INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Junze Tang,Xin Cheng,Rui Pan,Jinfeng Li,Ziqiao Li,Wanting Liang,Hongshan Xie,Hailiang Zhang,Ji Zhao,Kun Yu,Xiaoyu Zhao,Xiaofei Li,Xujie Liu,Yan He
Wound healing presents a persistent challenge, particularly in enhancing tissue regeneration and mitigating inflammation. Conventional wound dressings often fall short in providing adequate protection against microbial infections and do not fully support the regenerative processes necessary for effective healing. In this study, extracellular vesicles (PPEVs) were successfully isolated from Paris polyphylla var. yunnanensis , with an average particle size of 156.8 ± 13.15 nm and a zeta potential of −15 ± 2.54 mV. Transmission electron microscopy (TEM) images confirmed that the PPEVs exhibited an irregular spherical shape, characteristics of extracellular vesicles. PPEVs demonstrated significant anti-inflammatory properties, reducing the expression of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α by >1.5 times relative to the model group. Additionally, PPEVs promoted the expression of epidermal growth factor and collagen mRNA, exhibiting potent reactive oxygen species (ROS) scavenging activity, with 50 % reduction in ROS levels in the high-concentration group compared to the positive control. To facilitate the controlled delivery of PPEVs and promote wound healing, a composite hydrogel was developed by incorporating polyvinylpyrrolidone (PVP) and carboxymethyl chitosan (CMC) through physical crosslinking. The hydrogel exhibited high porosity (43.6 ± 7.2 %) and remarkable swelling capacity (445.4 ± 38.3 %), with a drug release of 61.3 ± 11.8 % within 6 h. Rheological analysis revealed that the hydrogel exhibited pseudoplastic behavior and elastic characteristics, with good thermal stability. In vivo studies demonstrated that the wound healing rate in the PPEVs@PVP/CMC hydrogel group on day 7 (82.17 ± 5.44 %) was significantly higher than that of the control group (58.5 ± 12.15 %). On day 14, the wounds in the PPEVs@PVP/CMC group were nearly completely healed, with a healing rate of 99.66 ± 0.42 %, significantly surpassing the control group (95.85 ± 0.90 %). Therefore, the PPEVs@PVP/CMC hydrogel can serve as a safe and efficient wound dressing to regulate the inflammatory response and accelerate wound healing in mice. This finding suggests that utilizing the PPEVs@PVP/CMC hydrogel may be a promising strategy for wound healing.
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POLYMER ENGINEERING AND SCIENCE
·
2024
·
IF 3.2
Yao Xiao,Yukun Zhou,Yinggang Huang,Biao Li,Yaqi Ge,Zhenchun Xu,Chuansheng Wang,Huiguang Bian
In this paper, chitosan (CS), which is naturally degradable and low-cost, was incorporated into nitrile butadiene rubber (NBR), the effects of chitosan amount on the properties of the NBR composites were investigated, and the optimal amount of chitosan was determined. On this basis, CS, silica and Si69 were modified by ball milling and plasma to prepare NBR composites with higher oil resistance and high temperature resistance. The results showed that the overall properties of NBR composites filled with 2phr CS is better. FTIR and SEM demonstrated the surface polarity of ball milling combined with plasma co-modified CS/silica was weakened, the dispersion of fillers in the NBR matrix was promoted, the oil resistance and high-temperature resistance of the composites were enhanced, the cross-linking density and tear strength were improved by 28.12%, and 51.76% compared with that of the NBR composites without CS. The investigation on the oil and high-temperature resistance of NBR composites for blowout preventer cores has been carried out, which promotes the development of blowout preventer cores toward high safety, low cost, and sustainability. Highlights The effect of chitosan amount on nitrile butadiene rubber (NBR) composites was explored. Chitosan, silica, and coupling agent were modified by ball milling and plasma. The oil and high-temperature resistance of NBR composites were improved. The tear strength was increased by 28% under double destructive environment.
