ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Gao Haonan,Wen Mingzhen,Li Jiali,Hou Shili,Li Lifen,Liu Guangyan
This work develops an in situ electrodeposition strategy to construct a honeycomb-like Ni/Co-MOF/MXene heterojunction directly on the glassy carbon electrode (GCE) surface at −1.3 V vs. Ag/AgCl, enabling ultrasensitive enzymatic electrochemical detection of trace urea. The high catalytic activity of Ni/Co-MOF and the superior conductivity of MXene were synergistically integrated in a 3D hierarchical heterostructure. Compared with traditional modification methods, this strategy significantly enhances the kinetics of electron transfer and the stability of urease immobilization. Characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS), the heterojunction exhibits unique morphology and outstanding electroconductivity. Furthermore, the resulting Ni/Co-MOF/MXene/urease/GCE biosensor achieves a wide linear range of 1.0 × 10 –6 –1.0 × 10 –4 mol L −1 with a low detection limit of 4.9 × 10 –7 mol L −1 . The biosensor has been applied to the detection of practical samples, where the recoveries were 99.3–102.8% with a relative standard deviation (RSD) of 2.9–3.3%, which indicates that this biosensor has good practical applications and prospects for further development.
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高影响因子
CURRENT MICROBIOLOGY
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2026
·Vol. 83
·期 4
·207
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IF 2.8
Lu Xie-Feng,Gao Peng,Zhang Shu-Yi,Xu Yuan-Jia,Liu Guo-Hong,Chen Man,Zhou Shun-Gui
Two Gram-stain positive, motile, aerobic, yellowish rod-shaped bacterial strains sgz301303 and sgz301304 T were isolated from the paddy soils. The 16S rRNA gene phylogenetic analysis revealed that both strains belong to the genus Sphingobium , and exhibited the highest sequence similarity (98.3%) with reference strain Sphingobium amiense JCM 11777 T . The draft genome of sgz301304 T has a size of 4.3 Mbp, with DNA G + C content of 64.5%. Whole-genome relatedness analyses showed that the average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strain sgz301304 T and S. amiense JCM 11777 T were 82.3% and 25.7%, respectively, both below the accepted species delineation thresholds. The main quinone was Q-10, and the main fatty acids included C 14:0 2-OH (11.3%), and Summed Features 8 (46.6%). Phylogenetic, genomic and phenotypic analyses suggest that strain sgz301304 T belongs to a novel species within the genus of Sphingobium . Therefore, it is recommended to be named as Sphingobium agrisoil sp. nov. The type strain is sgz301304 T (= MCCC 1K09180 T = JCM 37704 T ), respectively.
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Nature Communications
·
2026
·
IF 18.1
Bing-Liang Leng,Xiu Lin,Hou-Yan Dong,Qi-Yuan Li,Shi-Nan Zhang,Jie-Sheng Chen,Xin-Hao Li
Recent studies on the electrocatalytic oxygen transfer from water to organic compounds have gained significant attention due to their sustainability and selectivity. However, the direct coactivation of inert hydrocarbons and water typically requires high oxidation potentials, leading to oxygen evolution reactions and low Faradaic efficiencies. Herein, a Ni-activated tungsten-oxygen covalency anode is designed for the efficient oxygen transfer from water to benzylic C(sp 3 )–H bonds via a Ni-regulated interfacial water structure between the anode and electrolyte. Both experimental and theoretical results reveal the critical role of W–O covalency sites with Ni-heteroatoms for boosting efficient oxygen transfer via breaking the dense interfacial hydrogen bond network and inhibiting the undesired oxygen evolution reactions, facilitating the coactivation of oxygen species and C(sp 3 )–H bonds. Thus, a Faradaic efficiency of > 56% in a water-involved system has been achieved. This work provides important insight into designing electrocatalytic systems for inert C–H oxidation. The direct coactivation of inert hydrocarbons and water typically requires high oxidation potentials. Here, the authors report that a Ni-activated tungsten-oxygen covalency anode is designed to steer the oxygen transfer from water to benzylic C(sp 3 )–H bonds via Ni-regulated interfacial water structure.
