CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Zhenlei Wang,Tingting Zhang,Yunliang Zhao,Yanhui Miao,Lingjie Zhang,Damiano Sarocchi,Shaoxian Song,Qiwu Zhang
Large scale of Cd-contaminated soil has become a serious threat to environmental safety and human health, whereas field applicability of existing remediation technologies has encountered numerous obstacles, such as poor stability, secondary pollution, long operation time, and high chemical cost. Herein, a novel activated calcite with significantly enhanced immobilization stability of Cd in soil has been synthesized based on mechanochemical technology. Our results demonstrate that the passivation rate of bioavailable Cd in Cd-contaminated soil (initial concentration 3 mg/kg) could be maintained at 65 % after 50 days of passivation cultured with activated calcite. Mechanistic studies have revealed that the outstanding performance is attributed to the enhancement of the CO 3 2– and Ca 2+ release properties of calcite through mechanical activation, leading to a 550 % increase in Ca 2+ release. The CO 3 2– fraction binds in situ to the free Cd in the soil, forming a stable carbonate-bound state. Simultaneously, the OH – released from the continuous hydrolysis of CO 3 2– effectively regulates and stabilizes the soil pH within the neutral range. Further, SEM-EDS and sequential extraction procedures (SEP) analyses implied that the specific adsorption of Cd by in-situ formed iron oxides in soil was visibly related to the release of OH – from activated calcite and immobilized the free state Cd in the more stable iron oxide-bound state. The current work shows the high sustainability and stability of Cd-contaminated soil immobilization by activated calcite materials.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
·
IF 5.3
Xin Tan,Peng Ke,Ziying Chen,Yi Zhou,Linjie Wu,Xiaoyan Bao,Yaxin Qin,Ruolin Jiang,Min Han
Currently, to overcome the short half-life of the local anesthetic ropivacaine, drug delivery systems such as nanoparticles and liposomes have been used to prolong the analgesic effect, but they are prone to abrupt release from the site of administration or have poor slow-release effects, which increases the risk of cardiotoxicity. In this study, injectable lipid suspensions based on ropivacaine-docusate sodium hydrophobic ion pairing (HIP) were designed to significantly prolong the duration of analgesia. The resulting ion-paired lipid suspension (HIP/LIPO) had a micrometer scale and a high zeta potential, which facilitates stable in situ retention. The strong interaction between docusate sodium and ropivacaine was verified using thermal and spectroscopic analyses, and the formation of micron-sized polymorphic vesicles was attributed to the mutual stabilizing interactions between ropivacaine-docusate sodium HIP, docusate sodium and lecithin. The HIP/LIPO delivery system could maintain drug release for more than 5 days in vitro and achieve high analgesic efficacy for more than 10 days in vivo , reducing the side effects associated with high drug doses. The stable HIP/LIPO delivery system is a promising strategy that offers a clinically beneficial alternative for postoperative pain management and other diseases.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Xinling Wu,Qiang Zhang,Deyi Zhou,Li Zhang,Haigen Zhou,Xiaodi Gao,Xuwen Fang,Chao Huo,Jinsong Zhang
Pickering emulsions (PEs) have wide applications in delivering nutraceuticals. However, the impact of extracting nanocellulose from corn stover on stabilizing PEs and delivering nutraceuticals remains unclear. In this study, four types of nanocellulose, cellulose nanocrystals (CNC), cellulose nanofibers (CNF), lignin-containing cellulose nanocrystals (LCNC), and lignin-containing cellulose nanofibers (LCNF) were successfully prepared from corn stover, an agricultural waste. Among them, LCNC and LCNF exhibited stable reticulated microstructures, lower crystallinity, and excellent thermal stability. Besides, lignin enhanced the nanoparticles' hydrophobicity, promoting the formation of more ideally amphiphilic particles, resulting in denser emulsions at the oil-water interface. Furthermore, emulsions stabilized by LCNC and LCNF demonstrated remarkable resistance to quercetin degradation under UV light exposure (with residual level exceeding 90 %) and improved quercetin's bioaccessibility during the in vitro digestion tests, achieving the highest bioaccessibility of 48.3 %. This study provided an innovative perspective on utilizing stover-derived materials for stabilizing PEs and delivering lipophilic nutrients.
