1/6 Eu 1/6 Gd 1/6 )PO 4 (HE (6RE 1/6 )PO 4 ) ceramics was prepared by combining the high-entropy method with the pore-forming agent method and the effect of different starch contents (0–60vol%) on this ceramic properties was systematically investigated. The results show that the porous HE (6RE 1/6 )PO 4 ceramics with 60vol% starch exhibit the lowest thermal conductivity of 0.061 W·m −1 ·K −1 at room temperature and good pore structure stability with a linear shrinkage of approximately 1.67%. Moreover, the effect of large regular spherical pores (>10 µm) on its thermal insulation performance was discussed, and an optimal thermal conductivity prediction model was screened. The superior properties of the prepared porous HE (6RE 1/6 )PO 4 ceramics allow them to be promising insulation materials in the future.
研究领域:
材料科学
·
热能工程
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产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Jiajun Feng,Yongxin Yu,Hongji Song,Zibo Chen,Yingxiang Zhu,Jiahui Liu,Jingtian Xie,Lianfen Chen,Junhao Li
A structural design strategy was employed to develop NaGd2Ga2InGe2O12:Sm3+ (NGGIG:Sm3+) garnet phosphors, optimizing the local coordination environment to enhance luminescence performance. By tailoring site occupation, Sm3+ ions were incorporated into an asymmetric crystal field, where a statistical probability model confirmed that ∼97% of Sm3+ ions reside in distorted coordination environments, promoting electric dipole(ED) transitions. The phosphors exhibit a high red-to-orange (R/O) intensity ratio of 2.97, contributing to enhanced red emission. CIE chromaticity coordinates of (0.61, 0.39) indicate a significant shift toward the red region, and the phosphors retain over 70% of their luminescence intensity at 400 K, demonstrating good thermal stability. These characteristics make NGGIG:Sm3+ a promising candidate for high-performance red phosphors in solid-state lighting applications, highlighting the effectiveness of site engineering in garnet structures for optimizing luminescence efficiency and stability.
研究领域:
材料科学
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光学材料
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固态照明
·
无机化学
·
发光学
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产品关联
DOI
PubMed
高影响因子
GIANT
·
2022
·
IF 0
Yifan Jia,Weiwen Yuan,Mengmeng Xu,Congyi Yang,Lei Chen,Shuo Wang,Paul D. Topham,Guoxuan Luo,Mo Wang,Yong Zhang,Guihua Jiang,Qianqian Yu,LinGe Wang
Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T 1 positive MRI visibility, MRI contrast agent (CA), Gd(OH) 3 , is introduced in a new, extremely convenient method. Crucially, GdCl 3 is reacted with NaOH in situ during electrospinning, with flexibility to deliver both well-dispersed and aggregated Gd(OH) 3 clusters within a poly(ethylene terephthalate) (PET) matrix. T 1 and T 2 relaxivities of Gd(OH) 3 in PET nanofibers are studied. Well-dispersed Gd(OH) 3 (sub-nanometer in size) exhibits 34 times higher T 1 relaxivity than aggregated nanoparticles when embedded within the fibers. The morphology, structure, magnetic properties, tensile properties, imaging performance and biosafety of the PET/Gd(OH) 3 composite fibers are evaluated to identify the optimum conditions to produce new materials with balanced properties, excellent in vivo positive contrast and approximately 139 days imaging lifetime. Comparing this sample with a commercial CA, only 0.32 wt.% Gd loading is needed to attain similar MRI signal intensity. In summary, PET/Gd(OH) 3 long-term MRI-active fibers show great potential for future biomedical applications and the study also provides a promising new general strategy to enhance the MRI T 1 positive contrast of electrospun fibers of a whole host of other systems.
研究领域:
材料科学
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医学影像学
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生物医学工程
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产品关联
DOI
Nano-Micro Letters
·
2020
·Vol. 12
·期 1
·1-14
·
IF 12.264
Fang Hanyi,Li Mengting,Liu Qingyao,Gai Yongkang,Yuan Lujie,Wang Sheng,Zhang Xiao,Ye Min,Zhang Yongxue,Gao Mingyuan,Hou Yi,Lan Xiaoli
A biomimetic nanoprobe was built with cancer cell membrane-coated and Gd 3+ -doped upconversion nanoparticles.