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Chinese Medicine
·
2026
·
IF 7.4
Qing Zhang,Ziyun Chen,Qingyong Yu,Hanwen Wang,Yucui Jiang,Lan Zhou,Guang Yu,Zongxiang Tang,Changming Wang
Background Cancer-induced bone pain (CIBP) remains a debilitating clinical challenge due to its complex pathogenesis and limited therapeutic options. Tetrahydropalmatine (THP), an active alkaloid from Corydalis tuber , has shown analgesic potential, but its specific mechanisms in mitigating CIBP- especially its interactions with neural factors and immune cells-remain incompletely understood. This study aimed to investigate the efficacy of THP in alleviating CIBP and clarify its underlying mechanisms, with a focus on the roles of transient receptor potential vanilloid 1 (TRPV1), substance P (SP), and macrophage dynamics in a mouse model of CIBP. Methods Using a multidisciplinary approach, we established a CIBP model in male C57BL/6 mice (and TRPV1-knockout mice) via intramedullary injection of lung cancer cells. Behavioral assessments were performed to evaluate mechanical, thermal, and cold allodynia, as well as spontaneous pain, following daily oral administration of THP (80 mg/kg) from day 7 post-modeling. Molecular and cellular analyses included immunofluorescence staining, real-time PCR, ELISA (to quantify SP, cytokines, and Tac1 expression), calcium imaging (to measure TRPV1-mediated calcium influx in DRG neurons), scratch assays (to assess macrophage migration), and flow cytometry (to analyze macrophage polarization in RAW 264.7 cells). Results THP significantly alleviated CIBP-related allodynia and spontaneous pain in mice. Mechanistically, THP directly inhibited TRPV1 function in the primary phase (≤ 14 days post-modeling) (with an IC 50 of 77.9 µM), reducing SP release from DRG neurons and suppressing macrophage recruitment to DRG and sciatic nerve via the TRPV1-SP pathway. Importantly, THP directly promoted the polarization of recruited macrophages toward the anti-inflammatory M2 phenotype, as evidenced by downregulated iNOS, TNF-α, IL-1β and upregulated CD206, IL-4, IL-10 in vitro (RAW264.7 cells) and in vivo. These effects were abrogated in TRPV1-knockout mice, confirming TRPV1 as a critical mediator in the primary phase. Conclusion In conclusion, THP mitigates CIBP through a dual mechanism: regulating macrophage recruitment via the TRPV1-SP pathway in the early stage to inhibit CIBP initiation and directly modulating the migrated macrophage polarization. This study provides novel insights into THP’s analgesic mechanisms and supports its potential as a preclinical candidate for CIBP treatment. Graphical Supplementary Information The online version contains supplementary material available at 10.1186/s13020-026-01359-3.
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Nature Communications
·
2026
·
IF 18.1
Zhang Jun-Ye,Yue Kaihang,Zhao Yuqi,Li Rongyao,Li Qixuan,Hu Yanjie,Wang Wendi,Liu Lu,Li Jialong,Zhao Hao,Yan Ya,Xu Zhe,Zu Lianhai,Yang Hui,Lan Kun,Zhao Dongyuan
The development of stable Ru-based anodes for acidic proton exchange membrane water electrolysis is promising, but strictly limited by Ru over-oxidation and structural collapse due to lattice oxygen participation under high current densities. Rational design of competitive Ru-based catalyst is, thereby, highly desired. Here, by exploring a customized self-assembly route, we report a type of mesoporous Ru-Ti-O solid solution catalyst delivering competitive performance (1 A cm -2 for over 450 h at 0.4mg Ru cm -2 ). Mechanistic investigations reveal that the enhanced performance arises from the integration of atomic-scale electronic structure tuning and mesoscopic triple phase interface engineering. The electron delocalization forms a conductive network and suppresses Ru overoxidation through electron donation. Atomically dispersed Ru-O-Ti motifs favor the oxygen pathway mechanism over the lattice oxygen mechanism, suppressing lattice oxygen release and enhancing structural stability. Simultaneously, the ordered mesoporous architecture and radially aligned nanorod bundles establish a robust, super-hydrophilic triple phase interface, enabling effective water and gas exchange and mitigating concentration overpotentials. This cross-scale design strategy offers a possible route to non-Ir catalysts with measurable activity and long-term durability for scalable acidic water electrolysis.
