JOURNAL OF ELECTRONIC MATERIALS
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2026
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IF 2.8
Yue Lei,Wan Yu,Wang Yanting,Feng Changhao
Effective detection of n -butanol is essential for human health and environmental protection. Bismuth ferrite is a gas-sensitive material candidate with excellent potential, and rare earth element doping is an effective modification strategy to enhance the gas-sensitive performances of gas sensors. In this work, a series of Y-doped BiFeO 3 nanofibers (BFO, 1% Y-BFO, 3% Y-BFO, and 5% Y-BFO) were prepared by electrospinning. Among them, the gas sensors based on 3% Y-BFO nanofibers exhibited significantly enhanced gas-sensing performances for n -butanol. At an optimum operating temperature of 150°C, the synthesized 3% Y-BFO sensor has a response of 60.2 and a response/recovery time of 9/47 s for 100 ppm n -butanol. In addition, it has a lower limit of detection as low as 0.5 ppm and excellent repeatability. Therefore, gas sensors based on Y-doped BiFeO 3 nanofibers represent a promising solution for the efficient detection of n -butanol.
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Scientific Reports
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2026
·
IF 4.9
Wang Xiang,Luo Kai,Bai He,Zhang Xudong,Qu Jialin,Wang Xiaoqing,Sun Xu,Zhao Yuting,Wang Bin,Zhang Guixin
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive liver malignancy with rising global incidence and poor prognosis. Despite recent advances in treatment strategies, effective therapeutic options for ICC remain limited. Solamargine (SM), a natural steroidal alkaloid, has demonstrated anticancer activity, yet its mechanisms in ICC are not fully understood. This study shows that SM inhibits ICC progression by inducing both apoptosis and ferroptosis in vitro and in vivo. SM significantly suppressed proliferation, migration, and invasion of ICC cells (HUCCT-1 and HCCC-9810), with minimal cytotoxicity toward normal biliary epithelial cells (HIBEC). Mechanistically, SM induced mitochondrial dysfunction, ROS accumulation, and lipid peroxidation, leading to apoptosis and ferroptosis. Transcriptome sequencing and gene set enrichment analysis (GSEA) revealed that SM treatment activated apoptosis- and ferroptosis-related pathways, including MAPK signaling. Western blot analysis and pharmacological inhibition assays confirmed that p38 MAPK activation was essential for SM-induced cell death, with ROS acting as an upstream activator. In vivo, SM significantly inhibited tumor growth in both orthotopic and subcutaneous ICC mouse models and showed better tolerability than gemcitabine. Tumor tissue analysis further confirmed increased markers of apoptosis and ferroptosis, along with p38 MAPK activation. These findings suggest that SM exerts dual antitumor effects in ICC, which are associated with the induction of apoptosis and ferroptosis and may involve the ROS/p38 MAPK signaling axis, highlighting its potential as a therapeutic candidate for ICC.