The nanoprobe could be applied to in vivo UCL/MRI/PET multimodality precise imaging and successfully differentiated MDA-MB-231 tumor models through in vivo tri-modality imaging, which may be used for breast cancer molecular classification.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
医学成像
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2019
·
IF 13.903
Peiru Wang,Weitao Yang,Shuzhan Shen,Chao Wu,Long Wen,Qian Cheng,Bingbo Zhang,Xiuli Wang
Elevated hydrogen peroxide (H2O2) in biological tissues is generally recognized to be relevant to the carcinogenesis process that regulates the proliferative activity of cancer cells and the transformation of malignant features. Inspired by this observation, it can be hypothesized that imaging H2O2 in the tumor microenvironment (TME) could help diagnose tumor types and malignancy, and even guide precise therapy. Thus, in this study, a noninvasive photomedicine strategy is demonstrated that leverages the different levels of H2O2 in the TME, and two representative skin cancers, malignant melanoma (MM, clinically higher incidence of metastasis and recurrence) and cutaneous squamous cell carcinoma (cSCC, relatively less dangerous), are differentially diagnosed. The working probe used here is one we previously developed, namely, intelligent H2O2 responsive ABTS-loaded HRP@Gd nanoprobes (iHRANPs). In this study, iHRANPs have advantages over ratiometric imaging due to their bimodal imaging elements, in which the inherent magnetic resonance imaging (MR) mode can be used as the internal imaging reference and the H2O2 responsive photoacoustic (PA) imaging modality can be used for differential diagnosis. Results showed that after intravenous injection of iHRANPs, the tumor signals on both MM and cSCC are obviously enhanced without significant difference under the MR modality. However, under the PA modality, MM and cSCC can be easily distinguished with obvious variations in signal enhancement. Particularly, guided by PA imaging, photothermal therapy (PTT) can be precisely applied on MM, and a strong antitumor effect was achieved owing to the excessive H2O2 in the TME of MM. Furthermore, exogenous H2O2 was injected into cSCC to remedy H2O2 deficiency in the TME of cSCC, and an evident therapeutic efficacy on cSCC can also be realized. This study demonstrated that MM can be differentially diagnosed from cSCC by noninvasive imaging of H2O2 in the TME with iHRANPs; meanwhile, it further enabled imaging-guided precision PTT ablation, even for those unsatisfactory tumor types (cSCC) through exogenously delivering H2O2.
研究领域:
肿瘤学
·
光医学
·
生物医学工程
·
分子影像
·
诊疗一体化
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产品关联
DOI
PubMed
高影响因子
Science of Advanced Materials
·
2021
·Vol. 13
·期 7
·1364-1373
·
IF 1.474
Zhang Yumei,Pei Ruina,Luo Tao
ABSTRACT
The development of nanomaterials, especially the development of multi-modality imaging nanoprobe technology has become a reality for tumor imaging diagnosis. In this study, the gadolinium ion chelating agent (2,2′,2′′-(10-(2-(2, 5-dioxopyrrolidin-1-oxyl)-2
oxoethyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7-tri)triacetic acid) (DOTA-NHS) and polyethylene glycol (PEG)-modified targeting ligand PEG-folic acid (FA) were grafted onto the PEG-modified fifth-generation polyamide-amine dendrimer (P5-NH2), which were undertaken as standards
to wrap gold nanoparticles. Then, remaining amino group was acetylated to acquire Gd–Au DENPS-FA nanoparticles. Biocompatibility and cytotoxicity of nanoparticles were analyzed while characterizing them. The cases with unidentified tumors (mass diameter >4.5 cm) of abdominal or pelvic
origin were selected and used for clinical study of computed tomography (CT)/magnetic resonance imaging (MRI) dual-modality abdominal tumors. In the test, average particle size of Gd-Au DENPs-FA nanoparticles was 4.2 nm, and they had good water solubility and stability in aqueous solution.
When concentration of Au+ nanoparticles increased, the cell morphology remained normal, only a small number of round cells appeared, and the cell activity remained above 80%. GD-Au DENPs-FA nanoparticles had a good targeting specificity for KB cells with high folate receptor expression.
