查找使用阿拉丁产品的科研文献

NIR-triggered all-in-one polydopamine nanocomposite hydrogel toward synergistic chemo-photothermal therapy

Mengxia Guan,Wenlong Kan,Jiaqi Tang,Tao Chen,Chunxia Wu,Jing Xia,Dong Jiang,Shuyao Zhong,Xingwang Yang,Yan Zou,Lihua Zhou,Xuefeng Li,Dongfang Liu,Yuanyuan Zhang

An "all-in-one" polydopamine platform integrates injectable hydrogel, NIR-triggered release, and photothermal therapy for superior combinatory tumor treatment. • This dual-functional design integrates injectable gelation for tumor localization with potent NIR-triggered photothermal conversion. • This design enables on-demand drug release, powered by the synergy between NIR-triggered photothermal heating and the acidic tumor microenvironment. • The resulting hydrogel achieves superior combinatory therapy outcomes, demonstrating high efficacy for localized tumor treatment. Localized therapy is pivotal for overcoming the drawbacks of traditional chemotherapy, including systemic toxicity and inadequate intratumoral drug accumulation. The development of intelligent, biocompatible, and efficient local drug delivery system is therefore essential for precise synergistic therapy. In this study, an injectable all-in-one polydopamine (PDA) nanocomposite hydrogel triggered by near-infrared (NIR) light is reported for synergistic chemo-photothermal therapy of tumors. The system was constructed from doxorubicin (DOX)-loaded mesoporous polydopamine nanoparticles (MPDA NPs) into a hydrogel network consisting of PDA and carboxymethyl chitosan (CMCS), and was found to exhibit excellent injectability, potent photothermal responsiveness, and high biocompatibility. In vitro and in vivo studies demonstrated that NIR light irradiation effectively induced mild photothermal effects, which significantly enhanced both the release rate of DOX from the hydrogel and its penetration and distribution within tumor tissues. This chemo-photothermal synergistic effect effectively promoted tumor cell apoptosis and inhibited proliferation, achieving highly efficient tumor growth suppression in 4 T1 tumor-bearing mouse models. Benefiting from the localized drug retention capability of the hydrogel, the system significantly reduced the systemic toxicity of DOX while ensuring therapeutic efficacy. This study provides a promising strategy for developing efficient and low-toxicity localized tumor therapy. An injectable, NIR-triggered integrated polydopamine nanocomposite hydrogel exhibits high photothermal conversion efficiency and on-demand release capability, enabling localized and efficient tumor therapy. Download: Download high-res image (289KB) Download: Download full-size image

Aptamer Regulated NIR Carbon Dot/AuNP Fluorescence Sensing Platform for Selective Sarcosine Detection

Huang Haiyin,Zhou Shuping,Yang Mei,Xie Shenghui,Jiang Xiaohua,Yue Jiahui,Yang Haipeng

A near-infrared (NIR) fluorescence sensing platform based on NIR carbon dots (CDs), gold nanoparticles (AuNPs) and sarcosine-specific aptamers (SA-Apt) was developed for the sensitive and selective detection of sarcosine (SA), a potential biomarker associated with prostate cancer. Nitrogen- and sulfur-co-doped NIR-CDs were synthesized via a solvothermal method using L-glutathione and formamide, while AuNPs were prepared through a classical citrate-reduction approach. The sensing mechanism is based on an aptamer-regulated inner filter effect (IFE) between NIR-CDs and aggregated AuNPs. In the absence of SA, SA-Apt adsorbs onto the AuNP surface, stabilizing the nanoparticles against salt-induced aggregation and preserving the fluorescence of the NIR-CDs. Upon target recognition, SA-Apt preferentially binds to sarcosine and detaches from the AuNP surface, triggering salt-induced aggregation of AuNPs. This aggregation produces significant spectral overlap with the NIR-CD emission band, resulting in efficient fluorescence quenching via the inner filter effect. The incorporation of NIR-CDs enhances detection sensitivity by providing strong fluorescence emission, minimal background interference, and improved photostability. Under optimized conditions, the NIR-CDs/AuNPs/SA-Apt platform exhibited a linear response to sarcosine over the range of 1–15 µM, with a correlation coefficient (R 2 ) of 0.996 and a limit of detection of 0.32 µM (S/ N  = 3). The sensing system demonstrates high selectivity, good reproducibility, and stable NIR fluorescence performance. By integrating NIR-emissive carbon dots with plasmonic aggregation and aptamer-mediated regulation, this work provides a robust non-enzymatic strategy for sarcosine detection.