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Nature Biomedical Engineering
·
2026
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IF 26.3
Lai Keren,He Peiyi,He Yuejian,Xu Mingheng,Zhao Xiaoxi,Wang Xinyue,Miao Guifeng,Feng Yanqiu,Wang Xiaorui
Nanomedicines are susceptible to immunogenic clearance before reaching their disease targets, thereby limiting their pharmacodynamic efficacy. To overcome this challenge, PEGylation has been developed and widely used. However, in therapies that necessitate multiple repeated administrations, the immunogenicity of PEGylated nanoparticles often becomes non-negligible, resulting in an accelerated blood clearance (ABC) effect and declining therapeutic efficacy. Here we propose a simple and clinically applicable strategy of pre-intervention with FDA-approved intravenous immunoglobulin (IVIG) before injection of nanoparticles. Pretreatment with IVIG was found to regulate the organism’s immunologic macroenvironment and transiently block the mononuclear phagocyte system, thereby circumventing the anti-PEG antibody-mediated clearance of nanomedicines. The universal applicability of the IVIG pretreatment strategy is demonstrated by its consistent reversal of the ABC effect across five structurally diverse nanomaterials, with sizes of 10–120 nm. IVIG significantly enhances therapeutic efficiency in breast tumours, particularly in large tumours (~350 mm 3 ), with up to a 3.9-fold improvement. Overall, pre-intervention with IVIG opens a new paradigm for addressing the immunogenic clearance issue and enhancing the performance of nanomedicines.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 14
·791
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IF 3.5
Yu Lian,Lu Jiarui,Yu Meng,Duan Yajing,Zhang Baofeng,Zhang Xuan,Wang Xiaoyue,Liang Cunzhen
Cu(I) doped Fe 3 O 4 nanoparticles was loaded onto graphene oxide, Cu-Fe 3 O 4 /GO with binary active sites and accelerated Fe(III)/Fe(II) cycle showed higher tetracycline hydrochloride oxidation efficiency than Fe 3 O 4 and Cu-Fe 3 O 4 , the influences of initial H 2 O 2 concentration, reaction pH, catalyst dosage, reaction temperature and radical scavengers on catalytic performance of Cu-Fe 3 O 4 /GO were investigated. The heterogeneous Fenton reaction over Cu-Fe 3 O 4 /GO surface contained Fe(III)/Fe(II) and Cu(II)/Cu(I) active sites, Fe species were the dominant active centers. Cu-Fe 3 O 4 nanoparticles and GO combined via C–O–Fe bond and formed a stable Cu-Fe 3 O 4 /GO conductive structure, which promoted electrons transfer between Cu-Fe 3 O 4 and H 2 O 2 , thus accelerating Fe(III)/Fe(II) and Cu(II)/Cu(I) cycles. GO significantly improved specific surface area, Cu-Fe 3 O 4 nanoparticles dispersibility, and adsorption performance of catalyst. Furthermore, the strong interaction between GO and Cu-Fe 3 O 4 prevented ions from leach, GO captured the soluble Fe(III) which was efficiently reduced to Fe(II) surf by surrounding H 2 O 2 and Cu(I) surf . The degradation efficiency maintained 80.7% after six cycles, the excellent stability can be ascribed to the strong interaction between Cu-Fe 3 O 4 and GO. Reactive oxygen species scavenging results indicated that surface-bound • OH surf played a dominating role, followed by aqueous • OH aq and superoxide radicals (O 2 •− ).
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Advanced Fiber Materials
·
2026
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IF 22.6
Liu Haoran,Sun Jiahui,Dong Jiancheng,Zhu Haijun,Peng Yidong,Gu Yanqing,Huang Yunpeng,Liu Tianxi
Excessive exudate accumulation and chronic inflammation are major barriers to diabetic wound repair, leading to infection risk and impaired tissue regeneration. Conventional dressings lack elasticity and intimate skin conformability, often adhering to fragile tissue and causing secondary trauma. Herein, we developed an ultra-conformable Janus dressing composed of a gentamicin sulfate (GS)-loaded styrene–ethylene–butylene–styrene (SEBS) immune-modulating layer and a PEO–PPO–PEO triblock copolymer (F127)/curcumin (Cur)-loaded thermoplastic polyurethane (TPU) pH-visualizing layer. The asymmetric design integrates differences in surface wettability and fiber porosity between the two layers and enables unidirectional and anti-gravity transport of wound exudate from the SEBS/GS side to the TPU/F127/Cur side, effectively preventing fluid reflux and reducing infection risk. The soft and elastic polymeric matrix ensures intimate wound conformity and mechanical protection, while facilitating angiogenesis and collagen deposition. Furthermore, the pH-responsive dressing not only absorbs inflammatory exudates, but also provides visual, dynamic monitoring of the healing process through pH-dependent color changes. In vitro assays and histological analyses demonstrated that GS-mediated immunomodulation via inflammation suppression and microenvironment improvement markedly accelerated wound closure in diabetic models within 12 days. This multifunctional dressing offers a promising pathway toward next-generation, intelligent, and patient-friendly therapies for chronic diabetic wounds. Graphical
