ACS Nano
·
2025
·
IF 16
Ao Li,Jing Hao,Kai Wu,CaiYun Chang,XiangYong Zhang,He Gan,Jin Tan,Ting Xie,Fu Zhou,PengCheng Wang,CuiPing Han,HongDa Du,BaoHua Li,Qi Liu
Due to the inherent redox potential of the zinc metal anode (ZMA), it is susceptible to corrosion and dendrite formation in aqueous electrolytes. These issues compromise the electroplating-stripping process at the electrolyte–electrode interface, adversely affecting the reversibility of aqueous zinc-ion batteries (AZIBs). Here, we propose a chelating-ligand additive (i.e., DS) strategy to construct in situ an inorganic/organic hybrid bilayer interface. The organic molecule enriched in -PO3 groups is calculated to preferentially adsorb onto the surface of ZMA. During subsequent reactions, these adsorbed molecules decompose preferentially due to their low lowest unoccupied molecular orbital energy level (0.34 eV), forming a Zn(PO3)2-enriched inorganic solid electrolyte interphase (SEI) layer. Simultaneously, the intermediate carbon skeleton cross-links, creating an organic layer atop the SEI, thereby forming an inorganic/organic hybrid SEI bilayer interface. This bilayer SEI interface effectively inhibits corrosion and hydrogen evolution reactions (HERs) while regulating the Zn2+ ion flux at the interface, inducing uniform Zn depositions. Consequently, the Zn||Zn symmetric battery demonstrates a long-term cycling lifespan exceeding 1700 h at 5 mA cm–2. The Zn||I2 pouch battery yielded a capacity retention of 71.3% after 1100 cycles. This synergistic modulation strategy offers insights into the development of ZMA stabilizer additives, potentially advancing the performance and durability of AZIBs.
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OPTICAL MATERIALS
·
2025
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IF 4.2
Bing Xu,Xiaoying Xiang,Yan Li,Liu Yang,Zhihui Luo,Jianglou Huang
To tackle the demand for highly accurate and real-time diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly sensitive optical fiber SARS-CoV-2 antigen sensor based on triangular gold nanosheets/gold film coupling is proposed. The coupling effect between the local surface plasmon resonance effect of the triangular gold nanosheets and the surface plasmon resonance effect of the gold film increases the local electric field, resulting in higher sensitivity and lower detection limit of the sensor, and the refractive index sensitivity of the sensor is increased to 3894.3 nm/RIU. The antigen reacts specifically with the viral antibody adsorbed on the surface of the optical fiber, which leads to a small change in refractive index, which ultimately leads to a shift in the resonance peak of the optical fiber, thus enabling antigen detection. The biosensor showed good response in the range of SARS-CoV-2 antigen concentration from 0.035 to 100 ng/mL, and the limit of detection (LOD) was 0.017 ng/mL (S/N=3). The biosensor has good selectivity and stability, possesses a short response time (10 min), which provides a new idea for the detection of SARS-CoV-2 in the biomedical field.
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Advanced Energy Materials
·
2025
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IF 26
Yueteng Gao,Xiaodie Ma,Yangtian Yan,Shuhua Zhang,Jin Liang,Baohua Li,Feiyu Kang,Dengyun Zhai
Graphite stands out as the most promising anode material for potassium-ion batteries (PIBs) due to its cost-effectiveness and ideal low-potential platform. However, the perceived poor rate capability of graphite has become a key concern for its commercial application in PIBs. Herein, the above understanding on the poor rate capability of graphite is updated. Without modifying graphite structure, by simply introducing a tin trifluoromethanesulfonate (Sn(OTf) 2 ) additive in phosphate-based electrolyte, the graphite in K||graphite half-cell can deliver a capacity of 240 mAh g −1 at a high rate of 2 C (1 C = 279 mA g −1 ) and operates for 1000 cycles with negligible degradation. Moreover, an unprecedented rate capacity of ≈200 mAh g −1 for graphite anode at 4 C is achieved in a three-electrode K|K ref|graphite cell configuration where the interference of the K metal counter electrode is eliminated. Unlike structure modification strategies, such remarkable rate performance is originated from the low-impedance inorganic-rich KF/SnF 2 hybrid interphase on graphite. Thus, the effectiveness of the electrolyte regulation strategy highlights the underestimated rate capability of graphite anode. This renewed insight dispels the concern regarding the commercial applicability of graphite anode and enriches the advantages of PIBs for high-power density.