Programmable Organic A2S-TT NPs for NIR-II/Photoacoustic Imaging-Enabled Precision Therapy

Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by significant treatment challenges and poor prognosis. Traditional therapies such as surgical resection, radiotherapy, and chemotherapy often suffer from limitations including insufficient therapeutic specificity, potential damage to normal tissues, and limited imaging capability. The integrated diag{Pareja, 2018 #13}nosis-treatment platform combines diagnostic and therapeutic functions, offering a novel approach for real-time tumor monitoring and precision therapy.Methods: Accordingly, this study designed and developed an integrated diagnostic and therapeutic platform called A2S-TT NPs, utilizing self-assembled nanoparticles incorporating organic conjugated molecules for precise photodynamic therapy (PDT) guided by dual modalities of Near-infrared II (NIR-II) fluorescence imaging and photoacoustic imaging (PA).Results: Under 808 nm laser excitation, A2S-TT NPs efficiently generated reactive oxygen species (ROS) at the tumor site, inducing mitochondrial membrane potential disruption and DNA damage to activate apoptosis. In vitro experiments demonstrated that A2S-TT NPs exhibited intense NIR-II fluorescence and photoacoustic signals, showcasing excellent dual-modal imaging potential. Moreover, it demonstrated minimal cytotoxicity in the absence of light exposure but significantly enhanced tumor cell killing under laser irradiation, demonstrating superior biosafety and photodynamic efficacy. In vivo studies further confirmed that A2S-TT NPs effectively accumulated at tumor sites, enabling visualization-based monitoring through its mediated NIR-II and PA dual-modal imaging. Additionally, A2S-TT NPs-mediated PDT exhibited remarkable tumor-suppressive effects while avoiding significant damage to normal tissues.Discussion: This study constructs a novel PA/NIR-II dual-modal imaging-guided PDT platform based on donor–acceptor conjugated polymer A2S-TT NPs for integrated TNBC theranostics. PA provides high-resolution deep-tissue imaging, while NIR-II fluorescence offers high sensitivity and deep penetration; their complementary strengths support precise tumor localization and real-time therapeutic monitoring. Under dual-modal guidance, A2S-TT NPs enrich in tumors and generate abundant ROS upon 808 nm laser irradiation to boost PDT efficacy. In vitro and in vivo biosafety tests confirm its favorable biocompatibility with minimal systemic toxicity at therapeutic doses.Conclusions: In conclusion, A2S-TT NPs achieved precise, efficient, safe, and controllable PDT through dual-mode imaging using NIR-II and PA, providing a novel strategy with clinical translation potential for the integrated diagnosis and treatment of TNBC.

NIR-Absorbing Organic Charge Transfer Complexes for Photothermal Antibacterial Therapy and Wounds Healing

Peirong Bai,Qiong Zhang,Xiaoyu Zhang,Yating Huang,Jian Gao,Binrong Zhang,Liping Li,Yating Wen,Ruiping Zhang

Bacterial infections and subsequent inflammation are major obstacles to efficient wound healing and present an increasing clinical challenge due to rising antimicrobial resistance. Recently, photothermal therapy (PTT) offers a non-antibiotic, spatiotemporally controllable strategy to eradicate pathogens. However, the development of promising photothermal agents with high NIR response, biocompatibility and facile preparation is still challenging. Here we report supramolecular assembled donor-acceptor charge-transfer complex (CTC) nanoparticles TPD-TCB (TT NPs) achieved by precise modulation of energy-level engineering between commercially available donor and acceptor molecules. CTC formation yields a narrowed effective HOMO-LUMO gap, which enables TT NPs to exhibit broad NIR absorption extending toward ∼1200 nm and a photothermal conversion efficiency of 38%. Notably, under 808 nm irradiation TT NPs achieve potent photothermal killing of Gram-positive (90.7%) and Gram-negative (94.9%) bacteria in vitro and effectively suppress infection in an in vivo wound model. Additionally, TT NPs + NIR accelerate wound closure by clearing pathogens, resolving inflammation and promoting epidermal differentiation and regeneration. This work establishes a practical and generalizable CTC-based bandgap engineering strategy for creating high-performance organic photothermal agents suitable for antibacterial therapy and wound repair.

