FIBERS AND POLYMERS
·
2025
·
IF 2.3
Wang Mengya,Zhu Peng,Ruan Fangtao,Zhang Huapeng
Due to the smooth and chemically inert surface of poly(p-phenylenebenzobisoxazole) (PBO) fibers, leading to poor interfacial properties in epoxy resin, which severely limits their applications in composite materials. The vast majority of research on PBO fiber interfaces is focused on PBO-HM type, while there is little research on PBO-AS type. Here, a modification strategy of in-situ regeneration of cellulose on PBO-AS fiber surface to enhance its interfacial properties in epoxy resin was proposed for the first time. First, PBO-AS fibers were oxidized and then underwent acyl chlorination, followed by chemical bonding with cellulose molecules. Second, cellulose molecules were in-situ regenerated on the fiber surface in different regeneration solvents. The results show that cellulose molecules were successfully in-situ regenerated on the fiber surface. Due to the physical and chemical properties of PBO-AS itself, the modification process inevitably damaged its mechanical properties, especially the oxidation process. In addition, the oxidation step slightly enhanced its interfacial strength in epoxy resin, while the rougher surface formed by cellulose regeneration was the main reason for the improvement of interfacial performance; the IFSS increased by 38.87% compared with untreated ones.
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DYES AND PIGMENTS
·
2025
·
IF 4.2
Ningxi Wu,Sirui Hang,Shuying Chen,Kai Wang,Yue Zheng
We report the design and synthesis of CatP, a sulfur-substituted hemicyanine-based activatable probe, for the sensitive detection of cathepsin B (CatB) activity. This probe was applied to study the dynamic changes of hepatic CatB in diabetic mellitus (DM), a prevalent metabolic disease. The probe incorporates a Val-Cit linker specifically cleaved by CatB, triggering an intramolecular charge transfer (ICT) mechanism that generates strong near-infrared (750 nm) fluorescence and photoacoustic signals. Structural optimization through sulfur substitution significantly enhanced photoacoustic signal intensity compared to conventional oxygen-substituted analogs. In diabetic mouse models, CatP revealed significantly elevated hepatic CatB activity, which was normalized by metformin treatment as confirmed by both in vivo imaging and ex vivo immunofluorescence. Comprehensive biosafety evaluation demonstrated excellent biocompatibility with >90 % cell viability and no observable organ toxicity. These findings establish sulfur-modified hemicyanine as a promising scaffold for developing high-performance activatable probes, and demonstrate the value of CatP as a functional dye for studying protease activity in biomedical research.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Yunhao Hu,Depeng Zhang,Zhengkun Liu,Hanwen He,Hongyang Wang,Chao Deng,Sen Zhang
Aqueous Zn-ion batteries with high theoretical capacity, low price and high safety are promising energy storage devices. However, their development is restricted by manganese oxide (MnO 2 ) cathodes, which have the drawbacks of inferior electron conduction, irreversible dissolution and limited stability. Herein, a synergistic cation/anion (Ca/N) co-doping strategy is introduced to modulate the electric structure of birnessite-type MnO 2 (CACO–δ-MnO 2 ) to enhance its electron/ion-migration capability, improve structural stability and promote electrochemical performance. Theoretical analysis reveals that the synergistic effects of Ca/N co-doping considerably reduces the bandgap, decreases the adsorption energy and lowers the ion-diffusion energy barrier for CACO–δ-MnO 2 , thereby increasing its conductivity and ion-diffusion capability. Ex situ and in situ analyses reveal that the dual ions of the Zn 2+ and H + insertion mechanism and the superior structural stability of CACO–δ-MnO 2 during charging/discharging processes. Galvanostatic intermittent titration technique and electrochemical impedance spectroscopy results confirm its fast kinetics, low charge-transfer resistance and good stability. Moreover, electrochemical tests demonstrate its superior stability in high-rate and long-term cycling, which delivers a high capacity of 213.5 mAh g −1 following 2000 cycles at a high current density of 4 A g −1 . Integrated with the CACO–δ-MnO 2 cathode, the flexible Zn–MnO 2 battery demonstrates high flexibility and reliability in a wide temperature range (−20 °C–25 °C). Moreover, a long lifespan of 1000 cycles and a high capacity retention of 89.2 % are obtained for the flexible Zn–MnO 2 battery even at a low temperature of −20 °C. Therefore, this study not only introduces a novel Ca/N synergistic modulation strategy for high-performance δ-MnO 2 cathode but also propels the development of advanced Zn-ion batteries for various electronic items.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2025