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Biosensors-Basel
·
2024
·Vol. 14
·期 7
·332
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IF 4.9
Xiaonan Zhang,Lizhong Zhang,Han Li,Yang Xu,Lingqin Meng,Gengyu Liang,Bei Wang,Le Liu,Tian Guan,Cuixia Guo,Yonghong He
The demand for accurate and efficient immunoassays calls for the development of precise, high-throughput analysis methods. This paper introduces a novel approach utilizing a weak measurement interface sensor for immunoassays, offering a solution for high throughput analysis. Weak measurement is a precise quantum measurement method that amplifies the weak value of a system in the weak interaction through appropriate pre- and post-selection states. To facilitate the simultaneous analysis of multiple samples, we have developed a chip with six flow channels capable of conducting six immunoassays concurrently. We can perform real-time immunoassay to determine the binding characteristics of spike protein and antibody through real-time analysis of the flow channel images and calculating the relative intensity. The proposed method boasts a simple structure, eliminating the need for intricate nano processes. The spike protein concentration and relative intensity curve were fitted using the Log-Log fitting regression equation, and R2was 0.91. Utilizing a pre-transformation approach to account for slight variations in detection sensitivity across different flow channels, the present method achieves an impressive limit of detection(LOD) of 0.85 ng/mL for the SARS-CoV-2 the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, with a system standard deviation of 5.61. Furthermore, this method has been successfully verified for monitoring molecular-specific binding processes and differentiating binding capacities.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
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IF 8.2
Sujing Wang,Na Zheng,Qirui An,Xiaoqian Li,Yining Ji,Yunyang Li,Changcheng Chen,Zhifei Xiu
The flame retardant tri (1, 3-dichloro-2-propyl) phosphate (TDCIPP) is widely present in environmental media and organisms. People have paid much attention to the growth and developmental toxicity of TDCIPP, but there is little information about its cardiotoxicity and potential mechanisms. In this study, marine medaka ( Oryzias melastigma ) embryos were exposed to TDCIPP solutions (0, 0.05, 0.5, 5, and 50 μg/L) for 21 days to investigate the adverse effects of TDCIPP on cardiac development. The results showed that TDCIPP exposure altered the heart rate at different stages of embryonic development. In addition, 50 μg/L TDCIPP resulted in increased sinus venosus (SV)–bulbus arteriosus (BA) distance, pericardial cysts, and cardiac linearization in newly hatched fish. During embryonic development, the expression level of key genes regulating cardiac development is disturbed. The early stage of cardiac development is the sensitive window period for the toxic effects of TDCIPP. Oxidative stress was observed in newly hatched juveniles, but no significant lipid peroxidation damage was observed. In addition, vitellogenin (VTG) levels in juvenile fish were significantly reduced. Our results show that TDCIPP exposure induces cardiotoxicity in marine medaka embryos, which is induced in the early stages and promotes heart defects by amplifying inflammatory responses at a later stage.