During 6–24 hours of injection, the signal at the tumor site of the patient was enhanced markedly, namely the targeted gold nanoparticles were bound to the tumor tissue and the metabolic rate was slow. Based on this material, CT/MRI imaging could be performed in the patient’s body
and further used for the early diagnosis of abdominal tumors.
研究领域:
医学影像学
·
纳米生物学
·
肿瘤学
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Xing-Hui Ren,Hai-Yan Wang,Si Li,Xi-Wen He,Wen-You Li,Yu-Kui Zhang
Early and accurate detection of breast cancer plays an important role in improving the survival rates of patients. In this work, we designed and synthesized the Gal-NAc-imprinted nanoparticles (GIPs) via boronate-affinity glycan-oriented surface imprinting strategy. Molecularly imprinted polymers (MIPs) were hybridized with fluorescent silicon nanoparticles (SiNPs) to target Tn antigens. However, the single fluorescent imaging mode is not conducive to obtaining accurate diagnosis, due to its poor tissue penetration. To resolve this obstacle, doping gadolinium (Gd) into SiNPs was adopted to emerge an extra significant magnetic resonance (MR) signal, achieving highly sensitive fluorescence imaging and magnetic resonance imaging (MRI) with high spatial resolution. GIPs had uniform particle size around 31.8 nm, and exhibited satisfactory fluorescence stability. The maximum adsorption capacity of GIPs was 1.15 μM/g with a high imprinting factor (IF) of 7.5. Confocal laser scanning microscope imaging revealed that the GIPs had excellent specific recognition ability with a low cytotoxicity. GIPs also showed an outstanding MR performance on cancer cells. Therefore, the synthesized nanoparticles had desirable performance in dual-model imaging to specifically target recognition cancer cells. It may have a tremendous potential in real biological samples.
研究领域:
材料科学
·
纳米技术
·
癌症研究
·
生物医学工程
·
医学成像
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产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 152
·期 12
·3772-3784
·
IF 2.936
Zhou Shuyu,Chen Zezhi,Gong Huijuan,Chen Lu,Yu Huiqiang
Nickel (Ni)-based catalyst is widely adopted for tar removing in the process of biomass gasification. In order to improve low-temperature catalytic activity of Ni-based catalyst, three-dimensional ordered macro/mesoporous (3DOM/m) Ce 0.8 Zr 0.1 M 0.1 (M = Gd, Pr and La) ternary solid solutions were prepared and used as the carriers of Ni/Ce 0.8 Zr 0.1 M 0.1 catalysts. The obtained catalysts were employed to catalyze the steam reforming of toluene (SRT). The results demonstrated that all the Ni/Ce 0.8 Zr 0.1 M 0.1 showed excellent low-temperature catalytic activity and presented higher toluene conversion than Ni/Ce 0.8 Zr 0.2 . Among the catalysts, Ni/Ce 0.8 Zr 0.1 Pr 0.1 exhibited the highest toluene conversion, reaching 96.1% at 550 ℃ (toluene = 185 μmol min −1 , S/C = 3). The characterization results of catalysts showed that all the catalysts presented ordered three-dimensional morphology containing interconnected periodic macropores with abundant mesopores existing on the wall. The rare earth dopants were incorporated into the lattice of cerium-zirconium solid solution. As a result, the thermal stability of the carrier was improved, which made the BET specific surface area of the carrier increase and the dispersion of active component of Ni increase. Moreover, the incorporation of dopants produced more oxygen vacancies, thus improved reactive oxygen mobility. These superior properties of 3DOM/m Ce 0.8 Zr 0.1 M 0.1 led to their excellent catalytic activity in SRT. Graphical Abstract
研究领域:
化学工程
·
催化材料
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产品关联
DOI
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2020
·Vol. 37
·期 4
·2000044
·
IF 3.099
Kehan Xu,Na Xu,Yanchao Zhu,Mengsi Zhang,Weijun Tang,Yun Ding,Aiguo Hu
Conformity of two biological imaging entities, magnetic resonance imaging (MRI) and fluorescence imaging, is achieved through co-assembly of a Gd(III)-based metallosurfactant, conjugated polymeric nanoparticles, and amphiphilic block copolymer F127 (PEO 106 PPO 70 PEO 106 ) followed by crosslinking with organosilica. The cross-linked micelles with a size around 100 nm exhibit outstanding dispersion stability in aqueous and phosphate buffered saline solutions, bright fluorescence emission, and high relaxivities, providing a new approach to synthesize highly efficient bimodal contrast agents. The relaxivities of the co-assembled micelles are synergistically enhanced by incorporation of Gd(III) complexes with high hydration number ( q = 3) and elongation of rotation correlation time to achieve r 1 values up to 105.37 m m −1 s −1 (at 1.5 T), which is over 20 times that of clinically used MRI contrast agents and among the highest values of all the nanoparticular MRI contrast agents. The external PEO layer endows these micelles with very low cytotoxicity for both in vitro and in vivo imaging. Meanwhile, thanks to the enhanced permeability and retention effect originating from their nanoscale sizes, the bimodal contrast agents show a prolonged blood circulation time in vivo and targeted accumulation at tumor regions to display outstanding MRI imaging performance.