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Gao Haonan,Wen Mingzhen,Li Jiali,Hou Shili,Li Lifen,Liu Guangyan
This work develops an in situ electrodeposition strategy to construct a honeycomb-like Ni/Co-MOF/MXene heterojunction directly on the glassy carbon electrode (GCE) surface at −1.3 V vs. Ag/AgCl, enabling ultrasensitive enzymatic electrochemical detection of trace urea. The high catalytic activity of Ni/Co-MOF and the superior conductivity of MXene were synergistically integrated in a 3D hierarchical heterostructure. Compared with traditional modification methods, this strategy significantly enhances the kinetics of electron transfer and the stability of urease immobilization. Characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS), the heterojunction exhibits unique morphology and outstanding electroconductivity. Furthermore, the resulting Ni/Co-MOF/MXene/urease/GCE biosensor achieves a wide linear range of 1.0 × 10 –6 –1.0 × 10 –4 mol L −1 with a low detection limit of 4.9 × 10 –7 mol L −1 . The biosensor has been applied to the detection of practical samples, where the recoveries were 99.3–102.8% with a relative standard deviation (RSD) of 2.9–3.3%, which indicates that this biosensor has good practical applications and prospects for further development.
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CURRENT MICROBIOLOGY
·
2026
·Vol. 83
·期 4
·207
·
IF 2.8
Lu Xie-Feng,Gao Peng,Zhang Shu-Yi,Xu Yuan-Jia,Liu Guo-Hong,Chen Man,Zhou Shun-Gui
Two Gram-stain positive, motile, aerobic, yellowish rod-shaped bacterial strains sgz301303 and sgz301304 T were isolated from the paddy soils. The 16S rRNA gene phylogenetic analysis revealed that both strains belong to the genus Sphingobium , and exhibited the highest sequence similarity (98.3%) with reference strain Sphingobium amiense JCM 11777 T . The draft genome of sgz301304 T has a size of 4.3 Mbp, with DNA G + C content of 64.5%. Whole-genome relatedness analyses showed that the average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strain sgz301304 T and S. amiense JCM 11777 T were 82.3% and 25.7%, respectively, both below the accepted species delineation thresholds. The main quinone was Q-10, and the main fatty acids included C 14:0 2-OH (11.3%), and Summed Features 8 (46.6%). Phylogenetic, genomic and phenotypic analyses suggest that strain sgz301304 T belongs to a novel species within the genus of Sphingobium . Therefore, it is recommended to be named as Sphingobium agrisoil sp. nov. The type strain is sgz301304 T (= MCCC 1K09180 T = JCM 37704 T ), respectively.
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Nature Communications
·
2026
·
IF 18.1
Bing-Liang Leng,Xiu Lin,Hou-Yan Dong,Qi-Yuan Li,Shi-Nan Zhang,Jie-Sheng Chen,Xin-Hao Li
Recent studies on the electrocatalytic oxygen transfer from water to organic compounds have gained significant attention due to their sustainability and selectivity. However, the direct coactivation of inert hydrocarbons and water typically requires high oxidation potentials, leading to oxygen evolution reactions and low Faradaic efficiencies. Herein, a Ni-activated tungsten-oxygen covalency anode is designed for the efficient oxygen transfer from water to benzylic C(sp 3 )–H bonds via a Ni-regulated interfacial water structure between the anode and electrolyte. Both experimental and theoretical results reveal the critical role of W–O covalency sites with Ni-heteroatoms for boosting efficient oxygen transfer via breaking the dense interfacial hydrogen bond network and inhibiting the undesired oxygen evolution reactions, facilitating the coactivation of oxygen species and C(sp 3 )–H bonds. Thus, a Faradaic efficiency of > 56% in a water-involved system has been achieved. This work provides important insight into designing electrocatalytic systems for inert C–H oxidation. The direct coactivation of inert hydrocarbons and water typically requires high oxidation potentials. Here, the authors report that a Ni-activated tungsten-oxygen covalency anode is designed to steer the oxygen transfer from water to benzylic C(sp 3 )–H bonds via Ni-regulated interfacial water structure.
