JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 26
·2039
·
IF 3.2
Wang Yue,Wang Xin,Chen Zhiwu,Lu Zhenya
BiFeO 3 –BaTiO 3 (BF–BT)-based piezoelectric ceramics have attracted significant attention due to their high Curie temperature ( T C ) and high residual polarization ( P r ), making them a highly promising lead-free piezoelectric ceramic system. However, their poor piezoelectric performance severely limits their practical applications. In this study, using the solid-state reaction method, we systematically investigated the addition of Sr(Zr 0.5 Ti 0.5 )O 3 (SZT) on the crystal structure, microstructure, dielectric, ferroelectric, and piezoelectric properties of (0.7− x )BiFeO 3 –0.3BaTiO 3− x Sr(Zr 0.5 Ti 0.5 )O 3 ( x = 0–0.008) ceramics. The results indicate that the introduction of SZT effectively suppresses the formation of Bi 25 FeO 40 , improves sintering density, and promotes grain growth (the average grain size reaches 4.82 μm at x = 0.006). More importantly, SZT doping caused Sr 2+ to further enhance the eccentric displacement of A-site ions; this localized structural distortion, in synergy with the transition of Bi 3+ from a disordered to an ordered arrangement under an external electric field, significantly improved the piezoelectric properties of the ceramics. At the same time, doping effectively suppressed changes in the valence state of Fe 3+ , thereby reducing leakage current. When x = 0.006, the material exhibited optimal overall electrical properties: The piezoelectric constant d 33 reached ~ 197 pC/N, and the electromechanical coupling coefficient k p was 0.336, representing increases of 48 and 39%, respectively, compared to the undoped sample ( d 33 = 133 pC/N, k p = 0.241). The residual polarization intensity P r reached as high as 29.9 μC/cm 2 , the Curie temperature reached 501 °C, and the material exhibited excellent temperature stability and large piezoelectric strain (0.249% @ 40 kV/cm, inverse piezoelectric coefficient d * 33 = 622.5 pm/V). This study not only verifies the significant performance enhancement of SZT doping on BF–BT-based piezoelectric ceramics but also provides an effective strategy and experimental basis for the development of lead-free piezoelectric materials that combine high-voltage electroactivity with high thermal stability.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2015
·Vol. 19
·期 11
·3347-3353
·
IF 2.446
Pan Wanjing,Liu Xiaolin,Miao Xiaowei,Yang Jun,Wang Jiulin,Nuli Yanna,Hirano Shin-ichi
A new type of hybrid battery has been assembled with magnesium metal anode, hollow MoO 2 microsphere cathode, and dual-salt electrolyte containing Mg 2+ and Li + ions. This kind of hybrid battery not only avoids metallic dendrite formation, which occurs in rechargeable lithium battery, but also ensures high-capacity intercalation reaction in the cathode, which is still a bottleneck for rechargeable magnesium battery. It is found that the morphology of MoO 2 electrode has a great effect on its electrochemical performance. The hollow MoO 2 microsphere cathode delivers an initial discharge capacity of 217.2 mAh g −1 with the coulombic efficiency of ca. 88 %. In the following cycles, its coulombic efficiency reaches nearly 100 %. In contrast, MoO 2 solid particles with a size of 1–10 μm exhibit a capacity less than 50 mAh g −1 . Inductively coupled plasma (ICP) analysis reveals that both of Mg 2+ and Li + ions take part in the cathode intercalation reaction.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 9
·1-9
·
IF 5.479
Yue Qiaoli,Hu Yingying,Tao Lixia,Zhang Baoqian,Liu Chen,Wang Yongping,Chen Chunying,Zhao Jinsheng,Li Chen-Zhong
A fluorometric method is described for “turn-on” sensing of pH values via black phosphorus quantum dots (BPQD). Water-stable BPQD were synthesized by a liquid exfoliation method and characterized by TEM, FT-IR, XPS, and absorption and fluorescence spectra. The nanoparticles of BPQD have a uniform distribution with an average size of 5.2 nm. They exhibit bright green fluorescence, with excitation/emission maxima at 420/515 nm. The fluorescence of the BPQD is likely to arise from the quasi-molecular fluorophores of polycyclic aromatic compounds carrying P-P, P-O-P, and P x O y functions on its surface. The protonation and deprotonation of hydroxyl groups of BPQD causes a different degree of quenching of the BPQD. At pH values below 4.0, protons bind to BPQD to form non-fluorescent ground state complexes. At pH values above 4.0, the hydroxyl groups become deprotonated, and this induces the recovery of fluorescence. The sensor has a linear response in the pH range of 1.0–9.0. It was successfully applied to the determination of the pH values in human urine and serum samples.
