JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Zilong Cui,Jingling Ye,Liang Yao,Zhi Wang,Ting Wang,Yonghong Hu
In this study, the data on solid–liquid equilibrium of l-prolinamide were studied using the gravimetric method. The solubility of l-prolinamide was measured in ten pure solvents (tetrahydrofuran, n-heptane, n-propanol, acetone, acetonitrile, ethyl acetate, N,N-dimethylformamide, n-hexane, cyclohexane, and isopropanol) and three binary solvent mixtures(ethyl acetate + tetrahydrofuran, n-heptane + ethyl acetate, and n-hexane + acetone) in the temperature range of 278.15–323.15 K at atmospheric pressure. The experimental values showed that the solubility increased with the increase of temperature in all solvents. The solubility data in different pure solvents were fitted using the modified Apelblat model and the Buchowski–Ksiazaczak λh model. For the solubility data of three binary solvent mixtures, the modified Apelblat model, the combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) model, and the Jouyban–Acree model were used to fit. In all four models, the modified Apelblat model had a better correlation with the solubility of l-prolinamide weather in pure solvents or binary solvent mixtures. The experimental results showed that n-heptane and n-hexane could be used as antisolvents, which could be used in the purification process of l-prolinamide and guide the large-scale production of many drugs such as Alpelisib in industries.
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高影响因子
Journal of Biomedical Nanotechnology
·
2016
·Vol. 12
·期 1
·69-78
·
IF 3.929
Yu Haiyang,Tang Zhaohui,Li Mingqiang,Song Wantong,Zhang Dawei,Zhang Ying,Yang Yan,Sun Hai,Deng Mingxiao,Chen Xuesi
A series of novel polypeptide-based graft copolymer poly(L-glutamic acid)-graft-methoxy poly(ethylene glycol) (PLG-g-mPEG) was synthesized through a Steglich esterification reaction of PLG with mPEG. The structure of the copolymers was confirmed by nuclear magnetic resonance
spectra (NMR) and gel permeation chromatography (GPC). MTT assay demonstrated that the PLG-g-mPEGs had good cell compatibility. The unreacted carboxyl groups of the PLG-g-mPEGs were used to complex cisplatin to form polymer-metal complex nanoparticles (CDDP/PLG-g-mPEG)
for cancer therapy. The average hydrodynamic radius of the CDDP/PLG-g-mPEG nanoparticles was in the range of 14–25 nm, which was beneficial for solid tumor targeting delivery. A sustained release without initial burst was achieved for the CDDP/PLG-g-mPEG nanoparticles,
indicating that the CDDP-loaded nanoparticles had great potential to suppress the drug release in blood circulation before the nanoparticles had arrived at targeting tumors. The CDDP/PLG-g-mPEG nanoparticles showed a much longer blood retention profile as compared with the free CDDP.
This indicated that the CDDP-loaded nanoparticles had much more opportunity to accumulate in tumor tissue by exerting the EPR effect. In vitro tests demonstrated that the CDDP/PLG-g-mPEG nanoparticles could inhibit the proliferation of HeLa, MCF-7 and A549 cancer cells. At equal
dose (4 mg kg–1), the CDDP/PLG-g-mPEG nanoparticles showed comparable in vivo antitumor efficacy and significantly lower systemic toxicity as compared with free cis-Diaminedichloroplatinum (cisplatin, CDDP) in MCF-7 tumor bearing mice. These suggested that the
CDDP/PLG-g-mPEG nanoparticle drug delivery system had a great potential to be used for cancer therapy.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Peng Wang,Zijing Liu,Yanwei Xing,Bin Fan,Yulong He,Ting Gao,Wenlei Zhang,Yunfei Gao,Shuang Wang,Jinping Li
Electrocatalytic nitrogen reduction reaction (ENRR) is considered as a potential pathway for green synthesis of ammonia. However, the kinetic barriers of ENRR remain a tough challenge, which is imperative to design high effective electrocatalysts for accelerated activation of N N. Herein, the FeS/ZnS/ZIF-8-L with rich heterogeneous interfaces was successfully fabricated by governing the ordered lasso arrangement of Fe and Zn nodes in Fe-2MIM/ZIF-8-L precursor, where Fe and Zn were separately fixed in the confined space of ZIF-8-L and Fe-2MIM. Such intertwined Fe-2MIM/ZIF-8-L structure was beneficial to control the location and concentration of FeS and ZnS after sulfidation pyrolysis. The high-efficiency FeS/ZnS/ZIF-8-L exposed more catalytic active sites and possessed optimal electronic structure resulting in the lowered energy barrier of ENRR and the enhanced adsorption and activation of N 2 , which confirmed by experimental and theoretical characterization results. As a result, FeS/ZnS/ZIF-8-L displayed an optimal NH 3 yield rate of 89.52 μg h −1 mg −1 and Faradaic efficiency of 16.78 %, which surpassed most reported heterostructured ENRR catalysts. Our findings shed a new insight to govern the interfaces density of heterostructured electrocatalysts by predesigning the location of two metals in precursor, which can motivate an in-depth exploration to advanced catalysts for various electrocatalytic reactions.