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Chinese Medicine
·
2026
·
IF 7.4
Qing Zhang,Ziyun Chen,Qingyong Yu,Hanwen Wang,Yucui Jiang,Lan Zhou,Guang Yu,Zongxiang Tang,Changming Wang
Background Cancer-induced bone pain (CIBP) remains a debilitating clinical challenge due to its complex pathogenesis and limited therapeutic options. Tetrahydropalmatine (THP), an active alkaloid from Corydalis tuber , has shown analgesic potential, but its specific mechanisms in mitigating CIBP- especially its interactions with neural factors and immune cells-remain incompletely understood. This study aimed to investigate the efficacy of THP in alleviating CIBP and clarify its underlying mechanisms, with a focus on the roles of transient receptor potential vanilloid 1 (TRPV1), substance P (SP), and macrophage dynamics in a mouse model of CIBP. Methods Using a multidisciplinary approach, we established a CIBP model in male C57BL/6 mice (and TRPV1-knockout mice) via intramedullary injection of lung cancer cells. Behavioral assessments were performed to evaluate mechanical, thermal, and cold allodynia, as well as spontaneous pain, following daily oral administration of THP (80 mg/kg) from day 7 post-modeling. Molecular and cellular analyses included immunofluorescence staining, real-time PCR, ELISA (to quantify SP, cytokines, and Tac1 expression), calcium imaging (to measure TRPV1-mediated calcium influx in DRG neurons), scratch assays (to assess macrophage migration), and flow cytometry (to analyze macrophage polarization in RAW 264.7 cells). Results THP significantly alleviated CIBP-related allodynia and spontaneous pain in mice. Mechanistically, THP directly inhibited TRPV1 function in the primary phase (≤ 14 days post-modeling) (with an IC 50 of 77.9 µM), reducing SP release from DRG neurons and suppressing macrophage recruitment to DRG and sciatic nerve via the TRPV1-SP pathway. Importantly, THP directly promoted the polarization of recruited macrophages toward the anti-inflammatory M2 phenotype, as evidenced by downregulated iNOS, TNF-α, IL-1β and upregulated CD206, IL-4, IL-10 in vitro (RAW264.7 cells) and in vivo. These effects were abrogated in TRPV1-knockout mice, confirming TRPV1 as a critical mediator in the primary phase. Conclusion In conclusion, THP mitigates CIBP through a dual mechanism: regulating macrophage recruitment via the TRPV1-SP pathway in the early stage to inhibit CIBP initiation and directly modulating the migrated macrophage polarization. This study provides novel insights into THP’s analgesic mechanisms and supports its potential as a preclinical candidate for CIBP treatment. Graphical Supplementary Information The online version contains supplementary material available at 10.1186/s13020-026-01359-3.