Lithiation-Driven Phase Engineering Unlocking Broadband NIR Emission in Cr-Doped Zinc Tantalate

Xiaohong Zhang,Siyuan Lin,Changfu Xu,Haiyan Shi,Kai Li,Pan Zhou,Pengbo Lyu,Lizhong Sun

Structural phase evolution is among the most powerful tools for tuning material properties, enabling advancements in catalysis, dielectrics, optoelectronics, and photoluminescence. Such an evolution can significantly enhance the near-infrared (NIR) emission properties of Cr3+-doped phosphors. Herein, we present, to the best of our knowledge, the first observation of lithiation-induced continuous structural phase evolution in ZnTa2O6 phosphors, driven by Li+ incorporation. This evolution proceeds systematically from orthorhombic ZnTa2O6 (Pbcn) to tetragonal ZnTa2O6 (P42/mnm) and ultimately to trigonal (Li0.5Zn0.5)TaO3 (R3c) as the Li+ content increases. When doped with Cr3+, the NIR emission peak exhibits a progressive blue shift, moving from 949 to 885 nm and eventually to 862 nm, in tandem with the phase evolution. This phase evolution also yields significant enhancements in photoluminescent intensity, internal quantum yield (IQY), and photoluminescence thermal stability. Our findings establish a new paradigm for designing highly efficient ultra-broadband NIR phosphors and offer a foundation for developing tantalate-based materials with versatile functionalities, including improved dielectric properties.

High-Temperature Negative-Thermal-Quenching in Broadband NIR Light-Emitting ScF3:Cr3+ Phosphors

Yongjie Wang,Yingju Yan,Dongshuo Li,Qingzhou Bu,Guotao Xiang,Li Li,Sha Jiang,Xianju Zhou,Qilong Gao,Yaroslav Zhydachevskyy,Mikhail G. Brik,Andrzej Suchocki

Broadband near-infrared (NIR) phosphors with superior thermal stability are critical enablers of high-power NIR pc-LEDs, emerging as essential light sources for NIR spectroscopy applications. In this work, an unprecedented high-temperature negative thermal quenching (NTQ) phenomenon persisting up to 500 K is reported in Cr 3+ -activated ScF 3 phosphors, which emit broadband NIR emission in the 700–1200 nm (λ em = 850 nm, FWHM = 132 nm). The theoretical calculations employing the Exchange-Charge Model (EMC) for crystal field parameters of Cr 3+ ions in [ScF 6 ] octahedral sites remain in perfect agreement with the experimental results. Critically, Yb 3+ -codoping enables efficient Cr 3+ → Yb 3+ energy transfer, achieving substantial spectral broadening (FWHM = 254 nm) and significantly enhanced thermal stability. The temperature-dependent X-ray diffraction (XRD) and theoretical calculations reveal that anisotropic F-atom vibrations drive negative thermal expansion (NTE) in cubic ScF 3 , distorting [ScF 6 ] octahedra. It is demonstrated that synergistic electron-phonon coupling and NTE-driven structural dynamics underpin the superior thermal stability of NIR emission. These findings establish a design paradigm for new broadband NIR phosphors with outstanding thermal stability for next-generation high-power NIR pc-LED applications.

NIR Light-Triggered Degradable MoTe2 Nanosheets for Combined Photothermal and Chemotherapy of Cancer

Ning Ma,Ming-Kang Zhang,Xiao-Shuang Wang,Lu Zhang,Jun Feng,Xian-Zheng Zhang

Telluride molybdenum (MoTe 2 ) nanosheets with wide near-infrared (NIR) absorbance are functionalized with polyethylene glycol-cyclic arginine-glycine-aspartic acid tripeptide (PEG-cRGD). After loading a chemotherapeutic drug (doxorubicin, DOX), MoTe 2 -PEG-cRGD/DOX is used for combined photothermal therapy and chemotherapy. With the high photothermal conversion efficiency, MoTe 2 -PEG-cRGD/DOX exhibits favorable cells killing ability under NIR irradiation. Owing to the cRGD-mediated specific tumor targeting, MoTe 2 -PEG-cRGD/DOX shows efficient accumulation in tumors to induce a strong tumor ablation effect. MoTe 2 -PEG-cRGD nanosheets, which are relatively stable in the circulation, could be degraded under NIR ray. The in vitro and in vivo experimental results demonstrate that this theranostic nanoagent, which could accumulate in tumors to allow photothermal imaging and combined therapy, is readily degradable in normal organs to enable rapid excretion and avoid long-term retention/toxicity, holding great potential to treat tumor effectively.