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高影响因子
JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Chuan-jun Fu,Feng Hua,Hong-bo Huang,Cai-ling Liu,Ting-ting Liu,Xin Wang,Hai-yang Long,Shao-hua Luo,Mei-lan Xie,Dui Ma,Fan-yan Zeng,Xiao Liang
Hard carbons (HCs) are promising anode materials for potassium ion batteries (PIBs) because of their environmental benefits, cost-effectiveness, and sustainability. Nevertheless, the short lifespan, limited capacity, and poor reversibility of HCs restrict their application as PIB anodes. In this study, nitrogen doping Calophyllum inophyllum L.-derived hard carbon (NCHC-T) with a three-dimensional (3D) porous structure is created by a one-step carbonization process. The temperature effect on nitrogen doping and graphitization is systematically analyzed. The NCHC-1200, obtained at 1200 °C, exhibits high pyrrole N and pyridine N doping, with some short-range ordered graphitic nano-regions dispersed in the amorphous regions. It exhibits a high reversible capacity of 302.7 mAh g −1 at 100 mA g −1 and a capacity of 203.4 mAh g −1 after 1000 cycles at 500 mA g −1 . The enhanced potassium storage performance of NCHC-1200 can be attributed to its rich porosity, larger layer spacing, and the presence of graphite nano-regions. Furthermore, the formation of a robust solid electrolyte interface film, facilitated by the high electrolyte concentration, mitigates side reactions between the NCHC-1200 electrode and electrolyte, thereby enhancing electrochemical stability. This work gives a valuable understanding of the fabrication of high-performance PIB anodes, thus advancing the development of PIB technology.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 41
·期 7
·1115-1122
·
IF 3.815
Zhong Chan-Na,Liu Ya-Dong,Tang Juan,Chen Wei-Shuo,Li Shuang-Cheng,Shao Jun,Hou Hao-Qing
Blending of poly(levorotatory-lactic acid) (PLLA) and poly(dextrorotatory-lactic acid) (PDLA) produces the stereocomplex crystallites (PLA SC), which present higher melting temperature and mechanical properties than that of neat PLLA or PDLA. However, in the PLLA/PDLA blends with higher molecular weights, the phase separation occurs and the SC exhibits weak memory after melting, which lead to a small amount of SC together with a large amount of homochiral crystallites (HC) develop during crystallization from the melt. In this study, a small content of graphite oxide was blended with PLLA and PDLA to form ternary blends, and it was exciting to find that the formation of SC was enhanced gradually with the content of graphite oxide. The SC exclusively developed when 2 wt% graphite oxide was incorporated into the PLLA/PDLA, and the crystallinity with ∼50% was received even during fast cooling from the melt (−50 °C/min). The acceleration formation of SC was speculated due to the interaction between PLA molecular chains and the hydroxyl groups on the surface of graphite oxide and the obstruction of proliferation of graphite oxide.