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Environmental Technology & Innovation
·
2024
·
IF 6.7
Shiyuan Liu,Qin Qiu,Hong Yang,Lai Zhou,Xueqiang Zhu
Polycyclic Aromatic Hydrocarbons (PAHs) are persistent organic pollutants known for their carcinogenic, teratogenic, and mutagenic properties. A considerable amount of PAHs has been released into groundwater. Persulfate-based advanced oxidation processes (PS-AOP) are commonly employed to remediate such contamination. However, traditional in-situ chemical oxidation (ISCO) faces challenges such as concentration rebound and tailing. To address these issues, sodium persulfate sustained release materials (PDS@SA) and ferrous sulfate sustained release materials (FeSO 4 @SA) were developed using stearic acid (SA) as a binder. Batch and column experiments were conducted to evaluate the efficacy of pyrene degradation through PDS@SA activated by FeSO 4 @SA. The batch experiments showed that the optimal mass ratio of FeSO 4 @SA to PDS@SA was 1:2, achieving degradation efficiencies over 95 % for pyrene with various concentrations (5, 10, 15, 20 mg⸱L −1 ) within 2 h. The column experiments showed that sustained release materials (FeSO 4 @SA and PDS@SA) with a particle size of 5 mm achieved an average removal rate of 89.3 % during days 7–15, while those with particle sizes of 7.5 mm and 10 mm achieved average removal rates of 68.5 % and 74.6 % during days 15–23, respectively. Additionally, electron paramagnetic resonance (EPR) analysis confirmed sulfate radicals SO 4 - ⸱ and hydroxyl radicals ⸱OH as the primary oxidative species during pyrene degradation. These findings suggested that the sustained activation of PDS by sustained release Fe 2+ represents a viable method for degrading PAHs in groundwater.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
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IF 4.9
Wenjing Jiang,Qiuli Wang,Xiaoyan Zhang,Husheng Yang,Xinggang Yang
Semaglutide has the advantages of high efficacy and fewer side effects in the treatment of Type 2 diabetes (T2DM). However, the marketed formulations of semaglutide have issues such as poor compliance in individuals who require repeated injections and low oral bioavailability, limiting its use. To overcome the aforementioned issues, semaglutide microspheres with single-phase zero-order release behavior were created using two methods: polymer blending and surfactant addition. Their characteristics, in vitro release, and in vivo pharmacodynamics were investigated. Two types of semaglutide microspheres show a desirable encapsulation effectiveness and smaller particle size. When compared to ordinary semaglutide microspheres (SEM-MS), due to the introduction of hydrophilic substances such as low molecular weight PLGA and Tween 20, the lag phase disappears, it exhibits zero-order release, with better in vitro release behavior. When injected subcutaneously to T2DM rats, the drug was continuously released for about a month, and the blood drug concentration fluctuated little, exhibiting good hypoglycemic and repair β cell effects. The efficacy is superior to SEM-MS and consistent with injection. The semaglutide microspheres created by two ways in this investigation can address the issues with commercial formulations while remaining safe.
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Current Drug Delivery
·
2023
·Vol. 20
·期 9
·1337-1350
·
IF 2.4
Zhu Yameng,Wang Boyao,Chen Jian,He Jun,Qiu Xilong
Background: Mesoporous silica nanoparticles (MSNs) are one of the most promising carriers for drug delivery. MSNs have been widely used in pharmaceutical research as drug carriers because of their large pore volume, high surface area, excellent biocompatibility, nontoxicity, ease to
functionalize, and sustained release effects. MSNs have attracted much attention during drug delivery because of their special structure. Objective: The present study aimed to synthesize mesoporous silica nanoparticles (MSNs), dendritic mesoporous silica nanoparticles (DMSN), and hollow
mesoporous silica nanoparticles (HMSN) through facile methods, and to compare the drug release properties of nano-porous silica with different pore structures as a stroma for PUE drug. Methods: MSN, DMSN, and HMSN were characterized by SEM, TEM, FT-IR, nitrogen adsorptiondesorption isotherms,
XRD, and zeta potential methods. Subsequently, puerarin (PUE) was used as the active ingredient and loaded into the three mesoporous materials, respectively. And, the drug delivery behavior was measured in PBS solution with different pH values. The sustained-release properties of MSN, DMSN,
and HMSN loaded with PUE were investigated. Finally, the biocompatibility and stability of MSN, DMSN, and HMSN were studied by MTT assay and hemolysis assay. Results: Our results showed that MSN, DMSN, and HMSN were successfully synthesized and the three types of mesoporous silica nanoparticles
had higher drug loading and encapsulation efficiency. According to the first-order release equation curve and Higuchi equation parameters, the results showed that the PUE-loaded MSN, DMSN, and HMSN exhibited sustained-release properties. Finally, MTT and hemolysis methods displayed that MSN,
DMSN, and HMSN had good biocompatibility and stability. Conclusion: In this study, MSN, DMSN, and HMSN were successfully synthesized, and to compare the drug release properties of nano-porous silica with different pore structures as a stroma for PUE drug, we provided a theoretical and
practical basis for the application of PUE.
