INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yijin Wu,Shaofeng Wang,Hui Huang,Jingling Yu,Jieren Liang,Hai Huang,Jianying Guo,Zhaoxin Tang,Jianzhao Liao
Background With the increasing application of copper nanoparticles (CuNPs) across various fields, its toxicity and hazards are gradually being confirmed. Hesperidin (Hes), a flavonoid compound with extensive antioxidant and anti-inflammatory effects, has recently attracted public attention. Methods Molecular docking was employed to investigate the potential binding sites between Hes and SIRT3. The activation of the SIRT3-FOXO3A signaling pathway by Hes was further validated through a series of experiments in vitro and vivo. Results The results indicate that exposure to CuNPs can cause pathological damage to liver. Compared with the control group, exposure to CuNPs induced the accumulation of reactive oxygen species and mitochondrial UPR mt in broiler liver, specifically manifested as an increase in reactive oxygen species and the gene and protein levels of UPR mt related proteins. The molecular docking results indicate that Hes and SIRT3 have potential binding sites. However, after treatment with Hes, pathological damage in liver was alleviated. At the same time, we found that the SIRT3-FOXO3A signaling pathway was activated, leading to a significant decrease in the expression levels of proteins and genes related to UPR mt . Conclusion Hes can ameliorate hepatic oxidative damage and UPR mt induced by exposure to CuNPs by activating the SIRT3-FOXO3A pathway.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Hongyu Wang,Tao Wang,Gonghao Li,Bo Wu,Ruijun Gao
Balancing increased recoverable strain with high phase transformation temperature is crucial for Cu-Al-Mn SMAs to cost-effectively overcome the service temperature limitation (<100°C) of NiTi-based SMAs. This study fabricated four types of Cu-12.5Al-3Mn SMAs modified with nano-Al₂O₃ p (0, 0.5, 1.0, and 1.5 wt%) using wire arc additive manufacturing (WAAM) with cored wires. It investigated the effects of nano-Al₂O₃ p on shape memory properties, exploring mechanisms via microstructural, phase, and hardness analysis. Results show that adding an appropriate amount of nano-Al₂O₃ p significantly enhances memory performance while maintaining high martensite transformation temperatures. The 0.5 wt% nano-Al₂O₃ p modified alloy exhibited optimal properties: a shape recovery rate of 87.77 % (13.8 % higher than the base alloy) and a recoverable strain of 7.02 % (>40 % higher than the commonly reported 5 %) under 8 % bending pre-strain. Its Ms temperature remained above 100°C (As, Af, Mf were largely unchanged), and full recovery time was halved compared to the unmodified alloy. The enhancement is attributed to nano-Al₂O₃ p strengthening the parent phase and improving thermoelastic martensite order via pinning. Their high stability under WAAM's high-energy heat source minimizes impact on alloy composition, while dispersed particles create lattice distortion and stress fields, reducing the energy barrier for martensitic transformation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Bingxin Sun,Shuping Peng,Zihao Zhang,Weifan Dai,Jiaxiang Wu,Guoyong Wang,Cijun Shuai
Postoperative management of tumorous bone defects remains a formidable clinical challenge due to the persistence of residual malignant cells and substantial bone loss following tumor resection. To overcome this critical issue, an intelligent bifunctional scaffold was engineered through the strategic integration of SrCuSi 4 O 10 nanosheets (SC NSs) into 3D-printed poly (L-lactic acid) (PLLA) scaffold via selective laser sintering technology. This PLLA/SC scaffold achieves a sequential therapeutic mode that coordinates residual tumor eradication with subsequent bone regeneration through stage-specific mechanisms. During the primary therapeutic phase, the integrated SC NSs demonstrate exceptional photothermal conversion efficiency (η = 27.7%), enabling precise hyperthermia-mediated apoptosis of residual tumor cells under near infrared light II region irradiation. Following oncological clearance, the scaffold transitions to osteogenic promotion through sustained ion release kinetics, where strontium and silicate ions synergistically enhance osteoblast differentiation while copper (Cu 2+ ) ions stimulate angiogenic factor secretion. This sequential therapeutic strategy achieved remarkable tumor suppression coupled with substantial bone matrix deposition in Vitro models. This work presents a promising approach for reconstructing tumorous bone defects through multifunctional bio-scaffold engineering.
