DALTON TRANSACTIONS
·
2018
·Vol. 47
·期 36
·12759-12768
·
IF 4.099
Kun Qian,Xuguang Lv,Sheng Chen,Hang Luo,Dou Zhang
Dielectric polymer-based nanocomposites have attracted significant attention in recent years for energy storage applications because of their potential high permittivity and breakdown strength. The coupling effect of a nanofiller/matrix interface plays a crucial role in the dielectric and electric properties of polymer-based nanocomposites. In this paper, three kinds of side-chain liquid crystalline fluoric-polymers, denoted as P-nF (n = 3, 5 or 7, which is the number of terminal fluoric groups), were grafted on the surface of BaTiO3 nanoparticles by a surface-initiated reversible-addition–fragmentation chain transfer polymerization method. The nanocomposite films were prepared via core–shell BaTiO3 nanoparticles dispersed in a poly(vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) P(VDF-TrFE-CTFE) polymer matrix. The frequency dependent dielectric properties and energy storage capability of the polymer nanocomposites were studied. The results showed that the permittivity and energy densities of the polymer nanocomposites depended on the molecular structure of the modifier, especially the number of electron-rich fluoric groups. Firstly, all modified BaTiO3 nanoparticles were homogeneously dispersed in the polymer matrix, resulting in the polymer nanocomposites presenting a higher breakdown strength compared with the unmodified BaTiO3 nanoparticles. Secondly, the changes in the nanocomposites’ permittivity exhibited diversity for three modifiers due to many influential factors. Thirdly, compared with neat P(VDF-TrFE-CTFE), the discharge energy densities of the polymer nanocomposites are all significantly improved. The highest discharge energy densities of nanocomposites with 5 vol% P-3F@BT reached 14.5 J cm−3. These findings suggest that the optimal interfacial modifier should be carefully decided by combining various properties of the nanocomposites for energy storage.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Longhai Jin,Jianhua Liu,Ying Tang,Lanqing Cao,Tianqi Zhang,Qinghai Yuan,Yinghui Wang,Hongjie Zhang
Construction of stimuli-responsive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we constructed a novel theranostic agent with Co–P nanocomposites as core, mesoporous silica as shell, and manganese dioxide (MnO2) nanosheets as gatekeeper, which have been employed for pH-activatable T1/T2 dual-modality magnetic resonance imaging (MRI)-guided chemotherapeutical and photothermal combination anticancer therapy in vitro and in vivo. Co–P core-enabled theranostic platform could be applied for both photothermal therapy and T2-weighted MRI in the normal circulation owing to its strong near-infrared absorbance and intrinsic magnetic properties. In the acidic environment of tumors, MnO2 cap could be dissolved into Mn2+ ions to not only realize pH-responsive on-demand drug release but also activate T1-weighted MRI contrast enhancement. Such T1/T2 dual-mode MR imaging provides further comprehensive details and accurate information for tumor diagnosis, and the on-demand chemo-photothermal synergetic therapy greatly improved the therapeutic effectiveness and effectively mitigated side effects. These findings demonstrate that Co–P@mSiO2@DOX–MnO2 are promising as pH-responsive theranostic agents for tumor diagnosis and treatment, and stimulate interest in exploration of novel stimuli-responsive theranostic nanoagents which posssess good potential for clinical application in the future.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shaojie Zhang,Renjie Gao,Baocong Ding,Junhao Li,Tanggan Wang,Jiaheng Chen,Chong Li,Yukun Jiao,Lijun Song
Combining selenium nanoparticles (SeNPs) with bioactive polysaccharides is one of the effective ways to overcome the shortcomings of SeNPs and polysaccharide and obtain novel antitumor drug candidates. In this study, a heteropolysaccharide (MTP70) with moderate antihepatoma activity was isolated from the stems of Marsdenia tenacissima (Roxb.) Wight et Arn. To further improve the antihepatoma activity of MTP70 and the application of SeNPs, a novel stable nanoparticle (MTP-SeNP) was designed and fabricated. MTP-SeNPs (Se content of 8.25 %) were characterized as monodisperse spherical nanoparticles (50 nm) with MTP70 wrapped on the surface of the SeNPs by the formation of C O⋯Se bonds and possessed high stability and good dispersion in water for almost a month. In addition, MTP-SeNPs showed higher inhibitory effect compared with MTP70. MTP-SeNPs could effectively inhibit the proliferation, invasion, and metastasis of HePG2 cells by inducing apoptosis and arresting the cell cycle at the S phase, which were closely related to the activation of the Bax/Bcl-2/Caspases and p-21/Akt/Cyclin A2 signaling pathways. Our results provide a theoretical basis for further development and application of M. tenacissima polysaccharide, and show that MTP-SeNPs could be explored as a promising anti-hepatoma agent in the pharmaceutical and biomedical industries.
