Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Wu Chunfei,Bi Chuanlin,Kim Geun-soo,Yang Zizhen,Li Shuao,Dai Tong,Wu Xiaoyu,Tan Jiaojiao,He Ningning,Li Shangyong
Tofacitinib (Tof), a commercially available pan-Janus kinases inhibitor, is approved for the treatment of moderate to severe ulcerative colitis. However, its clinical application is limited due to dose-dependent systemic side effects. The present study aims to develop an efficient oral colon-targeted drug delivery systems using prebiotic pectin (Pcn) and chitosan (Csn) polysaccharides as a shell, with Tof loaded into a Bovine Serum Albumin (BSA) core, and improving it with chondroitin sulfate (Chs), thu s constructing Tof@BSA-Chs-CP nanoparticles (NPs). Our results suggest that th e pH-sensitive characteristics of the Pcn/Csn shell contribute to its capacity for attenuating absorption and systemic diffusion in the gastrointestinal tract, and exhibiting targeted localization at inflamed colonic sites in mice. Additionally, the gut microbiota-secreted polysaccharide-degrading enzyme acts as the triggering agent for Pcn/Csn shell degradation. In mice colitis models, we demonstrated that oral administration of Tof@BSA-Chs-CP NPs effectively ameliorated colitis and expedited its resolution by modulating the expression of pro-inflammatory cytokines and immune regulatory factors. Collectively, our synthetic NPs demonstrate the promising potential of Tof for the therapy of UC.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Qing Li,Xiaomin Lai,Yun Duan,Fuchen Jiang,Yingxi Li,Zhen Huang,Shuang Liu,Ying Wang,Can Jiang,Chen Zhang,Xiaoli Pan
Extensive traumatic injuries and difficult-to-heal wounds, induced by many circumstances, impose a significant social and economic burden on an annual basis. Thus, innovative wound dressings that encourage wound healing are greatly needed. In this work, we prepared a novel insect chitosan (MCS) using waste pupal shells from housefly ( Musca domestica L.) culture. After conducting comparative investigations with commercially available chitosan, it was shown that MCS exhibited comparable qualities and may be used as a substitute source of commercial chitosan. A quaternized chitosan/pullulan/citric acid three-dimensional nanofiber sponge (3D-NS) of natural origin was prepared by electrostatic spinning and gas foaming techniques after MCS was quaternized. In vitro , tests showed that the 3D-NS had a higher liquid absorption capacity than the two-dimensional nanofibrous membrane (2D-NM). Additionally, the 3D-NS showed improved hemostatic, pro-cell proliferation, antibacterial, and anti-inflammatory qualities. In vitro , tests demonstrated that 3D-NS could inhibit the release of inflammatory factors, promote angiogenesis, accelerate collagen deposition, and promote wound contraction. These effects considerably facilitated the healing process of wounds in rats with full-thickness skin damage. In conclusion, the great bioactivity and physicochemical properties of 3D-NS render it an optimal candidate for developing novel wound dressings.
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FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Mingxia Wang,Yaqian Li,Yuxuan Zhao,Huiling Gao,Zhaochu Xu,Liang Chen,Jianzhang Liu,Hao Liang
As a typical biofilm disease, dental caries is a public healthcare problem and high sugar diets increase the risk of dental caries. Cationic nanomaterials play an important role in targeting and removing of biofilms, but their negative effects on normal cells have always caused widespread concern. In this work, pH-triggered charge-switching nanoparticles (SC&CS NPs) with selectable targeting were skillfully constructed by electrostatic adsorption and chemical cross-linking of sodium caseinate (SC) and chitosan (CS) to develop functional foods. SC&CS NPs were negatively charged and stable at pH 7.4. Once encountering in acidic microenvironment below pH 5.7, the potential of SC&CS NPs converted to positive. Based on this property, SC&CS NPs could identify the infected sites of biofilms to selectively target bacteria, while not interacting with cells in the normal physiological environment, thereby avoiding damage to normal cells. Besides, SC&CS NPs were excellent delivery systems that could effectively encapsulate bioactive ingredients with high loading efficiency (12.16 ± 0.04%) and release bioactive ingredients on demand. Moreover, after being encapsulated by SC&CS NPs, the antibacterial and anti-biofilm activities of bioactive ingredients were significantly improved. The charge-switching nanomaterials are expected to provide a safer, more effective, and smarter strategy for functional foods.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Gaoyi Wu,Wei Shi,Moran Liu,Lixin Liang,Tao Wang,Jinyong Zhang,Jing Chen,Yongsheng Liang,Wei Tang,Hui Li