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ANALYTICA CHIMICA ACTA
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2025
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IF 6
Zhongyou Jiang,Shanshan Dong,Dingying He,Jiazheng Yang,Suqing Dai,Shuaitao Peng,Suhua Chen
Bonded nitrogen of lone pair electrons gives a chance for carbon-based substrates to complex with and consequently electrochemically analyze heavy metals, e.g., cadmium(II) (Cd(II)). However, the carbon atom bonded with nitrogen atom present positively charged and could electrostatically hinder Cd(II) adsorption, leading to a limited electroanalytical sensitivity. In this study, we adopted a sequential iron occupying and nitric acid etching strategy to elongate C–N bond in graphitic carbon nitride (CN), which could weaken the energy barrier for Cd(II) adsorption. Material characterizations show the iron occupying and nitric acid etching strategy successfully elongated C–N bond without damaging the skeletal structure of CN and significantly enhanced Cd(II) adsorption capacity. Experiments combined with first principle calculations verified the efficient and sensitive binding of Cd(II) with nitrogen in the elongated C–N. As a result, in comparison with pristine CN, the C–N elongated material (marked as EtCN–Fe 0.3 ) possessed a much higher sensitivity (22.34 vs. 16.92 μA ppb −1 cm −2 ) and a dramatically lower limit of detection (LOD) (0.29 vs. 2.22 ppb). The sensor demonstrates a broad linear range (1−500 ppb), exceptional reproducibility (relative standard deviation = 1.4 %), and long-term stability (only 1.1 % of sensitivity loss over 10 days). EtCN–Fe 0.3 electrode even showed high recovery rates (98.2−102.4 %) in various real waters, which were in agreement with Inductively coupled plasma-mass spectrometry (ICP-MS)/Atomic absorption spectrophotometry (AAS) methods. This study provides a facile strategy to activate carbon materials to electrochemically detect trace heavy metals with precision and cost-effectiveness.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
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IF 6.3
Xiangdong Ma,Shan Yue,Rui Liu,Hui Kan,Jiayi Gao,Mingjing Zhao,Haijiao Xie,Xiaohong Xia
Electrocatalytic oxidation of 5-hydroxymethylfurfural (HMFOR) is an effective way to realize the upgrading of high value-added chemicals coupled with electrolytic water to produce hydrogen under green conditions. However, the oxygen evolution reaction competition of the anodic water decomposition of HMFOR electrocatalysts at high current densities hinders the production efficiency of 2, 5-furan dicarboxylic acid (FDCA). Although Cu has excellent electrical conductivity and small molecule affinity, it does not perform well in OER. The catalytic activities of Co and Ni in the electrochemical oxidation of small organic molecules and OER were significant. By optimizing the electronic structure and morphology of Cu, Co, and Ni, the competitive reaction of OER can be effectively inhibited, and the catalytic efficiency of HER can be strengthened. Then, we have successfully constructed a micro-Ni-doped Co phosphide grown on Cu foam (Ni m CoP/CF) with an optimized interfacial structure for adsorption and conversion of reactants. At 1.43 V vs. RHE, Ni m CoP/CF achieves high current density (100 mA cm -2 ) and selectivity for FDCA. The Co site at Ni optimized interface was identified as the catalytic center for OH⁎ adsorption by electrochemical tests and Density Functional Theory calculations, and the synergistic adsorption between Ni-doped Co 2 P and Cu 3 P interfaces greatly enhanced the adsorption of HMF, further promoting the catalytic conversion of HMF to FDCA. This work has guiding significance for the selective upgrading of high value-added chemicals hydrogen evolution through interfacial regulatory strategies for micro-metal doping.