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Biomarker Research
·
2024
·Vol. 12
·期 1
·1-16
·
IF 9.5
Wang Zhen,Liu Zhongwen,Zhou Pan,Niu Xiaona,Sun Zhengdao,He Huan,Zhu Zunmin
Background Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner. Recent studies have suggested that krüppel-like transcription factor 2 (KLF2) is involved in the control of embryonic erythroid precursor cell differentiation and maturation. However, the function and mechanism of KLF2 in regulating megakaryocytic differentiation remain unclear. Methods The expression patterns of krüppel-like transcription factors (KLFs) during megakaryocytic differentiation were identified from public databases. Phorbol 12-myristate 13-acetate (PMA) treatment of the myeloid-erythroid-leukemic cell lines K562 and HEL were used as cellular megakaryocytic differentiation models. A lentiviral transduction system was utilized to achieve the goal of amplifying or reducing KLF2. The expression of KLF2 was examined using real-time PCR and western blot. The impact of KLF2 on the megakaryocytic differentiation of K562 cells was examined by flow cytometry, Giemsa staining, Phalloidin staining and western blot. RNA-sequencing (RNA-seq) and chromatin immunoprecipitation-sequencing (ChIP-seq) technologies were used to identify the KLF2-regulated targets. Results KLF2 is increased in the maturation process of megakaryocytes. KLF2 overexpression accelerated the PMA-induced megakaryocytic differentiation, as reflected by an increased percentage of CD41/CD61 cells, an increased number of polyploid cells, and an elevated expression of P21 and P27. KLF2 knockdown exhibited the opposite results, indicating that KLF2 knockdown suppressed the megakaryocytic differentiation. Further, combination of the RNA-seq and ChIP-seq results suggested that chimerin 1 (CHN1) and potassium voltage-gated channel subfamily Q member 5 (KCNQ5) may be target genes regulated of KLF2. Both CHN1 and KCNQ5 knockdown could block the megakaryocytic differentiation to some content. Conclusion This study implicated a regulatory role of KLF2 in megakaryocytic differentiation, which may suggest KLF2 as a target for illness with abnormal megakaryocytic differentiation.
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JOURNAL OF FOOD SCIENCE
·
2024
·
IF 3.2
Qian Du,Ruiyan Wang,Zeyuan Deng,Jianqun Zhou,Nan Li,Wenwen Li,Liufeng Zheng
Sucrose emerges as a chelating agent to form a stable sucrose-metal-ion chelate that can potentially improve metal-ion absorption. This study aimed to analyze the structure of sucrose-calcium chelate and its potential to promote calcium absorption in both Caco-2 monolayer cells and mice. The characterization results showed that calcium ions mainly chelated with hydroxyl groups in sucrose to produce sucrose-calcium chelate, altering the crystal structure of sucrose (forming polymer particles) and improving its thermal stability. Sucrose-calcium chelate dose dependently increased the amount of calcium uptake, retention, and transport in the Caco-2 monolayer cell model. Compared to CaCl 2 , there was a significant improvement in the proportion of absorbed calcium utilized for transport but not retention (93.13 ± 1.75% vs. 67.67 ± 7.55%). Further treatment of calcium channel inhibitors demonstrated the active transport of sucrose-calcium chelate through Cav1.3. Cellular thermal shift assay and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assays indicated that the ability of sucrose-calcium chelate to promote calcium transport was attributed to its superior ability to bind with PMCA1b, a calcium transporter located on the basement membrane, and stimulate its gene expression compared to CaCl 2 . Pharmacokinetic analysis of mice confirmed the calcium absorption-promoting effect of sucrose-calcium chelate, as evident by the higher serum calcium level (44.12 ± 1.90 mg/L vs. 37.42 ± 1.88 mmol/L) and intestinal PMCA1b gene expression than CaCl 2 . These findings offer a new understanding of how sucrose-calcium chelate enhances intestinal calcium absorption and could be used as an ingredient in functional foods to treat calcium deficiency. Practical Application The development of high-quality calcium supplements is crucial for addressing the various adverse symptoms associated with calcium deficiency. This study aimed to prepare a sucrose-calcium chelate and analyze its structure, as well as its potential to enhance calcium absorption in Caco-2 monolayer cells and mice. The results demonstrated that the sucrose-calcium chelate effectively promoted calcium absorption. Notably, its ability to enhance calcium transport was linked to its strong binding with PMCA1b, a calcium transporter located on the basement membrane, and its capacity to stimulate PMCA1b gene expression. These findings contribute to a deeper understanding of how the sucrose-calcium chelate enhances intestinal calcium absorption and suggest its potential use as an ingredient in functional foods for treating calcium deficiency.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Md G. Kabir,Zhiwen Tang,Xiqian Zhang,Frederic Coulon,Andreas Tiehm,Xin Song