Schematic representation of the preparation of black phosphorus quantum dots (BPQDs) from powdered BP crystals using liquid-phase exfoliation in N-methyl-2-pyrrolidone solution. The BPQDs display green fluorescence at high pH values but no fluorescence at very low pH values.
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高影响因子
PARASITOLOGY RESEARCH
·
2019
·Vol. 118
·期 4
·1239-1248
·
IF 2.067
Chen Jinglong,Ma Fuli,Li Xiangrui,Zhao Ruqian,Yang Xiaojing
Haemonchus contortus is a highly pathogenic gastrointestinal nematode of small ruminant animals. In modern intensive farming, livestock often suffer from different types of stress. However, whether host stress hormones influence H. contortus infection is largely unknown. Therefore, we treated H. contortus with norepinephrine (NE) and analyzed the changes in its excretory/secretory products (ESPs). Label-free quantitative proteomic analysis was used to identify differences in body proteins and ESPs between the control and NE-treated groups. We also investigated the changes in ESP action by analyzing cytokine secretion and goat peripheral blood mononuclear cell (PBMC) proliferation after incubation with ESPs secreted by NE-treated H. contortus . Thirty-two proteins in the body samples and 137 in the ESPs were differentially expressed between the groups. Gene ontology (GO) annotation showed that the functions of these different proteins might be involved in energy metabolism, protein metabolism, lipid metabolism, redox homeostasis, ion channel, and cell structure. NE treatment caused oxidative stress in H. contortus and changed the expression levels of some immunogenic proteins, such as the 15-kDa ESP . Meanwhile, the ESPs secreted by NE-treated H. contortus significantly decreased PBMC proliferation and the interleukin (IL)-2, IL-4, and interferon-gamma contents. Thus, NE treatment significantly affected the H. contortus body and ESP expression, and changes in the ESPs influenced PBMC function. The results reveal a relationship between host hormones and parasites and provide new clues to explain some of the variation in individual responses to infection.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-16
·
IF 14.919
Wang Yongchao,Gong Ningqiang,Ma Chi,Zhang Yuxuan,Tan Hong,Qing Guangchao,Zhang Jimei,Wang Yufei,Wang Jinjin,Chen Shizhu,Li Xianlei,Ni Qiankun,Yuan Yuan,Gan Yaling,Chen Junge,Li Fangzhou,Zhang Jinchao,Ou Caiwen,Zhao Yongxiang,Liu Xiaoxuan,Liang Xing-Jie
Immunological adjuvants are essential for successful cancer vaccination. However, traditional adjuvants have some limitations, such as lack of controllability and induction of systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), which is composed of a hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation with near-infrared light, the LIA not only induces tumour cell lysis and tumour antigen release, but also promotes the structural transformation of 2-nitroimidazole containing dendrimer to 2-aminoimidazole containing dendrimer which can activate dendritic cells via the Toll-like receptor 7-mediated signaling pathway. The LIA efficiently inhibits both primary and abscopal tumour growth and induces strong antigen-specific immune memory effect to prevent tumour metastasis and recurrence in vivo. Furthermore, LIA localizes the immunological adjuvant effect at the tumour site. We demonstrate this light-activable immunological adjuvant offers a safe and potent platform for in situ cancer vaccination.