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2024
·
IF 4.3
Yinlong Qiao,Qingguo Tang,Yuanhang Han,Xinhui Duan,Jinsheng Liang,Jian-Feng Sun
Water electrolysis is considered to be one of the most promising approaches for developing sustainable energy technologies, however, the high cost and lack of stability of traditional precious metal electrocatalysts have hindered the development of the field of water electrolysis. Covalent organic polymers have greater potential for the preparation of low-cost electrocatalysts with high efficiency and long-term stability due to their low cost, controllable chemical composition, and rich pore structure. Cobalt phthalocyanine-based covalent organic polymers were loaded onto few-layer graphene by a hydrothermal method and then pyrolyzed to produce Co, N, and P co-doped few-layer graphene (Co–N/P-FG-700). Co–N/P-FG-700 demonstrates superior performance for oxygen evolution reaction (OER) due to the synergistic effect of abundant active sites and conductive carriers, with an overpotential of 358 mV at a current density of 10 mA cm −2 and 90% of the current density after 50,000 s of stability testing. Co–N/P-FG-700 exhibits excellent results for hydrogen evolution reaction (HER) with an overpotential of −275 mV at a current density of −10 mA cm −2 and a current density retention of 93% after a 50,000 s stability test. This study provides a rational pathway for the design of low-cost, high-performance, stable bifunctional OER/HER electrocatalysts.
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Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 26
·13610-13624
·
IF 8.867
Qiang Shi,Lei Ni,Yufeng Zhang,Xianshe Feng,Qiuhui Chang,Jianqiang Meng
A new approach to improving the compaction resistance and polyamide skin layer adhesion onto the substrate in thin film composite (TFC) membranes was developed. It was based on in situ polymerization of p-phenylene terephthamide (PPTA) in a polysulfone (PSf) solution prior to membrane casting via the phase inversion process, thereby forming a PPTA-embedded PSf substrate. The TFC membrane was prepared by interfacial polymerization on such (PPTA/PSf) substrates. The crystal structure of the PPTA polymerized in the PSf/NMP solution was investigated by XRD and TEM. The immobilization of PPTA in the PSf substrate was confirmed by FTIR and XPS. The surface properties of the PPTA/PSf substrates were characterized by FESEM, AFM and WCA measurements. Incorporating PPTA into the substrates resulted in more open porous structures and a thinner dense layer, as well as a rougher and more hydrophilic surface. Both the compaction resistance of the TFC membrane and the polyamide skin layer adhesion onto the substrates were improved by the presence of PPTA. The TFC membranes exhibited a typical nanofiltration performance with salt rejections in the order of Na2SO4 > MgSO4 > MgCl2 > NaCl.
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DRUG DELIVERY
·
2016
·
IF 4.843
Jiang Ni,Fengchun Tian,Fatima Zohra Dahmani,Hui Yang,Deren Yue,Shuwang He,Jianping Zhou,Jing Yao
The low oral bioavailability of numerous drugs has been mostly attributed to the significant effect of P-gp-mediated efflux on intestinal drug transport. Herein, we developed mixed polymeric micelles (MPMs) comprised of curcumin-carboxymethyl chitosan (CNC) conjugate, as a potential inhibitor of P-gp-mediated efflux and gastrointestinal absorption enhancer, and low-molecular-weight heparin-all-trans-retinoid acid (LHR) conjugate, as loading material, with the aim to improve the oral absorption of P-gp substrate drugs. CNC conjugate was synthesized by chemical bonding of curcumin (Cur) and carboxymethyl chitosan (CMCS) taking advantage of the inhibition of intestinal P-gp-mediated secretion by Cur and the intestinal absorption enhancement by CMCS. The chemical structure of CNC conjugate was characterized by 1H NMR with a degree of substitution of Cur of 4.52–10.20%. More importantly, CNC conjugate markedly improved the stability of Cur in physiological pH. Cyclosporine A-loaded CNC/LHR MPMs (CsA-CNC/LHR MPMs) were prepared by dialysis method, with high drug loading 25.45% and nanoscaled particle size (∼200 nm). In situ single-pass perfusion studies in rats showed that both CsA + CNC mixture and CsA-CNC/LHR MPMs achieved significantly higher Ka and Peff than CsA suspension in the duodenum and jejunum segments (p < 0.01), which was comparable to verapamil coperfusion effect. Similarly, CsA + CNC mixture and CsA-CNC/LHR MPMs significantly increased the oral bioavailability of CsA as compared to CsA suspension. These results suggest that CNC conjugate might be considered as a promising gastrointestinal absorption enhancer, while CNC/LHR MPMs had the potential to improve the oral absorption of P-gp substrate drugs.