6:2 Fluorotelomer sulfonate (6:2 FTS), an alternative for PFOS, has become an environmental concern due to its toxicity. This study investigated the aerobic biotransformation of 6:2 FTS under sulfur-limiting conditions using an enrichment culture, SXC01. The enriched culture achieved ≥99.5% degradation of 6:2 FTS at initial concentrations of 0.5, 2.5, and 5 mg/L within 14 days, with notable corresponding defluorination ratios of 77.2%, 28%, and 16.8%, respectively. Eleven transformation products were identified and quantified over time, and the accumulation of intermediate product 6:2 FTUCA suggested that its further degradation may represent a rate-limiting step. Furthermore, the production of PFHxA is more significant than that of PFBA, suggesting the transformation of 6:2 FTUCA via 5:2 sFTOH pathway is more dominant than the other proposed alternative pathway. Metatranscriptomic analysis revealed the upregulation of key genes associated with desulfonation (e.g., ssuEADCB cluster, cysI, sbp, iscS) and defluorination (e.g., ladA, dehH, crcB, dhaA), indicating a synergistic metabolic network driving 6:2 FTS biotransformation. Active genera identified included Brucella, Rhodococcus, and Pseudoclavibacter. Moreover, the predominant Brucella anthropi SX009 was successfully isolated and shown to completely degrade 6:2 FTS within 14 days. This study provides novel insights into the mechanisms of 6:2 FTS biotransformation.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Yang Wan,Jia Li,Xi Wu,Pan Wu,Lin Zhang
Bisphenol A (BPA), a well-recognized endocrine-disrupting chemical, is a significant environmental contaminant linked to various health disorders. Therefore, the development of rapid and sensitive BPA detection methods is essential for accurate monitoring in complex matrices. In this study, an electrochemical biosensor was constructed that synergistically combines the catalytic activity of laccase with the conductive properties of multi-walled carbon nanotubes (MWCNTs). Laccase was effectively immobilized within a Co 3 (PO 4 ) 2 -based hybrid nanoflower through biomimetic mineralization, forming a spatially confined catalytic system. Structural characterization of the nanoflowers revealed their spherical morphology with hierarchical porosity and an average diameter of 6 μm. The laccase@Co 3 (PO 4 ) 2 /MWCNTs nanocomposite-modified glassy carbon electrode demonstrated good catalytic performance for BPA oxidation, exhibiting high sensitivity (3.592 μA·μmol −1 L) and a low detection limit of 0.015 μM (S/N = 3)). Practical applications in analyzing commercial bottled water and plastic infant bottles confirmed the biosensor's reliability. This research presents an efficient and cost-effective approach for BPA risk assessment, contributing to the protection of public health.
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MOLECULAR BIOLOGY REPORTS
·
2025
·Vol. 52
·期 1
·1-14
·
IF 2.8
Liang Chen,Guo Liping,Tian Xinyan,Mu Zhidan,Chen Mingyang,Hu Yarong,Su Juan
Objective By establishing a mouse model of hepatic ischemia–reperfusion injury (HIRI), to investigate the effects of cyclooxygenase-2 (COX-2) and endoplasmic reticulum stress (ERS) on HIRI and their interaction in HIRI. Methods C57BL/6J male mice were divided into four groups: Sham operation group (Sham group), hepatic ischemia–reperfusion (HIR) group, hepatic ischemia–reperfusion + Salubrinal (ER stress inhibitor) pretreatment group (HIR + Sal group), hepatic ischemia–reperfusion + NS398 (inhibitor of COX-2) pretreatment group (HIR + NS398 group). The levels of Aspartate transaminase (AST) and Alanine transaminase (ALT) in serum, the activity of Super Oxide Dismutase (SOD) and the content of malondialdehyde (MDA) in liver tissue were detected. The mRNA and protein expression of Glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), phosphorylated eukaryotic translation initiation factor 2α (p-eIF2α) and COX-2/PTGS (Prostaglandin-endoperoxide synthase) in liver tissue were detected. The morphological changes and apoptosis of liver tissue were observed. Results Compared with the Sham group, the serum ALT and AST levels of the HIR group were increased, the SOD activity in the liver tissue was decreased, the MDA content and the expression of COX-2, p-eIF2α, GRP78 and CHOP protein were increased, and the staining results showed that hepatic sinusoidal congestion, a large number of hepatocyte death, inflammatory cell infiltration and apoptotic cells were significantly increased. The levels of ALT and AST decreased after Sal or NS398 pretreatment. SOD activity was increased, MDA content, COX-2, GRP78, CHOP mRNA and protein were decreased in liver tissue, and staining showed that liver tissue injury was improved. Conclusion In mice with HIR, COX-2 interacts with ERS to cause liver injury by regulating oxidative stress and apoptosis.