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高影响因子
Food Science & Nutrition
·
2026
·Vol. 14
·期 7
·e72115
·
IF 5
Bin Li,Ruiyi Fan
Fingered citron ( Citrus medica L. var. sarcodactylis Swingle) is a medicinal and edible citrus fruit cultivated in several major production regions of China. However, comprehensive information on its regional metabolite variation and its chemical differentiation from chayote ( Sechium edule ), a botanically unrelated commodity that may be confused with fingered citron because of partially overlapping Chinese vernacular names, remains limited. In this study, untargeted UPLC‐Q‐Orbitrap MS/MS was used to profile fingered citron samples from Zhejiang (CF1), Sichuan (CF2), Guangdong/Guangxi (CF3), and Yunnan (CF4), together with chayote samples used as a targeted authentication comparator (CFM). A total of 380 metabolites were putatively annotated, including 47 secondary metabolites comprising 23 flavonoids, 8 terpenoids, 8 phenols, 3 coumarins, 3 alkaloids, and 2 steroids. Multivariate analyses and hierarchical clustering identified 65 differential metabolites, including 19 secondary metabolites, that clearly separated the five sample groups within the present dataset. The very high cross‐validated Q 2 values should nevertheless be interpreted cautiously because of the large taxonomic and metabolic distance between C. medica and S. edule and the limited sample size. The interspecific separation was therefore interpreted as an expected chemotaxonomic difference with practical authentication value, rather than as a comparison between biologically equivalent taxa. Phenylalanine metabolism and flavone and flavonol biosynthesis showed the strongest nominal enrichment, although neither remained significant after FDR correction. These results provide a metabolite reference for regional quality discrimination of fingered citron and identify candidate chemical features for its targeted authentication against chayote. Further validation using independent samples, additional production years, and other potential comparator commodities is required before routine application. Untargeted UPLC‐Q‐Orbitrap MS/MS metabolomics was used to profile fingered citron ( Citrus medica ) from four Chinese production regions (CF1–CF4) and chayote ( Sechium edule , CFM). Of 380 putatively annotated metabolites, 65 differential metabolites distinguished the five groups, clearly separating chayote from fingered citron and highlighting regional chemical variation among fingered citron cultivars.
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高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2026
·
IF 4
Xinyi Min,Yi Zhao,Yuhang Xiao,Xiangyu Zhao,Yaner Zhao,Dilinigaer Wumaier,Dajuan Dai,Hengye Chen,Wanjun Long,Wei Lan,Haiyan Fu
BACKGROUND l -Lysine ( l -Lys), an essential amino acid, serves as a core indicator for evaluating food nutritional quality. Although naturally abundant in ingredients such as soybeans, its content must be precisely regulated during processing to meet nutritional standards. Moreover, improper processing and storage can induce l -Lys degradation or conversion, compromising both nutritional value and food safety. Given its pivotal role in nutritional balance and quality assurance, there is an urgent need for simple, rapid, and highly sensitive analytical methods for l -Lys detection. RESULTS An innovative ‘off–on’ fluorescent sensor tailored for food-related applications was developed, utilizing CdTe quantum dots as the fluorophore and dodecyl trimethyl ammonium bromide self-assembled citrate-capped gold nanoparticles (DTAB-AuNPs) as the quencher for the rapid detection of l -lys. During the detection process, l -lys served as a binding bridge, facilitating the aggregation of DTAB-AuNPs. This reduction inhibited fluorescence resonance energy transfer between the fluorophore and the quencher, leading to fluorescence recovery. The degree of aggregation-induced fluorescence recovery exhibited a linear correlation with the concentration of l -lys within the range of 0.5–10 μ m ( R = 0.999). This newly developed sensing method demonstrated an impressive limit of detection of 3.22 n m . It was successfully applied to detect l -lys in various food-relevant samples, including milk, soybean, plasma and compound amino acid oral solution used in food-related nutritional supplements. CONCLUSION The results highlight its great potential for practical applications in multiple fields such as quality control of dairy and agricultural products, as well as clinical diagnosis related to nutritional status assessment. © 2026 Society of Chemical Industry.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121804