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TALANTA
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2025
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IF 6.1
Sen Wang,Yao Meng,Ruoyu Liu,Jian Wang,De-Wen Zhang
The light-addressable electrochemical sensor (LAES) enables spatially resolved electrochemical measurements without the need for physical interconnects and fixed electrode geometries. However, current LAES constructions predominantly rely on rigid inorganic semiconductors, limiting their compatibility with flexible electronics. Herein, we present a novel LAES platform based on the organic semiconductor poly(1,3,5-triethynylbenzene) (PTEB), synthesized via a mild copper-catalyzed Glaser coupling reaction. The resulting PTEB film exhibits an interconnected porous network morphology and a direct bandgap of 2.15 eV, along with strong photoelectrochemical responsiveness, high pH sensitivity, and microscale imaging resolution. Particularly, PTEB films deposited on conductive polyester substrates retained 95 % of their photocurrent response under mechanical bending, underscoring excellent mechanical stability. This work addresses key limitations of conventional inorganic semiconductor-based LAES and provides a promising material platform for the development of next-generation flexible and wearable LAES devices.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Tingting Hu,Haimei Zeng,Hao Peng,Guanchao Yin,Jihong Zhang,Jun Xie,Yang Jiang
With the increasing discharge of pollutants into air, water, and soil, the rapid and sensitive detection and treatment of chemical pollutants, including toxic organic dyes and heavy metal ions, have become critical for minimizing potential threats to the ecological cycle and human health. In the current research, an in-situ degradation approach for toxic substances is proposed, combined with surface-enhanced Raman scattering (SERS). Fiber probes based on a silver nanoparticles/ silver phosphate tetrapod (Ag/ Ag 3 PO 4 ) composite were fabricated using a sequence of ion exchange, chemical reduction, and subsequent coating processes. The fiber probes were deployed for ultra-sensitive SERS detection and in situ photocatalytic degradation of dyes (specifically crystal violet (CV)) and heavy metal ions (particularly Hg 2+ ). The probes were functionalized with 4-mercaptopyridine (4-MPY) to facilitate the detection of Hg 2+ . Notably, the probes demonstrated detection limits as low as 10 −14 M for crystal violet (CV) and 4-aminothiophenol (PATP), and 10 −12 M of Hg 2+ . Under light exposure, the substrate degraded 93.2 % of CV and 98.0 % of PATP within 60 min, and 82.3 % of Hg 2+ within 30 min, as monitored in situs. Finite element method analysis suggested that the high electromagnetic field intensity generated by Ag/ Ag 3 PO 4 resulted from the close packing of Ag nanoparticles. Furthermore, the SERS fiber probes exhibited outstanding stability, selectivity, and reusability. This research suggest that the recyclable Ag/ Ag 3 PO 4 fiber probes hold significant potential for the detection and in situ monitoring of the degradation of trace environmental contaminants.
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ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Jiaqi Zhu,Guoli Zhang,Lu Lin,Tong Qiu,Wenchao Fu,Fengzhi Liu,Baihua Qu,Dianxiao Jiang,Xiaopeng Lu,Yu Song,Xiao-Xia Liu,Xiaoyuan Zhou,Xiaoqi Sun
Rechargeable Mg batteries have gained great interest thanks to the abundant resources and high theoretical capacity of Mg metal anode. However, it suffers from severe passivation and extremely poor plating/stripping kinetics. Herein, a simple salt electrolyte system of Mg(OTf) 2 /MgCl 2 -DME is studied, and the poor Mg affinities on typical metal current collectors are revealed as the key factor for rapid cell failure. Accordingly, an interphase modification on Cu current collector by the in situ generation of a magnesiophilic Cu-thiourea (CuTU) complex is presented. It provides active sites for solvated Mg 2+ as well as Mg. This not only homogenizes Mg 2+ flux but also helps with the release of solvated species to lower the desolvation barrier. The high affinity with Mg further enables the dense and uniform growth of Mg deposits. Thanks to these merits, the facile and reversible plating/stripping of Mg is realized. As a result, the symmetric cells with Mg pre-deposited on CuTU-Cu electrodes stably operate for over 2600 h, which is a 34-fold increase in comparison to the standard Mg foil. Full cells coupling the Mg-CuTU-Cu anode and a PDI-EDA cathode with an N/P ratio of 3 deliver a high capacity of 251 mAh g −1 as well as stable cycling.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Huiling Huang,Xi Lin,Wenwen Li,Fuzhen Liu,Jing Gao
Haematococcus pluvialis ( H. pluvialis) is rich in bioactive compounds. Traditional microemulsions (ME) can efficiently solubilize multipolar constituents, while fail to separate target products. In this study, a novel microemulsion (ME) composed of ionic liquid-based deep eutectic solvents (DES) was developed for multi-component extraction from H. pluvialis . The ME exhibited temperature-responsive UCST behavior, forming stable nanoparticles at 30 °C and demulsifying at 4 °C due to weakened intermolecular interactions and enhanced hydration effects at lower temperatures. Microstructure analysis revealed bicontinuous ME optimized co-extraction of hydrophobic and hydrophilic compounds. As compared with IL-based ME and conventional solvents, DES-ME achieved higher extraction efficiencies (carotenoids: 111.3 mg/g, lipids: 313.6 mg/g, proteins: 150.1 mg/g, carbohydrates: 26.98 mg/g). Post-extraction, cooling-enabled demulsification facilitated selective separation: carotenoids and lipids partitioned into the DES-rich phase (logK >0) due to strong CH-π/O interactions, while proteins migrated to the water-rich phase. DES-based ME significantly enhanced storage stability, delaying carotenoid degradation by encapsulating pigments in hydrophobic cores (ΔE = 7.89 vs. 9.71 for IL-based ME). The extract exhibited potent bioactivity of DPPH scavenging >95 % and exceptional antimicrobial effects against E. coli . Environmental assessment (GAPI score: 88) confirmed low toxicity, recyclability, and energy efficiency, positioning DES-based ME as a sustainable, high-performance alternative for extraction applications.