研究领域:
生物医学工程
·
材料科学
·
影像医学
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产品关联
DOI
高影响因子
Materials
·
2023
·Vol. 16
·期 20
·6667
·
IF 3.4
Yukun Li,Svenja Hanson,Cheng Heng Pang,Peng Lyu,Jun Jiang
In order to attain phosphor ceramics with a high Color-Rendering Index (CRI), samples with the composition of Y0.997−xRexCe0.003)3(Al0.9748Mn2+0.024Cr3+0.0012)5O12(Rex= 0, Gd0.333, Gd0.666, Gd0.997, Tb0.333, Tb0.666, Tb0.997and Lu0.997were prepared by solid-state reaction and vacuum sintering, and exhibited potential for high-quality, solid-state lighting. Doping with Cr3+and Mn2+effectively enhanced the red component of Ce3+spectra through the intense energy transfer from Ce3+ions to Mn2+/Cr3+ions. The crystal field splitting of [GdO8] and [TbO8] was more extensive than that of [YO8], causing a massive redshift in the Ce3+emission peaks from 542 to 561 and 595 nm, while [LuO8] had an opposite effect and caused a blueshift with a peak position at 512 nm. White LED devices incorporating Ce/Mn/Cr: (Gd0.333Y0.664)3Al5O12phosphor ceramic exhibited a high CRI of 83.97, highlighting the potential for enhancing the red-light component of white LED lighting.Keywords:garnet phosphor;laser lighting;full spectrum;spectral modulation;Ce/Mn/Cr: (Re,Y)3Al5O12
研究领域:
材料科学
·
光学工程
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产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Nan Zhang,Shan-Shan Han,Yun Xie,Da-Li Chen,Wen-Dong Yao,Xiao Huang,Wenlong Liu,Sheng-Ping Guo
Rare-earth (RE) chalcogenide borates are very rarely discovered in view of the difficulties in synthesis though they have demonstrated attractive physical performances. Here, the first mixed RE chalcogenide borates Eu5.4Sm3.6MgS2B20O41 (1) and Eu3Gd6MgS2B20O41 (2) are synthesized by combining RE, sulfur, and borate ions into one structure. They crystallize in the centrosymmetric hexagonal space group P63/m, and their 3D honeycomb-like {[B20O41]22–}∞ open frameworks are built by [B6O9(O0.5)6]6– and [B7O13(O0.5)3]8– polyanionic clusters and consolidated by Mg2+ ions; both of which are formed by BO4 tetrahedra and BO3 planar triangles. The coordination modes of RE ions are rare REO6S2 bicapped trigonal prisms and REO8S irregular polyhedra, and their band gaps are determined to be 2.25 and 2.22 eV, respectively. They exhibit antiferromagnetic interactions and distinct photocurrent responses. The corresponding theoretical calculations are also performed. The study of 1 and 2 perhaps stimulates interest in exploring new functional RE chalcogenide borates.
研究领域:
无机化学
·
材料科学
·
固态化学
·
功能材料
·
晶体学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）