Improving and broadening luminescence in Gd2−xAlxGaSbO7:Cr3+ phosphors for NIR LED applications

Siyu Guo,Ligan Ma,Muniran Abudureyimu,Rongfei Wei,Fumin Lu,Fangfang Hu,Hai Guo

Near-infrared (NIR) spectroscopy has garnered substantial attention owing to its diverse merits and widespread applications. Meanwhile developing phosphors with broadband and efficient NIR emission is still an enormous challenge for constructing NIR light sources. Herein, enhanced and broadened NIR luminescence of Gd2−xAlxGaSbO7 (G2−xAxGSO):y%Cr3+ phosphors can be realized via modifying the crystal field environment of Cr3+ induced by Al3+ → Gd3+ cation substitution. Upon blue light irradiation, G1.4A0.6GSO:4%Cr3+ exhibits a broadband luminescence ranging from 650 to 1000 nm with a full width at half maximum (FWHM) of 136 nm, excellent thermal stability, and a tiny chromaticity shift. Through incorporating the resulting powders into a blue light-emitting diode (LED) chip, a NIR phosphor-converted (pc) LED with a high output power of 62.99 mW and a photoelectric conversion efficiency of 13.38% was manufactured. The fabricated pc-LED shows application potential in nondestructive food analysis. These findings confirm that the as-synthesized G2−xAxGSO:Cr3+ phosphor is a promising candidate for application in NIR pc-LEDs.

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy

Li Mengyue,Yang Geng,Zheng Yue,Lv Jiazhen,Zhou Wanyi,Zhang Hanxi,You Fengming,Wu Chunhui,Yang Hong,Liu Yiyao

Targeted chemo-phototherapy has received widespread attention in cancer treatment for its advantages in reducing the side effects of chemotherapeutics and improving therapeutic effects. However, safe and efficient targeted-delivery of therapeutic agents remains a major obstacle. Herein, we successfully constructed an AS1411-functionalized triangle DNA origami (TOA) to codeliver chemotherapeutic drug (doxorubicin, DOX) and a photosensitizer (indocyanine green, ICG), denoted as TOADI (DOX/ICG-loaded TOA), for targeted synergistic chemo-phototherapy. In vitro studies show that AS1411 as an aptamer of nucleolin efficiently enhances the nanocarrier’s endocytosis more than 3 times by tumor cells highly expressing nucleolin. Subsequently, TOADI controllably releases the DOX into the nucleus through the photothermal effect of ICG triggered by near-infrared (NIR) laser irradiation, and the acidic environment of lysosomes/endosomes facilitates the release. The downregulated Bcl-2 and upregulated Bax, Cyt c, and cleaved caspase-3 indicate that the synergistic chemo-phototherapeutic effect of TOADI induces the apoptosis of 4T1 cells, causing ~ 80% cell death. In 4T1 tumor-bearing mice, TOADI exhibits 2.5-fold targeted accumulation in tumor region than TODI without AS1411, and 4-fold higher than free ICG, demonstrating its excellent tumor targeting ability in vivo. With the synergetic treatment of DOX and ICG, TOADI shows a significant therapeutic effect of ~ 90% inhibition of tumor growth with negligible systemic toxicity. In addition, TOADI presents outstanding superiority in fluorescence and photothermal imaging. Taken together, this multifunctional DNA origami-based nanosystem with the advantages of specific tumor targeting and controllable drug release provides a new strategy for enhanced cancer therapy.