·Vol. 46
·期 5
·118008
·
IF 6.2
Xina Liang,Nuo cheng,Xiaokai Liu,Wenyu Zhang,Huiyu Zhang,Hetao Zhao,Yuanpei Yang,Jianhang Zhang,Wenhui Bi,Mingzhen Zhang,Benshuang Sun,Yang Liu,Jilin He
AZO films are regarded as a promising alternative to ITO due to their superior properties. However, excessive aluminum doping can lead to increased resistivity without enhancing carrier concentration. This study provides a systematic comparison between AZO and aluminum tungsten co-doped zinc oxide (AWZO) in terms of their preparation processes, which include powder synthesis, target sintering, and thin film sputtering. The investigation encompasses an analysis of the morphology, density, structure, and electrical properties of the sintered targets. The quality of the two sintered targets was assessed using RF magnetron sputtering, and the influence of pressure and sputtering power parameters on the films' properties was thoroughly examined. Additionally, the electrical and optical properties of the films were characterized and analyzed in detail. The experimental findings indicate that the AWZO target exhibits the lowest resistivity at 1.35 mΩ·cm. Furthermore, the AWZO film prepared at room temperature demonstrates a minimum sheet resistance of 52 Ω/□, an average transmittance of 91.59 %, and a band gap of 3.54 eV.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Yu Zhang,Dong Zhu,Jun Xie,Jiawei Xie,Chaolei Yuan,Xiaojun Shi
The vertical migration behavior of antibiotics in long-term manure-fertilized soils during rainfall remains unclear. Here, we examined antibiotics in soil profiles (0–60 cm) and leachates following each rainfall event throughout a year for three soils (acidic, neutral, and calcareous) with a 13-year history of manure application. The total concentrations of all the antibiotics in the soil profile (11.04–190.32 μg/kg) and the yearly cumulative load of these antibiotics in the leachate (4070–6900 ng/m 2 ) were significantly higher in the acidic and neutral soils than in the calcareous soil. Rainfall caused the migration of antibiotics (especially tetracyclines, quinolones, and sulfonamides) from soil to leachate, while the migration dynamics of some antibiotics differed among the three soil profiles. Random forest analysis revealed that precipitation, soil organic carbon content, pH, sand content, and the partition coefficient ( K ow ) of antibiotics were the key factors influencing the migration of antibiotics. Environmental risk assessment suggested that antibiotics in leachates pose low toxicity risks to aquatic organisms. Nevertheless, the vertical migration of some antibiotics (e.g., sulfachaloropyridazine and sufamerazine) was positively correlated with the dissemination of high-risk antibiotic resistance genes in leachates. This study advances our understanding of the precipitation-caused vertical migration of antibiotics in soil exposed to manure application, considering future increases in severe rainfall events.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Meng Wang,Xiaoqi Zhao,Xiaoyun Yang,Xueming He
The fluorescence characteristics of aflatoxin B 1 (AFB 1 ) have enabled the development of an effective and non-destructive screening method for AFB 1 in agro-products using fluorescence spectroscopy. However, the complex and varied matrices present in most foodstuffs can significantly distort the intrinsic fluorescence of AFB 1 . In this study, the absorption and scattering properties of vegetable oils were obtained using double integrating spheres (DIS), and fluorescence intensity was obtained using laser-induced fluorescence (LIF) technique. A six-parameter analytical model has been developed to recover AFB 1 intrinsic fluorescence based on the absorption and scattering features at excitation (375 nm) and emission (424 nm) wavelengths employing a one-dimensional convolutional neural network (1D-CNN). Prediction models for AFB 1 concentration in vegetable oils with gradient variations of matrices were calibrated using the disturbed and recovered intrinsic fluorescence intensity, respectively. The models were validated and compared to demonstrate the feasibility and superiority of the proposed method.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2025
·
IF 4.1
Run Cai,Jiahao Jiang,Pengfei Diao,Zihan Wei,Change Yao,Bosheng Zhou,Huijuan Zhang,Wenwen Liu,Zhong Ma
