ONCOLOGY REPORTS
·
2025
·Vol. 54
·期 6
·1-14
·
IF 3.9
Wei-Wei Zheng,Jia-Xuan Ding,Yang-Xin Liang,Ling Ye
Thymoquinone (TQ) is a quinone isolated from the black seed Nigella sativa and has been extensively investigated in the pharmaceutical field due to its promising therapeutic value. There have been reports on the potential anti‑cancer properties of TQ, whereas the clinical application of TQ is greatly restricted by its low water solubility and poor delivery. In the present study, TQ was encapsulated into hydroxypropyl‑β‑cyclodextrin (HP‑β‑CD) using the freeze‑drying method to form a TQ/HP‑β‑CD inclusion complex. Then, the TQ/HP‑β‑CD inclusion complex was characterized by Fourier transform infrared, differential scanning calorimetry, X‑ray diffraction and scanning electron microscopy. HP‑β‑CD as an excipient significantly enhances the water solubility of TQ, and TQ/HP‑β‑CD demonstrated excellent biocompatibility on normal cells both in vitro and in vivo. Moreover, the complexation with HP‑β‑CD enhanced the anticancer activity of TQ against non‑small cell lung cancer cells and its mechanism of action is related to ferroptosis mediated by NF‑κB. Such an enhanced cytotoxic effect may be attributed to the effective complexation of TQ in HP‑β‑CD, which enhances its water solubility and bioavailability.
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高影响因子
ADVANCED MATERIALS
·
2025
·Vol. 37
·期 41
·e03562
·
IF 26.8
Shangqing Qu,Tianhao Niu,Xianji Qiao,Yanran Shen,Guohong Cai,Xiaoge Wang,Yonggang Wang,Zhipeng Zhou,Shipeng Zhang,Zeyue Zhang,Guobao Li,Guanqun Cai,Junliang Sun
Na- β ″-Al 2 O 3 is a highly promising solid-state electrolyte (SSE) for solid-state sodium batteries (SSSBs) with a wide electrochemical stability window and excellent stability against metallic sodium. However, its practical application is hindered by the instability of β ″ phase ( R 3 ¯ $\bar 3$ m ) during sintering, low polycrystalline ionic conductivity at room temperature, and poor interfacial contact with sodium anodes. In this study, a stablized SSSB is obtained via doping Ga 3+ into Na 1.67 Mg 0.67 Al 10.33 O 17 (NMAO), which also suppresses the formation of the β ′ phase ( P 6 3 / mmc ) and decreases stacking faults. After sintering at 1550 °C for 2 h, Na 1.67 Mg 0.67 Al 9.33 GaO 17 (NMA9.33GO) exhibits an ionic conductivity of 9.2 × 10 −4 S cm −1 at 30 °C, ≈1.7 times greater than NMAO. Furthermore, Ga 3+ doping enhances the wettability with sodium, achieving superior contact stability and the formation of Na-Ga alloys at the interface significantly improves electrode-electrolyte contact stability, achieving a high critical current density (CCD) of 0.8 mA cm −2 and a low interfacial impedance of 16 Ω cm 2 . A quasi-solid-state battery assembled with Na 3 V 2 (PO 4 ) 3 (NVP) as the cathode demonstrates excellent cycling stability and rate performance, retaining a high discharge capacity of 91 mAh g −1 at 5 C, and maintaining 87% capacity retention after 1000 cycles at 1 C. This work provides new insights into improving electrolyte performance and interfacial engineering through doping strategies, thereby promoting the development of efficient and long-term SSSBs.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Kaibo Wang,Jin Wang,Mengmeng Dou,Chao Han,Wubin Wang,Xinyu Li,Yadong Hu,Guangxu Zhang
How to prepare polyvinylidene fluoride (PVDF) membranes with high flux, high rejection rate, strong anti-fouling ability and excellent durability is a crucial issue in the current production and application industries of PVDF membranes. In this work, an environmentally friendly mechanical grinding method was employed to composite β-cyclodextrin (CD) with titanium dioxide (TiO 2 ) nanoparticles, resulting in the preparation of CD@Ti composite nanomaterials. These were then incorporated into PVDF membranes to fabricate a series of nanocomposite membranes (NCM). Compared with the pristine PVDF membrane, the PVDF/CD@Ti 1.5 membrane exhibited a 1.67-fold increase in water flux, and its rejection rate for bovine serum albumin (BSA) improved from 86.6 % to 97.1 %. Compared to modification using TiO 2 alone, the CD@Ti composite modification effectively suppressed particle agglomeration within the membrane. The PVDF/CD@Ti 1.5 membrane demonstrated enhanced hydrophilicity, increased surface negative charge, and reduced surface roughness compared to the initial PVDF membrane, all of which contributed to improved antifouling performance. Specifically, after filtering BSA, humic acid (HA), and sodium alginate (SA), and subsequently rinsing with pure water, the flux recovery ratio (FRR) of the pristine PVDF membrane were 73.6 %, 64.8 %, and 53.5 %, respectively, whereas those of the modified PVDF/CD@Ti 1.5 membrane increased to 89.3 %, 83.5 %, and 78.4 %, respectively. Analysis based on the Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory indicated that the incorporation of CD@Ti effectively reduced the attractive interaction energy between the PVDF/CD@Ti membrane and foulants. Furthermore, the PVDF/CD@Ti 1.5 membrane demonstrated excellent stability in multiple filtration cycles, real lake water filtration tests, and acid–base immersion experiments, confirming its potential for practical applications.