·
IF 7.5
Chao Zhang,Xiaobo Li,Haojiang Meng,Tao Zhang,Junkang Guo
Multiple low-concentration heavy metals (HMs) often coexist in the wastewater discharged after pretreatment, which also pose a potential threat to the aquatic ecological environment. However, few of reported adsorbents are capable of simultaneously and effectively removing multiple HMs from wastewater. In this study, a novel microcrystalline cellulose-based adsorbent MCC@CaCO 3 /LPEI was synthesized via a facile precipitation reaction, and used for the separate and simultaneous removal of Cd(II), Pb(II), Cr(VI), Cu(II), and Zn(II) from aqueous solution. Results showed that MCC@CaCO 3 /LPEI could remove 99.2 %-99.9 % of low-level HMs (1–2 mg·L −1 ) in the mono-component system, and the remaining concentrations of HMs met the standards for drinking water quality of China (GB5749–2022). The electrostatic attraction, ion exchange, chemical precipitation, and the surface complexation of functional groups were the main removal mechanisms. HMs adsorption data of MCC@CaCO 3 /LPEI was well fitted to the Pseudo-second-order and Langmuir models. MCC@CaCO 3 /LPEI remained high HMs removal rate (above 95 %) after seven adsorption-desorption cycles. In the HMs multi-component system, MCC@CaCO 3 /LPEI also exhibited excellent adsorption for all HMs, and the equilibrium adsorption capacities of Cd(II), Pb(II), Cr(VI), Cu(II), and Zn(II) were 1.15, 1.30, 0.91, 0.78, and 0.73 mg·g −1 , respectively. All five HM ions were completely removed after five adsorption-desorption cycles in the HM multi-component system. Meanwhile, the high removal rate (>99 %) of HMs in the simulated wastewater demonstrated the excellent environmental stability of MCC@CaCO 3 /LPEI. Conclusively, MCC@CaCO 3 /LPEI can be used as an adsorbent with promising applications for removing multiple low-concentration HMs from wastewater.
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高影响因子
ENERGY & FUELS
·
2026
·
IF 6
Meng Gu,Wang Dai,Bochen Jiang,Songyuan Zhang,Qiong Wu,Yuanji Li,Qiang Zhang,Huiyuan Meng,Baoyong Zhang
Abstract Hydrate-based separation is an effective method for CH4 recovery from low-concentration coalbed methane. The hydrate separation performance, such as the generation rate and the efficiency of separation and purification, is influenced by kinetic promoters. In this work, a dual-promoter system consisting of l-tryptophan (l-Trp) and PCN-250-Fe2Co was developed to enhance hydrate-based CH4 separation. l-Trp regulates the gas–liquid interfacial microenvironment through its amphiphilic structure, suppressing compact ice crystal nucleation and enhancing CH4 diffusive transport across the interface. Meanwhile, the high specific surface area and abundant microporous structure of PCN-250-Fe2Co provide numerous heterogeneous nucleation sites for CH4, shorten the CH4 diffusion distance, and significantly enhance the mass transfer within the liquid phase. As a result, the optimized system containing 0.5 wt % l-Trp and 0.1 wt % PCN-250-Fe2Co framework achieved a CH4 recovery of 86.64%. This value is 11.46% and 5.02% higher than those obtained with PCN-250-Fe2Co alone and l-Trp alone, respectively. This significant enhancement is attributable to the synergistic interplay between the carboxylate anchors of l-Trp and the metal sites of PCN-250-Fe2Co, which simultaneously facilitate CH4 capture and mitigate mass-transfer resistance for CH4. Theoretical analysis further showed that the CH4/N2 selective adsorption ratio of the l-Trp&PCN-250-Fe2Co system (44.932) was 16.6% higher than that of the PCN-250-Fe2Co system (38.523). Overall, the l-Trp&PCN-250-Fe2Co composite system exhibits promising potential for hydrate-based CH4 separation and purification from low-concentration coalbed methane, providing a new method for hydrate-based gas separation.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Su Jinle,Ge Lingrui,Niu Chunyu,Chen Yan,Zhang Leifang,Chen Yin