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Chinese Medicine
·
2021
·Vol. 16
·期 1
·1-14
·
IF 5.455
Yu Yunru,Chen Jing,Zhang Xiaohui,Wang Yingchao,Wang Shufang,Zhao Lu,Wang Yi
Background Inflammatory bowel diseases (IBD) are chronic relapsing intestinal inflammations with increasing global incidence, and new drug development remains in urgent demand for IBD management. To identify effective traditional Chinese medicine (TCM) formulae and compounds in IBD treatment, we innovatively combined the techniques of knowledge mining, high-content screening and high-resolution mass spectrometry, to conduct a systematic screening in Zhongjing formulae, which is a large collection of TCM prescriptions with most abundant clinical evidences. Methods Using Word2vec-based text learning, the correlations between 248 Zhongjing formulae and IBD typical symptoms were analyzed. Next, from the top three formulae with predicted relationship with IBD, TCM fractions were prepared and screened on a transgenic zebrafish IBD model for their therapeutic effects. Subsequently, the chemical compositions of the fraction hits were analyzed by mass spectrometry, and the major compounds were further studied for their anti-IBD effects and potential mechanisms. Results Through knowledge mining, Peach Blossom Decoction, Pulsatilla Decoction, and Gegen Qinlian Decoction were predicted to be the three Zhongjing formulae mostly related to symptoms typical of IBD. Seventy-four fractions were prepared from the three formulae and screened in TNBS-induced zebrafish IBD model by high-content analysis, with the inhibition on the intestinal neutrophil accumulation and ROS level quantified as the screening criteria. Six herbal fractions showed significant effects on both pathological processes, which were subsequently analyzed by mass spectrometry to determine their chemical composition. Based on the major compounds identified by mass spectrometry, a second-round screen was conducted and six compounds (palmatine, daidzin, oroxyloside, chlorogenic acid, baicalin, aesculin) showed strong inhibitory effects on the intestinal inflammation phenotypes. The expression of multiple inflammatory factors, including il1β , clcx8a , mmp and tnfα , were increased in TNBS-treated fish, which were variously inhibited by the compounds, with aesculin showing the most potent effects. Moreover, aesculin and daidzin also upregulated e-cadherin’s expression. Conclusion Taken together, we demonstrated the regulatory effects of several TCM formulae and their active compounds in the treatment of IBD, through a highly efficient research strategy, which can be applied in the discovery of effective TCM formulae and components in other diseases. Graphic abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2019
·Vol. 17
·期 1
·1-15
·
IF 5.345
Qiang Lei,Cai Zheng,Jiang Wenjun,Liu Jiyong,Tai Zongguang,Li Guorui,Gong Chunai,Gao Shen,Gao Yuan
Background Macrophages with tumor-tropic migratory properties can serve as a cellular carrier to enhance the efficacy of anti neoplastic agents. However, limited drug loading (DL) and insufficient drug release at the tumor site remain the main obstacles in developing macrophage-based delivery systems. In this study, we constructed a biomimetic delivery system (BDS) by loading doxorubicin (DOX)-loaded reduced graphene oxide (rGO) into a mouse macrophage-like cell line (RAW264.7), hoping that the newly constructed BDS could perfectly combine the tumor-tropic ability of macrophages and the photothermal property of rGO. Results At the same DOX concentration, the macrophages could absorb more DOX/PEG-BPEI-rGO than free DOX. The tumor-tropic capacity of RAW264.7 cells towards RM-1 mouse prostate cancer cells did not undergo significant change after drug loading in vitro and in vivo. PEG-BPEI-rGO encapsulated in the macrophages could effectively convert the absorbed near-infrared light into heat energy, causing rapid release of DOX. The BDS showed excellent anti-tumor efficacy in vivo. Conclusions The BDS that we developed in this study had the following characteristic features: active targeting of tumor cells, stimuli-release triggered by near-infrared laser (NIR), and effective combination of chemotherapy and photothermotherapy. Using the photothermal effect produced by PEG-BPEI-rGO and DOX released from the macrophages upon NIR irradiation, MAs-DOX/PEG-BPEI-rGO exhibited a significant inhibitory effect on tumor growth.
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高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-8
·
IF 11.878
Li Huili,Lv Tian,Sun Huanhuan,Qian Guiju,Li Ning,Yao Yao,Chen Tao
Due to inherently poor healable and stretchable features, the most explored polyvinyl alcohol-based gel electrolytes cannot well meet the requirements of stretchable, healable and multifunctional supercapacitors. Here, we report a hydrogel of a copolymer cross-linked by double linkers of Laponite (synthetic hectorite-type clay) and graphene oxide. The resultant hydrogel shows high mechanical stretchability, excellent ionic conductivity, and superior healable performance. Along with designing wrinkled-structure electrodes, supercapacitors fabricated by using this hydrogel as a gel electrolyte not only exhibit ultrahigh mechanical stretchability of 1000%, but also achieve repeated healable performance under treatments of both infrared light irradiation and heating. More significantly, a broken/healed supercapacitor also possesses an ultrahigh stretchability up to 900% with slight performance decay. This hydrogel electrolyte could be easily functionalized by introducing other functional components, and extended for use in other portable and wearable energy related devices with multifunction.