It is crucial to develop low-cost and efficient electrocatalysts to facilitate oxygen reduction reaction (ORR) and transition metals incorporated into nitrogen-doped carbon matrices (M-NC) catalysts are regarded as a potential candidate to substitute platinum-based electrocatalyst. However, there is still a great challenge in real activity and stability, compared to Pt-based electrocatalysts, for large-scale applications. An effective way to improve the ORR performance for this category of single-atom catalysts is to increase the density of active sites. In this work, therefore, the highly dispersed ZIF-67-derived Co-NC confined in carbon pores electrocatalysts are synthesized by impregnating ZIF-67 precursors into the nanopores of Ketjenblack EC-600JD (KB) resulting in the in-situ growing of small crystals in the pores followed by the high temperature pyrolysis. The as-prepared CoNC-700@C electrocatalyst exhibits excellent ORR performance in alkaline media with an onset potential of 967 mV and a half-wave potential of 892 mV (vs. RHE), which is much higher than that of the commercial Pt/C catalyst. It is inferred that the excellent ORR activity of CoNC-700@C mainly results from the increased density and also enhanced dispersion of active sites due to the confinement effect offered by the pores of KB. This study also provides a simple and effective method to increase the density of active sites for single-atom category materials.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yang Cui,Jiayi Meng,Long Lv,Yongmei Chen,Tianyu Li
Electrodialysis utilizing monovalent selective cation exchange membranes have wide application prospects in waste acid recycling and lithium-ion extraction. While the multilayered modification of substrate membranes with polyelectrolytes is one of the effective ways to improve the monovalent selectivity of standard cation exchange membrane, the stability of such modified membranes is often poor owing to the detachment of the polyelectrolyte layers. This study proposes a novel strategy utilizing covalent bonding between the modification layers and the substrate. The approach involves doping poly (vinyl alcohol) (PVA) into a sulfonated polyphenyl sulfone (SPPSU) substrate, followed by the alternate deposition of polyethyleneimine (PEI) and poly (sodium 4-styrenesulfonate) (PSS) via the layer-by-layer (LBL) assembly method. Subsequently, glutaraldehyde (GA) was employed as a dual-functional crosslinker to achieve simultaneous crosslinking within the substrate and at the interface of substrate and modification layer. The optimized membrane, SPPSU@4PVA(PEI/PSS) 2.5 , exhibited a low surface resistance of 6.77 Ω·cm 2 , a high Na + /Mg 2+ selectivity over 13, and a Na + flux of 4.5 × 10 −8 mol·cm −2 ·s −1 . Most notably, the performance remained after 60 h of continuous electrodialysis operation. This dual-crosslinking strategy enhances both the selectivity and stability of polyelectrolyte-modified monovalent selective cation exchange membranes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xue Tang,Gisèle Ineza Urujeni,Xu Ni,Ziwei Lu,Dan Wang,Jie Gao,Fizir Meriem,Hua He,Deli Xiao,Pierre Dramou
An innovative and simple nanocomposite denoted as MHNTs@PEI was synthesized for gallic acid (GA) analytical sample pretreatment. Polyethyleneimine (PEI) functionalized was binded onto magnetic halloysite nanotubes (MHNTs) to inhence adsorption capacity. MHNTs@PEI was obtained only through two steps modification (amination and PEI modification). Characterizations showed that there are layers of synthetic PEI on the tubular structure of the material and magnetic spheres on its surface, both indicating successful synthesis of the nanocomposite. Furthermore, the adsorption isotherms and kinetic modeling showed that the Langmuir model and pseudo-first-order model fit the adsorption data, respectively. MHNTs@PEI achieved an adsorption capacity of 158 mg·g −1 . Overall, the abundant adsorption sites significantly improved the adsorption performance of the MHNTs@PEI. Regeneration tests demonstrated that the MHNTs@PEI exhibits effective adsorption, even after undergoing five consecutive cycles. Optimization of key parameters (ratio, volume of elution, elution time and frequency) in the process of adsorption and desorption was also conducted. The limit of detection (LOD) and that of the quantification (LOQ) were 0.19 and 0.63 μg·mL −1 , respectively, and the recoveries were 95.67–99.43 %. Finally, the excellent magnetism (43.5 emu·g −1 ) and the adsorption feature of MHNTs@PEI enabled its successful utilization in analytical sample pretreatment through the extraction of GA from green tea.