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Nature Sustainability
·
2026
·
IF 32.1
Jin Xianchun,Lei Lin,Du Jinyan,Wang Fuqiang,Long Zhihe,He Yongping,Xing Lili,Zhao Xiaochong,Xue Xinyu
Uranium (U) is essential for the nuclear power industry and plays an important role in decarbonizing the energy supply. However, concern regarding the sustainability of U supply is growing, as conventional U ore reserves are scarce and common mining practices have a notable environmental footprint. Exploring alternative U sources and developing sustainable extraction methods are therefore desired. Here we show a spontaneous U extraction strategy based on droplet falling. Specifically, naturally falling salt-lake water droplets interact with a film of aluminium–fluorinated ethylene propylene–chitosan coated on carbon felt, converting mechanical energy into electricity and driving an in situ electrochemical process for spontaneous U extraction. Electrons released at the solid–liquid interface on a superhydrophobic fluorinated ethylene propylene surface reduce U(VI) adsorbed by chitosan to U(IV), ultimately forming U(VI) precipitates. Field experiments conducted in real salt-lake environments with high salinity confirm the scalability and robustness of droplet U extraction, yielding magnesium uranate (MgU 2 O 7 ) and sodium polyuranate (Na 2 U 7 O 22 ) as the main products. A multistep device reduces the U concentration of salt-lake water from 173 μg l −1 to 34 μg l −1 (extraction efficiency of 80.3%) with minimal extraction of co-existing ions. Overall, this work offers a viable pathway to sustainable U resource extraction.
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MOLECULAR PSYCHIATRY
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2026
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IF 10.4
Huang Miaoqi,Ye Han,Xu Yong,Xie Jiaoyan,Wang Xinyu,Luo Yan,Liu Peng,Ma Xuanyue,Zhang Shiqing,Jiang Bin,Ye Wen-Cai,Peng Yinghui,Shi Lei
Perturbed protein synthesis plays a crucial role in the pathogenesis of autism spectrum disorder (ASD), but the altered translational pattern and underlying mechanism remain poorly understood. Here, we identified an exaggeration of global protein synthesis in the cerebral cortex of offspring mice following prenatal exposure of valproic acid (VPA), a well-established ASD model. Integrative analysis of polyribosome-based translatome and proteome data revealed remarkable upregulation of ribosomal and mitochondrial genes in VPA-exposed cortex at both translational and protein levels, but not transcriptional levels. Further analysis pinpoints that overactivation of the translation initiation factor eIF4E causes the aberrant translatome and mitochondrial impairments in VPA-exposed cortex. Pharmacological inhibition of eIF4E phosphorylation during juvenile displayed persistent effectiveness in mitigating ASD-like social deficits and stereotyped behavior in VPA mice until adulthood. Collectively, these findings demonstrate that eIF4E overactivation leads to imbalanced protein synthesis that favors translation of ribosomal and mitochondrial genes, causing core ASD-like behaviors.