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COMPOSITES PART B-ENGINEERING
·
2024
·
IF 12.7
Hang Zhang,Longhai Yi,Yezhou Ni,Zhenhua Jia,Hua Qiu,Kunlin Chen
Flexible conductive coatings have the potential to imbue traditional textiles with a range of functional or intelligent properties, including sensing, light emission, heat generation, etc. However, these flexible coatings are prone to damage from external forces in real-world applications. This study focuses on developing a chemically modified flexible coating with MXene as a conductive ligand, aiming to strike the characteristics of mechanical, conductive, and self-healing harmoniously. The process involves synthesizing modified 4-vinyl benzaldehyde into polyurethane (VPU), which is then cross-linked with chitosan to enhance the self-healing efficiency. The conductive ligand, MXene, was modified with tannic acid to strengthen hydrogen bonding with the VPUs. The resulting self-healing waterborne polyurethane conductive coating exhibits an impressive self-healing efficiency of 96 %, along with a high tensile strength at a break of 5.58 MPa and an elongation at a break of 340 %. It also demonstrates antimicrobial effects against Escherichia coli and Staphylococcus aureus of up to 86.8 % and 90.1 %, respectively. Importantly, this study also explores the wearable applications of flexible electronic devices. They can detect pressures up to 100 kPa in a maximum sensitivity of 0.204 kPa −1 in the initial pressure range from 1 to 15 kPa. They can also monitor the pressure response of the foot in different motion states, suggesting potential integration with insoles or socks. This work offers a practical method for combining the key properties of polymer conductive coatings with the design of carbon nanomaterial-based stress-strain sensors. They are potentially applied to this approach including smart robots, e-skins, wearable health management systems, and artificial intelligence, among others.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xinyue Cao,Zaimei Li,Che Han,Conglu Zhang
Pharmaceuticals and personal care products and dyes have low biodegradability and high toxicity, seriously threaten the human health and ecological environment. Therefore, seeking effective removal methods has become the focus of research. In this study, silver-based metal-organic framework (Ag-MOF) and chitosan (CS) hybrid adsorbent (Ag-MOF-CS) was synthesized via solvothermal one-pot synthesis to remove diclofenac sodium (DCF) and acid Red 1 (AR1) from water for the first time. The morphology and structure of Ag-MOF-CS were confirmed by various characterizations. The effect on adsorption was investigated by changing the adsorbent dosage, pH and other conditions. The adsorption kinetics, adsorption isotherms and thermodynamics were analyzed. Ag-MOF-CS showed a high adsorption capacity. And the maximum adsorption capacity of Ag-MOF-CS for DCF and AR1 was 351.75 mg/g and 678.83 mg/g, respectively. The adsorbent bound to DCF and AR1 may via electrostatic forces, π-π interactions, hydrogen bonding. Even after four cycles of Ag-MOF-CS, the DCF removal can still be higher than 80 %. The eco-friendly Ag-MOF-CS demonstrated significant potential for utilization in treating wastewater.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Jinfeng Zhao,Dehui Lin,Runguang Zhang,Di Wang,Aiqing Zhao,Honglei Tian,Xingbin Yang
In this work, we prepared the W/W emulsion gels based on chitosan (CS) and carboxymethyl cellulose (CMC) via associative phase separation without adding any extra stabilizers. The W/W emulsion gels system with different M CS /M CMC ratios (3:1, 2:1, 1:1, 1:2, 1:3, w/w) and concentrations (1 %, 1.25 %, 1.5 %, 1.75 %, w/v) were prepared, and their corresponding properties were further investigated in the present work. FTIR demonstrated that the formation of W/W emulsion gels was driven by electrostatic interactions and hydrogen bond interactions. The CLSM results confirmed that three types of W/W emulsion gels were formed in the prepared systems, and SEM results further suggested that the gel system with 1:1 M CS /M CMC ratio was belonging to W/W emulsion droplet-aggregated gels. Moreover, for the prepared gel systems, the W/W emulsion droplet-aggregated gels with 1.5 % polymer concentration and 1:1 M CS /M CMC ratio showed the most uniform three-dimensional network structure, the best rheological and mechanical properties, as well as the highest swelling ratio. Overall, these findings provide new reference for the preparation of W/W emulsion gels based on associative phase separation without adding any extra stabilizers.