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RSC Advances
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2025
·Vol. 15
·期 37
·30456-30465
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IF 4.6
Jiangpeng Tang,Chang-ye Hui,Shunyu Hu,Wanyan Wu,Peishuo Cao,Jingwen Ling,Xueqin Yang,Zhenlie Huang,Yan Guo
Rapid, low-cost trace inorganic Hg(II) detection in environmental waters remains a critical public-health challenge. Here, we engineered Escherichia coli into a naked-eye whole-cell biosensor by coupling a redesigned MerR-Pmer element to the pyomelanin biosynthetic pathway. Three 4-hydroxyphenylpyruvate dioxygenase (HppD) homologs from Aeromonas media WS, Aeromonas hydrophila 4AK4, and Pseudomonas aeruginosa PAO1 were codon-optimized and functionally screened. The sensor strain of TOP10/pHg-PAO1 exhibited the broadest quantitative range (4.9–1250 nM) and the lowest detection limit (1.2 nM), outperforming most fluorescent counterparts. The water-soluble red-brown pyomelanin product was measured directly in the culture supernatants by absorbance at 400 nm, without requiring extraction. It remained chromogenically stable for at least 14 hours. The biosensor demonstrated absolute selectivity for Hg(II) in the presence of other ions, including Mg(II), Ca(II), Cd(II), Mn(II), Cu(II), Pb(II), and Zn(II), all at a concentration of 5 μM. It retained quantitative accuracy in tap, lake, and coastal seawater matrices. These features enable on-site, equipment-free screening of environmental waters and establish pyomelanin as a robust, user-friendly chromogenic reporter for next-generation whole-cell sensors.
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ChemistrySelect
·
2025
·Vol. 10
·期 30
·e06084
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IF 2
Jiajun Cheng,Kaixuan Teng,Yao Chen,Yunfan Chen,Xinyue Zhang,Guo Tang,Shaohua You,Long Wang,Sufang Guo,Qi An,Zeguo Feng
Graphical A ready-to-use collagen triboelectric nanogenerator (TENG) wound dressing system has been developed. The electric field generated by the TENG promotes the release of the analgesic drug from the collagen patch to achieve rapid pain relief. This system provides stable electrical stimulation output and its low cost and portability also offer an effective strategy for emergency on-site applications. Healing of exposed wounds is a key process in the repair of skin injuries and is crucial to prevent infection, maintain fluid balance, and promote tissue regeneration. Conventional dressings have been widely used; however, they are often inconvenient to use and have limited analgesic effects. In this work, we have developed a ready to use, disposable collagen-triboelectric nanogenerator (Col-TENG) wound protection dressing system. A porous collagen patch acts as a drug reservoir and a contact layer for the skin to protect the wound and remove traumatic contaminants. The frictional electrical field generated by TENG effectively promotes the release of analgesic lidocaine drug from the collagen patch. In vitro and in vivo experiments have shown that compared to conventional drug release systems, this novel friction-facilitated drug release device achieves faster and more drug release, as well as superior analgesia effects, which is promising in application of pain management in wild environments.
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Advanced Energy Materials
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2025
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IF 26
Xinrui He,Hailong Sun,Peifeng Yu,Hezhang Li,Zezhan Zhang,Yi Niu,Jing Jiang,Chao Wang
Thermoelectric devices have garnered significant interest but face limitations due to their reliance on external equipment and relatively low energy density for energy storage. This study introduces an innovative integrated device that achieves both the function of thermoelectric conversion and energy storage within a single unit through a precipitation-driven Thermogalvanic effect. Strikingly, both the thermoelectric (P max = 3.51 W m −2 ) and electrochemical (E = 459 J m −2 , surpasses the reported highest value by 132%) performances are excellent. Furthermore, a large-area prototype module comprising 32 units manifests an open circuit voltage of 1.7 V and exhibits an energy density of 463.9 J m −2 . This work provides an innovative and effective approach to the high-performance recycling system of thermoelectric conversion and energy storage integrated devices.
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