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Nature Communications
·
2026
·
IF 18.1
Mao Congyang,Jin Wanyu,Dou Limeng,Guo Tong,Huang Jin,Wang Yi,Liu Xiangmei,Wu Shuilin,Qiao Wei,Xiang Yiming,Zhu Yizhou,Wu Jun,Yeung Kelvin Wai Kwok
The pandemic-scale progression of type 2 diabetes mellitus (T2DM) necessitates innovative interventions targeting the pathogenic triad of insulin resistance, dysregulation of lipid metabolism, and gut microbiome dysbiosis. Here, we report a synthetically bioengineered probiotic consortium (REcN-F/Ca) developed through directed metabolic adaptations of Escherichia coli Nissle 1917 (EcN) under iterative hydrogen peroxide selection, subsequently functionalized with fructooligosaccharide-calcium carbonate composites. REcN-F/Ca exhibits enhanced reactive oxygen species tolerance through upregulated antioxidant enzymes and hydrogen sulfide-mediated redox balancing, alongside improved gastrointestinal survivability. In high-fat diet-induced obese male mice, REcN-F/Ca restores gut microbiota diversity, enriches butyrogenic taxa (Lachnospiraceae and Blautia ), and rescues short-chain fatty acids depletion. Transcriptomic profiling reveals PPAR signaling activation, driving lipid metabolism and suppressing adipose inflammation. These effects translate to systemic metabolic improvements with attenuated weight gain (−25.4%), restored glucose homeostasis, and reduced insulin resistance (HOMA-IR: −73.2%) in the obesity and T2DM murine model. Our findings establish REcN-F/Ca as a synthetically engineered probiotic that simultaneously corrects intestinal ecological perturbations and reverses host metabolic dysfunction, proposing a paradigm for metabolic syndrome management.
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Nature Sustainability
·
2026
·
IF 32.1
Wu Shuxing,Huang Chuxiong,Shen Wenbin,Long Xianhao,Ye Zhihuan,Qiu Juncheng,Xie Liangxin,Zhou Wenbo,Zhang Shanqing,Wei Xiujuan,Lin Zhan
The substantial growth in the market for lithium-ion batteries has created a huge challenge for their end-of-life management and demands sustainable solutions. Direct recycling is a promising choice due to its superior energy efficiency and environmental benefits, particularly the advantage in preserving the original chemistry and structure of the target materials. However, binders hold the active electrode materials and the current collectors tightly together, and their separation usually involves energy-intensive thermal treatment and environmentally hazardous chemicals. Here we present a water-soluble binder by crosslinking natural sericin protein with sulfuric acid through supramolecular interactions. The as-fabricated binder demonstrates comparable electrochemical performance with the most common polyvinylidene fluoride formulation, when applied to a typical LiNi 1/3 Co 1/3 Mn 1/3 O 2 (NCM111) cathode. A 1.3-Ah pouch cell retained 85.0% of its initial capacity after 500 cycles. Equally importantly, after being soaked in water at 50 °C for less than 1 min, the NCM111 and graphite can be completely detached from the current collectors for recycling. By integrating the circular economy into the battery design, this work paves the way for the development of next-generation battery chemistries with enhanced sustainability.
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Nature Communications
·
2026
·
IF 18.1
Chen Bin,Ding Miaomiao,Feng Ye,Gao Chao,Rong Jinghui,Tan Haixin,Tian Hao,Wilson Daniela A.,Zhou Yecheng,Tu Yingfeng,Peng Fei
Anxiety and mood disorders, notably major depressive disorder characterized by suppressed neuronal excitability, involve disruption of endogenous molecular polarity homeostasis. Conventional monoamine antidepressants, constrained by delayed therapeutic onset and high risk of drug resistance, neglect and fail to address this pathological feature. Here, we report IC@His-ICG, a near-infrared-responsive photochemical nanomotor that enables polarity switching. Leveraging photochemically driven polarity change, the wireless nanomotors achieved ion-tolerant propulsion in physiological media and phototactic migration to predefined hippocampal targets. Spatiotemporal polarity tuning induced instantaneous calcium oscillations and hippocampal excitation transmission, restoring monoamine homeostasis and combating anxiety and depression in rodents. This polarity-based neuromodulation operates independently of ligand-receptor mechanisms, linking nanoscale polarity dynamics to neurochemical homeostasis and behavioral outcomes in a depressive mouse model. The noninvasive, precision nanomachine strategy differs from traditional intervention frameworks, offering a precise modulation approach for neural disorders.