NIR-propelled Janus nanomotors for active photoacoustic imaging and synergistic photothermal/chemodynamic therapy

Xiaolei Zhang,Chang Liu,Yangsai Lyu,Ningning Xing,Jia Li,Kun Song,Xiaohui Yan

Synthetic nanomotors have great application potential in deep tissue imaging and tumor treatment due to their active movement ability. Herein, a novel near infrared (NIR) light-driven Janus nanomotor is reported for active photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT). Au nanoparticles (Au NPs) are sputtered on the half-sphere surface of copper-doped hollow cerium oxide nanoparticles after bovine serum albumin (BSA) modification. Such Janus nanomotors exhibit a rapid autonomous motion with a maximum speed of 110.6 ± 0.2 μm/s under 808 nm laser irradiation with a density of 3.0 W/cm 2 . With the assistance of light-powered motion, the Au/Cu-CeO 2 @BSA nanomotors (ACCB Janus NMs) can effectively adhere to and mechanically perforate tumor cells, thereby causing the higher cellular uptake and significantly enhancing the tumor tissue permeability in the tumor microenvironment (TME). ACCB Janus NMs also exhibit high nanozyme activity that can catalyze the production of reactive oxygen species (ROS) to reduce the TME oxidative stress response. Meanwhile, the potential PA imaging capability of ACCB Janus NMs offer promise for early diagnosis of tumors due to the photothermal conversion efficiency of Au NPs. Therefore, the nanotherapeutic platform provides a new tool for effectively imaging of deep tumors site in vivo to achieve synergistic PTT/CDT and accurate diagnosis.

Synthesis and luminescence characteristics of an efficient broadband NIR phosphor: Cr3+ activated GaTa0.5Nb0.5O4

Sibang Liu,Gaoliang Wang,Liuyang Xu,Huanxia Jia,Xianke Sun,Honglei Yuan

NIR phosphor-converted light emitting diodes possess extensive application in a variety of occasions. And the exploration of NIR phosphors having outstanding quantum yield and thermostability is still a challenge. In this work, the layered structure and broadband GaTa 0.5 Nb 0.5 O 4 :Cr 3+ phosphors owning excellent performance were synthesized. The GaTa 0.5 Nb 0.5 O 4 :0.025Cr 3+ phosphor provides a quantum yield of 92.2%, as well as an activation energy of 0.329. The NIR pc-LED formed via the combination of GaTa 0.5 Nb 0.5 O 4 :0.025Cr 3+ phosphor and blue LED chip owns an output power of 4.56 mW and a photoelectric conversion efficiency of 9.37% when driven at 20 mA, and the output power increases to be 44.6 mW and the photoelectric conversion efficiency changes to be 7.19% when driven at 250 mA. The results of this work demonstrated that the Cr 3+ activated GaTa 0.5 Nb 0.5 O 4 phosphors may be a prospective candidate for NIR phosphor-converted light emitting diodes.

Fe/MOF based platform for NIR laser induced efficient PDT/PTT of cancer

Liang Zixing,Li Xiaofeng,Chen Xiaofang,Zhou Jiawei,Li Yanan,Peng Jianhui,Lin Zhousheng,Liu Gai,Zeng Xiancheng,Li Cheng,Hang Lifeng,Li Hailiang

Introduction: Photodynamic therapy (PDT) and photothermal therapy (PTT) are widely used in the treatment of tumors. However, their application in the treatment of clinical tumors is limited by the complexity and irreversible hypoxia environment generated by tumor tissues. To overcome this limitation, a nanoparticle composed of indocyanine green (ICG) and Fe-MOF-5 was developed.Methods: We prepared F-I@FM5 and measured its morphology, particle size, and stability. Its enzyme like ability and optical effect was verified. Then we used MTT, staining and flow cytometry to evaluated the anti-tumor effect on EMT-6 cells in vitro. Finally, the anti-tumor effect in vivo has been studied on EMT-6 tumor bearing mice.Results: For the composite nanoparticle, we confirmed that Fe-MOF-5 has the best nanozyme activity. In addition, it has excellent photothermal conversion efficiency and generates reactive oxygen species (ROS) under near-infrared light irradiation (808 nm). The composite nanoparticle showed good tumor inhibition effect in vitro and in vivo, which was superior to the free ICG or Fe-MOF-5 alone. Besides, there was no obvious cytotoxicity in major organs within the effective therapeutic concentration.Discussion: Fe-MOF-5 has the function of simulating catalase, which can promote the decomposition of excessive H2O2 in the tumor microenvironment and produce oxygen to improve the hypoxic environment. The improvement of tumor hypoxia can enhance the efficacy of PDT and PTT. This research not only provides an efficient and stable anti-tumor nano platform, but also has broad application prospects in the field of tumor therapy, and provides a new idea for the application of MOF as an important carrier material in the field of photodynamic therapy.