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Current Research in Toxicology
·
2024
·
IF 2.9
Yan Ma,Honggang Chen,Yuxin Jiang,Diya Wang,Michael Aschner,Wenjing Luo,Peng Su
Elevated manganese (Mn) exposure has been implicated in a broad spectrum of neurological disorders, including motor dysfunction and cognitive deficits. Previous studies have demonstrated that Mn induces neurotoxicity by disrupting the integrity of the blood–brain barrier (BBB), a critical regulator in maintaining central nervous system homeostasis and a contributing factor in the pathogenesis of numerous neurological disorders. However, the precise molecular mechanisms underlying Mn-induced BBB disruption and its role in facilitating neurotoxicity remain incompletely understood. The primary objectives of this study were to elucidate the mechanisms underlying the relationship between Mn exposure and BBB tight junction proteins (TJPs), and to further investigate potential neuroprotective strategies for mitigating Mn-induced cognitive impairments. In this investigation, we developed Mn exposure models utilizing both murine subjects and cell culture systems to elucidate the mechanisms underlying TJPs involvement and to assess the potential neuroprotective effects of gastrodin (GAS), a bioactive compound extracted from traditional Chinese medicine. Our findings revealed a significant reduction in TJPs expression, both in vivo and in vitro , in Mn-induced BBB disruption. The overexpression of Occludin (OCLN), a crucial component of TJPs, mitigated Mn-induced BBB damage. GAS administration effectively attenuated Mn-induced disruption of the BBB, enhanced the expression of TJPs, and mitigated Mn-induced cognitive dysfunctions, potentially through the modulation of the RhoA/ROCK2 signaling pathway. This research sought to advance our understanding of the molecular pathways involved in Mn-mediated BBB disruption and to identify novel therapeutic approaches for mitigating the deleterious effects of Mn exposure on cognitive function.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Kai Fan,Shuo Liu,Ye Ma,Qinming Wu,Sen Wang,Andree Pauschinger,Andrei-Nicolae Parvulescu,Nils Bottke,Toshiyuki Yokoi,Dirk E. De Vos,Xiangju Meng,Weiping Zhang,Feng-Shou Xiao
ITR zeolites exhibited excellent performance in methanol to propylene (MTP), where an important factor was the Al distribution of the ITR zeolites. However, optimization of the Al location in ITR zeolites in the conventional synthesis is challenging. In this work, the Al distribution in the ITR zeolites was efficiently adjusted by adding boron species in the synthesis gels due to the competitive occupancy of T sites in zeolites between boron and aluminum species. The obtained ITR with different boron content zeolites displayed similar nanosheet morphology, textural parameters, and strong acidic concentration but characterizations of Al distribution showed that the addition of boron species led to more Al species distributed in a relatively small sinusoidal channel and less Al species located in an intersection cavity. As a result, the aromatic cycle would be effectively suppressed due to the steric configuration of large aromatic cycle intermediates, whereas the alkene cycle will be enhanced correspondingly. As expected, catalytic tests in the conversion of MTP showed that the new ITR zeolites exhibited enhanced propylene selectivity and catalyst lifetime with the incorporation of boron species, which was attributed to different Al distribution in these ITR zeolites.
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Drug Design Development and Therapy
·
2025
·
IF 5.1
Junxi Zhou,Qinglian Zhang,Jingjing Guan,Xiuyun Peng,Zebei Lu,Quan Zhou,Abdullah Al Mamun,Shuanghu Wang
Background: Tofacitinib is an orally administered Janus kinase (JAK) inhibitor that has demonstrated significant efficacy in the treatment of rheumatoid arthritis. This study aimed to investigate the effects of gliquidone and linagliptin, two hypoglycemic agents on the pharmacokinetics of tofacitinib in vitro and in vivo.Methods: The mechanism of drug-drug interaction was studied in vitro using a murine liver microsome incubation system and in vivo by administering gliquidone and linagliptin orally to rats pretreated with various concentrations of tofacitinib. This study used waters ACQUITY UPLC I-Class/Xevo TQD ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer. Furthermore, molecular docking was performed to simulate the interaction using computer simulations.Results: Gliquidone and linagliptin inhibited the metabolism of tofacitinib by heparanase in vitro with IC50 values of 1.140 μM and 4.064 μM, respectively. Co-administration of gliquidone significantly increased the AUC(0–t) of tofacitinib by approximately 43.3%, accompanied by a 45.1% increase in Cmax and a 27.5% reduction in clearance (CLz/F). In contrast, linagliptin exhibited a more potent inhibitory effect, raising the AUC(0–t) approximately 4.4-fold, enhancing the Cmax by 2.86-fold, and decreasing clearance to 25.8% of the control level. These findings suggest that while both gliquidone and linagliptin significantly enhance the systemic exposure of tofacitinib, linagliptin demonstrates a markedly more significant inhibitory effect on tofacitinib’s metabolism and elimination.Conclusion: Gliquidone and linagliptin significantly altered the pharmacokinetics of tofacitinib in vitro and in vivo. This study demonstrated the drug-drug interactions between linagliptin, gliquidone, and tofacitinib, highlighting the need for clinical attention to this possibility.
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