Hydrogels have emerged as promising candidates for flexible sensors due to their softness, biocompatibility, and tunable physicochemical properties. However, achieving synchronous satisfaction of conformality, conductivity, and diverse biological functions in hydrogel sensors remains a challenge. Here, we proposed a multifunctional hydrogel sensor by incorporating silver-loaded polydopamine nanoparticles (Ag@PDA) into a thermally cross-linked methacrylamide chitosan (CSMA) and acrylamide network, namely, Ag@PDA/(CSMA-PAM). The Ag@PDA/(CSMA-PAM) hydrogel showed the capability to respond effectively to both strain and pressure, enabling its independent application as either a strain sensor or a pressure sensor. The sensitivity of the hydrogel can reach 2.13 within the strain range of 65 to 150%, exhibiting a response and recovery time of 550 ms when utilized as a strain sensor. In contrast, its sensitivity was 0.07 kPa–1 during pressures ranging from 0 to 2.15 kPa, with a response and recovery time of 136 ms when employed as a pressure sensor. Additionally, the hydrogel sensor demonstrated high linearity (0.998 for strain and 0.98 for pressure), stable cycling ability (500 cycles), and low detection limit (0.5% for strain and 150 Pa for pressure). Moreover, the Ag@PDA/(CSMA-PAM) hydrogel exhibited good stability and reliability for a variety of practical applications, including the detection of subtle and large deformations, as well as real-time physiological activity monitoring. Further, owing to the bioactive components of chitosan and Ag@PDA present in the hydrogel, the Ag@PDA/(CSMA-PAM) sensor exhibited satisfactory biocompatibility along with excellent antioxidant and antibacterial activities, making it highly promising for applications as wearable sensors in personalized healthcare.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Mingxiu Long,Hui Wang,Yongfu Li,Zhaojun Chen,Zhilong Zeng,Jingwen Luo,Xizhu Tian,Fang Zhang,Xiong Liu
This research explores the development of a polysaccharide-based nanogel by modifying chitosan (Cs) and konjac glucomannan (KGM). By introducing acyl groups, the water solubility of Cs was improved, while irradiation treatment and carboxymethylation modified the molecular weight distribution and viscosity of KGM, enhancing their suitability in nanogel formulations. The nanogel synthesis was optimized, the L ACs/CKGM8 nanogel (1:1) exhibited a positive surface charge, smaller and more uniform particle size, low aggregation, and high yield. Moreover, the inclusion of Rosa roxburghii Tratt polyphenols (RP) reduced the particle size and improved the structural integrity of nanogel (NG). The RP-loaded NG exhibited excellent encapsulation efficiency (EE) of 76.64% and a loading capacity (LC) of 56.99% for RP. The controlled RP release in simulated gastrointestinal conditions suggests these nanogels may improve oral polyphenol delivery system performance.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Haiyu Luo,Danyang Liang,Qing Liu,Li Niu,Khamiddolov Temirlan,Wenhao Li
Chitosan is used in food, medicine, and other fields because of its good biocompatibility, but its solubility restricts its application, and modification treatment can reduce the stability to improve its solubility in different pH solutions. This study investigated the effects of electron beam irradiation (EBI), cold plasma (CP), and their dual modification treatments on the structural, physicochemical, and functional properties of chitosan. The results showed that single EBI, CP treatment, and dual modification treatment did not significantly change the morphological structure of chitosan. Among them, the viscosity and thermal stability of single EBI- and CP-modified chitosan was reduced. Still, the antioxidant and antibacterial properties against Staphylococcus aureus and Escherichia coli were enhanced compared to native chitosan. Meanwhile, the viscosity, molecular weight, and thermal stability of dual-modified treated chitosan were further reduced, and the antioxidant and antibacterial properties were significantly improved compared to EBI and CP modification alone. This study shows that dual modification's effect was better than that of single modification treatment, especially single cold plasma treatment. This will also lead to the diversification of chitosan modification methods and promote its application in various aspects, such as preservation, food additives, functional food ingredients, and packaging materials.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2019