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高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Naisheng Wu,Fangling Wu,Sisi He,Jia Wang,Huiqing Ding,Chuan-Fan Ding
This study presents a novel approach for the rapid and high-resolution separation of estrogen isomers (α/β-estradiol and estriol: α/β-E2/E3) using trapped ion mobility mass spectrometry (TIMS-MS). Systematically, evaluating cyclodextrin (α-, β-, and γ-CD) as separation reagents and exploring metal ions as coordinating ligands, we achieved enhanced isomer differentiation, in which the separation resolution (RP–P) was increased from 0.204 to 1.533. Density functional theory (DFT) calculations and noncovalent interaction visualization analysis provided molecular-level insights into the structural and interaction differences driving these separations, highlighting the critical roles of host–guest interactions and metal coordination geometry. Additionally, quantitative analysis and method validation for the estrogen isomers were measured, with a good linearity of R2 value higher than 0.99 and RSD ≤ 2.28%. Finally, the method was applied to detect and quantify α/β-E2/E3 in human urine samples; good recoveries of ≥79.78% were obtained with RSD ≤ 4.35% for intraday and RSD ≤ 9.56% for interday. The combined experimental and theoretical results demonstrate the potential of this TIMS-MS-based strategy for clinical diagnostics and bioanalytical applications requiring precise estrogen isomer separation.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Lijuan Han,Yingxin Chen,Li Wang,Mingwen Chen,Junbo He,Weinong Zhang,Shuyi Li
This study developed and investigated inulin–lecithin-based bigels (ILBs) incorporating β-sitosterol (SIT) or beeswax (BW) as crystalline structuring agents, aiming to improve the limited plasticity and weak structural properties of conventional ILBs. Both β-sitosterol and beeswax were employed to modulate the physical properties of bigels for their potential use as solid fat replacers. The addition of β-sitosterol or beeswax converted the control formulation from a free-flowing system into a structured bigel, with beeswax forming denser and more homogeneous crystalline networks. Control ILBs exhibited a hardness of 0.040 N, compared to 0.391 N for 4.5 %BW-bigel, confirming the significant structural enhancement. Microscopy, texture profile analysis, and oil/water-binding capacity tests indicated that beeswax more effectively enhanced gel strength, plasticity, and stability, especially at higher concentrations. In the beeswax group, increasing concentration from 1.5 % to 4.5 % raised hardness from 0.056 N to 0.391 N, and decreased TSI from 0.83 to <0.15, indicating substantial enhancement in gel strength and stability. Rheological evaluations revealed that all bigels exhibited shear-thinning behavior, with BW-based bigels showing stronger viscoelastic properties than SIT-based ones. Thermal and crystallization studies further demonstrated that beeswax contributed to higher crystallinity, more thermally stable polymorphs, and BW-bigels showed a steep SFC decline from 20 °C to 40 °C, enhancing oral meltability while maintaining structure at refrigeration temperatures. Overall, beeswax showed greater efficacy than β-sitosterol in improving the structural and functional characteristics of ILBs, supporting its potential as a fat-structuring component in the development of reduced-fat spreadable systems. Sensory studies are needed to validate consumer acceptance in margarine-like spreadable products. Further studies are warranted to evaluate product stability and sensory attributes in real food applications.