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高影响因子
Journal of Pharmaceutical Innovation
·
2021
·Vol. 17
·期 4
·1109-1115
·
IF 2.75
Wang Wenhua,Yang Beibei,Huang Zhengwei,Huang Ying,Hu Ping,Pan Xin,Wu Chuanbin
Solid lipid nanoparticles (SLN) have been intensively exploited as nanocarriers for pulmonary drug delivery. However, no consensus on the underlying mechanisms between particle sizes and cell uptake behaviors was attained owing to their unclear in vivo fate after inhalation, which hindered the further development of a novel nanoparticle delivery system. Recently, aggregation-caused quenching (ACQ) probes had been developed to monitor the integrity of nanocarriers. In this study, an ACQ probe, P4, was employed to clarify the effect of particle size on SLN cellular uptake. SLN (120, 240, and 480 nm in size), incubated with epithelium cells (A549) and macrophages (RAW 264.7), mainly localized in the cytoplasm in an integrated pattern, showing a positive correlation relationship between particle size and cellular intake. In conclusion, this study established a firm basis to understand the effect of particle size on cellular uptake of nanoparticle systems and promoted the development of novel pulmonary drug delivery systems.
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高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Li Zhiwei,Xu Yinghong,Wu Langyuan,Cui Jiaxin,Dou Hui,Zhang Xiaogang
Flexible power supply devices provide possibilities for wearable electronics in the Internet of Things. However, unsatisfying capacity or lifetime of typical batteries or capacitors seriously limit their practical applications. Different from conventional heat-to-electricity generators, zinc ion thermal charging cells has been a competitive candidate for the self-power supply solution, but the lack of promising cathode materials has restricted the achievement of promising performances. Herein, we propose an attractive cathode material by rational heterostructure engineering of hydrated vanadium pentoxide. Owing to the integration of thermodiffusion and thermoextraction effects, the thermopower is significantly improved from 7.8 ± 2.6 mV K −1 to 23.4 ± 1.5 mV K −1 . Moreover, an impressive normalized power density of 1.9 mW m −2 K −2 is achieved in the quasi-solid-state cells. In addition, a wearable power supply constructed by three units can drive the commercial health monitoring system by harvesting body heat. This work demonstrates the effectiveness of electrodes design for wearable thermoelectric applications.
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高影响因子
JOURNAL OF SOILS AND SEDIMENTS
·
2017
·Vol. 17
·期 8
·2202-2213
·
IF 2.522
Ou Taosha,Guan Mengyun,Mai Yongrui,Deng Peiyan,Xiao Yutang,Deng Dayi
Purpose Surface sediments contaminated with high levels of multiple heavy metal(loid) species are very common environmental problems. Especially, the labile and bioaccessible fractions of heavy metal(loid)s in the sediments are posing serious risks to the biota and the overlaying water quality. This study aimed at developing a potential method to manage the activity of the labile fractions of heavy metal(loid)s in surface sediments. Materials and methods This study assessed the feasibility of adding iron powder, a low-cost industrial by-product, to sediments containing high levels of Pb, As, and Cd to adsorb labile fractions of heavy metal(loid)s onto the sorbent surfaces and to retrieve the heavy metal(loid) laden powders by applying external magnetic field. In addition, the redistribution of Pb, Cd, and As in different sediment fractions, the dissolved fraction and the sorbent-adsorbed fraction, was also investigated and characterized. Results and discussion The results indicate that the bioactive labile fractions (exchangeable and carbonate-bound fractions) of heavy metal(loid)s are prone to concentrating onto iron powders and can be selectively removed from the sediments by magnetic retrieval. In addition, iron addition induces conversion of labile fractions of heavy metal(loid)s into more stabilized fractions. Conclusions Overall, the process can effectively minimize the activity of labile fractions of heavy metal(loid)s in surface sediments.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Wang Chu-Ya,Zhou Heng-Deng,Wang Qi,Xu Bo-Xing,Zhu Guangcan
Phosphate removal is complicated by the need for resource recovery. Biochar shows promise for efficient phosphate adsorption, but it must be modified to enhance its adsorption capacity. In this work, magnesium (Mg)-loaded biochar was synthesized through a two-step dipping and calcination process, and the MgBC600 product was used to adsorb phosphate from simulated water and biogas slurry wastewater. The phosphate adsorption capacity of Mg-loaded biochar was 109.35 mg/g, which was 12 times higher than that of unmodified biochar. The R 2 of the Langmuir and pseudo-second-order kinetic models were 0.988 and 0.990, respectively, which fitted the phosphate adsorption process of MgBC600. Phosphate adsorption by MgBC600 was a spontaneous and endothermic process. The adsorption mechanism study showed that phosphate adsorption was controlled by the formation and electrostatic attraction of MgHPO 4 . In addition, 98% of chemically adsorbed phosphate was released after regeneration. Using phosphate-adsorbed MgBC600 as a soil amendment, Arabidopsis thaliana was 1.47 times higher than that in the biochar-only group, demonstrating that this is a promising strategy for enhancing phosphate adsorption efficiency and adsorbent recycling.
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高影响因子
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