SP0–1, a neutral polysaccharide fraction isolated from sea buckthorn berries ( Hippophae rhamnoides L.), was purified and structurally characterized, and its antioxidant-related intestinal protective effects were evaluated in Drosophila melanogaster . HPGPC analysis showed a single symmetrical peak and indicated a relatively homogeneous fraction with a moderate molecular weight (Mw, 5.59 × 10 4 Da; ≈55.9 kDa). PMP-HPLC analysis revealed that SP0–1 was mainly composed of galactose, xylose, and arabinose (Gal/Xyl/Ara-rich; Gal:Xyl:Ara = 1:0.38:0.93). Methylation analysis combined with 1D/2D NMR spectroscopy supported the presence of major →4)- and →4,6)-linked Galp motifs, →5)- and →3,5)-linked Araf motifs, and terminal Xylp residues. The consecutive Gal–Gal arrangement, the residue adjacent to Gal O-6, the overall connection of the Ara/Xyl-containing region to the Gal-containing region, and the O-3 substituent of residue D remain unresolved. Functionally, SP0–1 exhibited concentration-dependent radical-scavenging activities against DPPH, ABTS• + , and hydroxyl radicals in vitro. In a Drosophila oxidative-stress model, dietary SP0–1 supplementation significantly improved survival and climbing performance, enhanced endogenous antioxidant enzyme activities, and reduced malondialdehyde levels. Moreover, SP0–1 markedly alleviated H 2 O 2 -induced intestinal oxidative injury, as evidenced by decreased reactive oxygen species accumulation and reduced intestinal epithelial cell death. These findings suggest that the structural characteristics of SP0–1, including its proposed Gal-rich linkage features and Ara/Xyl-containing residue motifs, may be associated with the observed antioxidant-related intestinal protection. Collectively, this study provides a structural and functional basis for further investigation of SP0–1 as a potential bioactive polysaccharide fraction.
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高影响因子
Foods
·
2026
·Vol. 15
·期 8
·1396
·
IF 6
Xiang Li,Kevin Shyong Wei Tan,Pengxiao Chen
In this study, the chemical composition of highland barley (HB), microwave fluidization HB (HB-1), extrusion and puffing HB (HB-2), and ultrafine pulverization HB (HB-3) were investigated based on untargeted metabolomics. In addition, RNA-seq transcriptomics, real-time polymerase chain reaction (qRT-PCR) and Western blot (WB) analysis were used to investigate the lipid metabolism mechanism of HB-1, induced by a high fat and cholesterol diet (HFCD). The results indicated that a total of 1292 metabolites were detected and classified into 78 distinct classes in the untargeted metabolomics analysis including fatty acyls, carboxylic acids and derivatives, glycerophospholipids, organooxygen compounds, prenol lipids, and so on. HB-1, HB-2, and HB-3 all increased the levels of amino acids and their derivatives, phenols, and carboxylic acid and its derivatives compared with HB. Furthermore, RNA-seq transcriptomic results indicated that HB-1 significantly modulated key genes ofCyp2c38,Cyp2b13, andCyp2b9related to steroid hormone biosynthesis andCD36,Plin4, andFabp4related to the PPAR signaling pathway, which played key roles in lipid metabolism. Moreover, qRT-PCR and WB results indicated that HB-1 obviously enhanced ADIPOQ expression level, while it reduced SCD-1, CD36, Fabp4, and SREBP-1c expression levels, suggesting that the alleviation of lipid metabolic dysregulation by HB-1 in hyperlipidemia mice might be mediated via participating in the PPARγ pathway. This study provided essential theoretical insights for the development and utilization of HB.
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PubMed
高影响因子
Food Chemistry-X
·
2026
·
IF 9.2
Ling Tang,Yu Chen,Hui Zeng,Junhao Wu,Xueya Wang,Yong Yin,Zuojin Hu,Xuefei Zhang,Xiaogang Zhang
The impact of cutting prior to drying on quality of chili pepper remains understudied. Effects of cutting-drying (precut into 1.5 cm segments) and traditional whole-drying (intact drying post-harvest) at 50, 60 and 70 °C, respectively on the quality of Erjingtiao chili pepper were investigated. Cutting-drying reduced drying time by 67–77%, with 60 °C being most efficient, which prevented browning of pepper pulp and seed, retained total phenols, capsorubin and sugars in pulp, and led to higher total protein but lowered the total phenols and free amino group in seed. The fatty acids in seed were significantly higher under cutting-drying (e.g., increased 44–145% of total fatty acids) but declined with temperature. The taste characteristics of pulp and seed were not evidently changed, but the flavor characteristics and the volatile compounds of pulp were obviously altered. Thus, cutting-drying at 60 °C is a promising method for dried chili pepper with improved efficiency and quality.
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高影响因子
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