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高影响因子
IONICS
·
2025
·
IF 2.6
Sun Yuning,Chen Shenyu,Li You,Lv Jinjian,Sun Heng
Aqueous zinc-ion batteries (AZIBs) have emerged as a research focus in large-scale energy storage due to their advantages of high safety, low cost, and abundant zinc resources. However, manganese dioxide (MnO₂) cathode materials suffer from poor cycle stability and insufficient rate capability, limiting their practical applications. Herein, β-MnO₂ cathode materials with different Eu doping contents were prepared via a microwave hydrothermal method. Pure-phase β-MnO₂ exhibited a slender nanorod-like structure but suffered from agglomeration, delivering a specific capacity of only 142 mAh g⁻ 1 at 0.1 A g⁻ 1 . In contrast, Eu-doped MnO₂ materials formed a tunnel structure with a larger lattice constant, along with more uniformly distributed nanorods and reduced agglomeration. Electrochemical tests revealed that the Eu-doped MnO₂ cathode achieved a specific capacity of 425 mAh g⁻ 1 at 0.1 A g⁻ 1 (three times that of pure β-MnO₂). After 1000 cycles at 1 A g⁻ 1 , it retained 59.4% of its initial capacity, significantly outperforming the pure phase (44.7%). Kinetic analysis indicated that Eu doping enhanced the surface pseudocapacitive effect, shifted the reaction mechanism toward diffusion-capacitance mixed control, and improved reversibility and active site utilization efficiency remarkably.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Chenglin Zhang,Ya Wang,Qian Zhang,Baolian Liu,Xiupei Yang
The accurate determination of β-Lactoglobulin (β-LG), a major dairy allergen, is essential for susceptible individuals' health. Here, a multimodal β-LG sensor was developed by utilizing the aptamer (Apt) to regulate the metal-organic framework UiO-66-TCPP’ functions. The prepared UiO-66-TCPP had both fluorescence and peroxidase activity. After adsorbing β-LG Apt, the catalytic activity of UiO-66-TCPP was enhanced through increased substrate affinity and electron transfer, while the fluorescence of 6-carboxyfluorescein-labeled Apt was quenched via multiple interactions with the material, and the fluorescence of UiO-66-TCPP itself remained unchanged. After binding to β-LG, Apt desorbed from UiO-66-TCPP surface, thereby restoring Apt fluorescence and lowering UiO-66-TCPP’ catalytic activity. Thus, a colorimetric/ratiometric fluorescence platform for β-LG sensing in dairy products was constructed with low limits of detection (16.19, 47.69 ng/mL). On-site visual detection was further achieved by RGB analysis on a smartphone. This study proposes novel approaches to creating multi-modal platforms for accurate food allergen determination.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2016
·
IF 2.933
Rong Tu,Dingheng Zheng,Hong Cheng,Mingwei Hu,Song Zhang,Mingxu Han,Takashi Goto,Lianmeng Zhang
Halide chemical vapor deposition process was carried out for fast fabricating oriented stoichiometric β-SiC through controlling flow rate of precursors (SiCl 4 and CH 4 ). The effects of molar ratio of C and Si precursors ( R C/Si ) on composition, preferred orientation, microstructure and deposition rate ( R dep ) were investigated. The deposits transformed from silicon-rich to stoichiometric β-SiC to carbon-rich with increasing R C/Si . 〈110〉-oriented stoichiometric β-SiC with lower density of defects were obtained at R C/Si in the range of 0.86–1.00, where the maximum R dep was 883 μm/h at R C/Si = 1.00, leading to a thickness of 1.7 mm in 2 h deposition. Formation of ridge-like morphology has been discussed based on a twin plane propagation model .