·
IF 1.479
Jialiang Chen,Lirong Fu,Yan Li,Xiaodeng Yang,Beibei Wang,Chunlin Xu,Tianduo Li
To illuminate the interactions in N-[(2-hydroxyl)-propyl-3-trimethyl ammonium] chitosan chloride (HTCC)/sodium carboxymethyl cellulose (CMC) based films, the film-forming solutions were studied by rheology, and HTCC/CMC based films were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis. The HTCC/CMC based film-forming solutions with glycerol (polyvinyl alcohol (PVA) and anthocyanin) showed shear-thinning behavior. The apparent viscosity of the HTCC/CMC/glycerol (PVA and anthocyanin) film-forming solutions decreased slower than that of HTCC/CMC film-forming solution, due to the electrostatic interaction between HTCC and CMC, and hydrogen bonding interaction between the two biomacromolecules and glycerol, PVA and anthocyanin, which resulted in the formation of three-dimensional networks. The anthocyanin with rigid molecular structure formed different three-dimensional matrix with HTCC/CMC, resulted in viscosity dominated film-forming solution. The pH affected the electrostatic interaction between HTCC, CMC, and anthocyanin through neutralizing –COO− groups, and temperature showed a synergistic effect on both electrostatic interaction and hydrogen bonding. The inter-molecular interactions resulted in the red-shift of typical absorption peaks, and the increase of initial decomposition temperature and decomposition enthalpy of HTCC/CMC based films. The homogenous and smooth surface, and the compact texture of HTCC/CMC based films confirmed the intermolecular interaction between HTCC, CMC, and PVA (glycerol and anthocyanin).
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JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Guo Shanshan,Li Hua
Diabetes, particularly Type 2 Diabetes Mellitus (T 2 DM), is a chronic metabolic disorder with high and increasing global prevalence, characterized by insulin resistance and inadequate insulin secretion. Despite advancements in novel drug delivery systems, widespread and systematic treatment of advanced glycation end products (AGEs) remains challenging due to issues like drug toxicity, low water solubility, and uncontrolled release. Thus, developing nanoplatforms with controlled release capabilities has become a major research focus. Due to its excellent biocompatibility and drug delivery properties, chitosan has attracted considerable attention as a typical biopolymer. In this study, we designed and synthesized an intelligent fluorescence-pH sensitive nanopolymer material using chitosan. We loaded drug 1 and chromium phthalocyanine (CrPc) into folic acid-conjugated carboxymethyl chitosan (FA-CMCS) nanocarriers, forming FA-CMCS@1-CrPc. Comprehensive characterization of FA-CMCS@1-CrPc was conducted using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and gas adsorption analysis (BET). The results indicate that the nanomaterial was successfully synthesized and exhibits excellent specific surface area, biocompatibility, and fluorescence response. Further research revealed that FA-CMCS@1-CrPc not only achieved controlled drug release but also could regulate drug release by adjusting pH. Additionally, due to its strong fluorescence performance, the nanomaterial demonstrated higher detection sensitivity, especially for monitoring the release of 5% trace drugs. An in vitro model of insulin-resistant cells was established to evaluate the effects of the drug delivery system on glucose degradation and AGE-RAGE regulation, providing a foundation for the development of new T 2 DM drugs. Graphical Abstract
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Foods
·
2022
·Vol. 11
·期 9
·1360
·
IF 5.561
Zhiguo Jiang,Jiaolong Wang,Dong Xiang,Zhengke Zhang