研究领域:
药学
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材料科学
·
纳米技术
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JOURNAL OF CELLULAR PHYSIOLOGY
·
2018
·Vol. 234
·期 5
·6136-6146
·
IF 3.923
Yucang He,Xiaofang Yu,Zhuojie Chen,Liqun Li
Autologous fat transplantation is increasingly applied in plastic and reconstructive surgery. Stromal vascular fraction cells (SVFs) combined with angiogenic factors, such as VEGF (vascular endothelial growth factor A) and Ang-1 (angiogenin-1), can improve angiogenesis, which is a critical factor for graft survival. However, direct transplant with such a mixture is insufficient owing to the short half-life of angiogenic factors. In this study, we evaluated whether a double sustained release system of VEGF/ANG-1-PLGA (poly (lactic-co-glycolic acid)) microspheres plus SVFs can improve angiogenesis and graft survival after autologous fat transplantation. VEGF/ANG-1-PLGA-sustained release microspheres were fabricated by a modified double emulsion–solvent evaporation technique. Human aspirated fat was mixed with SVF suspension plus VEGF/ANG-1 sustained release microspheres (Group C), SVF suspension (Group B) alone, or Dulbecco’s modified Eagle’s medium as the control (Group A). Eighteen immunocompromised nude mice were injected with these three mixtures subcutaneously at random positions. After 8 weeks, the mean volume of grafts was greater in the SVFs plus VEGF/ANG-1-PLGA group than in the control and SVFs groups (1.08 ± 0.069 ml vs. 0.62 ± 0.036 ml, and 0.83 ± 0.059 ml, respectively). Histological assessments showed that lower fibrosis, but greater microvascular density in the SVFs plus VEGF/ANG-1-PLGA group than in the other groups, though the SVFs group also had an appropriate capillary density and reduced fibrosis. Our findings indicate that SVFs plus VEGF/ANG-1-PLGA-sustained release microspheres can improve angiogenesis and graft survival after autologous fat transplantation.
研究领域:
整形与重建外科
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生物医学工程
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组织工程
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Reaction Kinetics Mechanisms and Catalysis
·
2026
·
IF 2.1
Li Junlang,Yin Shaofeng,Chen Lixin,Chen Lei,Chen Yang,Xie TianTian,Wang Yingjie,Deng Xiaoting
This study aimed to investigate the regulatory mechanism of spinning solution composition on the structure and drug sustained-release behavior of inorganic–organic drug-loaded nanofiber membranes fabricated via emulsion electrospinning. By adjusting water content (0, 1, 1.5 g) and zeolite loading, nanofiber membranes with different porous structures were prepared. Results indicated that fiber morphology and release kinetics were significantly influenced by the spinning solution composition: Systems containing water (W 1 -Zeo@DS NFs, W 1.5 -Zeo@DS NFs) formed shallow surface pores due to the emulsion template effect, resulting in finer fiber diameters. The system without water (Zeo@DS NFs) formed deeper internal channels via solvent-induced phase separation, leading to larger fiber diameters. Based on comprehensive release profiles and cumulative release rates, W 1 -Zeo@DS NFs demonstrated the optimal sustained-release performance and the highest drug utilization efficiency (56.85%). This study demonstrates that synergistic regulation of water content and zeolite loading can effectively optimize the multi-level pore structure of fibers, enabling precise control over drug release behavior, thereby providing a reference for designing efficient composite sustained-release drug delivery systems.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 26
·18843-18865
·
IF 4.4
Yan Shiping,Liao Xizhi,Yao Jiaxing,Xiao Jialong,Lei Jiajie,Chen Yi,Yang Lingxiu,Yu Mengyi,Zhou Zheng,Liu Hairong
Polymer-based drug-loaded microspheres emerged as prevalent clinical modalities, exemplified by transarterial chemoembolization (TACE) and composite wound dressings, leveraging their sub-millimeter dimensions for versatile therapeutic deployment and targeted delivery. However, inherent limitations persist, including constrained drug loading capacity, rapid drug release kinetics, and non-degradability, thereby precluding the feasibility of repeat interventions. Based on these considerations, this study proposes a novel microsphere construction strategy that utilizes anionic monomer 2-acrylamide-2-methylpropanesulfonic acid (AMPS)-modified polyvinyl alcohol (PVA) as the primary raw material and incorporates cationic modified chitosan quaternary ammonium salt (QCS) to form a double-network microsphere. Owing to the abundant dynamic ionic interactions and the synergistic integration of soft and rigid molecular chains within the gel matrix, the resulting microsphere exhibits excellent mechanical properties, including a compressive deformation resistance exceeding 70%, high drug loading capacity, and prolonged sustained-release performance. When loaded with the cationic anticancer drug doxorubicin hydrochloride (DOX) and the antibacterial agent polyhexamethylene biguanide hydrochloride (PHMB), the microspheres achieved loading concentrations of 100.31 mg/mL and 132.25 mg/mL, respectively, with sustained release lasting over 12 days. In a rabbit hepatic artery embolization experiment, DOX-loaded microspheres effectively occluded blood flow and induced liver necrosis, thereby confirming their superior embolic performance. These features collectively demonstrate the promising application potential of this microsphere in the biomedical field.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 4