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Gels
·
2025
·Vol. 11
·期 9
·732
·
IF 5.3
Peng Ding,Yanfang Sun,Guohua Jiang,Lei Nie
Immunoregulation is an emerging treatment strategy to promote wound healing by modulating the local immune system at the wound site. In this study, an extracellular matrix biomimetic and polysaccharide-based hydrogel was engineered to regulate the wound immune environment through Michael-type addition between maleimidyl pullulan and chitosan modified with hydroxyproline. The proposed hydrogel exhibited favorable injectable and self-healing properties, which facilitated the full coverage of irregularly shaped wounds. A natural polyphenol, epigallocatechin-3-gallate (EGCG), was incorporated into hydrogels, which thereby exhibited excellent biocompatibility, good reactive oxygen species (ROS) scavenging ability, anti-inflammatory activity, and antibacterial properties against S. aureus and E. coli . Furthermore, evaluations of a full-thickness skin defect mice model showed that the hydrogel with EGCG effectively alleviated the inflammatory response by reducing pro-inflammatory cellular infiltration and down-regulating the inflammatory cytokine TNF-α, while up-regulating anti-inflammatory cytokine IL-10. Notably, a faster wound healing rate was also achieved by the better promotion effect of the hydrogel on increasing the formation of re-epithelialization, granulation tissue generation, collagen deposition, and angiogenesis. Therefore, our immunoregulatory strategy showed great potential in the design of biomaterials for wound management.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Saber A.S. Ahmed,Hongyan Zhai,Soon-Thiam Khu
Haloacetic acids (HAAs) constitute a critical concern in drinking water safety due to their high toxicity, persistence, and potential carcinogenicity. The activated carbon-chitosan (CS/CAC) was synthesized and used to eliminate HAAs from drinking water, including monobromoacetic acid (MBAA), bromochloroacetic acid (BCAA), dichloroacetic acid (DCAA), and dibromoacetic acid (DBAA). CS/CAC was described using FTIR, BET, SEM, and XRD techniques. The effects of adsorption time, CS/CAC dosage, pH, initial concentration, temperature, and coexisting anions of HAA adsorption on CS/CAC by batch adsorption mode were studied. Compared with coconut shell activated carbon (CAC), the removal efficiency of MBAA, DCAA, BCAA, and DBAA on CS/CAC was increased by 28 %, 37 %, 35 %, and 49 %, respectively. The adsorption of HAA by CS/CAC was consistent with the Langmuir isotherm (R 2 = 0.985–0.992) and pseudo-second-order kinetic models (R² = 0.991–0.998), indicating a monolayer adsorption mechanism involving both physisorption and chemisorption. Thermodynamic parameters confirmed the spontaneity and endothermic nature of the process. For column experiments, increasing the empty bed contact time (EBCT) enhanced HAA removal performance, achieving up to 94 %, 74 %, 78 %, and 94 % for MBAA, DCAA, BCAA, and DBAA, respectively (EBCT 15 min). The CS/CAC composite exhibited strong reusability after four adsorption/desorption cycles. These findings highlight CS/CAC as a promising adsorbent for HAA removal in water systems.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Miaomiao Zhao,Zezhou Zhang,Liying Wang,Xuan Xu,You Li,Ao Liu,Degang Ma,Chunfeng Song
Stable, treatment-resistant Cu complexes in practical wastewater are frequently neglected. Positively charged lysozyme amyloid fibrils (AF), however, exhibit unexplored potential for their adsorption. This study engineered an amyloid fibril-chitosan composite (AF-CS) xerogel and evaluated its adsorption performance in three systems: free Cu 2+ , Cu-Citrate binary, and Cu-EDTA binary. The characterization confirmed successful synthesis of AF-CS, revealing a porous and amine-rich structure with a more positive surface charge than that of pure AF xerogel. Systematic evaluation demonstrated adsorption capacities of 65.37 mg/g (free Cu 2+ ), 166.14 mg/g (Cu-Citrate), and 40.31 mg/g (Cu-EDTA). MINTEQ 3.0 speciation analysis identified anionic Cu-ligand complexes as dominant species in binary systems. Further investigation revealed synergistic adsorption mechanisms in the Cu-Citrate system: electrostatic attraction coupled with decomplexation-complexation pathways liberated citrate ligands, enabling electrostatic shielding and adsorption bridging that enhanced Cu coordination. Conversely, the high stability of Cu-EDTA chelates limited adsorption primarily to mechanisms involving electrostatic attraction, resulting in suboptimal performance. These findings advance the theoretical understanding of AF-CS interactions with diverse Cu species, demonstrating AF-CS as a promising material for Cu recovery from complex wastewater and providing guidance for designing novel remediation materials.
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TALANTA
·
2025
·
IF 6.1
Haiyun Deng,Weipeng Yu,Zhuqiao Fan,Jinfang Xue,Yanhua Gu,Xiaoqing Tang,Xiaomian Zhou,Nan Yu