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Nanoscale
·
2016
·Vol. 8
·期 6
·3711-3719
·
IF 7.76
Wei Chen,Tian-Yu Liu,Ting Huang,Xiao-Heng Liu,Xu-Jie Yang
In this report, we rationally designed and fabricated P-C3N4/ZnIn2S4 nanocomposites by in situ immobilizing ZnIn2S4 nanosheets onto the surface of mesoporous P-doped graphite carbon nitrogen (P-C3N4) nanosheets in a mixed solvothermal environment; their application to the photoreduction of 4-nitroaniline was used to estimate the photocatalytic performance. Different to the template route, here the mesoporous P-C3N4 nanosheets were prepared with a template-free strategy. The as-fabricated P-C3N4/ZnIn2S4 nanocomposites were systematically characterized by analyzing the phase structure, chemical components, electronic and optical properties and separation of charge carrier pairs. More importantly, these P-C3N4/ZnIn2S4 heterostructures have been proven to be highly efficient visible light responsive photocatalysts for photo-reduction, and meanwhile exhibit excellent photo-stability during recycling runs. The sufficient evidence reveals that the significantly improved photocatalytic performance is mainly attributed to the more efficient charge carrier separation based on the construction of a close heterogeneous interface. This work may provide new insights into the utilization of P-C3N4/ZnIn2S4 nanocomposites as visible light driven photocatalysts for comprehensive organic transformations in the field of fine chemical engineering.
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RSC Advances
·
2017
·Vol. 7
·期 5
·2650-2657
·
IF 3.108
Zhike Wang,Cunling Ye,Lingyun Chen,Haili Wu
Adsorptive removals of naphthols are often interfered by some coexisting anions of aqueous solutions. In this work, 1-vinyl-3-octadecylimidazolium cations and p-styrenesulphonate anions were chemically co-modified on silica (denoted as Sil-PImC18-SS) via the click chemistry reaction and were characterized. This material was created with the aim to explore the feasibility of removal of 1-naphthol (1-NAP) and 2-naphthol (2-NAP) from aqueous solutions. The prepared Sil-PImC18-SS was used as an adsorbent to remove 1-NAP and 2-NAP from aqueous solutions and the effects of various variables for the adsorption of 1-NAP and 2-NAP were systematically studied. Among the coexisting anions tested, 0.2 mol L−1 background NaCl or Na2SO4 aqueous solutions had no significant effect on the adsorption of 1-NAP and 2-NAP. The adsorption behaviors of 1-NAP and 2-NAP were well described by the pseudo-second order kinetic and the Dubinin–Radushkevich models with the maximum adsorption capacities of 84.4 mg g−1 and 71.9 mg g−1 for 1-naphthol and 2-naphthol, respectively. The adsorption was a spontaneous and exothermic process, and an adsorption mechanism was speculated to be the cooperative contributions from the hydrophobic interaction, hydrogen bonding interaction, and π–π stacking. Thus, Sil-PImC18-SS can be potentially used as an effective adsorption material for naphthol pollutant removal from the water environment.
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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
·
2014
·Vol. 372
·期 2013
·
IF 2.864
Fei Jiao,Chong-an Di,Yimeng Sun,Peng Sheng,Wei Xu,Daoben Zhu
In this article, we put forward a simple method for the synthesis of thermoelectric (TE) composite materials. Both n- and p-type composites were obtained by ball-milling the insoluble and infusible metal coordination polymers with other polymer solutions. The particle size, film morphology and composition were characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy and energy-dispersive X-ray spectroscopy. The TE properties of the drop-cast composite film were measured at different temperatures. An inkjet-printed flexible device was fabricated and the output voltage and short-circuit current at various hot-side temperatures (Thot) and temperature gradients (ΔT) were tested. The composite material not only highly maintained the TE properties of the pristine material but also greatly improved its processability. This method can be extended to other insoluble and infusible TE materials for solution-processed flexible TE devices.