·1642
·
IF 5.6
Shuang Wang,Keyi Wu,Meiqi Sun,Xinrui Wang,Jingying Li,Guorong Zhang,Zhidong Qiu
Tendinopathy is a common musculoskeletal disorder that increases the risk of tendon rupture if not properly treated. Current local injection therapies require frequent administration, and no fully effective drug is yet available. Curcumin (Cur) exhibits excellent anti-inflammatory and antioxidant effects, but its poor water solubility and low stability limit its clinical application. To overcome these challenges, this study encapsulated Cur into pluronic F127-based nanomicelles (Cur-F127) to improve its aqueous solubility and stability. Subsequently, the micelles were incorporated into a hydrogel network (Cur-F127&gel) formed by oxidized hyaluronic acid (oxi-HA) and adipic acid dihydrazide (ADH) to achieve sustained release. The resulting Cur-F127 micelles had a particle size of 20.14 ± 0.287 nm, an encapsulation efficiency (EE%) of 89.95 ± 0.60%, and a drug loading (DL%) of 5.57 ± 0.05%. The composite hydrogel possessed a loose, porous three-dimensional network, excellent biocompatibility, and favorable degradation behavior. The system enabled sustained release of Cur for over 20 days without an initial burst. In a rat model of tendinopathy, Cur-F127&gel significantly promoted tendon repair, as evidenced by reduced inflammatory cell infiltration, improved collagen fiber alignment, restored expression of key mitochondrial-related proteins (Ndufs3, Uqcrq, Uqcr10, Atp5mc3), and alleviated oxidative stress damage demonstrated by increased SOD activity and decreased MDA content in tendon tissue, thereby suppressing disease progression. This injectable sustained-release hydrogel system for poorly soluble drugs provides an effective approach for the local, long-acting delivery of Cur and long-term repair of tendinopathy, highlighting its potential value for clinical application.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Yanan Liu,Yuhao Huang,Qileng Aori,Yu Wang,Sai Zhao,Zhen-Lin Xu
Antibacterial hydrogel packaging often adheres poorly to hydrophobic prefabricated meat surfaces. Metal-polyphenol networks, combining metal ion antibacterial properties with polyphenol adhesion, offer promising preservation potential. In this study, tannic acid -Fe III metal polyphenol network-coated gallic acid -loaded ovalbumin/chitosan nanoparticles with adhesion and sustainable antibacterial properties were prepared and embedded into the gelatin hydrogel to elongate the shelf life of prefabricated meat. The composite hydrogel exhibited high adhesion, with an average adhesion force of 1.4-fold ∼1.9-fold larger than the other groups. It also exhibited good antibacterial properties, the colony-forming units (CFU) of 4 type of bacteria was reduced by 0.69, 0.34, 1.05 and 0.90 log 10 (CFU/mL). The composite hydrogel delayed pH, total volatile basic nitrogen (TVB-N), microorganism growth, and the marginally acceptable limit was delayed by 4 days compared with the other groups in applications. These results demonstrate the composite hydrogel's significant potential as a preservation material for prefabricated meat.
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Small
·
2026
·
IF 11.8
Jiaofan Sun,Yuanyuan Rao,Xin Zhang,Jing Liu,Shasha Feng,Yutang Kang,Sheng Wang,Yicheng Wang,Kai Yuan,Daoming Xu,Lanying Liu,Zhaoxiang Zhong,Weihong Xing
As one of the most distinctive therapeutic methods in traditional Chinese medicine, moxibustion therapy has garnered significant attention for its analgesic, anti-inflammatory, and anti-tumor effects. However, traditional moxibustion therapy lacks portability, generates substantial harmful gas emissions during combustion, and exhibits uncontrollable burning temperatures, which lead to unstable therapeutic outcomes. In this work, a smart thermo-responsive and sustained-release dressing with a three-layer structure is developed. Within this design, the electrothermal carbon fiber layer is responsible for heat generation, while the thermochromic nanofiber membrane layer enables temperature visualization. The core functional layer is a polylactic acid/hollow carbon nanosphere/mugwort essential oil nanofiber membrane fabricated via electrospinning. Leveraging its hierarchical porous structure and the microencapsulation effect of the hollow carbon nanospheres, the membrane achieves a high mugwort essential oil loading capacity of 164.32%, effectively maintaining sustained release over 10 days. The dressing exhibits excellent temperature responsiveness and reusability, maintaining accurate temperature control even after 200 consecutive cycles. Experiments using a porcine skin model demonstrated that the active components of the essential oil can penetrate into both the stratum corneum and stratum corneum-removed tissue, with thermotherapy significantly enhancing their transdermal absorption. This study provides a green, safe, and convenient solution for modernizing traditional moxibustion therapy.
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