Enzyme-linked immunosorbent assay (ELISA) is widely employed. Enhancing the surface of ELISA plate wells to increase the number of immobilized antibody molecules per unit area represents a viable strategy for improving the assay's detection sensitivity. Chitosan is particularly suitable for biomolecule attachment due to its porous structure and high density of amine groups. We aimed to enhance ELISA performance by applying a chitosan hydrogel layer onto polystyrene (PS) surfaces. The primary challenge was the instability of the hydrogel membrane formed on the PS surface, which was susceptible to detachment and cracking. To address this, a standardized three-step protocol was developed for the immobilization of chitosan hydrogel onto PS wells, comprising O 2 plasma pretreatment, vacuum drying for 3 h to enhance membrane adhesion, and glutaraldehyde-based chemical activation. The modified PS microplates exhibited stability for at least 1 year. The chitosan hydrogel membrane-based ELISA for alpha-fetoprotein (AFP) detection (AFP-CHM-ELISA) demonstrated excellent linearity (R 2 = 0.9992), with a limit of detection (LOD) of 1.98 ng/mL—comparable to the 1.00 ng/mL LOD of chemiluminescence—achieving a sensitivity approximately 2.5 times higher than that of conventional ELISA (5 ng/mL), and an extended upper linear range of 280 ng/mL. Intra- and inter-batch coefficients of variation were below 6 %, with spiked serum recovery rates ranging from 99.67 % to 103.48 %. Comparative analysis revealed a 95.54 % agreement with commercial chemiluminescence methods, along with a strong correlation (R 2 = 0.9236). This chitosan hydrogel-based surface modification approach significantly improves ELISA performance and demonstrates promising potential for diagnostic applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qiuyun Shao,Yue Zheng,Zixuan Qin,Kaihui Nan,Ravin Narain,Yangjun Chen
Open wounds not only cause bleeding but also increase the risk of bacterial contamination, which can lead to infection and inflammation. Therefore, it is imperative to develop wound dressings that integrate both antibacterial and hemostatic functionalities. Herein, we report a natural polysaccharide-based cationic hydrogel (QFCG) via the phenylboronic ester reaction between QCS-FPBA and cationic guar gum (CGG). Owing to the superior reversibility of phenylboronic ester bonds, this hydrogel demonstrated remarkable self-healing, adaptive, and injectable properties. Moreover, through both electrostatic interactions and phenylboronic ester chemistry on the bacterial surface, the antibiotic-free cationic hydrogel efficiently aggregated a substantial number of bacteria, leading to their effective inactivation. In vitro blood coagulation study demonstrated that the positively charged QFCG hydrogel could significantly enhance blood cell aggregation via electrostatic adsorption. Further in vivo results demonstrated that the QFCG hydrogel can rapidly achieve hemostasis in a liver hemorrhage model, highlighting its significant potential for wound healing applications. Therefore, the QFCG hydrogel represents a new effective wound dressing, and our study may provide valuable insights for the rational design of polysaccharide-based hydrogels for wound healing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hui Li,Hai-Jing Zhong,Jie Liu,Bingyao Wang,Xu Yang,Changpeng Wang,Yuandong Zhang,Xiaoxu Liang,Hongyao Ding,Xiaodong Shen
Conductive hydrogels have revolutionized wearable electronics due to their biocompatibility and tunable properties. However, it remains a great challenge for hydrogel-based sensors to maintain both conductivity and mechanical integrity in harsh environments. Synergistic dynamic interactions provide a promising strategy to address this issue. Herein, we report a tough and conductive organohydrogel that can be readily prepared by immersing a dried polyacrylamide/carboxymethyl chitosan matrix in an ethylene glycol/water mixture containing tannic acid and calcium chloride. Multiple dynamic hydrogen bonds and metal coordination interactions were formed within the organohydrogel network, synergistically reinforcing the structure and leading to a tensile strength of 2.69 MPa, a breaking strain of 1292 %, and a toughness of 14.21 MJ/m 3 . Incorporating calcium chloride and ethylene glycol into the gel system imparted multifunctionality, such as high conductivity (1.16 S/m), strong anti-freezing capability, and long-term water retention. Benefiting from their low modulus and high conductivity, the organohydrogels were well-suited for flexible strain sensors. The resulting sensors exhibited high sensitivity with a gauge factor of 1.92, a wide sensing range, and good linearity, thereby enabling precise monitoring of diverse human motions. These results demonstrate the great potential of the organohydrogels in the field of flexible electronic devices even under extreme environments.
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ChemistrySelect
·
2025
·Vol. 10
·期 35
·e01362
·
IF 2
Changshun Lv,Xiangru Feng,Boyuan Jian,Xue Jiang,Tianhui Liu,Leijiao Li,Qingshuang Wang
One of the main challenges in wound healing is bacterial infection, and the emergence of antibiotic resistant superbugs in recent years has exacerbated these concerns. In this study, we developed a chitosan/tannic acid/poloxamer 407/poloxamer 188 thermo-sensitive hydrogel (CTPP). The bioactive compound α-Mangostin (α-M) extracted from mangosteen fruit was incorporated into CTPP (CTPP@α-M). The results indicate that CTPP@α-M can slowly and continuously release α-M within 11.5 h. In addition, CTPP@α-M effectively inhibits bacterial proliferation, accelerates collagen deposition, reduces inflammatory response, and promotes rapid wound healing in the presence of wound infection. The biosafety experiment showed that the hydrogel had excellent biocompatibility. Overall, these findings suggest that CTPP@α-M has the potential to become a potential treatment for repairing infectious wounds. Graphical In this study, CTPP hydrogel and CTPP @ α - M drug carrying hydrogel were prepared by physical crosslinking method. CTPP shows excellent performance and can be converted to semi-solid gel at 37 ° C. CTPP @ α - M showed strong inhibitory effects on MRSA and accelerated wound healing, reducing the expression of pro-inflammatory cytokines. The data show that CTPP @ α - M is a highly effective antibacterial thermosensitive hydrogel with excellent performance.
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