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ACTA PHARMACOLOGICA SINICA
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2026
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IF 10.4
Chen Chuan-jun,Guo Ding-wen,Yuan Qing-yun,Zhuo You-qiong,Yang Shi-fen,Xu Hao-min,Wang You-rong,Guan Xiao-hui,Deng Ke-yu,Xin Hong-bo
Macrophage migration inhibitory factor (MIF) is a cytokine that possesses multiple enzymatic activities, such as keto-enol tautomerase and thiol-oxidoreductase. We previously found that lack of MIF tautomerase activity significantly alleviated high fat diet (HFD)-induced obesity in mice. In this study, we investigated the regulatory mechanisms of MIF tautomerase in obesity. HFD-induced obese mouse model was established. Adipogenic differentiation was induced in mouse preadipocyte cell line 3T3-L1 and mouse adipose-derived mesenchymal stem cells (ADSCs) in vitro. We showed that MIF tautomerase inhibitors ISO-1 or 4-IPP dose-dependently promoted lipid degradation and mitochondrial thermogenesis by enhancing basal oxygen consumption rate and proton leak, accompanied by increased expression of browning markers (UCP1, PGC-1α, DIO2, CD137) in 3T3-L1 cells under adipogenic induction conditions. In HFD-induced obese mice, administration of 4-IPP (5, 10 mg/kg, i.p.) every 2 days for 12 weeks significantly ameliorated HFD-induced obesity, improved insulin sensitivity, and enhanced energy expenditure. In white adipocytes, 4-IPP (1, 5, 10 μM) dose-dependently promoted CD137 expression, and restored CD137-mediated activation of the PI3K/AKT signaling to improve lipid metabolism. CD137 deficiency abrogated the browning effect of 4-IPP in white adipocytes in vitro. CD137 −/− mice exhibited increased susceptibility to HFD-induced obesity and almost abolished the anti-obesity effects of 4-IPP. Simulation of the protein interaction revealed a direct interaction between MIF and CD137: MIF competitively bound to CD137 on white adipocytes with the endogenous ligand of CD137, which was further confirmed by co-immunoprecipitation. Furthermore, 4-IPP and recombinant CD137 protein inhibited the tautomerase activity of MIF in vitro. In conclusion, MIF promotes obesity by binding CD137 through its tautomerase domain, suppressing CD137-mediated the activation of the PI3K/AKT signaling. MIF tautomerase inhibitors disrupt this interaction, restore CD137 function, and enhance adipocyte browning, offering a promising therapeutic strategy for obesity management.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 5
·402
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IF 3.2
Li Jing,Su Yuchang,Wang Jionghui,Zhang Jing,Zhu Yinyin
As lithium-ion batteries and electronic devices proliferate rapidly, recycling spent batteries and developing advanced electromagnetic microwave absorbers have become increasingly crucial. Upcycling spent graphite anodes into high-performance microwave-absorbing materials provides a value-added pathway for graphite resource reutilization while mitigating electromagnetic pollution. In this study, spent graphite anode waste was directly upcycled to construct PSG@Co (Pre-treated Spent Graphite @ Cobalt) composites via a liquid-phase impregnation followed by a carbothermal reduction process. The cobalt loading and morphology of PSG@Co composites were readily tuned by adjusting the concentration of the cobalt precursor solution, thereby further altering microwave absorption performance. Benefiting from the retained bulk graphitic structure and abundant defective sites of the pre-treated spent graphite, the composites exhibited excellent conductive loss and defect polarization. Moreover, cobalt incorporation significantly improved interfacial polarization, magnetic loss, and impedance matching. Under an optimal cobalt precursor concentration of 0.34 M, the PSG@Co-2 composite delivered remarkable microwave absorption performance, achieving minimum reflection loss of − 63.12 dB at 11.20 GHz and a maximum effective absorption bandwidth of 5.68 GHz at a thickness of only 1.65 mm. The study offers a practical and value-added approach to transforming spent graphite anode waste into high-performance microwave-absorbing materials.
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危险品化学品经营许可证（带存储）