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Nature Communications
·
2026
·
IF 18.1
Zhang Jun-Ye,Yue Kaihang,Zhao Yuqi,Li Rongyao,Li Qixuan,Hu Yanjie,Wang Wendi,Liu Lu,Li Jialong,Zhao Hao,Yan Ya,Xu Zhe,Zu Lianhai,Yang Hui,Lan Kun,Zhao Dongyuan
The development of stable Ru-based anodes for acidic proton exchange membrane water electrolysis is promising, but strictly limited by Ru over-oxidation and structural collapse due to lattice oxygen participation under high current densities. Rational design of competitive Ru-based catalyst is, thereby, highly desired. Here, by exploring a customized self-assembly route, we report a type of mesoporous Ru-Ti-O solid solution catalyst delivering competitive performance (1 A cm -2 for over 450 h at 0.4mg Ru cm -2 ). Mechanistic investigations reveal that the enhanced performance arises from the integration of atomic-scale electronic structure tuning and mesoscopic triple phase interface engineering. The electron delocalization forms a conductive network and suppresses Ru overoxidation through electron donation. Atomically dispersed Ru-O-Ti motifs favor the oxygen pathway mechanism over the lattice oxygen mechanism, suppressing lattice oxygen release and enhancing structural stability. Simultaneously, the ordered mesoporous architecture and radially aligned nanorod bundles establish a robust, super-hydrophilic triple phase interface, enabling effective water and gas exchange and mitigating concentration overpotentials. This cross-scale design strategy offers a possible route to non-Ir catalysts with measurable activity and long-term durability for scalable acidic water electrolysis.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2026
·Vol. 41
·期 3
·612-622
·
IF 1.4
Zhu Liangliang,Yi Guoqiang,Chang Ying,Wei Zhishun,Xiong Yan,Chen Sha
Using (Na) 2 TiF 6 and CO(NH 2 ) 2 as raw materials, we proposed a simple one-pot hydrothermal method for synthesizing single-phase anatase TiO 2 across a broad pH range of the precursor solution. The results showed that, irrespective of whether the precursor solution was acidic (pH=1.43, 3.43, 5.37), neutral (pH= 7.23), or alkaline (pH=9.45, 11.18, 13.15) prior to the hydrothermal reaction, the post-reaction solution pH stabilized between 8 and 9, and all resultant TiO 2 materials were identified as single-phase anatase. This finding contrasted with previous reports where phase transformations among anatase, rutile, or brookite were observed under varying pH conditions of the precursor solution. This discrepancy was attributed to the continuous decomposition of urea during the hydrothermal process, which maintained the pH of the reaction solution within a relatively stable range. Comprehensive investigations revealed that anatase TiO 2 synthesized at pH 7.23 exhibited optimal light absorption ability, enhanced charge dynamics, and a larger electrochemically active surface area. As a result, TiO 2 (pH 7.23) showcased the highest photocatalytic activity toward tetracycline (TC), achieving a degradation efficiency of 97.7%. Mechanistic studies indicated that O 2 •− was the predominant reactive species accounting for TC degradation.
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Plasmonics
·
2026
·
IF 5.6
Han Huibo,Singh Ragini,Niu Ben,Zhou Penglei,Zhang Bingyuan,Kumar Santosh
Ochratoxin A (OTA) is a potentially harmful mycotoxin that is widely found in agricultural products and animal by-products. In order to ensure our physical health, OTA testing is very important. Therefore, we chose to use an optical fiber biosensor based on the principle of local surface plasmon resonance (LSPR), and we designed an asymmetric optical fiber structure using single-mode optical fiber (SMF) to detect different concentrations of OTA. Gold nanoparticles (AuNPs) were applied to the sensing region to stimulate the LSPR effect, and then Nb 2 CTxMXene and CeO 2 -nanorods were sequentially fixed on the probe to change the dielectric environment around the sensing region to improve the performance of the sensor. The sensor has a linear range of 0.5 ng/mL to 60 ng/mL, a sensitivity of 0.0805 nm/(ng/mL), and a limit of detection (LOD) of 3.95 ng/mL. After that, we evaluated it through a series of tests, including repeatability, reproducibility, pH, stability, and selectivity. Finally, we also tested and verified the real samples. According to the experimental results, the sensor shows good performance in OTA detection, indicating that the sensor has good application potential and broad development prospects. This work designed an asymmetric optical fiber biosensor based on LSPR, achieving a broad detection range and a low LOD for OTA detection by coating with AuNPs, Nb 2 CTxMXene, and CeO 2 -nanorods. Its reliability and vast prospects in practical applications were validated through repeatability, stability, and real sample testing.
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