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Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 32
·5187-5194
·
IF 0
Dian Li,Yuting Zhang,Sha Jin,Jia Guo,Haifeng Gao,Changchun Wang
Intelligent nanomaterials that are able to respond to environmental stimuli for sequential release of multiple payloads are highly desirable in applications of drug delivery systems. In this study, a core/shell-structured nanocarrier with an acid-dissolvable magnetic supraparticle (MSP) as core and a redox-degradable poly(methylacrylic acid-co-N,N-bis(acryloyl)cystamine) (P(MAA-Cy)) as shell was prepared using the distillation-precipitation polymerization technique, in which the magnetic core and the polymer shell were loaded with different guest molecules. Under physiological conditions similar to the cytoplasm of tumour cells, this MSP@P(MAA-Cy) microsphere showed a sequential degradation profile of the shell and the core. With dyes of fluorescein isothiocyanate (FITC) loaded in the core and rhodamine in the shell, the produced MSP-FITC@P(MAA-Cy)-Rho microspheres were applied in HeLa cell and HEK 293T cell cultures, showing selective degradation of the microspheres in HeLa cells to release the rhodamine and FITC dyes in sequence. When two anticancer drugs, i.e., paclitaxel (TXL) and doxorubicin (DOX), were loaded separately into the core and the shell domains of the microspheres, the experimental results showed that the MSP-TXL@P(MAA-Cy)-DOX nanodrug exhibited better inhibitive efficacy than the free drugs under the same dosing level, demonstrating the great potential of this stimuli-sensitive drug delivery system for programmed and stimuli-responsive drug release characteristics.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Shenjie Li,Tianyong Zha,Qiang Wang,Chengyu Wang,Yujiao Ren,Yanyan Chen,Daocheng Pan
We present a facile route for the fabrication of P-type Cu x S transparent and conducting thin films (TCTFs) using copper (I) oxide and butyl-dithiocarbamic acid as precursors by pulling method on glass. The as-deposited highly conductive crystalline Cu x S films showed high carrier concentration (∼3.11 × 10 22 cm −3 ), low electrical resistivity (∼1.02 × 10 −4 Ω cm) and conclusive p-type conduction. X-ray diffraction studies showed high crystallinity, and the optical transmission spectra in UV–vis–NIR region of such films were recorded, indicating that the transparency was over 75% with a band gap of 1.52 eV. The room-temperature sheet resistance increased from 9.9 to 302.4 Ω sq −1 with increasing baking temperature. The Cu x S/quantum dot bifacial thin films have been fabricated, and the experimental results indicated that luminescent, transparent, and conductive Cu x S/Cu-doped Zn y Cd 1-y S thin films have a very high potential application in thin film solar cells.
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JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Wangbing Yao,Zhuoyuan Zheng,Xudong Zhang,Jie Zhou,Jinbao Song,Dongming Liu,Yusong Zhu
In the quest for high-energy-density lithium metal batteries (LMBs), the stabilization of lithium (Li) metal anodes during fast charging remains a formidable challenge. In this study, a novel copolymer , Poly(methyl methacrylate- co -styrene) (namely PMS) is synthesized and blended with Poly(vinylidene fluoride) to fabricate a porous gel polymer electrolyte (GPE, namely PMS-PVDF) through the nonsolvent-induced phase separation technique, which significantly enhances the electrochemical stability and fast-charging capabilities of LMBs. The developed GPE exhibits a high ionic conductivity of 5.62 mS cm −1 , thereby reducing the formation of detrimental Li dendrites and leading to over 400 h stripping/plating process at 0.5 mA cm −2 . Extensive electrochemical tests show that the LMBs with the obtained PMS-PVDF GPE achieve exceptional cycle stability over 600 and 1000 cycles at the C-rates of 0.5 and 3 C, respectively, outperforming traditional electrolytes. Furthermore, the ultra-stability of the quasi-solid-state electrolyte is demonstrated in a 375 mAh pouch cell setup, suggesting an essential trait for the practical application of high-power devices. This work marks a pivotal contribution to the field of energy storage, delivering insights and a clear methodology that pave the way for the development of next-generation LMBs poised for commercial viability.
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