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ATMOSPHERIC ENVIRONMENT
·
2025
·
IF 3.7
Yixuan An,Lingdong Kong,Beibei Liu,Jiandong Shen,Yu Lu,Yuwen Wang,Jie Tan,Lin Wang
The heterogeneous conversion of SO 2 plays a crucial role in atmospheric sulfate formation. In recent years, it has been recognized that light-absorbing brown carbon can generate reactive oxygen species and enhance the oxidative capacity of the atmosphere. However, the influence of atmospheric brown carbon on the heterogeneous conversion of SO 2 on mineral oxide surfaces has not yet achieved sufficient attention. In this study, the impact of imidazole-2-carboxaldehyde (2-IC), a ubiquitous atmospheric brown carbon, on the heterogeneous conversion of SO 2 on hematite particle surfaces was investigated in the absence and presence of simulated solar irradiation by using in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS). Results indicated that 2-IC can significantly influence the heterogeneous reactivities of hematite. Under dry conditions, the heterogeneous reactivities decreased with the increase of the loaded 2-IC mass fraction in the absence of light, but in the presence of light, the higher reactivities were observed at an appropriate mass fraction range of 2-IC when compared to pure hematite, showing the promoting effects in this mass fraction range. Under the condition of 58% relative humidity, the heterogeneous reactivities in the absence of light decreased with the increasing mass fractions of 2-IC, and pure hematite showed the highest reactivity. However, in the presence of light, the heterogeneous reactivities increased first and then decreased with the increasing mass fractions of 2-IC, and the mixture containing 1×10 -4 % 2-IC showed the highest reactivity. Water molecules can renew surface reactive sites and facilitate the photosensitization reaction of 2-IC, and further enhance sulfate formation. A possible mechanism for the impact of 2-IC on the heterogeneous conversion of SO 2 on hematite is proposed. This study reveals a new pathway for brown carbon to enhance SO 2 conversion and sulfate formation in the atmosphere, providing new insights into its atmospheric impact.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Mengnan Xu,Mingjie Xia,Lina Yang,Hong Song,Jinxin Li,Hongliang Fan,He Liu
This study investigated the effect of particle size on the hypoglycaemic activity of polysaccharide nanomicelles. Different sizes of soy hull polysaccharide (SHP) nanomicelles were prepared through sonication-assisted self-assembly. These nanomicelles were characterized through nanoparticle sizing, dynamic light scattering, Fourier-transform infrared spectroscopy, X-ray diffraction, atomic force microscopy and thermal analysis. The particle size of SHP nanomicelles first decreased and then increased with an increase in ultrasonic powers. At an ultrasonic power of 90 W, the particle size and polydispersity index decreased to 202.17 nm and 0.1056, respectively. The characteristic peaks corresponding to the stretching vibrations of the O H and C H bonds showed broadening in the range of 3600–3200 cm −1 for the sonicated SHP nanomicelles. Hydrogen bonding interactions were significantly strengthened in the sonicated micelles, increasing their intermolecular cohesion. The sonicated nanomicelles exhibited enhanced thermal stability. The survival rate of HepG2 cells was above 95 % after 48 h of incubation with 1.0 mg/mL of SHP nanomicelles, indicating that the nanomicelles were non-cytotoxic and cytocompatible. The hypoglycaemic effect of the SHP nanomicelles was evaluated using a type 2 diabetes zebrafish model. Treatment with SHP nanomicelles prepared at an ultrasonic power of 60 W significantly reduced the levels of glucose, triglycerides, total cholesterol and low-density lipoprotein cholesterol. In conclusion, SHP nanomicelles have the potential to be used as glucose-lowering therapeutics.
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危险品化学品经营许可证（带存储）