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高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2014
·Vol. 37
·期 24
·3738-3744
·
IF 2.594
Jiliang Cao,Jinchao Wei,Ke Tian,Huanxing Su,Jianbo Wan,Peng Li
A capillary zone electrophoresis method was developed for the simultaneous determination of seven phenolic acids, including protocatechuic aldehyde ( 1 ), salvianolic acid C ( 2 ), rosmarinic acid ( 3 ), salvianolic acid A ( 4 ), danshensu ( 5 ), salvianolic acid B ( 6 ), and protocatechuic acid ( 7 ), in Danshen and related medicinal plants. A running buffer composed of 20 mM sodium tetraborate adjusted to pH 9.0, and containing 12 mM β-cyclodextrin as modifier. Baseline separation was achieved within 17 min running at the voltage of 20 kV, temperature of 25°C and detection wavelength of 280 nm. The relative standard deviations of migration time ranged from 0.2 to 0.7% and the peak area ranged from 1.5 to 3.7% for the seven analytes, indicating the good repeatability of the proposed method. The method was extensively validated by evaluating the linearity ( R 2 ≥ 0.9992), limits of detection (0.14–0.36 μg/mL), limits of quantification (0.47–1.19 μg/mL), and recovery (96.0–102.6%). Under the optimum conditions, samples of Danshen and related medicinal plants were analyzed using the developed method with high separation efficiency.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 8
·3604-3623
·
IF 3.5
Wang Xintong,Yang Jiang,Chen Xu,Wang Yefei,Yang Zhen,Ding Wei
To mitigate CO 2 corrosion in the oil and gas industry, a green non-toxic β -N-butyl amino propionic acid (BAA) was synthesized using a low-energy and zero-waste one-pot method. The effectiveness of BAA as a corrosion inhibitor for N80 steel in CO 2 -saturated brine water was investigated through experimental measurements and theoretical modeling. The results demonstrate that BAA functions as an effective mixed-type corrosion inhibitor. BAA molecules interact with F (1 1 0) with the–COO– and–NH 2 + -moiety in the hydrophilic head group, and the hydrophobic groups are adsorbed on the steel surface in a configuration 45° away from the steel surface. The adsorption is a mixture of physical and chemical processes and is consistent with the Langmuir isothermal adsorption formula. When the concentration is greater than 50 ppm, a complete corrosion inhibitor film with high hydrophobicity can be adsorbed on the steel surface, which can effectively impede the diffusion of corrosive species from brine to the steel surface. Graphical abstract
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2013
·
IF 4.612
Qiaoxuan Zhang,Jialiang Guo,Feng Wang,Jacques Crommen,Zhengjin Jiang
A novel and facile one-pot copolymerization approach was developed for the preparation of a β-cyclodextrin (β-CD) functionalized organic polymer monolith. The proposed one-pot process involved two major reactions occurring in sequence in the same vial: (1) the ring opening reaction between the epoxy groups of glycidyl methacrylate (GMA) and the primary amino groups of ethylenediamine-β-CD (EDA-β-CD); (2) the copolymerization of glycidyl methacrylate-ethylenediamine-β-CD (GMA-EDA-β-CD) and ethylene dimethacrylate (EDMA) using 2,2′-azobisisobutyronitrile (AIBN) as the polymerization initiator. This approach avoids the time-consuming post-polymerization derivatization of the traditional two-step strategy. Compared to the previously reported two-step strategy, the monolith prepared by this one-pot method exhibited higher β-CD ligand density and better column efficiency in HPLC. Satisfactory column permeability and separation selectivity were also obtained on the optimized poly(GMA-EDA-β-CD- co -EDMA) monolithic column. Additionally, the column was also applied to the enantioseparation of some racemic acidic compounds with promising results.
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高影响因子
Small
·
2017
·Vol. 14
·期 7
·1702288
·
IF 8.643
Meiling Zhu,Kongchang Wei,Sien Lin,Xiaoyu Chen,Chia-Ching Wu,Gang Li,Liming Bian
Targeted and sustained delivery of drugs to diseased tissues/organs, where body fluid exchange and catabolic activity are substantial, is challenging due to the fast cleansing and degradation of the drugs by these harsh environmental factors. Herein, a multifunctional and bioadhesive polycaprolactone-β-cyclodextrin (PCL-CD) polymersome is developed for localized and sustained co-delivery of hydrophilic and hydrophobic drug molecules. This PCL-CD polymersome affords multivalent crosslinking action via surface CD-mediated host–guest interactions to generate a supramolecular hydrogel that exhibits evident shear thinning and efficient self-healing behavior. The co-delivery of small molecule and proteinaceous agents by the encapsulated PCL-CD polymersomes enhances the differentiation of stem cells seeded in the hydrogel. Furthermore, the PCL-CD polymersomes are capable of in situ grafting to biological tissues via host–guest complexation between surface CD and native guest groups in the tissue matrix both in vitro and in vivo, thereby effectively extending the retention of loaded cargo in the grafted tissue. It is further demonstrated that the co-delivery of small molecule and proteinaceous drugs via PCL-CD polymersomes averts cartilage degeneration in animal osteoarthritic (OA) knee joints, which are known for their biochemically harsh and fluidically dynamic environment.
研究领域:
药物递送
·
生物材料
·
组织工程
·
纳米医学
·
再生医学
·
关节生物学
·
转化医学
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