In the present study, p-hydroxybenzoic acid-grafted chitosan (PA-g-CS) conjugates with different grafting degrees were synthesized by a free radical-regulated grafting approach. The conjugates were further developed into films by casting, and their characteristics and preservative effects on fresh-cut jackfruit were evaluated. Compared to the CS film, the PA-g-CS film showed comprehensive performance improvements, including enhancements of water solubility, anti-ultraviolet capacity, antioxidation, and antibacterial activity. Moreover, compared with CS film, some appreciable and favorable changes of physical properties were observed in the PA-g-CS films, which included water vapor permeability, oxygen permeability, surface morphology, moisture content, and mechanical intensity. Furthermore, compared to CS alone, the application of PA-g-CS films to fresh-cut jackfruit exerted a beneficial effect on the quality of products, as indicated by the inhibition of weight loss, softening, and membrane damage, the maintenance of soluble solids and ascorbic acids contents, as well as a reduced bacterial count and a higher sensory score. Among these PA-g-CS films, the best preservation effect was achieved with the highest degree of grafting (PA-g-CS III). The results suggested that the PA-g-CS film has the potential to be explored as a new type of packaging material for the preservation of fresh-cut fruits and vegetables.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Yini Liu,Debao Wang,Zhilan Sun,Fang Liu,Lihui Du,Daoying Wang
In this study, antibacterial nanofiber films were prepared by electrospinning gelatin, chitosan, and 3-phenyllactic acid (PLA). The addition of PLA improved the microstructures of the nanofibers, and the nanofiber films (GCP-1 and GCP-2) had uniform and continuous structures with a diameter range of 40‐–70 nm when the PLA concentrations in the polymers were 1% and 2%. Under acidic conditions, chitosan and PLA interacted and formed hydrogen bonds , which decreased the crystallinity of the nanofiber films. The GCP-2 nanofiber film had the best thermal stability , water stability, and water vapor permeability. Compared with the control GCP-0 film, the four nanofiber films with PLA (GCP-1, GCP-2, GCP-3, and GCP-4) had more effective antibacterial effects, and GCP-2 film reduced approximately 4 log CFU/mL of Salmonella enterica Enteritidis and Staphylococcus aureus in 30 min. Results suggested that the GCP-2 nanofiber film mat can be used as an active food packaging.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
He Meng,Wenyan Ye,Chunlei Wang,Zeyu Gao,Bingxuan Hu,Caiqi Wang
Hydrogels constructed by traditional polymer networks usually have poor mechanical properties limiting their applications. Here, we proposed a new strategy for ionic interaction modulation of crystalline micro-nanoparticles (CMNPs) to enhance the mechanical properties of polyacrylamide hydrogels. CMNPs were formed via confinement assembly under an aggregated state based on host-guest interactions between chitosan-grafted polyethylene glycol (CS-PEG) and γ-cyclodextrin (γ-CD). Furthermore, the aggregation behavior of the CMNPs was achieved based on the ionic interaction of CS with citrate (Cit 3− ). These Cit 3− -regulated CMNPs were introduced into PAM hydrogels. The modulus (618.44 kPa, 67.6 times), fracture stress (1054.59 kPa, 25.3 times), and toughness (6.23 MJ m −3 , 41.7 times) of the composite hydrogels were greatly improved without affecting the tensile properties (fracture strain, ~1000 %). Finally, we further designed a strain sensor that could monitor human motion, and we verified its potential application in the field of wearable flexible electronics.
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ENVIRONMENTAL RESEARCH
·
2023
·
IF 8.3
Lucheng Li,Jie Ni,Zehua Zhu,Xiaojun Zuo
A novel Mg-loaded chitosan carbonized microsphere (MCCM) was prepared for simultaneous adsorption of ammonium and phosphate in this study, through the investigation of preparation procedures, addition ratio, and preparation temperature. Pollutants removals by MCCM were more acceptable with 64.71% for ammonium and 99.26% for phosphorus, compared with chitosan carbonized microspheres (CCM), Mg-loaded chitosan hydrogel beads (MCH) and MgCl 2 ·6H 2 O. Addition ratio of 0.6:1 (m chitosan : m MgCl2 ) and preparation temperature of 400 °C in MCCM preparation were responsible for pollutant removal and yield. The effect analysis of MCCM dosage, solution pH, pollutant concentration , adsorption mode and coexisting ions on the removal for both ammonium and phosphate indicated that pollutants removals were increased with increasing MCCM dosages, and achieved the peak at pH 8.5, but presented to be stable with Na + , K + , Ca 2+ , Cl − , NO 3 − , CO 3 2− and SO 4 2− , except for Fe 3+ .Adsorption mechanisms discussion implied that simultaneous ammonium and phosphate removal with MCCM was attributed to struvite precipitation, ion exchange, hydrogen bonding, electrostatic attraction and Mg–P complexation, suggesting that MCCM presents a new way for simultaneous concentrated ammonium and phosphate removal in wastewater treatment .
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